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Gene: IGF2R |
Gene summary for IGF2R |
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Gene information | Species | Human | Gene symbol | IGF2R | Gene ID | 3482 |
Gene name | insulin like growth factor 2 receptor | |
Gene Alias | CD222 | |
Cytomap | 6q25.3 | |
Gene Type | protein-coding | GO ID | GO:0000003 | UniProtAcc | P11717 |
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Malignant transformation analysis |
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Entrez ID | Symbol | Replicates | Species | Organ | Tissue | Adj P-value | Log2FC | Malignancy |
3482 | IGF2R | HTA11_2487_2000001011 | Human | Colorectum | SER | 1.53e-19 | 1.30e+00 | -0.1808 |
3482 | IGF2R | HTA11_2951_2000001011 | Human | Colorectum | AD | 2.55e-25 | 1.66e+00 | 0.0216 |
3482 | IGF2R | HTA11_1938_2000001011 | Human | Colorectum | AD | 2.73e-18 | 1.02e+00 | -0.0811 |
3482 | IGF2R | HTA11_78_2000001011 | Human | Colorectum | AD | 3.22e-07 | 5.96e-01 | -0.1088 |
3482 | IGF2R | HTA11_347_2000001011 | Human | Colorectum | AD | 1.30e-27 | 9.29e-01 | -0.1954 |
3482 | IGF2R | HTA11_411_2000001011 | Human | Colorectum | SER | 9.60e-07 | 1.00e+00 | -0.2602 |
3482 | IGF2R | HTA11_2112_2000001011 | Human | Colorectum | SER | 3.53e-04 | 8.33e-01 | -0.2196 |
3482 | IGF2R | HTA11_3361_2000001011 | Human | Colorectum | AD | 6.34e-50 | 2.23e+00 | -0.1207 |
3482 | IGF2R | HTA11_83_2000001011 | Human | Colorectum | SER | 1.33e-11 | 8.41e-01 | -0.1526 |
3482 | IGF2R | HTA11_696_2000001011 | Human | Colorectum | AD | 2.18e-26 | 1.08e+00 | -0.1464 |
3482 | IGF2R | HTA11_866_2000001011 | Human | Colorectum | AD | 1.27e-42 | 1.11e+00 | -0.1001 |
3482 | IGF2R | HTA11_1391_2000001011 | Human | Colorectum | AD | 3.08e-24 | 1.17e+00 | -0.059 |
3482 | IGF2R | HTA11_546_2000001011 | Human | Colorectum | AD | 3.55e-06 | 7.34e-01 | -0.0842 |
3482 | IGF2R | HTA11_8622_2000001021 | Human | Colorectum | SER | 4.41e-36 | 1.94e+00 | 0.0528 |
3482 | IGF2R | HTA11_7663_2000001011 | Human | Colorectum | SER | 1.46e-06 | 9.21e-01 | 0.0131 |
3482 | IGF2R | HTA11_6818_2000001011 | Human | Colorectum | AD | 6.20e-24 | 1.31e+00 | 0.0112 |
3482 | IGF2R | HTA11_6818_2000001021 | Human | Colorectum | AD | 2.32e-14 | 9.11e-01 | 0.0588 |
3482 | IGF2R | HTA11_99999970781_79442 | Human | Colorectum | MSS | 7.44e-03 | 5.04e-01 | 0.294 |
3482 | IGF2R | HTA11_99999965062_69753 | Human | Colorectum | MSI-H | 8.50e-19 | 1.93e+00 | 0.3487 |
3482 | IGF2R | HTA11_99999965104_69814 | Human | Colorectum | MSS | 1.23e-02 | 5.33e-01 | 0.281 |
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∗log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage. |
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Malignant transformation related pathway analysis |
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Tissue | Disease Stage | Enriched GO biological Processes |
Colorectum | AD | ![]() |
Colorectum | SER | ![]() |
Colorectum | MSS | ![]() |
Colorectum | MSI-H | ![]() |
Colorectum | FAP | ![]() |
∗Top 15 enriched GO BP terms are showed in the bar plot of each disease state in each tissue. Each row represents a significant GO biological process which is colored according to the -log10(p.adjust). |
Page: 1 2 3 4 5 6 7 8 9 |
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GO ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | Count |
GO:0016032113 | Thyroid | PTC | viral process | 236/5968 | 415/18723 | 2.48e-26 | 8.24e-24 | 236 |
GO:0044403113 | Thyroid | PTC | biological process involved in symbiotic interaction | 151/5968 | 290/18723 | 5.83e-13 | 2.85e-11 | 151 |
GO:0007034110 | Thyroid | PTC | vacuolar transport | 90/5968 | 157/18723 | 3.74e-11 | 1.35e-09 | 90 |
GO:0048732113 | Thyroid | PTC | gland development | 193/5968 | 436/18723 | 2.88e-08 | 6.42e-07 | 193 |
GO:005181716 | Thyroid | PTC | modulation of process of other organism involved in symbiotic interaction | 50/5968 | 81/18723 | 3.03e-08 | 6.73e-07 | 50 |
GO:0001889112 | Thyroid | PTC | liver development | 79/5968 | 147/18723 | 3.08e-08 | 6.82e-07 | 79 |
GO:0061008112 | Thyroid | PTC | hepaticobiliary system development | 80/5968 | 150/18723 | 3.94e-08 | 8.55e-07 | 80 |
GO:000704115 | Thyroid | PTC | lysosomal transport | 63/5968 | 114/18723 | 1.97e-07 | 3.54e-06 | 63 |
GO:000979114 | Thyroid | PTC | post-embryonic development | 48/5968 | 80/18723 | 1.99e-07 | 3.56e-06 | 48 |
GO:005185117 | Thyroid | PTC | modulation by host of symbiont process | 37/5968 | 60/18723 | 1.93e-06 | 2.64e-05 | 37 |
GO:0006898110 | Thyroid | PTC | receptor-mediated endocytosis | 112/5968 | 244/18723 | 2.87e-06 | 3.74e-05 | 112 |
GO:003582117 | Thyroid | PTC | modulation of process of other organism | 53/5968 | 106/18723 | 7.63e-05 | 6.54e-04 | 53 |
GO:004479417 | Thyroid | PTC | positive regulation by host of viral process | 11/5968 | 13/18723 | 1.34e-04 | 1.05e-03 | 11 |
GO:003110017 | Thyroid | PTC | animal organ regeneration | 37/5968 | 76/18723 | 1.64e-03 | 9.02e-03 | 37 |
GO:005170218 | Thyroid | PTC | biological process involved in interaction with symbiont | 44/5968 | 94/18723 | 1.72e-03 | 9.44e-03 | 44 |
GO:0031099110 | Thyroid | PTC | regeneration | 82/5968 | 198/18723 | 2.83e-03 | 1.40e-02 | 82 |
GO:004478817 | Thyroid | PTC | modulation by host of viral process | 17/5968 | 30/18723 | 4.31e-03 | 2.04e-02 | 17 |
GO:00480095 | Thyroid | PTC | insulin-like growth factor receptor signaling pathway | 19/5968 | 37/18723 | 1.07e-02 | 4.29e-02 | 19 |
GO:001603234 | Thyroid | ATC | viral process | 241/6293 | 415/18723 | 5.50e-25 | 2.04e-22 | 241 |
GO:004440334 | Thyroid | ATC | biological process involved in symbiotic interaction | 153/6293 | 290/18723 | 1.12e-11 | 4.12e-10 | 153 |
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Pathway ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | qvalue | Count |
hsa04144 | Colorectum | AD | Endocytosis | 111/2092 | 251/8465 | 5.95e-12 | 1.42e-10 | 9.08e-11 | 111 |
hsa041441 | Colorectum | AD | Endocytosis | 111/2092 | 251/8465 | 5.95e-12 | 1.42e-10 | 9.08e-11 | 111 |
hsa041442 | Colorectum | SER | Endocytosis | 81/1580 | 251/8465 | 1.14e-07 | 2.36e-06 | 1.71e-06 | 81 |
hsa04142 | Colorectum | SER | Lysosome | 38/1580 | 132/8465 | 2.87e-03 | 2.03e-02 | 1.47e-02 | 38 |
hsa041443 | Colorectum | SER | Endocytosis | 81/1580 | 251/8465 | 1.14e-07 | 2.36e-06 | 1.71e-06 | 81 |
hsa041421 | Colorectum | SER | Lysosome | 38/1580 | 132/8465 | 2.87e-03 | 2.03e-02 | 1.47e-02 | 38 |
hsa041444 | Colorectum | MSS | Endocytosis | 102/1875 | 251/8465 | 1.85e-11 | 4.43e-10 | 2.71e-10 | 102 |
hsa041445 | Colorectum | MSS | Endocytosis | 102/1875 | 251/8465 | 1.85e-11 | 4.43e-10 | 2.71e-10 | 102 |
hsa041446 | Colorectum | FAP | Endocytosis | 78/1404 | 251/8465 | 6.20e-09 | 2.96e-07 | 1.80e-07 | 78 |
hsa041447 | Colorectum | FAP | Endocytosis | 78/1404 | 251/8465 | 6.20e-09 | 2.96e-07 | 1.80e-07 | 78 |
hsa041448 | Colorectum | CRC | Endocytosis | 65/1091 | 251/8465 | 1.27e-08 | 1.06e-06 | 7.19e-07 | 65 |
hsa041449 | Colorectum | CRC | Endocytosis | 65/1091 | 251/8465 | 1.27e-08 | 1.06e-06 | 7.19e-07 | 65 |
hsa0414420 | Endometrium | AEH | Endocytosis | 56/1197 | 251/8465 | 2.58e-04 | 2.15e-03 | 1.57e-03 | 56 |
hsa04144110 | Endometrium | AEH | Endocytosis | 56/1197 | 251/8465 | 2.58e-04 | 2.15e-03 | 1.57e-03 | 56 |
hsa0414424 | Endometrium | EEC | Endocytosis | 57/1237 | 251/8465 | 3.34e-04 | 2.82e-03 | 2.10e-03 | 57 |
hsa0414434 | Endometrium | EEC | Endocytosis | 57/1237 | 251/8465 | 3.34e-04 | 2.82e-03 | 2.10e-03 | 57 |
hsa04144210 | Esophagus | ESCC | Endocytosis | 186/4205 | 251/8465 | 9.74e-16 | 4.66e-14 | 2.39e-14 | 186 |
hsa0414222 | Esophagus | ESCC | Lysosome | 102/4205 | 132/8465 | 5.11e-11 | 7.13e-10 | 3.65e-10 | 102 |
hsa0414437 | Esophagus | ESCC | Endocytosis | 186/4205 | 251/8465 | 9.74e-16 | 4.66e-14 | 2.39e-14 | 186 |
hsa0414232 | Esophagus | ESCC | Lysosome | 102/4205 | 132/8465 | 5.11e-11 | 7.13e-10 | 3.65e-10 | 102 |
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Cell-cell communication analysis |
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Ligand | Receptor | LRpair | Pathway | Tissue | Disease Stage |
IGF2 | IGF2R | IGF2_IGF2R | IGF | CRC | MSS |
IGF2 | IGF2R | IGF2_IGF2R | IGF | Endometrium | Healthy |
IGF2 | IGF2R | IGF2_IGF2R | IGF | Esophagus | ESCC |
IGF2 | IGF2R | IGF2_IGF2R | IGF | HNSCC | ADJ |
IGF2 | IGF2R | IGF2_IGF2R | IGF | HNSCC | OSCC |
IGF2 | IGF2R | IGF2_IGF2R | IGF | HNSCC | Precancer |
IGF2 | IGF2R | IGF2_IGF2R | IGF | Liver | Healthy |
IGF2 | IGF2R | IGF2_IGF2R | IGF | Liver | Precancer |
IGF2 | IGF2R | IGF2_IGF2R | IGF | Lung | ADJ |
IGF2 | IGF2R | IGF2_IGF2R | IGF | Prostate | ADJ |
IGF2 | IGF2R | IGF2_IGF2R | IGF | Prostate | Tumor |
IGF2 | IGF2R | IGF2_IGF2R | IGF | Skin | cSCC |
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Single-cell gene regulatory network inference analysis |
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TF | Cell Type | Tissue | Disease Stage | Target Gene | RSS | Regulon Activity |
∗The dot plots of a searched regulon are shown for all cell subpopulations in each disease state of each tissue based on the regulon specific score inferred using pySCENIC and by calculating the average expression. |
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Somatic mutation of malignant transformation related genes |
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Hugo Symbol | Variant Class | Variant Classification | dbSNP RS | HGVSc | HGVSp | HGVSp Short | SWISSPROT | BIOTYPE | SIFT | PolyPhen | Tumor Sample Barcode | Tissue | Histology | Sex | Age | Stage | Therapy Types | Drugs | Outcome |
IGF2R | SNV | Missense_Mutation | c.6655N>T | p.Asp2219Tyr | p.D2219Y | P11717 | protein_coding | deleterious(0.01) | probably_damaging(0.993) | TCGA-A2-A25A-01 | Breast | breast invasive carcinoma | Female | <65 | I/II | Unspecific | Cytoxan | SD | |
IGF2R | SNV | Missense_Mutation | c.6210C>G | p.Asp2070Glu | p.D2070E | P11717 | protein_coding | tolerated(0.19) | benign(0.003) | TCGA-A8-A07R-01 | Breast | breast invasive carcinoma | Female | >=65 | III/IV | Ancillary | zoledronic | SD | |
IGF2R | SNV | Missense_Mutation | c.1468N>T | p.Val490Phe | p.V490F | P11717 | protein_coding | deleterious(0.04) | possibly_damaging(0.522) | TCGA-AN-A0AK-01 | Breast | breast invasive carcinoma | Female | >=65 | I/II | Unknown | Unknown | SD | |
IGF2R | SNV | Missense_Mutation | rs756307482 | c.4067N>A | p.Arg1356Gln | p.R1356Q | P11717 | protein_coding | tolerated(0.21) | possibly_damaging(0.51) | TCGA-AO-A128-01 | Breast | breast invasive carcinoma | Female | <65 | I/II | Chemotherapy | doxorubicin | SD |
IGF2R | SNV | Missense_Mutation | c.4799C>T | p.Ser1600Phe | p.S1600F | P11717 | protein_coding | deleterious(0) | possibly_damaging(0.697) | TCGA-BH-A0B0-01 | Breast | breast invasive carcinoma | Female | <65 | I/II | Chemotherapy | adriamycin | CR | |
IGF2R | SNV | Missense_Mutation | c.4868N>A | p.Arg1623Lys | p.R1623K | P11717 | protein_coding | tolerated(0.47) | benign(0.006) | TCGA-BH-A0HF-01 | Breast | breast invasive carcinoma | Female | >=65 | I/II | Hormone Therapy | arimidex | SD | |
IGF2R | SNV | Missense_Mutation | novel | c.619N>G | p.Leu207Val | p.L207V | P11717 | protein_coding | deleterious(0.01) | probably_damaging(0.92) | TCGA-BH-A2L8-01 | Breast | breast invasive carcinoma | Female | <65 | I/II | Chemotherapy | cytoxan | CR |
IGF2R | SNV | Missense_Mutation | c.3778C>T | p.Arg1260Trp | p.R1260W | P11717 | protein_coding | deleterious(0) | probably_damaging(0.995) | TCGA-E2-A574-01 | Breast | breast invasive carcinoma | Female | <65 | I/II | Chemotherapy | adriamycin | SD | |
IGF2R | SNV | Missense_Mutation | c.6049C>G | p.Leu2017Val | p.L2017V | P11717 | protein_coding | tolerated(0.08) | benign(0.007) | TCGA-E9-A1N5-01 | Breast | breast invasive carcinoma | Female | <65 | I/II | Chemotherapy | doxorubicin | SD | |
IGF2R | SNV | Missense_Mutation | c.2171N>G | p.Ala724Gly | p.A724G | P11717 | protein_coding | deleterious(0.01) | benign(0.162) | TCGA-E9-A1RE-01 | Breast | breast invasive carcinoma | Female | >=65 | III/IV | Hormone Therapy | tamoxiphen | SD |
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Related drugs of malignant transformation related genes |
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(DGIdb 4.0) |
Entrez ID | Symbol | Category | Interaction Types | Drug Claim Name | Drug Name | PMIDs |
3482 | IGF2R | ENZYME, DRUGGABLE GENOME, CELL SURFACE | EP-128504 | |||
3482 | IGF2R | ENZYME, DRUGGABLE GENOME, CELL SURFACE | Juvidex | MANNOSE 6-PHOSPHATE | 20927486 | |
3482 | IGF2R | ENZYME, DRUGGABLE GENOME, CELL SURFACE | PXS-25 |
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