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Gene: CTSL |
Gene summary for CTSL |
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Gene information | Species | Human | Gene symbol | CTSL | Gene ID | 1514 |
Gene name | cathepsin L | |
Gene Alias | CATL | |
Cytomap | 9q21.33 | |
Gene Type | protein-coding | GO ID | GO:0001775 | UniProtAcc | A0A024R276 |
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Malignant transformation analysis |
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Entrez ID | Symbol | Replicates | Species | Organ | Tissue | Adj P-value | Log2FC | Malignancy |
1514 | CTSL | AEH-subject1 | Human | Endometrium | AEH | 4.79e-03 | -1.85e-01 | -0.3059 |
1514 | CTSL | AEH-subject2 | Human | Endometrium | AEH | 4.71e-02 | -1.72e-01 | -0.2525 |
1514 | CTSL | AEH-subject5 | Human | Endometrium | AEH | 4.58e-06 | -2.75e-01 | -0.2953 |
1514 | CTSL | EEC-subject1 | Human | Endometrium | EEC | 3.06e-06 | -2.28e-01 | -0.2682 |
1514 | CTSL | EEC-subject2 | Human | Endometrium | EEC | 1.02e-07 | -2.21e-01 | -0.2607 |
1514 | CTSL | EEC-subject3 | Human | Endometrium | EEC | 1.48e-29 | -2.28e-01 | -0.2525 |
1514 | CTSL | EEC-subject4 | Human | Endometrium | EEC | 6.26e-04 | -1.14e-01 | -0.2571 |
1514 | CTSL | EEC-subject5 | Human | Endometrium | EEC | 3.98e-02 | -8.70e-02 | -0.249 |
1514 | CTSL | GSM5276934 | Human | Endometrium | EEC | 1.12e-24 | 7.89e-01 | -0.0913 |
1514 | CTSL | GSM5276937 | Human | Endometrium | EEC | 2.93e-38 | 1.07e+00 | -0.0897 |
1514 | CTSL | GSM6177620_NYU_UCEC1_lib1_lib1 | Human | Endometrium | EEC | 3.75e-11 | -9.39e-02 | -0.1869 |
1514 | CTSL | GSM6177620_NYU_UCEC1_lib2_lib2 | Human | Endometrium | EEC | 6.18e-10 | -2.59e-01 | -0.1875 |
1514 | CTSL | GSM6177620_NYU_UCEC1_lib3_lib3 | Human | Endometrium | EEC | 3.30e-12 | -2.11e-01 | -0.1883 |
1514 | CTSL | GSM6177621_NYU_UCEC2_lib1_lib1 | Human | Endometrium | EEC | 6.68e-18 | -1.99e-01 | -0.1934 |
1514 | CTSL | GSM6177622_NYU_UCEC3_lib1_lib1 | Human | Endometrium | EEC | 9.67e-26 | -2.75e-01 | -0.1917 |
1514 | CTSL | GSM6177622_NYU_UCEC3_lib2_lib2 | Human | Endometrium | EEC | 2.69e-11 | -2.48e-01 | -0.1916 |
1514 | CTSL | LZE2T | Human | Esophagus | ESCC | 2.61e-07 | 6.09e-01 | 0.082 |
1514 | CTSL | LZE4T | Human | Esophagus | ESCC | 2.01e-13 | 2.43e-01 | 0.0811 |
1514 | CTSL | LZE6T | Human | Esophagus | ESCC | 1.10e-07 | 1.08e+00 | 0.0845 |
1514 | CTSL | P2T-E | Human | Esophagus | ESCC | 1.24e-15 | 3.13e-01 | 0.1177 |
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∗log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage. |
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Malignant transformation related pathway analysis |
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Tissue | Disease Stage | Enriched GO biological Processes |
Colorectum | AD | ![]() |
Colorectum | SER | ![]() |
Colorectum | MSS | ![]() |
Colorectum | MSI-H | ![]() |
Colorectum | FAP | ![]() |
∗Top 15 enriched GO BP terms are showed in the bar plot of each disease state in each tissue. Each row represents a significant GO biological process which is colored according to the -log10(p.adjust). |
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GO ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | Count |
GO:00329633 | Thyroid | ATC | collagen metabolic process | 52/6293 | 104/18723 | 3.94e-04 | 2.38e-03 | 52 |
GO:001648515 | Thyroid | ATC | protein processing | 100/6293 | 225/18723 | 4.39e-04 | 2.62e-03 | 100 |
GO:004800228 | Thyroid | ATC | antigen processing and presentation of peptide antigen | 34/6293 | 62/18723 | 4.66e-04 | 2.74e-03 | 34 |
GO:000247831 | Thyroid | ATC | antigen processing and presentation of exogenous peptide antigen | 23/6293 | 38/18723 | 6.05e-04 | 3.44e-03 | 23 |
GO:001988431 | Thyroid | ATC | antigen processing and presentation of exogenous antigen | 27/6293 | 47/18723 | 6.69e-04 | 3.77e-03 | 27 |
GO:00330281 | Thyroid | ATC | myeloid cell apoptotic process | 17/6293 | 29/18723 | 4.95e-03 | 2.03e-02 | 17 |
GO:000910011 | Thyroid | ATC | glycoprotein metabolic process | 153/6293 | 387/18723 | 7.90e-03 | 3.06e-02 | 153 |
GO:00970672 | Thyroid | ATC | cellular response to thyroid hormone stimulus | 11/6293 | 17/18723 | 8.56e-03 | 3.26e-02 | 11 |
GO:19011363 | Thyroid | ATC | carbohydrate derivative catabolic process | 73/6293 | 172/18723 | 9.43e-03 | 3.47e-02 | 73 |
GO:009706621 | Thyroid | ATC | response to thyroid hormone | 15/6293 | 26/18723 | 9.95e-03 | 3.63e-02 | 15 |
GO:000250423 | Thyroid | ATC | antigen processing and presentation of peptide or polysaccharide antigen via MHC class II | 19/6293 | 36/18723 | 1.37e-02 | 4.77e-02 | 19 |
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Pathway ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | qvalue | Count |
hsa0541826 | Endometrium | AEH | Fluid shear stress and atherosclerosis | 43/1197 | 139/8465 | 2.47e-07 | 3.49e-06 | 2.55e-06 | 43 |
hsa0520518 | Endometrium | AEH | Proteoglycans in cancer | 53/1197 | 205/8465 | 5.43e-06 | 6.53e-05 | 4.78e-05 | 53 |
hsa0461225 | Endometrium | AEH | Antigen processing and presentation | 26/1197 | 78/8465 | 1.33e-05 | 1.55e-04 | 1.13e-04 | 26 |
hsa0414524 | Endometrium | AEH | Phagosome | 41/1197 | 152/8465 | 2.12e-05 | 2.22e-04 | 1.63e-04 | 41 |
hsa0532316 | Endometrium | AEH | Rheumatoid arthritis | 23/1197 | 93/8465 | 4.43e-03 | 2.46e-02 | 1.80e-02 | 23 |
hsa0421010 | Endometrium | AEH | Apoptosis | 30/1197 | 136/8465 | 7.72e-03 | 4.05e-02 | 2.96e-02 | 30 |
hsa05418112 | Endometrium | AEH | Fluid shear stress and atherosclerosis | 43/1197 | 139/8465 | 2.47e-07 | 3.49e-06 | 2.55e-06 | 43 |
hsa0520519 | Endometrium | AEH | Proteoglycans in cancer | 53/1197 | 205/8465 | 5.43e-06 | 6.53e-05 | 4.78e-05 | 53 |
hsa04612111 | Endometrium | AEH | Antigen processing and presentation | 26/1197 | 78/8465 | 1.33e-05 | 1.55e-04 | 1.13e-04 | 26 |
hsa04145111 | Endometrium | AEH | Phagosome | 41/1197 | 152/8465 | 2.12e-05 | 2.22e-04 | 1.63e-04 | 41 |
hsa0532317 | Endometrium | AEH | Rheumatoid arthritis | 23/1197 | 93/8465 | 4.43e-03 | 2.46e-02 | 1.80e-02 | 23 |
hsa0421015 | Endometrium | AEH | Apoptosis | 30/1197 | 136/8465 | 7.72e-03 | 4.05e-02 | 2.96e-02 | 30 |
hsa0541827 | Endometrium | EEC | Fluid shear stress and atherosclerosis | 45/1237 | 139/8465 | 7.76e-08 | 1.22e-06 | 9.07e-07 | 45 |
hsa0461226 | Endometrium | EEC | Antigen processing and presentation | 27/1237 | 78/8465 | 7.66e-06 | 9.58e-05 | 7.14e-05 | 27 |
hsa0414525 | Endometrium | EEC | Phagosome | 42/1237 | 152/8465 | 2.01e-05 | 2.28e-04 | 1.70e-04 | 42 |
hsa0520524 | Endometrium | EEC | Proteoglycans in cancer | 52/1237 | 205/8465 | 3.01e-05 | 3.19e-04 | 2.38e-04 | 52 |
hsa0532323 | Endometrium | EEC | Rheumatoid arthritis | 24/1237 | 93/8465 | 3.14e-03 | 1.78e-02 | 1.33e-02 | 24 |
hsa0421024 | Endometrium | EEC | Apoptosis | 31/1237 | 136/8465 | 6.72e-03 | 3.25e-02 | 2.42e-02 | 31 |
hsa0541836 | Endometrium | EEC | Fluid shear stress and atherosclerosis | 45/1237 | 139/8465 | 7.76e-08 | 1.22e-06 | 9.07e-07 | 45 |
hsa0461235 | Endometrium | EEC | Antigen processing and presentation | 27/1237 | 78/8465 | 7.66e-06 | 9.58e-05 | 7.14e-05 | 27 |
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Cell-cell communication analysis |
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Ligand | Receptor | LRpair | Pathway | Tissue | Disease Stage |
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Single-cell gene regulatory network inference analysis |
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TF | Cell Type | Tissue | Disease Stage | Target Gene | RSS | Regulon Activity |
∗The dot plots of a searched regulon are shown for all cell subpopulations in each disease state of each tissue based on the regulon specific score inferred using pySCENIC and by calculating the average expression. |
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Somatic mutation of malignant transformation related genes |
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Hugo Symbol | Variant Class | Variant Classification | dbSNP RS | HGVSc | HGVSp | HGVSp Short | SWISSPROT | BIOTYPE | SIFT | PolyPhen | Tumor Sample Barcode | Tissue | Histology | Sex | Age | Stage | Therapy Types | Drugs | Outcome |
CTSL | SNV | Missense_Mutation | c.751G>A | p.Ala251Thr | p.A251T | P07711 | protein_coding | deleterious(0.03) | possibly_damaging(0.534) | TCGA-A8-A09Z-01 | Breast | breast invasive carcinoma | Female | >=65 | I/II | Unknown | Unknown | SD | |
CTSL | SNV | Missense_Mutation | c.724G>A | p.Val242Met | p.V242M | P07711 | protein_coding | tolerated(0.05) | probably_damaging(0.931) | TCGA-AO-A128-01 | Breast | breast invasive carcinoma | Female | <65 | I/II | Chemotherapy | doxorubicin | SD | |
CTSL | SNV | Missense_Mutation | c.545N>C | p.Leu182Pro | p.L182P | P07711 | protein_coding | deleterious(0.01) | probably_damaging(0.998) | TCGA-AA-3715-01 | Colorectum | colon adenocarcinoma | Male | >=65 | I/II | Unknown | Unknown | PD | |
CTSL | SNV | Missense_Mutation | c.542N>A | p.Gly181Asp | p.G181D | P07711 | protein_coding | deleterious(0) | probably_damaging(1) | TCGA-AA-3811-01 | Colorectum | colon adenocarcinoma | Female | >=65 | III/IV | Unknown | Unknown | PD | |
CTSL | SNV | Missense_Mutation | c.956G>T | p.Arg319Ile | p.R319I | P07711 | protein_coding | deleterious(0) | benign(0.007) | TCGA-AA-A00N-01 | Colorectum | colon adenocarcinoma | Male | >=65 | I/II | Unknown | Unknown | PD | |
CTSL | SNV | Missense_Mutation | c.450G>T | p.Gln150His | p.Q150H | P07711 | protein_coding | deleterious(0.01) | probably_damaging(0.999) | TCGA-G4-6588-01 | Colorectum | colon adenocarcinoma | Female | <65 | I/II | Unknown | Unknown | SD | |
CTSL | SNV | Missense_Mutation | novel | c.774N>A | p.Phe258Leu | p.F258L | P07711 | protein_coding | tolerated(0.21) | possibly_damaging(0.686) | TCGA-AG-A002-01 | Colorectum | rectum adenocarcinoma | Male | <65 | I/II | Unknown | Unknown | SD |
CTSL | SNV | Missense_Mutation | c.956N>T | p.Arg319Ile | p.R319I | P07711 | protein_coding | deleterious(0) | benign(0.007) | TCGA-F5-6814-01 | Colorectum | rectum adenocarcinoma | Male | <65 | I/II | Unknown | Unknown | SD | |
CTSL | SNV | Missense_Mutation | rs200642380 | c.119N>G | p.Tyr40Cys | p.Y40C | P07711 | protein_coding | deleterious(0) | probably_damaging(1) | TCGA-A5-A0G1-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | >=65 | I/II | Unknown | Unknown | SD |
CTSL | SNV | Missense_Mutation | rs769759603 | c.121N>A | p.Gly41Ser | p.G41S | P07711 | protein_coding | tolerated(1) | benign(0.006) | TCGA-A5-A0G2-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | <65 | III/IV | Unknown | Unknown | SD |
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Related drugs of malignant transformation related genes |
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(DGIdb 4.0) |
Entrez ID | Symbol | Category | Interaction Types | Drug Claim Name | Drug Name | PMIDs |
1514 | CTSL | PROTEASE, DRUGGABLE GENOME, ENZYME | PMID27998201-Compound-6 | |||
1514 | CTSL | PROTEASE, DRUGGABLE GENOME, ENZYME | inhibitor | 405067337 | ||
1514 | CTSL | PROTEASE, DRUGGABLE GENOME, ENZYME | HORMONES | 16099855 | ||
1514 | CTSL | PROTEASE, DRUGGABLE GENOME, ENZYME | PMID27998201-Compound-19 | |||
1514 | CTSL | PROTEASE, DRUGGABLE GENOME, ENZYME | KGP94 | |||
1514 | CTSL | PROTEASE, DRUGGABLE GENOME, ENZYME | PMID27998201-Compound-5 | |||
1514 | CTSL | PROTEASE, DRUGGABLE GENOME, ENZYME | Phenylalanine derivative 1 | |||
1514 | CTSL | PROTEASE, DRUGGABLE GENOME, ENZYME | inhibitor | 318164817 | ||
1514 | CTSL | PROTEASE, DRUGGABLE GENOME, ENZYME | PMID27998201-Compound-1 | |||
1514 | CTSL | PROTEASE, DRUGGABLE GENOME, ENZYME | PMID27998201-Compound-9 |
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