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Gene: F11R |
Gene summary for F11R |
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Gene information | Species | Human | Gene symbol | F11R | Gene ID | 50848 |
Gene name | F11 receptor | |
Gene Alias | CD321 | |
Cytomap | 1q23.3 | |
Gene Type | protein-coding | GO ID | GO:0000902 | UniProtAcc | Q9Y624 |
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Malignant transformation analysis |
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Entrez ID | Symbol | Replicates | Species | Organ | Tissue | Adj P-value | Log2FC | Malignancy |
50848 | F11R | CA_HPV_2 | Human | Cervix | CC | 1.25e-06 | 2.80e-01 | 0.0391 |
50848 | F11R | CCI_1 | Human | Cervix | CC | 4.54e-02 | 5.33e-01 | 0.528 |
50848 | F11R | Tumor | Human | Cervix | CC | 4.05e-24 | 5.09e-01 | 0.1241 |
50848 | F11R | sample1 | Human | Cervix | CC | 2.70e-04 | 4.11e-01 | 0.0959 |
50848 | F11R | sample3 | Human | Cervix | CC | 1.69e-58 | 7.73e-01 | 0.1387 |
50848 | F11R | H2 | Human | Cervix | HSIL_HPV | 5.46e-10 | 3.67e-01 | 0.0632 |
50848 | F11R | L1 | Human | Cervix | CC | 7.15e-10 | 4.98e-01 | 0.0802 |
50848 | F11R | T1 | Human | Cervix | CC | 5.61e-07 | 3.51e-01 | 0.0918 |
50848 | F11R | T2 | Human | Cervix | CC | 6.61e-03 | 4.22e-01 | 0.0709 |
50848 | F11R | T3 | Human | Cervix | CC | 8.29e-50 | 7.45e-01 | 0.1389 |
50848 | F11R | HTA11_2487_2000001011 | Human | Colorectum | SER | 1.17e-07 | 5.41e-01 | -0.1808 |
50848 | F11R | HTA11_1938_2000001011 | Human | Colorectum | AD | 1.55e-06 | 5.22e-01 | -0.0811 |
50848 | F11R | HTA11_78_2000001011 | Human | Colorectum | AD | 2.82e-05 | 3.47e-01 | -0.1088 |
50848 | F11R | HTA11_347_2000001011 | Human | Colorectum | AD | 1.26e-14 | 4.78e-01 | -0.1954 |
50848 | F11R | HTA11_411_2000001011 | Human | Colorectum | SER | 4.29e-04 | 9.02e-01 | -0.2602 |
50848 | F11R | HTA11_83_2000001011 | Human | Colorectum | SER | 3.86e-03 | 3.98e-01 | -0.1526 |
50848 | F11R | HTA11_696_2000001011 | Human | Colorectum | AD | 3.96e-04 | 2.67e-01 | -0.1464 |
50848 | F11R | HTA11_1391_2000001011 | Human | Colorectum | AD | 3.64e-11 | 5.58e-01 | -0.059 |
50848 | F11R | HTA11_5212_2000001011 | Human | Colorectum | AD | 5.83e-04 | 5.08e-01 | -0.2061 |
50848 | F11R | HTA11_866_3004761011 | Human | Colorectum | AD | 8.02e-06 | 3.51e-01 | 0.096 |
Page: 1 2 3 4 5 6 7 8 9 |
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∗log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage. |
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Malignant transformation related pathway analysis |
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Tissue | Disease Stage | Enriched GO biological Processes |
Colorectum | AD | ![]() |
Colorectum | SER | ![]() |
Colorectum | MSS | ![]() |
Colorectum | MSI-H | ![]() |
Colorectum | FAP | ![]() |
∗Top 15 enriched GO BP terms are showed in the bar plot of each disease state in each tissue. Each row represents a significant GO biological process which is colored according to the -log10(p.adjust). |
Page: 1 2 3 4 5 6 7 8 9 |
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GO ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | Count |
GO:00514942 | Colorectum | MSS | negative regulation of cytoskeleton organization | 47/3467 | 163/18723 | 8.45e-04 | 8.71e-03 | 47 |
GO:00714962 | Colorectum | MSS | cellular response to external stimulus | 82/3467 | 320/18723 | 9.30e-04 | 9.44e-03 | 82 |
GO:01201922 | Colorectum | MSS | tight junction assembly | 25/3467 | 74/18723 | 1.25e-03 | 1.20e-02 | 25 |
GO:00705272 | Colorectum | MSS | platelet aggregation | 23/3467 | 67/18723 | 1.51e-03 | 1.39e-02 | 23 |
GO:00018851 | Colorectum | MSS | endothelial cell development | 22/3467 | 64/18723 | 1.86e-03 | 1.64e-02 | 22 |
GO:00310322 | Colorectum | MSS | actomyosin structure organization | 53/3467 | 196/18723 | 2.04e-03 | 1.75e-02 | 53 |
GO:00300382 | Colorectum | MSS | contractile actin filament bundle assembly | 32/3467 | 106/18723 | 2.41e-03 | 1.96e-02 | 32 |
GO:00431492 | Colorectum | MSS | stress fiber assembly | 32/3467 | 106/18723 | 2.41e-03 | 1.96e-02 | 32 |
GO:00905572 | Colorectum | MSS | establishment of endothelial intestinal barrier | 7/3467 | 12/18723 | 2.45e-03 | 1.97e-02 | 7 |
GO:00513461 | Colorectum | MSS | negative regulation of hydrolase activity | 92/3467 | 379/18723 | 2.85e-03 | 2.22e-02 | 92 |
GO:00226001 | Colorectum | MSS | digestive system process | 31/3467 | 104/18723 | 3.46e-03 | 2.59e-02 | 31 |
GO:00031581 | Colorectum | MSS | endothelium development | 38/3467 | 136/18723 | 4.53e-03 | 3.19e-02 | 38 |
GO:00708302 | Colorectum | MSS | bicellular tight junction assembly | 22/3467 | 70/18723 | 6.42e-03 | 4.27e-02 | 22 |
GO:01100202 | Colorectum | MSS | regulation of actomyosin structure organization | 29/3467 | 100/18723 | 6.99e-03 | 4.49e-02 | 29 |
GO:00454461 | Colorectum | MSS | endothelial cell differentiation | 33/3467 | 118/18723 | 7.66e-03 | 4.81e-02 | 33 |
GO:00322312 | Colorectum | MSS | regulation of actin filament bundle assembly | 30/3467 | 105/18723 | 7.74e-03 | 4.84e-02 | 30 |
GO:2000249 | Colorectum | MSS | regulation of actin cytoskeleton reorganization | 14/3467 | 39/18723 | 7.79e-03 | 4.84e-02 | 14 |
GO:0016032111 | Esophagus | ESCC | viral process | 301/8552 | 415/18723 | 3.34e-29 | 1.32e-26 | 301 |
GO:0019058111 | Esophagus | ESCC | viral life cycle | 226/8552 | 317/18723 | 1.17e-20 | 1.76e-18 | 226 |
GO:0071496111 | Esophagus | ESCC | cellular response to external stimulus | 215/8552 | 320/18723 | 4.29e-15 | 2.43e-13 | 215 |
Page: 1 2 3 4 5 6 7 8 9 10 11 12 13 14 15 16 17 18 19 20 21 22 23 24 25 26 27 28 29 30 31 32 33 34 35 36 37 38 39 40 41 42 43 44 45 46 47 48 49 50 51 52 53 |
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Pathway ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | qvalue | Count |
hsa0453020 | Cervix | CC | Tight junction | 49/1267 | 169/8465 | 1.87e-06 | 1.78e-05 | 1.05e-05 | 49 |
hsa0467020 | Cervix | CC | Leukocyte transendothelial migration | 36/1267 | 114/8465 | 5.22e-06 | 4.83e-05 | 2.86e-05 | 36 |
hsa051207 | Cervix | CC | Epithelial cell signaling in Helicobacter pylori infection | 24/1267 | 70/8465 | 4.35e-05 | 3.09e-04 | 1.83e-04 | 24 |
hsa045147 | Cervix | CC | Cell adhesion molecules | 36/1267 | 157/8465 | 4.94e-03 | 1.67e-02 | 9.86e-03 | 36 |
hsa04530110 | Cervix | CC | Tight junction | 49/1267 | 169/8465 | 1.87e-06 | 1.78e-05 | 1.05e-05 | 49 |
hsa04670110 | Cervix | CC | Leukocyte transendothelial migration | 36/1267 | 114/8465 | 5.22e-06 | 4.83e-05 | 2.86e-05 | 36 |
hsa0512014 | Cervix | CC | Epithelial cell signaling in Helicobacter pylori infection | 24/1267 | 70/8465 | 4.35e-05 | 3.09e-04 | 1.83e-04 | 24 |
hsa0451412 | Cervix | CC | Cell adhesion molecules | 36/1267 | 157/8465 | 4.94e-03 | 1.67e-02 | 9.86e-03 | 36 |
hsa0451421 | Cervix | HSIL_HPV | Cell adhesion molecules | 20/459 | 157/8465 | 3.03e-04 | 3.06e-03 | 2.47e-03 | 20 |
hsa0467025 | Cervix | HSIL_HPV | Leukocyte transendothelial migration | 16/459 | 114/8465 | 4.04e-04 | 3.49e-03 | 2.82e-03 | 16 |
hsa0451431 | Cervix | HSIL_HPV | Cell adhesion molecules | 20/459 | 157/8465 | 3.03e-04 | 3.06e-03 | 2.47e-03 | 20 |
hsa0467035 | Cervix | HSIL_HPV | Leukocyte transendothelial migration | 16/459 | 114/8465 | 4.04e-04 | 3.49e-03 | 2.82e-03 | 16 |
hsa04530 | Colorectum | AD | Tight junction | 76/2092 | 169/8465 | 5.49e-09 | 9.69e-08 | 6.18e-08 | 76 |
hsa04670 | Colorectum | AD | Leukocyte transendothelial migration | 41/2092 | 114/8465 | 4.60e-03 | 2.20e-02 | 1.40e-02 | 41 |
hsa045301 | Colorectum | AD | Tight junction | 76/2092 | 169/8465 | 5.49e-09 | 9.69e-08 | 6.18e-08 | 76 |
hsa046701 | Colorectum | AD | Leukocyte transendothelial migration | 41/2092 | 114/8465 | 4.60e-03 | 2.20e-02 | 1.40e-02 | 41 |
hsa045302 | Colorectum | SER | Tight junction | 59/1580 | 169/8465 | 3.24e-07 | 5.98e-06 | 4.34e-06 | 59 |
hsa046702 | Colorectum | SER | Leukocyte transendothelial migration | 37/1580 | 114/8465 | 2.77e-04 | 2.56e-03 | 1.86e-03 | 37 |
hsa045303 | Colorectum | SER | Tight junction | 59/1580 | 169/8465 | 3.24e-07 | 5.98e-06 | 4.34e-06 | 59 |
hsa046703 | Colorectum | SER | Leukocyte transendothelial migration | 37/1580 | 114/8465 | 2.77e-04 | 2.56e-03 | 1.86e-03 | 37 |
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Cell-cell communication analysis |
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Ligand | Receptor | LRpair | Pathway | Tissue | Disease Stage |
F11R | ITGAL_ITGB2 | JAM1_ITGAL_ITGB2 | JAM | Breast | ADJ |
F11R | F11R | F11R_F11R | JAM | Breast | ADJ |
F11R | JAM2 | F11R_JAM2 | JAM | Breast | ADJ |
F11R | JAM3 | F11R_JAM3 | JAM | Breast | ADJ |
JAM2 | F11R | JAM2_F11R | JAM | Breast | ADJ |
JAM3 | F11R | JAM3_F11R | JAM | Breast | ADJ |
F11R | ITGAL_ITGB2 | JAM1_ITGAL_ITGB2 | JAM | Breast | DCIS |
F11R | F11R | F11R_F11R | JAM | Breast | DCIS |
F11R | JAM2 | F11R_JAM2 | JAM | Breast | DCIS |
F11R | JAM3 | F11R_JAM3 | JAM | Breast | DCIS |
JAM2 | F11R | JAM2_F11R | JAM | Breast | DCIS |
JAM3 | F11R | JAM3_F11R | JAM | Breast | DCIS |
F11R | ITGAL_ITGB2 | JAM1_ITGAL_ITGB2 | JAM | Breast | IDC |
F11R | F11R | F11R_F11R | JAM | Breast | IDC |
F11R | F11R | F11R_F11R | JAM | Breast | Precancer |
F11R | ITGAL_ITGB2 | JAM1_ITGAL_ITGB2 | JAM | Cervix | ADJ |
F11R | F11R | F11R_F11R | JAM | Cervix | ADJ |
F11R | JAM2 | F11R_JAM2 | JAM | Cervix | ADJ |
JAM2 | F11R | JAM2_F11R | JAM | Cervix | ADJ |
F11R | ITGAL_ITGB2 | JAM1_ITGAL_ITGB2 | JAM | Cervix | CC |
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Single-cell gene regulatory network inference analysis |
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TF | Cell Type | Tissue | Disease Stage | Target Gene | RSS | Regulon Activity |
∗The dot plots of a searched regulon are shown for all cell subpopulations in each disease state of each tissue based on the regulon specific score inferred using pySCENIC and by calculating the average expression. |
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Somatic mutation of malignant transformation related genes |
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Hugo Symbol | Variant Class | Variant Classification | dbSNP RS | HGVSc | HGVSp | HGVSp Short | SWISSPROT | BIOTYPE | SIFT | PolyPhen | Tumor Sample Barcode | Tissue | Histology | Sex | Age | Stage | Therapy Types | Drugs | Outcome |
F11R | SNV | Missense_Mutation | c.282N>G | p.Ile94Met | p.I94M | Q9Y624 | protein_coding | deleterious(0) | probably_damaging(0.965) | TCGA-A2-A0YD-01 | Breast | breast invasive carcinoma | Female | <65 | I/II | Chemotherapy | cytoxan | SD | |
F11R | SNV | Missense_Mutation | c.593T>A | p.Val198Asp | p.V198D | Q9Y624 | protein_coding | deleterious(0.01) | benign(0.443) | TCGA-AC-A5EH-01 | Breast | breast invasive carcinoma | Female | >=65 | I/II | Unknown | Unknown | SD | |
F11R | SNV | Missense_Mutation | rs574502480 | c.554N>G | p.Asn185Ser | p.N185S | Q9Y624 | protein_coding | deleterious(0) | probably_damaging(0.995) | TCGA-BH-A1FU-01 | Breast | breast invasive carcinoma | Female | <65 | I/II | Unknown | Unknown | PD |
F11R | insertion | In_Frame_Ins | novel | c.838_839insCAC | p.Tyr280delinsSerHis | p.Y280delinsSH | Q9Y624 | protein_coding | TCGA-E9-A244-01 | Breast | breast invasive carcinoma | Female | <65 | I/II | Chemotherapy | cyclophosphamide | SD | ||
F11R | SNV | Missense_Mutation | c.124N>C | p.Glu42Gln | p.E42Q | Q9Y624 | protein_coding | deleterious(0.04) | probably_damaging(0.957) | TCGA-DR-A0ZM-01 | Cervix | cervical & endocervical cancer | Female | <65 | III/IV | Unspecific | Cisplatin | SD | |
F11R | SNV | Missense_Mutation | novel | c.234G>C | p.Lys78Asn | p.K78N | Q9Y624 | protein_coding | deleterious(0.01) | possibly_damaging(0.743) | TCGA-EA-A3HU-01 | Cervix | cervical & endocervical cancer | Female | <65 | I/II | Unknown | Unknown | SD |
F11R | SNV | Missense_Mutation | c.137T>C | p.Val46Ala | p.V46A | Q9Y624 | protein_coding | tolerated(1) | benign(0.028) | TCGA-AA-A022-01 | Colorectum | colon adenocarcinoma | Female | >=65 | I/II | Unknown | Unknown | SD | |
F11R | SNV | Missense_Mutation | rs373771702 | c.179T>C | p.Val60Ala | p.V60A | Q9Y624 | protein_coding | deleterious(0) | benign(0.351) | TCGA-AA-A02R-01 | Colorectum | colon adenocarcinoma | Female | >=65 | I/II | Unknown | Unknown | PD |
F11R | SNV | Missense_Mutation | novel | c.811A>C | p.Lys271Gln | p.K271Q | Q9Y624 | protein_coding | deleterious(0.02) | possibly_damaging(0.451) | TCGA-AZ-4315-01 | Colorectum | colon adenocarcinoma | Male | <65 | I/II | Unknown | Unknown | SD |
F11R | SNV | Missense_Mutation | c.662N>A | p.Pro221His | p.P221H | Q9Y624 | protein_coding | deleterious(0) | possibly_damaging(0.709) | TCGA-D5-6928-01 | Colorectum | colon adenocarcinoma | Male | >=65 | I/II | Unknown | Unknown | SD |
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Related drugs of malignant transformation related genes |
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(DGIdb 4.0) |
Entrez ID | Symbol | Category | Interaction Types | Drug Claim Name | Drug Name | PMIDs |
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