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Gene: FBP1 |
Gene summary for FBP1 |
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Gene information | Species | Human | Gene symbol | FBP1 | Gene ID | 2203 |
Gene name | fructose-bisphosphatase 1 | |
Gene Alias | FBP | |
Cytomap | 9q22.32 | |
Gene Type | protein-coding | GO ID | GO:0000122 | UniProtAcc | P09467 |
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Malignant transformation analysis |
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Entrez ID | Symbol | Replicates | Species | Organ | Tissue | Adj P-value | Log2FC | Malignancy |
2203 | FBP1 | HTA11_1938_2000001011 | Human | Colorectum | AD | 3.61e-02 | 3.22e-01 | -0.0811 |
2203 | FBP1 | HTA11_1391_2000001011 | Human | Colorectum | AD | 3.96e-09 | 6.07e-01 | -0.059 |
2203 | FBP1 | HTA11_866_3004761011 | Human | Colorectum | AD | 2.99e-02 | 2.81e-01 | 0.096 |
2203 | FBP1 | HTA11_7696_3000711011 | Human | Colorectum | AD | 3.50e-02 | 2.47e-01 | 0.0674 |
2203 | FBP1 | HTA11_6818_2000001021 | Human | Colorectum | AD | 1.05e-02 | 2.69e-01 | 0.0588 |
2203 | FBP1 | HTA11_99999971662_82457 | Human | Colorectum | MSS | 6.08e-09 | 4.21e-01 | 0.3859 |
2203 | FBP1 | LZE24T | Human | Esophagus | ESCC | 9.58e-06 | 2.63e-01 | 0.0596 |
2203 | FBP1 | P8T-E | Human | Esophagus | ESCC | 9.53e-09 | 1.91e-01 | 0.0889 |
2203 | FBP1 | P28T-E | Human | Esophagus | ESCC | 5.15e-11 | 3.01e-01 | 0.1149 |
2203 | FBP1 | P57T-E | Human | Esophagus | ESCC | 1.78e-03 | 1.06e-01 | 0.0926 |
2203 | FBP1 | P74T-E | Human | Esophagus | ESCC | 3.83e-04 | 2.67e-01 | 0.1479 |
2203 | FBP1 | P75T-E | Human | Esophagus | ESCC | 2.70e-39 | 1.11e+00 | 0.1125 |
2203 | FBP1 | P76T-E | Human | Esophagus | ESCC | 1.96e-05 | 1.24e-01 | 0.1207 |
2203 | FBP1 | P82T-E | Human | Esophagus | ESCC | 9.61e-07 | 5.53e-01 | 0.1072 |
2203 | FBP1 | P94T-E | Human | Esophagus | ESCC | 1.55e-13 | 1.76e+00 | 0.0879 |
2203 | FBP1 | P104T-E | Human | Esophagus | ESCC | 3.89e-05 | 4.92e-01 | 0.0931 |
2203 | FBP1 | P130T-E | Human | Esophagus | ESCC | 1.75e-25 | 5.56e-01 | 0.1676 |
2203 | FBP1 | NAFLD1 | Human | Liver | NAFLD | 4.79e-07 | 5.92e-01 | -0.04 |
2203 | FBP1 | S43 | Human | Liver | Cirrhotic | 1.95e-17 | -2.48e-01 | -0.0187 |
2203 | FBP1 | HCC1_Meng | Human | Liver | HCC | 5.66e-30 | -4.31e-01 | 0.0246 |
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∗log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage. |
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Malignant transformation related pathway analysis |
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Tissue | Disease Stage | Enriched GO biological Processes |
Colorectum | AD | ![]() |
Colorectum | SER | ![]() |
Colorectum | MSS | ![]() |
Colorectum | MSI-H | ![]() |
Colorectum | FAP | ![]() |
∗Top 15 enriched GO BP terms are showed in the bar plot of each disease state in each tissue. Each row represents a significant GO biological process which is colored according to the -log10(p.adjust). |
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GO ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | Count |
GO:000913212 | Liver | Cirrhotic | nucleoside diphosphate metabolic process | 58/4634 | 124/18723 | 7.88e-08 | 2.33e-06 | 58 |
GO:000600611 | Liver | Cirrhotic | glucose metabolic process | 82/4634 | 196/18723 | 1.01e-07 | 2.93e-06 | 82 |
GO:000989512 | Liver | Cirrhotic | negative regulation of catabolic process | 121/4634 | 320/18723 | 1.21e-07 | 3.39e-06 | 121 |
GO:000913512 | Liver | Cirrhotic | purine nucleoside diphosphate metabolic process | 50/4634 | 103/18723 | 1.43e-07 | 3.87e-06 | 50 |
GO:000917912 | Liver | Cirrhotic | purine ribonucleoside diphosphate metabolic process | 50/4634 | 103/18723 | 1.43e-07 | 3.87e-06 | 50 |
GO:004343412 | Liver | Cirrhotic | response to peptide hormone | 149/4634 | 414/18723 | 1.70e-07 | 4.49e-06 | 149 |
GO:004693912 | Liver | Cirrhotic | nucleotide phosphorylation | 49/4634 | 101/18723 | 1.95e-07 | 5.07e-06 | 49 |
GO:004603112 | Liver | Cirrhotic | ADP metabolic process | 45/4634 | 90/18723 | 2.01e-07 | 5.21e-06 | 45 |
GO:006201212 | Liver | Cirrhotic | regulation of small molecule metabolic process | 124/4634 | 334/18723 | 2.74e-07 | 6.79e-06 | 124 |
GO:007137511 | Liver | Cirrhotic | cellular response to peptide hormone stimulus | 110/4634 | 290/18723 | 3.73e-07 | 8.82e-06 | 110 |
GO:000609012 | Liver | Cirrhotic | pyruvate metabolic process | 50/4634 | 106/18723 | 4.39e-07 | 1.02e-05 | 50 |
GO:004346712 | Liver | Cirrhotic | regulation of generation of precursor metabolites and energy | 58/4634 | 130/18723 | 5.81e-07 | 1.28e-05 | 58 |
GO:001605212 | Liver | Cirrhotic | carbohydrate catabolic process | 66/4634 | 154/18723 | 6.10e-07 | 1.32e-05 | 66 |
GO:000616512 | Liver | Cirrhotic | nucleoside diphosphate phosphorylation | 47/4634 | 99/18723 | 7.63e-07 | 1.61e-05 | 47 |
GO:004593612 | Liver | Cirrhotic | negative regulation of phosphate metabolic process | 154/4634 | 441/18723 | 8.78e-07 | 1.83e-05 | 154 |
GO:001056312 | Liver | Cirrhotic | negative regulation of phosphorus metabolic process | 154/4634 | 442/18723 | 1.02e-06 | 2.11e-05 | 154 |
GO:190165311 | Liver | Cirrhotic | cellular response to peptide | 129/4634 | 359/18723 | 1.23e-06 | 2.49e-05 | 129 |
GO:003286911 | Liver | Cirrhotic | cellular response to insulin stimulus | 80/4634 | 203/18723 | 2.55e-06 | 4.63e-05 | 80 |
GO:004232612 | Liver | Cirrhotic | negative regulation of phosphorylation | 135/4634 | 385/18723 | 3.17e-06 | 5.58e-05 | 135 |
GO:000609612 | Liver | Cirrhotic | glycolytic process | 39/4634 | 81/18723 | 4.22e-06 | 7.06e-05 | 39 |
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Pathway ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | qvalue | Count |
hsa01200 | Colorectum | AD | Carbon metabolism | 55/2092 | 115/8465 | 5.53e-08 | 8.42e-07 | 5.37e-07 | 55 |
hsa00010 | Colorectum | AD | Glycolysis / Gluconeogenesis | 34/2092 | 67/8465 | 3.63e-06 | 4.34e-05 | 2.77e-05 | 34 |
hsa04152 | Colorectum | AD | AMPK signaling pathway | 47/2092 | 121/8465 | 3.74e-04 | 2.82e-03 | 1.80e-03 | 47 |
hsa04922 | Colorectum | AD | Glucagon signaling pathway | 41/2092 | 107/8465 | 1.18e-03 | 7.75e-03 | 4.94e-03 | 41 |
hsa00051 | Colorectum | AD | Fructose and mannose metabolism | 17/2092 | 34/8465 | 1.25e-03 | 8.02e-03 | 5.12e-03 | 17 |
hsa012001 | Colorectum | AD | Carbon metabolism | 55/2092 | 115/8465 | 5.53e-08 | 8.42e-07 | 5.37e-07 | 55 |
hsa000101 | Colorectum | AD | Glycolysis / Gluconeogenesis | 34/2092 | 67/8465 | 3.63e-06 | 4.34e-05 | 2.77e-05 | 34 |
hsa041521 | Colorectum | AD | AMPK signaling pathway | 47/2092 | 121/8465 | 3.74e-04 | 2.82e-03 | 1.80e-03 | 47 |
hsa049221 | Colorectum | AD | Glucagon signaling pathway | 41/2092 | 107/8465 | 1.18e-03 | 7.75e-03 | 4.94e-03 | 41 |
hsa000511 | Colorectum | AD | Fructose and mannose metabolism | 17/2092 | 34/8465 | 1.25e-03 | 8.02e-03 | 5.12e-03 | 17 |
hsa000104 | Colorectum | MSS | Glycolysis / Gluconeogenesis | 28/1875 | 67/8465 | 2.36e-04 | 1.81e-03 | 1.11e-03 | 28 |
hsa049224 | Colorectum | MSS | Glucagon signaling pathway | 39/1875 | 107/8465 | 5.00e-04 | 3.45e-03 | 2.11e-03 | 39 |
hsa041522 | Colorectum | MSS | AMPK signaling pathway | 41/1875 | 121/8465 | 1.91e-03 | 9.83e-03 | 6.03e-03 | 41 |
hsa04910 | Colorectum | MSS | Insulin signaling pathway | 43/1875 | 137/8465 | 7.37e-03 | 2.84e-02 | 1.74e-02 | 43 |
hsa000105 | Colorectum | MSS | Glycolysis / Gluconeogenesis | 28/1875 | 67/8465 | 2.36e-04 | 1.81e-03 | 1.11e-03 | 28 |
hsa049225 | Colorectum | MSS | Glucagon signaling pathway | 39/1875 | 107/8465 | 5.00e-04 | 3.45e-03 | 2.11e-03 | 39 |
hsa041523 | Colorectum | MSS | AMPK signaling pathway | 41/1875 | 121/8465 | 1.91e-03 | 9.83e-03 | 6.03e-03 | 41 |
hsa049101 | Colorectum | MSS | Insulin signaling pathway | 43/1875 | 137/8465 | 7.37e-03 | 2.84e-02 | 1.74e-02 | 43 |
hsa0120023 | Esophagus | ESCC | Carbon metabolism | 79/4205 | 115/8465 | 2.50e-05 | 1.21e-04 | 6.22e-05 | 79 |
hsa0415210 | Esophagus | ESCC | AMPK signaling pathway | 80/4205 | 121/8465 | 1.73e-04 | 6.67e-04 | 3.42e-04 | 80 |
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Cell-cell communication analysis |
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Ligand | Receptor | LRpair | Pathway | Tissue | Disease Stage |
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Single-cell gene regulatory network inference analysis |
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TF | Cell Type | Tissue | Disease Stage | Target Gene | RSS | Regulon Activity |
∗The dot plots of a searched regulon are shown for all cell subpopulations in each disease state of each tissue based on the regulon specific score inferred using pySCENIC and by calculating the average expression. |
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Somatic mutation of malignant transformation related genes |
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Hugo Symbol | Variant Class | Variant Classification | dbSNP RS | HGVSc | HGVSp | HGVSp Short | SWISSPROT | BIOTYPE | SIFT | PolyPhen | Tumor Sample Barcode | Tissue | Histology | Sex | Age | Stage | Therapy Types | Drugs | Outcome |
FBP1 | SNV | Missense_Mutation | novel | c.1007N>T | p.Ser336Phe | p.S336F | P09467 | protein_coding | deleterious(0.01) | benign(0.284) | TCGA-A8-A08L-01 | Breast | breast invasive carcinoma | Female | >=65 | III/IV | Unknown | Unknown | SD |
FBP1 | SNV | Missense_Mutation | c.747N>A | p.Met249Ile | p.M249I | P09467 | protein_coding | deleterious(0) | possibly_damaging(0.476) | TCGA-A8-A09I-01 | Breast | breast invasive carcinoma | Female | >=65 | I/II | Hormone Therapy | anastrozole | SD | |
FBP1 | SNV | Missense_Mutation | novel | c.145G>C | p.Val49Leu | p.V49L | P09467 | protein_coding | deleterious(0.02) | benign(0.366) | TCGA-AR-A2LE-01 | Breast | breast invasive carcinoma | Female | >=65 | I/II | Hormone Therapy | tamoxiphen | PD |
FBP1 | SNV | Missense_Mutation | novel | c.923N>T | p.Pro308Leu | p.P308L | P09467 | protein_coding | deleterious(0) | probably_damaging(0.992) | TCGA-AR-A5QM-01 | Breast | breast invasive carcinoma | Female | <65 | I/II | Hormone Therapy | anastrozole | PD |
FBP1 | SNV | Missense_Mutation | novel | c.323N>A | p.Pro108Gln | p.P108Q | P09467 | protein_coding | tolerated(0.21) | benign(0.028) | TCGA-VS-A9UJ-01 | Cervix | cervical & endocervical cancer | Female | <65 | I/II | Unknown | Unknown | PD |
FBP1 | SNV | Missense_Mutation | novel | c.299N>C | p.Asp100Ala | p.D100A | P09467 | protein_coding | tolerated(0.05) | benign(0.069) | TCGA-AA-A02R-01 | Colorectum | colon adenocarcinoma | Female | >=65 | I/II | Unknown | Unknown | PD |
FBP1 | SNV | Missense_Mutation | c.88N>A | p.Glu30Lys | p.E30K | P09467 | protein_coding | deleterious(0) | benign(0.247) | TCGA-AZ-6599-01 | Colorectum | colon adenocarcinoma | Male | >=65 | I/II | Unknown | Unknown | SD | |
FBP1 | SNV | Missense_Mutation | novel | c.931N>G | p.Ile311Val | p.I311V | P09467 | protein_coding | deleterious(0.02) | possibly_damaging(0.47) | TCGA-G4-6295-01 | Colorectum | colon adenocarcinoma | Female | >=65 | I/II | Unknown | Unknown | SD |
FBP1 | deletion | Frame_Shift_Del | c.881delN | p.Gly294GlufsTer11 | p.G294Efs*11 | P09467 | protein_coding | TCGA-A6-5661-01 | Colorectum | colon adenocarcinoma | Female | >=65 | I/II | Unknown | Unknown | SD | |||
FBP1 | SNV | Missense_Mutation | novel | c.1010N>T | p.Ala337Val | p.A337V | P09467 | protein_coding | tolerated(0.08) | benign(0) | TCGA-A5-A0G1-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | >=65 | I/II | Unknown | Unknown | SD |
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Related drugs of malignant transformation related genes |
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(DGIdb 4.0) |
Entrez ID | Symbol | Category | Interaction Types | Drug Claim Name | Drug Name | PMIDs |
2203 | FBP1 | DRUGGABLE GENOME, ENZYME | MB07803 | MB-07803 | ||
2203 | FBP1 | DRUGGABLE GENOME, ENZYME | MB07803 | MB-07803 | ||
2203 | FBP1 | DRUGGABLE GENOME, ENZYME | Managlinat dialanetil |
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