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Gene: CCDC88A |
Gene summary for CCDC88A |
 Gene summary. |
| Gene information | Species | Human | Gene symbol | CCDC88A | Gene ID | 55704 |
| Gene name | coiled-coil domain containing 88A | |
| Gene Alias | APE | |
| Cytomap | 2p16.1 | |
| Gene Type | protein-coding | GO ID | GO:0000226 | UniProtAcc | O14997 |
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Malignant transformation analysis |
| Identification of the aberrant gene expression in precancerous and cancerous lesions by comparing the gene expression of stem-like cells in diseased tissues with normal stem cells |
| Malignant transformation involving gene list. |
| Entrez ID | Symbol | Replicates | Species | Organ | Tissue | Adj P-value | Log2FC | Malignancy |
| 55704 | CCDC88A | LZE4T | Human | Esophagus | ESCC | 1.25e-06 | 3.19e-01 | 0.0811 |
| 55704 | CCDC88A | LZE22T | Human | Esophagus | ESCC | 1.16e-02 | 2.19e-01 | 0.068 |
| 55704 | CCDC88A | LZE24T | Human | Esophagus | ESCC | 2.93e-05 | 1.78e-01 | 0.0596 |
| 55704 | CCDC88A | P2T-E | Human | Esophagus | ESCC | 5.62e-61 | 1.16e+00 | 0.1177 |
| 55704 | CCDC88A | P4T-E | Human | Esophagus | ESCC | 7.50e-27 | 6.16e-01 | 0.1323 |
| 55704 | CCDC88A | P5T-E | Human | Esophagus | ESCC | 3.29e-11 | 3.29e-01 | 0.1327 |
| 55704 | CCDC88A | P8T-E | Human | Esophagus | ESCC | 3.41e-06 | 1.01e-01 | 0.0889 |
| 55704 | CCDC88A | P9T-E | Human | Esophagus | ESCC | 9.61e-07 | 2.04e-01 | 0.1131 |
| 55704 | CCDC88A | P10T-E | Human | Esophagus | ESCC | 4.74e-18 | 3.72e-01 | 0.116 |
| 55704 | CCDC88A | P11T-E | Human | Esophagus | ESCC | 1.58e-09 | 3.54e-01 | 0.1426 |
| 55704 | CCDC88A | P12T-E | Human | Esophagus | ESCC | 1.33e-20 | 5.22e-01 | 0.1122 |
| 55704 | CCDC88A | P15T-E | Human | Esophagus | ESCC | 4.46e-18 | 5.72e-01 | 0.1149 |
| 55704 | CCDC88A | P16T-E | Human | Esophagus | ESCC | 1.55e-18 | 4.15e-01 | 0.1153 |
| 55704 | CCDC88A | P17T-E | Human | Esophagus | ESCC | 2.93e-03 | 2.53e-01 | 0.1278 |
| 55704 | CCDC88A | P19T-E | Human | Esophagus | ESCC | 1.70e-03 | 4.84e-01 | 0.1662 |
| 55704 | CCDC88A | P20T-E | Human | Esophagus | ESCC | 8.36e-13 | 3.71e-01 | 0.1124 |
| 55704 | CCDC88A | P21T-E | Human | Esophagus | ESCC | 1.69e-20 | 5.56e-01 | 0.1617 |
| 55704 | CCDC88A | P22T-E | Human | Esophagus | ESCC | 3.62e-07 | 3.69e-02 | 0.1236 |
| 55704 | CCDC88A | P23T-E | Human | Esophagus | ESCC | 6.12e-07 | 2.69e-01 | 0.108 |
| 55704 | CCDC88A | P24T-E | Human | Esophagus | ESCC | 3.86e-09 | 1.96e-01 | 0.1287 |
| Page: 1 2 3 4 5 6 |
| Transcriptomic changes along malignancy continuum. |
| Tissue | Expression Dynamics | Abbreviation |
| Esophagus |  | ESCC: Esophageal squamous cell carcinoma |
| HGIN: High-grade intraepithelial neoplasias | ||
| LGIN: Low-grade intraepithelial neoplasias | ||
| Liver |  | HCC: Hepatocellular carcinoma |
| NAFLD: Non-alcoholic fatty liver disease | ||
| Oral Cavity |  | EOLP: Erosive Oral lichen planus |
| LP: leukoplakia | ||
| NEOLP: Non-erosive oral lichen planus | ||
| OSCC: Oral squamous cell carcinoma | ||
| Prostate |  | BPH: Benign Prostatic Hyperplasia |
| Thyroid |  | ATC: Anaplastic thyroid cancer |
| HT: Hashimoto's thyroiditis | ||
| PTC: Papillary thyroid cancer |
| ∗log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage. |
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Malignant transformation related pathway analysis |
| Find out the enriched GO biological processes and KEGG pathways involved in transition from healthy to precancer to cancer |
| Figure of enriched GO biological processes. |
| Tissue | Disease Stage | Enriched GO biological Processes |
| Colorectum | AD |  |
| Colorectum | SER |  |
| Colorectum | MSS |  |
| Colorectum | MSI-H |  |
| Colorectum | FAP |  |
| ∗Top 15 enriched GO BP terms are showed in the bar plot of each disease state in each tissue. Each row represents a significant GO biological process which is colored according to the -log10(p.adjust). |
| Page: 1 2 3 4 5 6 7 8 9 |
| Enriched GO biological processes. |
| GO ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | Count |
| GO:005123517 | Prostate | Tumor | maintenance of location | 78/3246 | 327/18723 | 1.56e-03 | 9.55e-03 | 78 |
| GO:003003213 | Prostate | Tumor | lamellipodium assembly | 22/3246 | 72/18723 | 4.15e-03 | 2.08e-02 | 22 |
| GO:1903829113 | Thyroid | PTC | positive regulation of cellular protein localization | 162/5968 | 276/18723 | 2.40e-20 | 3.52e-18 | 162 |
| GO:1902903113 | Thyroid | PTC | regulation of supramolecular fiber organization | 202/5968 | 383/18723 | 1.16e-17 | 1.15e-15 | 202 |
| GO:0007015112 | Thyroid | PTC | actin filament organization | 225/5968 | 442/18723 | 3.76e-17 | 3.44e-15 | 225 |
| GO:0072659112 | Thyroid | PTC | protein localization to plasma membrane | 153/5968 | 284/18723 | 9.90e-15 | 6.50e-13 | 153 |
| GO:1990778111 | Thyroid | PTC | protein localization to cell periphery | 172/5968 | 333/18723 | 3.71e-14 | 2.30e-12 | 172 |
| GO:0032956113 | Thyroid | PTC | regulation of actin cytoskeleton organization | 182/5968 | 358/18723 | 4.64e-14 | 2.79e-12 | 182 |
| GO:0032970113 | Thyroid | PTC | regulation of actin filament-based process | 197/5968 | 397/18723 | 8.91e-14 | 4.89e-12 | 197 |
| GO:0110053112 | Thyroid | PTC | regulation of actin filament organization | 146/5968 | 278/18723 | 5.87e-13 | 2.85e-11 | 146 |
| GO:0045185113 | Thyroid | PTC | maintenance of protein location | 64/5968 | 94/18723 | 5.92e-13 | 2.85e-11 | 64 |
| GO:1902905113 | Thyroid | PTC | positive regulation of supramolecular fiber organization | 114/5968 | 209/18723 | 8.48e-12 | 3.57e-10 | 114 |
| GO:005149526 | Thyroid | PTC | positive regulation of cytoskeleton organization | 121/5968 | 226/18723 | 1.04e-11 | 4.27e-10 | 121 |
| GO:0031346110 | Thyroid | PTC | positive regulation of cell projection organization | 173/5968 | 353/18723 | 1.09e-11 | 4.40e-10 | 173 |
| GO:0032507112 | Thyroid | PTC | maintenance of protein location in cell | 47/5968 | 65/18723 | 2.54e-11 | 9.66e-10 | 47 |
| GO:0030705111 | Thyroid | PTC | cytoskeleton-dependent intracellular transport | 104/5968 | 195/18723 | 3.87e-10 | 1.24e-08 | 104 |
| GO:0045860111 | Thyroid | PTC | positive regulation of protein kinase activity | 176/5968 | 386/18723 | 8.89e-09 | 2.17e-07 | 176 |
| GO:0051017112 | Thyroid | PTC | actin filament bundle assembly | 83/5968 | 157/18723 | 3.73e-08 | 8.18e-07 | 83 |
| GO:0061572112 | Thyroid | PTC | actin filament bundle organization | 84/5968 | 161/18723 | 6.75e-08 | 1.40e-06 | 84 |
| GO:0010975110 | Thyroid | PTC | regulation of neuron projection development | 194/5968 | 445/18723 | 1.05e-07 | 2.08e-06 | 194 |
| Page: 1 2 3 4 5 6 7 8 9 10 11 12 13 14 15 16 17 18 19 |
| Enriched KEGG pathways. |
| Pathway ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | qvalue | Count |
| Page: 1 |
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Cell-cell communication analysis |
| Identification of potential cell-cell interactions between two cell types and their ligand-receptor pairs for different disease states |
| Ligand | Receptor | LRpair | Pathway | Tissue | Disease Stage |
| Page: 1 |
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Single-cell gene regulatory network inference analysis |
| Find out the significant the regulons (TFs) and the target genes of each regulon across cell types for different disease states |
| TF | Cell Type | Tissue | Disease Stage | Target Gene | RSS | Regulon Activity |
| ∗The dot plots of a searched regulon are shown for all cell subpopulations in each disease state of each tissue based on the regulon specific score inferred using pySCENIC and by calculating the average expression. |
| Page: 1 |
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Somatic mutation of malignant transformation related genes |
| Annotation of somatic variants for genes involved in malignant transformation |
| Hugo Symbol | Variant Class | Variant Classification | dbSNP RS | HGVSc | HGVSp | HGVSp Short | SWISSPROT | BIOTYPE | SIFT | PolyPhen | Tumor Sample Barcode | Tissue | Histology | Sex | Age | Stage | Therapy Types | Drugs | Outcome |
| CCDC88A | SNV | Missense_Mutation | c.353C>G | p.Thr118Arg | p.T118R | Q3V6T2 | protein_coding | deleterious(0) | possibly_damaging(0.809) | TCGA-A1-A0SO-01 | Breast | breast invasive carcinoma | Female | >=65 | I/II | Chemotherapy | SD | ||
| CCDC88A | SNV | Missense_Mutation | c.1198N>G | p.Met400Val | p.M400V | Q3V6T2 | protein_coding | tolerated(0.11) | benign(0.029) | TCGA-A8-A09Z-01 | Breast | breast invasive carcinoma | Female | >=65 | I/II | Unknown | Unknown | SD | |
| CCDC88A | SNV | Missense_Mutation | c.5200N>C | p.Val1734Leu | p.V1734L | Q3V6T2 | protein_coding | tolerated(0.35) | benign(0.001) | TCGA-AC-A23H-01 | Breast | breast invasive carcinoma | Female | >=65 | I/II | Unknown | Unknown | PD | |
| CCDC88A | SNV | Missense_Mutation | c.4197N>A | p.Met1399Ile | p.M1399I | Q3V6T2 | protein_coding | tolerated(0.07) | benign(0.311) | TCGA-AC-A23H-01 | Breast | breast invasive carcinoma | Female | >=65 | I/II | Unknown | Unknown | PD | |
| CCDC88A | SNV | Missense_Mutation | c.427N>A | p.Glu143Lys | p.E143K | Q3V6T2 | protein_coding | deleterious(0.04) | probably_damaging(0.997) | TCGA-AC-A23H-01 | Breast | breast invasive carcinoma | Female | >=65 | I/II | Unknown | Unknown | PD | |
| CCDC88A | SNV | Missense_Mutation | c.255N>C | p.Gln85His | p.Q85H | Q3V6T2 | protein_coding | tolerated(0.72) | benign(0.052) | TCGA-AC-A23H-01 | Breast | breast invasive carcinoma | Female | >=65 | I/II | Unknown | Unknown | PD | |
| CCDC88A | SNV | Missense_Mutation | novel | c.802N>A | p.Glu268Lys | p.E268K | Q3V6T2 | protein_coding | deleterious(0) | probably_damaging(0.94) | TCGA-AC-A3W5-01 | Breast | breast invasive carcinoma | Female | >=65 | I/II | Chemotherapy | docetaxel | CR |
| CCDC88A | SNV | Missense_Mutation | novel | c.3964N>C | p.Glu1322Gln | p.E1322Q | Q3V6T2 | protein_coding | deleterious(0.01) | probably_damaging(0.981) | TCGA-AC-A3W6-01 | Breast | breast invasive carcinoma | Female | >=65 | III/IV | Unknown | Unknown | SD |
| CCDC88A | SNV | Missense_Mutation | novel | c.5256N>G | p.Phe1752Leu | p.F1752L | Q3V6T2 | protein_coding | tolerated(0.54) | benign(0) | TCGA-AN-A046-01 | Breast | breast invasive carcinoma | Female | >=65 | I/II | Unknown | Unknown | SD |
| CCDC88A | SNV | Missense_Mutation | c.1774N>A | p.Leu592Ile | p.L592I | Q3V6T2 | protein_coding | deleterious(0) | probably_damaging(0.997) | TCGA-AN-A046-01 | Breast | breast invasive carcinoma | Female | >=65 | I/II | Unknown | Unknown | SD |
| Page: 1 2 3 4 5 6 7 8 9 10 11 12 13 14 15 16 17 18 19 20 21 22 |
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Related drugs of malignant transformation related genes |
| Identification of chemicals and drugs interact with genes involved in malignant transfromation |
| (DGIdb 4.0) |
| Entrez ID | Symbol | Category | Interaction Types | Drug Claim Name | Drug Name | PMIDs |
| Page: 1 |
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