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Gene: FBXW11 |
Gene summary for FBXW11 |
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Gene information | Species | Human | Gene symbol | FBXW11 | Gene ID | 23291 |
Gene name | F-box and WD repeat domain containing 11 | |
Gene Alias | BTRC2 | |
Cytomap | 5q35.1 | |
Gene Type | protein-coding | GO ID | GO:0000003 | UniProtAcc | Q9UKB1 |
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Malignant transformation analysis |
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Entrez ID | Symbol | Replicates | Species | Organ | Tissue | Adj P-value | Log2FC | Malignancy |
23291 | FBXW11 | CCI_2 | Human | Cervix | CC | 4.29e-09 | 1.26e+00 | 0.5249 |
23291 | FBXW11 | CCI_3 | Human | Cervix | CC | 3.70e-06 | 5.27e-01 | 0.516 |
23291 | FBXW11 | HTA11_3410_2000001011 | Human | Colorectum | AD | 7.53e-17 | -6.42e-01 | 0.0155 |
23291 | FBXW11 | HTA11_2487_2000001011 | Human | Colorectum | SER | 6.18e-07 | -5.24e-01 | -0.1808 |
23291 | FBXW11 | HTA11_3361_2000001011 | Human | Colorectum | AD | 9.31e-05 | -5.59e-01 | -0.1207 |
23291 | FBXW11 | HTA11_696_2000001011 | Human | Colorectum | AD | 1.55e-05 | -3.65e-01 | -0.1464 |
23291 | FBXW11 | HTA11_866_2000001011 | Human | Colorectum | AD | 3.67e-10 | -3.77e-01 | -0.1001 |
23291 | FBXW11 | HTA11_866_3004761011 | Human | Colorectum | AD | 4.49e-07 | -4.91e-01 | 0.096 |
23291 | FBXW11 | HTA11_10711_2000001011 | Human | Colorectum | AD | 1.02e-05 | -4.87e-01 | 0.0338 |
23291 | FBXW11 | HTA11_7696_3000711011 | Human | Colorectum | AD | 6.28e-12 | -4.81e-01 | 0.0674 |
23291 | FBXW11 | HTA11_99999970781_79442 | Human | Colorectum | MSS | 9.82e-09 | -3.84e-01 | 0.294 |
23291 | FBXW11 | HTA11_99999974143_84620 | Human | Colorectum | MSS | 1.64e-15 | -5.01e-01 | 0.3005 |
23291 | FBXW11 | A001-C-207 | Human | Colorectum | FAP | 1.95e-04 | -2.91e-01 | 0.1278 |
23291 | FBXW11 | A015-C-203 | Human | Colorectum | FAP | 6.61e-32 | -4.60e-01 | -0.1294 |
23291 | FBXW11 | A015-C-204 | Human | Colorectum | FAP | 6.71e-07 | -3.51e-01 | -0.0228 |
23291 | FBXW11 | A014-C-040 | Human | Colorectum | FAP | 8.81e-05 | -5.07e-01 | -0.1184 |
23291 | FBXW11 | A002-C-201 | Human | Colorectum | FAP | 9.09e-18 | -4.34e-01 | 0.0324 |
23291 | FBXW11 | A002-C-203 | Human | Colorectum | FAP | 8.57e-04 | -2.65e-01 | 0.2786 |
23291 | FBXW11 | A001-C-119 | Human | Colorectum | FAP | 1.93e-06 | -4.33e-01 | -0.1557 |
23291 | FBXW11 | A001-C-108 | Human | Colorectum | FAP | 3.23e-18 | -3.49e-01 | -0.0272 |
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∗log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage. |
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Malignant transformation related pathway analysis |
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Tissue | Disease Stage | Enriched GO biological Processes |
Colorectum | AD | ![]() |
Colorectum | SER | ![]() |
Colorectum | MSS | ![]() |
Colorectum | MSI-H | ![]() |
Colorectum | FAP | ![]() |
∗Top 15 enriched GO BP terms are showed in the bar plot of each disease state in each tissue. Each row represents a significant GO biological process which is colored according to the -log10(p.adjust). |
Page: 1 2 3 4 5 6 7 8 9 |
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GO ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | Count |
GO:00076237 | Lung | IAC | circadian rhythm | 48/2061 | 210/18723 | 6.13e-07 | 3.67e-05 | 48 |
GO:00104988 | Lung | IAC | proteasomal protein catabolic process | 90/2061 | 490/18723 | 6.69e-07 | 3.89e-05 | 90 |
GO:00431618 | Lung | IAC | proteasome-mediated ubiquitin-dependent protein catabolic process | 78/2061 | 412/18723 | 1.10e-06 | 6.02e-05 | 78 |
GO:00002096 | Lung | IAC | protein polyubiquitination | 49/2061 | 236/18723 | 8.51e-06 | 2.89e-04 | 49 |
GO:00163116 | Lung | IAC | dephosphorylation | 75/2061 | 417/18723 | 1.21e-05 | 3.64e-04 | 75 |
GO:00307056 | Lung | IAC | cytoskeleton-dependent intracellular transport | 40/2061 | 195/18723 | 7.30e-05 | 1.54e-03 | 40 |
GO:00316483 | Lung | IAC | protein destabilization | 15/2061 | 46/18723 | 7.40e-05 | 1.55e-03 | 15 |
GO:00427526 | Lung | IAC | regulation of circadian rhythm | 27/2061 | 121/18723 | 2.53e-04 | 4.24e-03 | 27 |
GO:00516506 | Lung | IAC | establishment of vesicle localization | 32/2061 | 161/18723 | 6.53e-04 | 8.87e-03 | 32 |
GO:00516566 | Lung | IAC | establishment of organelle localization | 64/2061 | 390/18723 | 7.12e-04 | 9.50e-03 | 64 |
GO:00070976 | Lung | IAC | nuclear migration | 8/2061 | 20/18723 | 7.91e-04 | 1.02e-02 | 8 |
GO:00516486 | Lung | IAC | vesicle localization | 34/2061 | 177/18723 | 8.53e-04 | 1.09e-02 | 34 |
GO:0099111 | Lung | IAC | microtubule-based transport | 35/2061 | 190/18723 | 1.55e-03 | 1.64e-02 | 35 |
GO:00080885 | Lung | IAC | axo-dendritic transport | 17/2061 | 75/18723 | 2.79e-03 | 2.52e-02 | 17 |
GO:00516475 | Lung | IAC | nucleus localization | 8/2061 | 24/18723 | 3.09e-03 | 2.71e-02 | 8 |
GO:19028503 | Lung | IAC | microtubule cytoskeleton organization involved in mitosis | 27/2061 | 147/18723 | 5.23e-03 | 3.97e-02 | 27 |
GO:0008090 | Lung | IAC | retrograde axonal transport | 7/2061 | 21/18723 | 5.59e-03 | 4.12e-02 | 7 |
GO:00109704 | Lung | IAC | transport along microtubule | 28/2061 | 155/18723 | 5.72e-03 | 4.18e-02 | 28 |
GO:001605512 | Lung | AIS | Wnt signaling pathway | 91/1849 | 444/18723 | 9.38e-12 | 5.47e-09 | 91 |
GO:019873812 | Lung | AIS | cell-cell signaling by wnt | 91/1849 | 446/18723 | 1.22e-11 | 6.13e-09 | 91 |
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Pathway ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | qvalue | Count |
hsa0412014 | Cervix | CC | Ubiquitin mediated proteolysis | 49/1267 | 142/8465 | 4.26e-09 | 7.68e-08 | 4.54e-08 | 49 |
hsa0513120 | Cervix | CC | Shigellosis | 69/1267 | 247/8465 | 7.64e-08 | 1.03e-06 | 6.10e-07 | 69 |
hsa0421810 | Cervix | CC | Cellular senescence | 49/1267 | 156/8465 | 1.30e-07 | 1.63e-06 | 9.61e-07 | 49 |
hsa0517016 | Cervix | CC | Human immunodeficiency virus 1 infection | 55/1267 | 212/8465 | 1.80e-05 | 1.42e-04 | 8.40e-05 | 55 |
hsa043109 | Cervix | CC | Wnt signaling pathway | 43/1267 | 171/8465 | 3.03e-04 | 1.64e-03 | 9.68e-04 | 43 |
hsa043908 | Cervix | CC | Hippo signaling pathway | 40/1267 | 157/8465 | 3.64e-04 | 1.82e-03 | 1.07e-03 | 40 |
hsa0412015 | Cervix | CC | Ubiquitin mediated proteolysis | 49/1267 | 142/8465 | 4.26e-09 | 7.68e-08 | 4.54e-08 | 49 |
hsa05131110 | Cervix | CC | Shigellosis | 69/1267 | 247/8465 | 7.64e-08 | 1.03e-06 | 6.10e-07 | 69 |
hsa0421815 | Cervix | CC | Cellular senescence | 49/1267 | 156/8465 | 1.30e-07 | 1.63e-06 | 9.61e-07 | 49 |
hsa0517017 | Cervix | CC | Human immunodeficiency virus 1 infection | 55/1267 | 212/8465 | 1.80e-05 | 1.42e-04 | 8.40e-05 | 55 |
hsa0431012 | Cervix | CC | Wnt signaling pathway | 43/1267 | 171/8465 | 3.03e-04 | 1.64e-03 | 9.68e-04 | 43 |
hsa0439013 | Cervix | CC | Hippo signaling pathway | 40/1267 | 157/8465 | 3.64e-04 | 1.82e-03 | 1.07e-03 | 40 |
hsa05131 | Colorectum | AD | Shigellosis | 109/2092 | 247/8465 | 1.09e-11 | 2.44e-10 | 1.55e-10 | 109 |
hsa04120 | Colorectum | AD | Ubiquitin mediated proteolysis | 58/2092 | 142/8465 | 1.46e-05 | 1.53e-04 | 9.76e-05 | 58 |
hsa05170 | Colorectum | AD | Human immunodeficiency virus 1 infection | 72/2092 | 212/8465 | 1.40e-03 | 8.46e-03 | 5.39e-03 | 72 |
hsa04218 | Colorectum | AD | Cellular senescence | 53/2092 | 156/8465 | 5.55e-03 | 2.48e-02 | 1.58e-02 | 53 |
hsa04310 | Colorectum | AD | Wnt signaling pathway | 56/2092 | 171/8465 | 1.03e-02 | 3.93e-02 | 2.51e-02 | 56 |
hsa051311 | Colorectum | AD | Shigellosis | 109/2092 | 247/8465 | 1.09e-11 | 2.44e-10 | 1.55e-10 | 109 |
hsa041201 | Colorectum | AD | Ubiquitin mediated proteolysis | 58/2092 | 142/8465 | 1.46e-05 | 1.53e-04 | 9.76e-05 | 58 |
hsa051701 | Colorectum | AD | Human immunodeficiency virus 1 infection | 72/2092 | 212/8465 | 1.40e-03 | 8.46e-03 | 5.39e-03 | 72 |
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Cell-cell communication analysis |
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Ligand | Receptor | LRpair | Pathway | Tissue | Disease Stage |
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Single-cell gene regulatory network inference analysis |
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TF | Cell Type | Tissue | Disease Stage | Target Gene | RSS | Regulon Activity |
∗The dot plots of a searched regulon are shown for all cell subpopulations in each disease state of each tissue based on the regulon specific score inferred using pySCENIC and by calculating the average expression. |
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Somatic mutation of malignant transformation related genes |
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Hugo Symbol | Variant Class | Variant Classification | dbSNP RS | HGVSc | HGVSp | HGVSp Short | SWISSPROT | BIOTYPE | SIFT | PolyPhen | Tumor Sample Barcode | Tissue | Histology | Sex | Age | Stage | Therapy Types | Drugs | Outcome |
FBXW11 | deletion | Frame_Shift_Del | novel | c.716delN | p.Asn239IlefsTer35 | p.N239Ifs*35 | Q9UKB1 | protein_coding | TCGA-EW-A2FV-01 | Breast | breast invasive carcinoma | Female | <65 | III/IV | Chemotherapy | docetaxel | SD | ||
FBXW11 | SNV | Missense_Mutation | c.816N>G | p.Cys272Trp | p.C272W | Q9UKB1 | protein_coding | deleterious(0) | probably_damaging(0.994) | TCGA-FU-A3HZ-01 | Cervix | cervical & endocervical cancer | Female | <65 | I/II | Chemotherapy | cisplatin | CR | |
FBXW11 | SNV | Missense_Mutation | c.1219N>A | p.Ala407Thr | p.A407T | Q9UKB1 | protein_coding | tolerated(0.06) | possibly_damaging(0.688) | TCGA-ZJ-AAXI-01 | Cervix | cervical & endocervical cancer | Female | >=65 | I/II | Unknown | Unknown | SD | |
FBXW11 | SNV | Missense_Mutation | c.847N>A | p.Val283Ile | p.V283I | Q9UKB1 | protein_coding | deleterious(0.01) | probably_damaging(0.997) | TCGA-A6-6653-01 | Colorectum | colon adenocarcinoma | Male | >=65 | I/II | Unknown | Unknown | SD | |
FBXW11 | SNV | Missense_Mutation | c.364G>A | p.Ala122Thr | p.A122T | Q9UKB1 | protein_coding | tolerated(0.48) | benign(0.123) | TCGA-AA-3864-01 | Colorectum | colon adenocarcinoma | Male | >=65 | I/II | Unknown | Unknown | SD | |
FBXW11 | SNV | Missense_Mutation | c.509G>A | p.Arg170Gln | p.R170Q | Q9UKB1 | protein_coding | deleterious(0.02) | possibly_damaging(0.815) | TCGA-AA-3977-01 | Colorectum | colon adenocarcinoma | Male | >=65 | I/II | Unknown | Unknown | SD | |
FBXW11 | SNV | Missense_Mutation | c.856N>A | p.Leu286Met | p.L286M | Q9UKB1 | protein_coding | deleterious(0) | probably_damaging(1) | TCGA-AA-A010-01 | Colorectum | colon adenocarcinoma | Female | <65 | I/II | Chemotherapy | folinic | CR | |
FBXW11 | SNV | Missense_Mutation | c.8C>A | p.Pro3His | p.P3H | Q9UKB1 | protein_coding | deleterious_low_confidence(0.01) | benign(0.365) | TCGA-AD-5900-01 | Colorectum | colon adenocarcinoma | Male | >=65 | I/II | Unknown | Unknown | SD | |
FBXW11 | SNV | Missense_Mutation | c.449N>C | p.Val150Ala | p.V150A | Q9UKB1 | protein_coding | deleterious(0.03) | probably_damaging(1) | TCGA-AM-5821-01 | Colorectum | colon adenocarcinoma | Female | >=65 | I/II | Unknown | Unknown | SD | |
FBXW11 | SNV | Missense_Mutation | rs778006732 | c.293N>A | p.Arg98Gln | p.R98Q | Q9UKB1 | protein_coding | tolerated(0.15) | benign(0.055) | TCGA-CA-6717-01 | Colorectum | colon adenocarcinoma | Male | <65 | I/II | Chemotherapy | oxaliplatin | CR |
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Related drugs of malignant transformation related genes |
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(DGIdb 4.0) |
Entrez ID | Symbol | Category | Interaction Types | Drug Claim Name | Drug Name | PMIDs |
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