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Gene: CRIP1 |
Gene summary for CRIP1 |
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Gene information | Species | Human | Gene symbol | CRIP1 | Gene ID | 1396 |
Gene name | cysteine rich protein 1 | |
Gene Alias | CRHP | |
Cytomap | 14q32.33 | |
Gene Type | protein-coding | GO ID | GO:0000003 | UniProtAcc | P50238 |
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Malignant transformation analysis |
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Entrez ID | Symbol | Replicates | Species | Organ | Tissue | Adj P-value | Log2FC | Malignancy |
1396 | CRIP1 | GSM4909287 | Human | Breast | IDC | 1.96e-07 | 3.17e-01 | 0.2057 |
1396 | CRIP1 | GSM4909289 | Human | Breast | IDC | 4.59e-13 | 8.46e-01 | 0.1064 |
1396 | CRIP1 | GSM4909290 | Human | Breast | IDC | 1.24e-95 | 1.65e+00 | 0.2096 |
1396 | CRIP1 | GSM4909293 | Human | Breast | IDC | 8.65e-42 | 7.39e-01 | 0.1581 |
1396 | CRIP1 | GSM4909294 | Human | Breast | IDC | 2.97e-21 | 7.03e-01 | 0.2022 |
1396 | CRIP1 | GSM4909295 | Human | Breast | IDC | 2.87e-07 | 4.80e-01 | 0.0898 |
1396 | CRIP1 | GSM4909296 | Human | Breast | IDC | 2.46e-106 | 1.73e+00 | 0.1524 |
1396 | CRIP1 | GSM4909297 | Human | Breast | IDC | 7.02e-07 | 4.21e-01 | 0.1517 |
1396 | CRIP1 | GSM4909301 | Human | Breast | IDC | 3.22e-136 | 1.75e+00 | 0.1577 |
1396 | CRIP1 | GSM4909302 | Human | Breast | IDC | 5.62e-53 | 1.09e+00 | 0.1545 |
1396 | CRIP1 | GSM4909303 | Human | Breast | IDC | 1.66e-05 | 5.34e-01 | 0.0438 |
1396 | CRIP1 | GSM4909304 | Human | Breast | IDC | 4.37e-102 | 1.32e+00 | 0.1636 |
1396 | CRIP1 | GSM4909305 | Human | Breast | IDC | 5.81e-15 | 4.88e-01 | 0.0436 |
1396 | CRIP1 | GSM4909306 | Human | Breast | IDC | 2.60e-52 | 1.02e+00 | 0.1564 |
1396 | CRIP1 | GSM4909307 | Human | Breast | IDC | 6.43e-20 | 5.89e-01 | 0.1569 |
1396 | CRIP1 | GSM4909308 | Human | Breast | IDC | 3.87e-02 | 1.36e-01 | 0.158 |
1396 | CRIP1 | GSM4909309 | Human | Breast | IDC | 1.44e-16 | 7.14e-01 | 0.0483 |
1396 | CRIP1 | GSM4909311 | Human | Breast | IDC | 2.56e-44 | 1.14e+00 | 0.1534 |
1396 | CRIP1 | GSM4909312 | Human | Breast | IDC | 5.70e-52 | 1.16e+00 | 0.1552 |
1396 | CRIP1 | GSM4909313 | Human | Breast | IDC | 9.10e-42 | 1.23e+00 | 0.0391 |
Page: 1 2 3 4 5 6 7 8 9 10 11 12 |
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∗log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage. |
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Malignant transformation related pathway analysis |
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Tissue | Disease Stage | Enriched GO biological Processes |
Colorectum | AD | ![]() |
Colorectum | SER | ![]() |
Colorectum | MSS | ![]() |
Colorectum | MSI-H | ![]() |
Colorectum | FAP | ![]() |
∗Top 15 enriched GO BP terms are showed in the bar plot of each disease state in each tissue. Each row represents a significant GO biological process which is colored according to the -log10(p.adjust). |
Page: 1 2 3 4 5 6 7 8 9 |
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GO ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | Count |
GO:00712141 | Stomach | CAG with IM | cellular response to abiotic stimulus | 31/1050 | 331/18723 | 3.66e-03 | 3.26e-02 | 31 |
GO:01040041 | Stomach | CAG with IM | cellular response to environmental stimulus | 31/1050 | 331/18723 | 3.66e-03 | 3.26e-02 | 31 |
GO:0071236 | Stomach | CAG with IM | cellular response to antibiotic | 4/1050 | 14/18723 | 6.26e-03 | 4.75e-02 | 4 |
GO:009719321 | Stomach | CSG | intrinsic apoptotic signaling pathway | 42/1034 | 288/18723 | 8.01e-09 | 7.57e-07 | 42 |
GO:001003821 | Stomach | CSG | response to metal ion | 45/1034 | 373/18723 | 7.02e-07 | 3.75e-05 | 45 |
GO:004873221 | Stomach | CSG | gland development | 43/1034 | 436/18723 | 1.70e-04 | 3.33e-03 | 43 |
GO:00093142 | Stomach | CSG | response to radiation | 43/1034 | 456/18723 | 4.45e-04 | 6.98e-03 | 43 |
GO:00086302 | Stomach | CSG | intrinsic apoptotic signaling pathway in response to DNA damage | 14/1034 | 99/18723 | 1.06e-03 | 1.34e-02 | 14 |
GO:00100432 | Stomach | CSG | response to zinc ion | 10/1034 | 58/18723 | 1.17e-03 | 1.42e-02 | 10 |
GO:00712142 | Stomach | CSG | cellular response to abiotic stimulus | 31/1034 | 331/18723 | 2.92e-03 | 2.74e-02 | 31 |
GO:01040042 | Stomach | CSG | cellular response to environmental stimulus | 31/1034 | 331/18723 | 2.92e-03 | 2.74e-02 | 31 |
GO:00712361 | Stomach | CSG | cellular response to antibiotic | 4/1034 | 14/18723 | 5.93e-03 | 4.66e-02 | 4 |
GO:009719331 | Stomach | CAG | intrinsic apoptotic signaling pathway | 31/552 | 288/18723 | 5.37e-10 | 1.47e-07 | 31 |
GO:001003831 | Stomach | CAG | response to metal ion | 34/552 | 373/18723 | 6.12e-09 | 8.53e-07 | 34 |
GO:00093143 | Stomach | CAG | response to radiation | 31/552 | 456/18723 | 1.53e-05 | 5.84e-04 | 31 |
GO:00100433 | Stomach | CAG | response to zinc ion | 9/552 | 58/18723 | 4.63e-05 | 1.45e-03 | 9 |
GO:00086303 | Stomach | CAG | intrinsic apoptotic signaling pathway in response to DNA damage | 10/552 | 99/18723 | 6.79e-04 | 1.08e-02 | 10 |
GO:0009416 | Stomach | CAG | response to light stimulus | 19/552 | 320/18723 | 3.17e-03 | 3.09e-02 | 19 |
GO:0071478 | Stomach | CAG | cellular response to radiation | 13/552 | 186/18723 | 3.57e-03 | 3.34e-02 | 13 |
GO:004873231 | Stomach | CAG | gland development | 23/552 | 436/18723 | 5.41e-03 | 4.53e-02 | 23 |
Page: 1 2 3 4 5 6 7 8 9 10 11 12 13 14 15 16 17 18 |
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Pathway ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | qvalue | Count |
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Cell-cell communication analysis |
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Ligand | Receptor | LRpair | Pathway | Tissue | Disease Stage |
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Single-cell gene regulatory network inference analysis |
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TF | Cell Type | Tissue | Disease Stage | Target Gene | RSS | Regulon Activity |
∗The dot plots of a searched regulon are shown for all cell subpopulations in each disease state of each tissue based on the regulon specific score inferred using pySCENIC and by calculating the average expression. |
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Somatic mutation of malignant transformation related genes |
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Hugo Symbol | Variant Class | Variant Classification | dbSNP RS | HGVSc | HGVSp | HGVSp Short | SWISSPROT | BIOTYPE | SIFT | PolyPhen | Tumor Sample Barcode | Tissue | Histology | Sex | Age | Stage | Therapy Types | Drugs | Outcome |
CRIP1 | deletion | Frame_Shift_Del | c.121delN | p.Gly42AlafsTer? | p.G42Afs*? | P50238 | protein_coding | TCGA-KK-A5A1-01 | Prostate | prostate adenocarcinoma | Male | >=65 | 9 | Unknown | Unknown | PD | |||
CRIP1 | SNV | Missense_Mutation | c.193N>T | p.Gly65Cys | p.G65C | P50238 | protein_coding | deleterious(0.02) | benign(0.284) | TCGA-BR-4368-01 | Stomach | stomach adenocarcinoma | Female | >=65 | III/IV | Unknown | Unknown | SD | |
CRIP1 | SNV | Missense_Mutation | c.182N>C | p.Phe61Ser | p.F61S | P50238 | protein_coding | deleterious(0) | probably_damaging(0.99) | TCGA-CD-A4MG-01 | Stomach | stomach adenocarcinoma | Male | >=65 | I/II | Unknown | Unknown | PD | |
CRIP1 | SNV | Missense_Mutation | novel | c.143N>A | p.Gly48Asp | p.G48D | P50238 | protein_coding | deleterious(0.05) | benign(0.169) | TCGA-VQ-A8P2-01 | Stomach | stomach adenocarcinoma | Male | >=65 | III/IV | Unspecific | Complete Response | |
CRIP1 | deletion | Frame_Shift_Del | c.121delN | p.Gly42AlafsTer? | p.G42Afs*? | P50238 | protein_coding | TCGA-HU-A4GU-01 | Stomach | stomach adenocarcinoma | Male | >=65 | I/II | Unknown | Unknown | SD |
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Related drugs of malignant transformation related genes |
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(DGIdb 4.0) |
Entrez ID | Symbol | Category | Interaction Types | Drug Claim Name | Drug Name | PMIDs |
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