Schematic overview of the cellular and molecular mechanisms involved in the cancer progression, including the proposed cellular and molecular mechanisms in cancer cells trajectory. AT1: alveolar type 1 cells; AT2: alveolar type 2 cells; AAH: atypical adenomatous hyperplasia; AIS: adenocarcinoma in situ; MIA: minimally invasive adenocarcinoma; IA: invasive adenocarcinoma; EMT: epithelial-mesenchymal transition

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Center for Computational Systems Medicine
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Gene summary

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Malignant transformation analysis

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Malignant transformation related pathway analysis

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Cell-cell communication analysis

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Single-cell gene regulatory network inference analysis

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Somatic mutation of malignant transformation related genes

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Related drugs of malignant transformation related genes

Gene: FNBP1

Gene summary for FNBP1

check button Gene summary.

Gene informationSpeciesHuman
Gene symbol

FNBP1

Gene ID

23048

Gene nameformin binding protein 1
Gene AliasFBP17
Cytomap9q34.11
Gene Typeprotein-coding
GO ID

GO:0006810

UniProtAcc

Q96RU3


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Malignant transformation analysis

check button Identification of the aberrant gene expression in precancerous and cancerous lesions by comparing the gene expression of stem-like cells in diseased tissues with normal stem cells
check button Malignant transformation involving gene list.
Entrez IDSymbolReplicatesSpeciesOrganTissueAdj P-valueLog2FCMalignancy
23048FNBP1HTA11_3410_2000001011HumanColorectumAD3.37e-16-6.04e-010.0155
23048FNBP1HTA11_1938_2000001011HumanColorectumAD1.41e-02-4.30e-01-0.0811
23048FNBP1HTA11_347_2000001011HumanColorectumAD1.20e-126.76e-01-0.1954
23048FNBP1HTA11_1391_2000001011HumanColorectumAD8.64e-04-3.79e-01-0.059
23048FNBP1HTA11_866_3004761011HumanColorectumAD7.46e-07-4.08e-010.096
23048FNBP1HTA11_10711_2000001011HumanColorectumAD2.72e-06-5.07e-010.0338
23048FNBP1HTA11_7696_3000711011HumanColorectumAD2.58e-13-5.25e-010.0674
23048FNBP1HTA11_99999970781_79442HumanColorectumMSS9.12e-03-3.03e-010.294
23048FNBP1HTA11_99999971662_82457HumanColorectumMSS1.15e-07-3.60e-010.3859
23048FNBP1HTA11_99999973899_84307HumanColorectumMSS7.62e-03-5.00e-010.2585
23048FNBP1HTA11_99999974143_84620HumanColorectumMSS1.61e-14-4.61e-010.3005
23048FNBP1F007HumanColorectumFAP9.04e-03-2.73e-010.1176
23048FNBP1A002-C-010HumanColorectumFAP1.82e-07-3.47e-010.242
23048FNBP1A001-C-207HumanColorectumFAP7.92e-05-3.56e-010.1278
23048FNBP1A015-C-203HumanColorectumFAP2.13e-27-3.94e-01-0.1294
23048FNBP1A015-C-204HumanColorectumFAP6.55e-08-3.43e-01-0.0228
23048FNBP1A014-C-040HumanColorectumFAP4.29e-03-3.27e-01-0.1184
23048FNBP1A002-C-201HumanColorectumFAP4.13e-17-5.09e-010.0324
23048FNBP1A002-C-203HumanColorectumFAP6.61e-04-2.42e-010.2786
23048FNBP1A001-C-119HumanColorectumFAP1.72e-04-2.98e-01-0.1557
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check button Transcriptomic changes along malignancy continuum.
TissueExpression DynamicsAbbreviation
Colorectum (GSE201348)The image shows the transcriptomic changes along malignancy continuum.log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage.FAP: Familial adenomatous polyposis
CRC: Colorectal cancer
Colorectum (HTA11)The image shows the transcriptomic changes along malignancy continuum.log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage.AD: Adenomas
SER: Sessile serrated lesions
MSI-H: Microsatellite-high colorectal cancer
MSS: Microsatellite stable colorectal cancer
EndometriumThe image shows the transcriptomic changes along malignancy continuum.log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage.AEH: Atypical endometrial hyperplasia
EEC: Endometrioid Cancer
EsophagusThe image shows the transcriptomic changes along malignancy continuum.log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage.ESCC: Esophageal squamous cell carcinoma
HGIN: High-grade intraepithelial neoplasias
LGIN: Low-grade intraepithelial neoplasias
LiverThe image shows the transcriptomic changes along malignancy continuum.log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage.HCC: Hepatocellular carcinoma
NAFLD: Non-alcoholic fatty liver disease
LungThe image shows the transcriptomic changes along malignancy continuum.log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage.AAH: Atypical adenomatous hyperplasia
AIS: Adenocarcinoma in situ
IAC: Invasive lung adenocarcinoma
MIA: Minimally invasive adenocarcinoma
Oral CavityThe image shows the transcriptomic changes along malignancy continuum.log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage.EOLP: Erosive Oral lichen planus
LP: leukoplakia
NEOLP: Non-erosive oral lichen planus
OSCC: Oral squamous cell carcinoma
ProstateThe image shows the transcriptomic changes along malignancy continuum.log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage.BPH: Benign Prostatic Hyperplasia
ThyroidThe image shows the transcriptomic changes along malignancy continuum.log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage.ATC: Anaplastic thyroid cancer
HT: Hashimoto's thyroiditis
PTC: Papillary thyroid cancer
∗log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage.

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Malignant transformation related pathway analysis

check buttonFind out the enriched GO biological processes and KEGG pathways involved in transition from healthy to precancer to cancer
check button Figure of enriched GO biological processes.
TissueDisease StageEnriched GO biological Processes
ColorectumADGO analysis - Figure of enriched GO biological processes: Top 15 enriched GO BP terms are showed in the bar plot of each disease state in each tissue. Each row represents a significant GO biological process which is colored according to the -log10(p.adjust).
ColorectumSERGO analysis - Figure of enriched GO biological processes: Top 15 enriched GO BP terms are showed in the bar plot of each disease state in each tissue. Each row represents a significant GO biological process which is colored according to the -log10(p.adjust).
ColorectumMSSGO analysis - Figure of enriched GO biological processes: Top 15 enriched GO BP terms are showed in the bar plot of each disease state in each tissue. Each row represents a significant GO biological process which is colored according to the -log10(p.adjust).
ColorectumMSI-HGO analysis - Figure of enriched GO biological processes: Top 15 enriched GO BP terms are showed in the bar plot of each disease state in each tissue. Each row represents a significant GO biological process which is colored according to the -log10(p.adjust).
ColorectumFAPGO analysis - Figure of enriched GO biological processes: Top 15 enriched GO BP terms are showed in the bar plot of each disease state in each tissue. Each row represents a significant GO biological process which is colored according to the -log10(p.adjust).
∗Top 15 enriched GO BP terms are showed in the bar plot of each disease state in each tissue. Each row represents a significant GO biological process which is colored according to the -log10(p.adjust).
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check button Enriched GO biological processes.
GO IDTissueDisease StageDescriptionGene RatioBg Ratiopvaluep.adjustCount
GO:0120032111ThyroidPTCregulation of plasma membrane bounded cell projection assembly92/5968186/187234.12e-076.83e-0692
GO:006049120ThyroidPTCregulation of cell projection assembly92/5968188/187237.55e-071.18e-0592
GO:01200349ThyroidPTCpositive regulation of plasma membrane bounded cell projection assembly57/5968105/187231.60e-062.25e-0557
GO:0006898110ThyroidPTCreceptor-mediated endocytosis112/5968244/187232.87e-063.74e-05112
GO:007258310ThyroidPTCclathrin-dependent endocytosis30/596847/187236.62e-067.83e-0530
GO:00995187ThyroidPTCvesicle cytoskeletal trafficking38/596873/187232.69e-041.91e-0338
GO:00514891ThyroidPTCregulation of filopodium assembly26/596847/187237.38e-044.59e-0326
GO:009951517ThyroidPTCactin filament-based transport14/596821/187231.11e-036.51e-0314
GO:0051491ThyroidPTCpositive regulation of filopodium assembly18/596830/187231.38e-037.74e-0318
GO:004684711ThyroidPTCfilopodium assembly31/596862/187232.23e-031.18e-0231
GO:00973202ThyroidPTCplasma membrane tubulation13/596820/187232.37e-031.24e-0213
GO:003005010ThyroidPTCvesicle transport along actin filament12/596819/187234.93e-032.29e-0212
GO:005165625ThyroidATCestablishment of organelle localization206/6293390/187232.62e-151.84e-13206
GO:001605023ThyroidATCvesicle organization166/6293300/187236.14e-153.92e-13166
GO:003134623ThyroidATCpositive regulation of cell projection organization186/6293353/187237.99e-144.23e-12186
GO:003070532ThyroidATCcytoskeleton-dependent intracellular transport105/6293195/187234.31e-099.70e-08105
GO:000690027ThyroidATCvesicle budding from membrane42/629361/187231.94e-083.84e-0742
GO:0051650110ThyroidATCestablishment of vesicle localization87/6293161/187237.16e-081.25e-0687
GO:012003414ThyroidATCpositive regulation of plasma membrane bounded cell projection assembly60/6293105/187236.10e-078.47e-0660
GO:012003223ThyroidATCregulation of plasma membrane bounded cell projection assembly95/6293186/187236.13e-078.49e-0695
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check button Enriched KEGG pathways.
Pathway IDTissueDisease StageDescriptionGene RatioBg Ratiopvaluep.adjustqvalueCount
hsa05131ColorectumADShigellosis109/2092247/84651.09e-112.44e-101.55e-10109
hsa051311ColorectumADShigellosis109/2092247/84651.09e-112.44e-101.55e-10109
hsa051314ColorectumMSSShigellosis94/1875247/84656.82e-091.34e-078.23e-0894
hsa051315ColorectumMSSShigellosis94/1875247/84656.82e-091.34e-078.23e-0894
hsa051318ColorectumFAPShigellosis76/1404247/84651.57e-085.84e-073.55e-0776
hsa051319ColorectumFAPShigellosis76/1404247/84651.57e-085.84e-073.55e-0776
hsa0513110ColorectumCRCShigellosis59/1091247/84651.19e-065.41e-053.66e-0559
hsa0513111ColorectumCRCShigellosis59/1091247/84651.19e-065.41e-053.66e-0559
hsa0513126EndometriumAEHShigellosis78/1197247/84659.23e-132.00e-111.46e-1178
hsa05131111EndometriumAEHShigellosis78/1197247/84659.23e-132.00e-111.46e-1178
hsa0513127EndometriumEECShigellosis79/1237247/84651.80e-123.95e-112.95e-1179
hsa0513136EndometriumEECShigellosis79/1237247/84651.80e-123.95e-112.95e-1179
hsa05131211EsophagusESCCShigellosis176/4205247/84652.27e-124.01e-112.05e-11176
hsa05131310EsophagusESCCShigellosis176/4205247/84652.27e-124.01e-112.05e-11176
hsa0513114LiverNAFLDShigellosis48/1043247/84657.82e-041.17e-029.39e-0348
hsa0513115LiverNAFLDShigellosis48/1043247/84657.82e-041.17e-029.39e-0348
hsa0513142LiverHCCShigellosis150/4020247/84651.53e-051.04e-045.81e-05150
hsa0513152LiverHCCShigellosis150/4020247/84651.53e-051.04e-045.81e-05150
hsa0513116LungIACShigellosis58/1053247/84658.21e-073.81e-052.53e-0558
hsa0513117LungIACShigellosis58/1053247/84658.21e-073.81e-052.53e-0558
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Cell-cell communication analysis

check buttonIdentification of potential cell-cell interactions between two cell types and their ligand-receptor pairs for different disease states
LigandReceptorLRpairPathwayTissueDisease Stage
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Single-cell gene regulatory network inference analysis

check buttonFind out the significant the regulons (TFs) and the target genes of each regulon across cell types for different disease states
TFCell TypeTissueDisease StageTarget GeneRSSRegulon Activity
∗The dot plots of a searched regulon are shown for all cell subpopulations in each disease state of each tissue based on the regulon specific score inferred using pySCENIC and by calculating the average expression.
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Somatic mutation of malignant transformation related genes

check buttonAnnotation of somatic variants for genes involved in malignant transformation
Hugo SymbolVariant ClassVariant ClassificationdbSNP RSHGVScHGVSpHGVSp ShortSWISSPROTBIOTYPESIFTPolyPhenTumor Sample BarcodeTissueHistologySexAgeStageTherapy TypesDrugsOutcome
FNBP1SNVMissense_Mutationc.1411G>Ap.Glu471Lysp.E471KQ96RU3protein_codingdeleterious(0)possibly_damaging(0.857)TCGA-GM-A2D9-01Breastbreast invasive carcinomaFemale>=65I/IIHormone TherapyarimidexSD
FNBP1insertionNonsense_Mutationnovelc.418_419insAGGAGAATCGCTTGAGCACAGGAGGCGTTGGCTGCAGTGAGCCAAGATp.Arg140delinsGlnGluAsnArgLeuSerThrGlyGlyValGlyCysSerGluProArgTerp.R140delinsQENRLSTGGVGCSEPR*Q96RU3protein_codingTCGA-A8-A07R-01Breastbreast invasive carcinomaFemale>=65III/IVAncillaryzoledronicSD
FNBP1insertionIn_Frame_Insnovelc.29_30insTCTTTTAATGATGAGp.Gln10delinsHisLeuLeuMetMetArgp.Q10delinsHLLMMRQ96RU3protein_codingTCGA-AN-A0FX-01Breastbreast invasive carcinomaFemale<65I/IIUnknownUnknownSD
FNBP1insertionNonsense_Mutationnovelc.27_28insTAAGTACTTTGGATCTCCTTAp.Asp9_Gln10insTerp.D9_Q10ins*Q96RU3protein_codingTCGA-AN-A0FX-01Breastbreast invasive carcinomaFemale<65I/IIUnknownUnknownSD
FNBP1insertionNonsense_Mutationnovelc.804_805insCCATGTTAATAACTTGGTTTTGAATTCATGTTAACATp.Ile269ProfsTer3p.I269Pfs*3Q96RU3protein_codingTCGA-BH-A0HF-01Breastbreast invasive carcinomaFemale>=65I/IIHormone TherapyarimidexSD
FNBP1SNVMissense_Mutationc.1754N>Ap.Gly585Aspp.G585DQ96RU3protein_codingdeleterious(0)probably_damaging(0.999)TCGA-EK-A2RC-01Cervixcervical & endocervical cancerFemale<65I/IIUnknownUnknownSD
FNBP1SNVMissense_Mutationc.1411N>Cp.Glu471Glnp.E471QQ96RU3protein_codingdeleterious(0)probably_damaging(0.953)TCGA-EK-A3GK-01Cervixcervical & endocervical cancerFemale<65I/IIUnknownUnknownSD
FNBP1SNVMissense_Mutationc.835N>Gp.Pro279Alap.P279AQ96RU3protein_codingdeleterious(0)probably_damaging(0.98)TCGA-IR-A3LH-01Cervixcervical & endocervical cancerFemale<65I/IIChemotherapycisplatinCR
FNBP1SNVMissense_Mutationrs764532868c.1447N>Ap.Glu483Lysp.E483KQ96RU3protein_codingtolerated(0.08)benign(0.04)TCGA-VS-A958-01Cervixcervical & endocervical cancerFemale<65I/IIChemotherapycisplatinCR
FNBP1SNVMissense_Mutationrs374562503c.1775G>Ap.Arg592Glnp.R592QQ96RU3protein_codingdeleterious(0.04)probably_damaging(0.986)TCGA-A6-6654-01Colorectumcolon adenocarcinomaFemale>=65III/IVChemotherapyoxaliplatinSD
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Related drugs of malignant transformation related genes

check buttonIdentification of chemicals and drugs interact with genes involved in malignant transfromation
(DGIdb 4.0)
Entrez IDSymbolCategoryInteraction TypesDrug Claim NameDrug NamePMIDs
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