Schematic overview of the cellular and molecular mechanisms involved in the cancer progression, including the proposed cellular and molecular mechanisms in cancer cells trajectory. AT1: alveolar type 1 cells; AT2: alveolar type 2 cells; AAH: atypical adenomatous hyperplasia; AIS: adenocarcinoma in situ; MIA: minimally invasive adenocarcinoma; IA: invasive adenocarcinoma; EMT: epithelial-mesenchymal transition

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Center for Computational Systems Medicine
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Gene summary

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Malignant transformation analysis

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Malignant transformation related pathway analysis

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Cell-cell communication analysis

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Single-cell gene regulatory network inference analysis

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Somatic mutation of malignant transformation related genes

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Related drugs of malignant transformation related genes

Gene: ARHGAP35

Gene summary for ARHGAP35

check button Gene summary.

Gene informationSpeciesHuman
Gene symbol

ARHGAP35

Gene ID

2909

Gene nameRho GTPase activating protein 35
Gene AliasGRF-1
Cytomap19q13.32
Gene Typeprotein-coding
GO ID

GO:0000902

UniProtAcc

Q9NRY4


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Malignant transformation analysis

check button Identification of the aberrant gene expression in precancerous and cancerous lesions by comparing the gene expression of stem-like cells in diseased tissues with normal stem cells
check button Malignant transformation involving gene list.
Entrez IDSymbolReplicatesSpeciesOrganTissueAdj P-valueLog2FCMalignancy
2909ARHGAP35CA_HPV_2HumanCervixCC6.92e-032.37e-010.0391
2909ARHGAP35CCI_2HumanCervixCC1.53e-035.15e-010.5249
2909ARHGAP35CCI_3HumanCervixCC2.99e-097.42e-010.516
2909ARHGAP35LZE2THumanEsophagusESCC7.30e-035.68e-010.082
2909ARHGAP35LZE4THumanEsophagusESCC1.68e-042.24e-010.0811
2909ARHGAP35LZE7THumanEsophagusESCC9.73e-042.16e-010.0667
2909ARHGAP35LZE20THumanEsophagusESCC3.89e-041.02e-010.0662
2909ARHGAP35LZE24THumanEsophagusESCC1.37e-122.26e-010.0596
2909ARHGAP35LZE21THumanEsophagusESCC3.21e-032.81e-010.0655
2909ARHGAP35P1T-EHumanEsophagusESCC7.87e-063.14e-010.0875
2909ARHGAP35P2T-EHumanEsophagusESCC1.33e-081.17e-010.1177
2909ARHGAP35P4T-EHumanEsophagusESCC7.36e-091.63e-010.1323
2909ARHGAP35P5T-EHumanEsophagusESCC3.95e-02-1.07e-030.1327
2909ARHGAP35P8T-EHumanEsophagusESCC1.22e-256.39e-010.0889
2909ARHGAP35P9T-EHumanEsophagusESCC3.34e-111.43e-010.1131
2909ARHGAP35P10T-EHumanEsophagusESCC2.20e-244.35e-010.116
2909ARHGAP35P12T-EHumanEsophagusESCC8.36e-172.68e-010.1122
2909ARHGAP35P15T-EHumanEsophagusESCC5.88e-255.03e-010.1149
2909ARHGAP35P16T-EHumanEsophagusESCC9.98e-046.79e-020.1153
2909ARHGAP35P17T-EHumanEsophagusESCC5.48e-031.54e-010.1278
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check button Transcriptomic changes along malignancy continuum.
TissueExpression DynamicsAbbreviation
CervixThe image shows the transcriptomic changes along malignancy continuum.log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage.CC: Cervix cancer
HSIL_HPV: HPV-infected high-grade squamous intraepithelial lesions
N_HPV: HPV-infected normal cervix
EsophagusThe image shows the transcriptomic changes along malignancy continuum.log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage.ESCC: Esophageal squamous cell carcinoma
HGIN: High-grade intraepithelial neoplasias
LGIN: Low-grade intraepithelial neoplasias
LiverThe image shows the transcriptomic changes along malignancy continuum.log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage.HCC: Hepatocellular carcinoma
NAFLD: Non-alcoholic fatty liver disease
Oral CavityThe image shows the transcriptomic changes along malignancy continuum.log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage.EOLP: Erosive Oral lichen planus
LP: leukoplakia
NEOLP: Non-erosive oral lichen planus
OSCC: Oral squamous cell carcinoma
ProstateThe image shows the transcriptomic changes along malignancy continuum.log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage.BPH: Benign Prostatic Hyperplasia
SkinThe image shows the transcriptomic changes along malignancy continuum.log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage.AK: Actinic keratosis
cSCC: Cutaneous squamous cell carcinoma
SCCIS:squamous cell carcinoma in situ
ThyroidThe image shows the transcriptomic changes along malignancy continuum.log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage.ATC: Anaplastic thyroid cancer
HT: Hashimoto's thyroiditis
PTC: Papillary thyroid cancer
∗log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage.

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Malignant transformation related pathway analysis

check buttonFind out the enriched GO biological processes and KEGG pathways involved in transition from healthy to precancer to cancer
check button Figure of enriched GO biological processes.
TissueDisease StageEnriched GO biological Processes
ColorectumADGO analysis - Figure of enriched GO biological processes: Top 15 enriched GO BP terms are showed in the bar plot of each disease state in each tissue. Each row represents a significant GO biological process which is colored according to the -log10(p.adjust).
ColorectumSERGO analysis - Figure of enriched GO biological processes: Top 15 enriched GO BP terms are showed in the bar plot of each disease state in each tissue. Each row represents a significant GO biological process which is colored according to the -log10(p.adjust).
ColorectumMSSGO analysis - Figure of enriched GO biological processes: Top 15 enriched GO BP terms are showed in the bar plot of each disease state in each tissue. Each row represents a significant GO biological process which is colored according to the -log10(p.adjust).
ColorectumMSI-HGO analysis - Figure of enriched GO biological processes: Top 15 enriched GO BP terms are showed in the bar plot of each disease state in each tissue. Each row represents a significant GO biological process which is colored according to the -log10(p.adjust).
ColorectumFAPGO analysis - Figure of enriched GO biological processes: Top 15 enriched GO BP terms are showed in the bar plot of each disease state in each tissue. Each row represents a significant GO biological process which is colored according to the -log10(p.adjust).
∗Top 15 enriched GO BP terms are showed in the bar plot of each disease state in each tissue. Each row represents a significant GO biological process which is colored according to the -log10(p.adjust).
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check button Enriched GO biological processes.
GO IDTissueDisease StageDescriptionGene RatioBg Ratiopvaluep.adjustCount
GO:011005319ProstateTumorregulation of actin filament organization94/3246278/187231.77e-111.25e-0994
GO:007149619ProstateTumorcellular response to external stimulus103/3246320/187235.29e-113.41e-09103
GO:004206019ProstateTumorwound healing127/3246422/187235.32e-113.41e-09127
GO:000716317ProstateTumorestablishment or maintenance of cell polarity74/3246218/187232.00e-098.86e-0874
GO:000726514ProstateTumorRas protein signal transduction101/3246337/187236.29e-092.44e-07101
GO:003166818ProstateTumorcellular response to extracellular stimulus78/3246246/187232.34e-088.08e-0778
GO:003253518ProstateTumorregulation of cellular component size109/3246383/187233.56e-081.12e-06109
GO:000815417ProstateTumoractin polymerization or depolymerization70/3246218/187236.91e-081.97e-0670
GO:000806416ProstateTumorregulation of actin polymerization or depolymerization60/3246188/187237.30e-071.47e-0560
GO:003083215ProstateTumorregulation of actin filament length60/3246189/187238.91e-071.75e-0560
GO:000836015ProstateTumorregulation of cell shape51/3246154/187231.42e-062.56e-0551
GO:006056214ProstateTumorepithelial tube morphogenesis90/3246325/187231.93e-063.34e-0590
GO:001097514ProstateTumorregulation of neuron projection development115/3246445/187233.34e-065.44e-05115
GO:003134614ProstateTumorpositive regulation of cell projection organization94/3246353/187236.96e-061.05e-0494
GO:190211711ProstateTumorpositive regulation of organelle assembly27/324667/187237.76e-061.16e-0427
GO:004431912ProstateTumorwound healing, spreading of cells17/324634/187231.28e-051.78e-0417
GO:009050512ProstateTumorepiboly involved in wound healing17/324634/187231.28e-051.78e-0417
GO:009050412ProstateTumorepiboly17/324635/187232.09e-052.71e-0417
GO:000201112ProstateTumormorphogenesis of an epithelial sheet23/324657/187233.51e-054.11e-0423
GO:005105613ProstateTumorregulation of small GTPase mediated signal transduction80/3246302/187233.96e-054.57e-0480
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check button Enriched KEGG pathways.
Pathway IDTissueDisease StageDescriptionGene RatioBg Ratiopvaluep.adjustqvalueCount
hsa0451010CervixCCFocal adhesion59/1267203/84651.53e-071.84e-061.09e-0659
hsa0481016CervixCCRegulation of actin cytoskeleton64/1267229/84652.24e-072.59e-061.53e-0664
hsa0467020CervixCCLeukocyte transendothelial migration36/1267114/84655.22e-064.83e-052.86e-0536
hsa046115CervixCCPlatelet activation28/1267124/84651.50e-024.45e-022.63e-0228
hsa0451014CervixCCFocal adhesion59/1267203/84651.53e-071.84e-061.09e-0659
hsa0481017CervixCCRegulation of actin cytoskeleton64/1267229/84652.24e-072.59e-061.53e-0664
hsa04670110CervixCCLeukocyte transendothelial migration36/1267114/84655.22e-064.83e-052.86e-0536
hsa0461113CervixCCPlatelet activation28/1267124/84651.50e-024.45e-022.63e-0228
hsa0451020EsophagusESCCFocal adhesion127/4205203/84651.25e-044.99e-042.56e-04127
hsa0481028EsophagusESCCRegulation of actin cytoskeleton133/4205229/84655.94e-031.48e-027.56e-03133
hsa04510111EsophagusESCCFocal adhesion127/4205203/84651.25e-044.99e-042.56e-04127
hsa04810112EsophagusESCCRegulation of actin cytoskeleton133/4205229/84655.94e-031.48e-027.56e-03133
hsa0481010LiverNAFLDRegulation of actin cytoskeleton50/1043229/84653.01e-057.59e-046.11e-0450
hsa0467014LiverNAFLDLeukocyte transendothelial migration25/1043114/84652.65e-032.71e-022.19e-0225
hsa045106LiverNAFLDFocal adhesion38/1043203/84655.13e-034.43e-023.57e-0238
hsa0481011LiverNAFLDRegulation of actin cytoskeleton50/1043229/84653.01e-057.59e-046.11e-0450
hsa0467015LiverNAFLDLeukocyte transendothelial migration25/1043114/84652.65e-032.71e-022.19e-0225
hsa0451011LiverNAFLDFocal adhesion38/1043203/84655.13e-034.43e-023.57e-0238
hsa0451021LiverCirrhoticFocal adhesion93/2530203/84659.27e-071.10e-056.80e-0693
hsa0481021LiverCirrhoticRegulation of actin cytoskeleton100/2530229/84655.28e-065.50e-053.39e-05100
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Cell-cell communication analysis

check buttonIdentification of potential cell-cell interactions between two cell types and their ligand-receptor pairs for different disease states
LigandReceptorLRpairPathwayTissueDisease Stage
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Single-cell gene regulatory network inference analysis

check buttonFind out the significant the regulons (TFs) and the target genes of each regulon across cell types for different disease states
TFCell TypeTissueDisease StageTarget GeneRSSRegulon Activity
∗The dot plots of a searched regulon are shown for all cell subpopulations in each disease state of each tissue based on the regulon specific score inferred using pySCENIC and by calculating the average expression.
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Somatic mutation of malignant transformation related genes

check buttonAnnotation of somatic variants for genes involved in malignant transformation
Hugo SymbolVariant ClassVariant ClassificationdbSNP RSHGVScHGVSpHGVSp ShortSWISSPROTBIOTYPESIFTPolyPhenTumor Sample BarcodeTissueHistologySexAgeStageTherapy TypesDrugsOutcome
ARHGAP35SNVMissense_Mutationnovelc.3966N>Cp.Lys1322Asnp.K1322NQ9NRY4protein_codingdeleterious(0)probably_damaging(0.989)TCGA-5L-AAT1-01Breastbreast invasive carcinomaFemale<65III/IVHormone TherapyletrozolSD
ARHGAP35SNVMissense_Mutationnovelc.2231G>Tp.Arg744Leup.R744LQ9NRY4protein_codingdeleterious(0.01)possibly_damaging(0.82)TCGA-A2-A0D1-01Breastbreast invasive carcinomaFemale>=65I/IIChemotherapytaxotereSD
ARHGAP35SNVMissense_Mutationnovelc.1097N>Gp.Ala366Glyp.A366GQ9NRY4protein_codingtolerated(0.08)possibly_damaging(0.583)TCGA-A2-A0D2-01Breastbreast invasive carcinomaFemale<65I/IIChemotherapyadriamycinSD
ARHGAP35SNVMissense_Mutationrs778118639c.1301N>Ap.Arg434Lysp.R434KQ9NRY4protein_codingtolerated(1)benign(0.017)TCGA-A2-A0D4-01Breastbreast invasive carcinomaFemale<65I/IIChemotherapyadriamycinSD
ARHGAP35SNVMissense_Mutationrs376792949c.2495N>Ap.Arg832Glnp.R832QQ9NRY4protein_codingdeleterious(0.03)possibly_damaging(0.856)TCGA-A2-A0EV-01Breastbreast invasive carcinomaFemale>=65I/IIUnknownUnknownSD
ARHGAP35SNVMissense_Mutationrs751013716c.844A>Gp.Ser282Glyp.S282GQ9NRY4protein_codingtolerated(0.39)benign(0.138)TCGA-AQ-A04H-01Breastbreast invasive carcinomaFemale<65III/IVChemotherapytaxotereSD
ARHGAP35SNVMissense_Mutationc.4001N>Tp.Pro1334Leup.P1334LQ9NRY4protein_codingdeleterious(0)probably_damaging(0.997)TCGA-B6-A0IC-01Breastbreast invasive carcinomaFemale>=65I/IIUnknownUnknownSD
ARHGAP35SNVMissense_Mutationc.2456N>Gp.Ser819Cysp.S819CQ9NRY4protein_codingtolerated(0.06)possibly_damaging(0.614)TCGA-BH-A0AY-01Breastbreast invasive carcinomaFemale<65I/IIChemotherapySD
ARHGAP35SNVMissense_Mutationc.4204N>Ap.Pro1402Thrp.P1402TQ9NRY4protein_codingdeleterious(0)probably_damaging(1)TCGA-BH-A0C0-01Breastbreast invasive carcinomaFemale<65I/IIChemotherapycarboplatinSD
ARHGAP35SNVMissense_Mutationc.3090N>Cp.Glu1030Aspp.E1030DQ9NRY4protein_codingtolerated(0.29)benign(0.283)TCGA-D8-A1JN-01Breastbreast invasive carcinomaFemale>=65III/IVHormone TherapyanastrozolumSD
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Related drugs of malignant transformation related genes

check buttonIdentification of chemicals and drugs interact with genes involved in malignant transfromation
(DGIdb 4.0)
Entrez IDSymbolCategoryInteraction TypesDrug Claim NameDrug NamePMIDs
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