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Gene: MAN2A1 |
Gene summary for MAN2A1 |
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Gene information | Species | Human | Gene symbol | MAN2A1 | Gene ID | 4124 |
Gene name | mannosidase alpha class 2A member 1 | |
Gene Alias | AMan II | |
Cytomap | 5q21.3 | |
Gene Type | protein-coding | GO ID | GO:0001654 | UniProtAcc | Q16706 |
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Malignant transformation analysis |
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Entrez ID | Symbol | Replicates | Species | Organ | Tissue | Adj P-value | Log2FC | Malignancy |
4124 | MAN2A1 | CCI_2 | Human | Cervix | CC | 3.14e-07 | 7.64e-01 | 0.5249 |
4124 | MAN2A1 | CCI_3 | Human | Cervix | CC | 1.57e-06 | 5.86e-01 | 0.516 |
4124 | MAN2A1 | HTA11_3410_2000001011 | Human | Colorectum | AD | 4.79e-18 | -6.25e-01 | 0.0155 |
4124 | MAN2A1 | HTA11_3361_2000001011 | Human | Colorectum | AD | 3.67e-03 | -5.15e-01 | -0.1207 |
4124 | MAN2A1 | HTA11_696_2000001011 | Human | Colorectum | AD | 1.06e-04 | -3.50e-01 | -0.1464 |
4124 | MAN2A1 | HTA11_866_2000001011 | Human | Colorectum | AD | 1.40e-07 | -4.05e-01 | -0.1001 |
4124 | MAN2A1 | HTA11_1391_2000001011 | Human | Colorectum | AD | 1.03e-06 | -4.60e-01 | -0.059 |
4124 | MAN2A1 | HTA11_866_3004761011 | Human | Colorectum | AD | 4.03e-10 | -5.51e-01 | 0.096 |
4124 | MAN2A1 | HTA11_8622_2000001021 | Human | Colorectum | SER | 2.02e-03 | -6.56e-01 | 0.0528 |
4124 | MAN2A1 | HTA11_10711_2000001011 | Human | Colorectum | AD | 6.42e-04 | -4.79e-01 | 0.0338 |
4124 | MAN2A1 | HTA11_7696_3000711011 | Human | Colorectum | AD | 7.80e-19 | -5.04e-01 | 0.0674 |
4124 | MAN2A1 | HTA11_11156_2000001011 | Human | Colorectum | AD | 4.56e-02 | -7.28e-01 | 0.0397 |
4124 | MAN2A1 | HTA11_99999974143_84620 | Human | Colorectum | MSS | 2.28e-12 | -4.35e-01 | 0.3005 |
4124 | MAN2A1 | F007 | Human | Colorectum | FAP | 9.49e-03 | -3.16e-01 | 0.1176 |
4124 | MAN2A1 | A001-C-207 | Human | Colorectum | FAP | 3.90e-02 | -1.59e-01 | 0.1278 |
4124 | MAN2A1 | A015-C-203 | Human | Colorectum | FAP | 8.91e-24 | -3.71e-01 | -0.1294 |
4124 | MAN2A1 | A015-C-204 | Human | Colorectum | FAP | 7.91e-05 | -2.54e-01 | -0.0228 |
4124 | MAN2A1 | A014-C-040 | Human | Colorectum | FAP | 2.69e-04 | -4.96e-01 | -0.1184 |
4124 | MAN2A1 | A002-C-201 | Human | Colorectum | FAP | 5.23e-16 | -4.65e-01 | 0.0324 |
4124 | MAN2A1 | A002-C-203 | Human | Colorectum | FAP | 8.55e-07 | -1.95e-01 | 0.2786 |
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∗log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage. |
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Malignant transformation related pathway analysis |
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Tissue | Disease Stage | Enriched GO biological Processes |
Colorectum | AD | ![]() |
Colorectum | SER | ![]() |
Colorectum | MSS | ![]() |
Colorectum | MSI-H | ![]() |
Colorectum | FAP | ![]() |
∗Top 15 enriched GO BP terms are showed in the bar plot of each disease state in each tissue. Each row represents a significant GO biological process which is colored according to the -log10(p.adjust). |
Page: 1 2 3 4 5 6 7 8 9 |
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GO ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | Count |
GO:003032321 | Thyroid | ATC | respiratory tube development | 93/6293 | 181/18723 | 5.67e-07 | 8.02e-06 | 93 |
GO:003032421 | Thyroid | ATC | lung development | 90/6293 | 177/18723 | 1.53e-06 | 1.88e-05 | 90 |
GO:005196014 | Thyroid | ATC | regulation of nervous system development | 195/6293 | 443/18723 | 2.62e-06 | 3.06e-05 | 195 |
GO:006054121 | Thyroid | ATC | respiratory system development | 100/6293 | 203/18723 | 2.66e-06 | 3.08e-05 | 100 |
GO:005196221 | Thyroid | ATC | positive regulation of nervous system development | 126/6293 | 272/18723 | 8.17e-06 | 8.27e-05 | 126 |
GO:001931814 | Thyroid | ATC | hexose metabolic process | 111/6293 | 237/18723 | 1.51e-05 | 1.41e-04 | 111 |
GO:000599615 | Thyroid | ATC | monosaccharide metabolic process | 118/6293 | 257/18723 | 2.56e-05 | 2.20e-04 | 118 |
GO:001908213 | Thyroid | ATC | viral protein processing | 18/6293 | 29/18723 | 1.58e-03 | 7.98e-03 | 18 |
GO:000648612 | Thyroid | ATC | protein glycosylation | 94/6293 | 226/18723 | 7.11e-03 | 2.82e-02 | 94 |
GO:004341312 | Thyroid | ATC | macromolecule glycosylation | 94/6293 | 226/18723 | 7.11e-03 | 2.82e-02 | 94 |
GO:000910011 | Thyroid | ATC | glycoprotein metabolic process | 153/6293 | 387/18723 | 7.90e-03 | 3.06e-02 | 153 |
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Pathway ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | qvalue | Count |
hsa00510 | Colorectum | AD | N-Glycan biosynthesis | 21/2092 | 53/8465 | 1.15e-02 | 4.24e-02 | 2.71e-02 | 21 |
hsa005101 | Colorectum | AD | N-Glycan biosynthesis | 21/2092 | 53/8465 | 1.15e-02 | 4.24e-02 | 2.71e-02 | 21 |
hsa0051023 | Esophagus | ESCC | N-Glycan biosynthesis | 39/4205 | 53/8465 | 3.26e-04 | 1.15e-03 | 5.89e-04 | 39 |
hsa005136 | Esophagus | ESCC | Various types of N-glycan biosynthesis | 31/4205 | 42/8465 | 1.23e-03 | 3.78e-03 | 1.93e-03 | 31 |
hsa0051033 | Esophagus | ESCC | N-Glycan biosynthesis | 39/4205 | 53/8465 | 3.26e-04 | 1.15e-03 | 5.89e-04 | 39 |
hsa0051313 | Esophagus | ESCC | Various types of N-glycan biosynthesis | 31/4205 | 42/8465 | 1.23e-03 | 3.78e-03 | 1.93e-03 | 31 |
hsa005104 | Liver | Cirrhotic | N-Glycan biosynthesis | 32/2530 | 53/8465 | 3.82e-06 | 4.10e-05 | 2.53e-05 | 32 |
hsa005134 | Liver | Cirrhotic | Various types of N-glycan biosynthesis | 26/2530 | 42/8465 | 1.65e-05 | 1.41e-04 | 8.69e-05 | 26 |
hsa0051011 | Liver | Cirrhotic | N-Glycan biosynthesis | 32/2530 | 53/8465 | 3.82e-06 | 4.10e-05 | 2.53e-05 | 32 |
hsa0051311 | Liver | Cirrhotic | Various types of N-glycan biosynthesis | 26/2530 | 42/8465 | 1.65e-05 | 1.41e-04 | 8.69e-05 | 26 |
hsa0051021 | Liver | HCC | N-Glycan biosynthesis | 40/4020 | 53/8465 | 2.95e-05 | 1.87e-04 | 1.04e-04 | 40 |
hsa005132 | Liver | HCC | Various types of N-glycan biosynthesis | 30/4020 | 42/8465 | 1.41e-03 | 5.07e-03 | 2.82e-03 | 30 |
hsa0051031 | Liver | HCC | N-Glycan biosynthesis | 40/4020 | 53/8465 | 2.95e-05 | 1.87e-04 | 1.04e-04 | 40 |
hsa005133 | Liver | HCC | Various types of N-glycan biosynthesis | 30/4020 | 42/8465 | 1.41e-03 | 5.07e-03 | 2.82e-03 | 30 |
hsa005105 | Oral cavity | OSCC | N-Glycan biosynthesis | 39/3704 | 53/8465 | 9.77e-06 | 4.36e-05 | 2.22e-05 | 39 |
hsa005135 | Oral cavity | OSCC | Various types of N-glycan biosynthesis | 29/3704 | 42/8465 | 8.03e-04 | 2.32e-03 | 1.18e-03 | 29 |
hsa0051012 | Oral cavity | OSCC | N-Glycan biosynthesis | 39/3704 | 53/8465 | 9.77e-06 | 4.36e-05 | 2.22e-05 | 39 |
hsa0051312 | Oral cavity | OSCC | Various types of N-glycan biosynthesis | 29/3704 | 42/8465 | 8.03e-04 | 2.32e-03 | 1.18e-03 | 29 |
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Cell-cell communication analysis |
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Ligand | Receptor | LRpair | Pathway | Tissue | Disease Stage |
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Single-cell gene regulatory network inference analysis |
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TF | Cell Type | Tissue | Disease Stage | Target Gene | RSS | Regulon Activity |
∗The dot plots of a searched regulon are shown for all cell subpopulations in each disease state of each tissue based on the regulon specific score inferred using pySCENIC and by calculating the average expression. |
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Somatic mutation of malignant transformation related genes |
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Hugo Symbol | Variant Class | Variant Classification | dbSNP RS | HGVSc | HGVSp | HGVSp Short | SWISSPROT | BIOTYPE | SIFT | PolyPhen | Tumor Sample Barcode | Tissue | Histology | Sex | Age | Stage | Therapy Types | Drugs | Outcome |
MAN2A1 | SNV | Missense_Mutation | novel | c.1679N>A | p.Arg560Lys | p.R560K | Q16706 | protein_coding | deleterious(0.01) | probably_damaging(0.997) | TCGA-5L-AAT1-01 | Breast | breast invasive carcinoma | Female | <65 | III/IV | Hormone Therapy | letrozol | SD |
MAN2A1 | SNV | Missense_Mutation | novel | c.2344N>C | p.Glu782Gln | p.E782Q | Q16706 | protein_coding | tolerated(0.26) | benign(0.026) | TCGA-5L-AAT1-01 | Breast | breast invasive carcinoma | Female | <65 | III/IV | Hormone Therapy | letrozol | SD |
MAN2A1 | SNV | Missense_Mutation | rs748133805 | c.2626N>T | p.Arg876Cys | p.R876C | Q16706 | protein_coding | tolerated(0.06) | possibly_damaging(0.901) | TCGA-A8-A09G-01 | Breast | breast invasive carcinoma | Female | >=65 | III/IV | Unknown | Unknown | SD |
MAN2A1 | SNV | Missense_Mutation | c.599N>C | p.Val200Ala | p.V200A | Q16706 | protein_coding | deleterious(0.05) | possibly_damaging(0.838) | TCGA-A8-A09Z-01 | Breast | breast invasive carcinoma | Female | >=65 | I/II | Unknown | Unknown | SD | |
MAN2A1 | SNV | Missense_Mutation | c.3373N>G | p.Asn1125Asp | p.N1125D | Q16706 | protein_coding | deleterious(0.05) | possibly_damaging(0.627) | TCGA-AR-A0TP-01 | Breast | breast invasive carcinoma | Female | <65 | I/II | Chemotherapy | doxorubicin | SD | |
MAN2A1 | SNV | Missense_Mutation | rs758664411 | c.3191N>G | p.Asn1064Ser | p.N1064S | Q16706 | protein_coding | tolerated(0.35) | benign(0.012) | TCGA-AR-A0TU-01 | Breast | breast invasive carcinoma | Female | <65 | I/II | Unspecific | Doxorubicin | SD |
MAN2A1 | SNV | Missense_Mutation | novel | c.2626N>A | p.Arg876Ser | p.R876S | Q16706 | protein_coding | deleterious(0.03) | possibly_damaging(0.548) | TCGA-BH-A0BM-01 | Breast | breast invasive carcinoma | Female | <65 | I/II | Chemotherapy | adriamycin | SD |
MAN2A1 | SNV | Missense_Mutation | c.3393N>C | p.Leu1131Phe | p.L1131F | Q16706 | protein_coding | deleterious(0) | possibly_damaging(0.795) | TCGA-C8-A26Y-01 | Breast | breast invasive carcinoma | Female | >=65 | I/II | Unknown | Unknown | SD | |
MAN2A1 | SNV | Missense_Mutation | c.746N>T | p.Gly249Val | p.G249V | Q16706 | protein_coding | deleterious(0) | probably_damaging(0.999) | TCGA-D8-A140-01 | Breast | breast invasive carcinoma | Female | <65 | I/II | Chemotherapy | doxorubicin+cyclophosphamid | SD | |
MAN2A1 | SNV | Missense_Mutation | c.1255C>T | p.Leu419Phe | p.L419F | Q16706 | protein_coding | deleterious(0) | probably_damaging(0.976) | TCGA-C5-A3HE-01 | Cervix | cervical & endocervical cancer | Female | <65 | I/II | Unknown | Unknown | PD |
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Related drugs of malignant transformation related genes |
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(DGIdb 4.0) |
Entrez ID | Symbol | Category | Interaction Types | Drug Claim Name | Drug Name | PMIDs |
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