![]() |
|||||
|
![]() | |
![]() | |
![]() | |
![]() | |
![]() | |
![]() | |
![]() |
Gene: AP2M1 |
Gene summary for AP2M1 |
![]() |
Gene information | Species | Human | Gene symbol | AP2M1 | Gene ID | 1173 |
Gene name | adaptor related protein complex 2 subunit mu 1 | |
Gene Alias | AP50 | |
Cytomap | 3q27.1 | |
Gene Type | protein-coding | GO ID | GO:0002090 | UniProtAcc | Q96CW1 |
Top |
Malignant transformation analysis |
![]() |
![]() |
Entrez ID | Symbol | Replicates | Species | Organ | Tissue | Adj P-value | Log2FC | Malignancy |
1173 | AP2M1 | GSM4909281 | Human | Breast | IDC | 3.07e-26 | 6.98e-01 | 0.21 |
1173 | AP2M1 | GSM4909282 | Human | Breast | IDC | 1.15e-14 | 5.71e-01 | -0.0288 |
1173 | AP2M1 | GSM4909285 | Human | Breast | IDC | 1.13e-46 | 9.11e-01 | 0.21 |
1173 | AP2M1 | GSM4909288 | Human | Breast | IDC | 4.19e-03 | 1.77e-01 | 0.0988 |
1173 | AP2M1 | GSM4909293 | Human | Breast | IDC | 1.22e-05 | 3.57e-01 | 0.1581 |
1173 | AP2M1 | GSM4909294 | Human | Breast | IDC | 3.12e-04 | -1.73e-02 | 0.2022 |
1173 | AP2M1 | GSM4909296 | Human | Breast | IDC | 5.29e-11 | -1.27e-01 | 0.1524 |
1173 | AP2M1 | GSM4909297 | Human | Breast | IDC | 8.49e-17 | 6.05e-02 | 0.1517 |
1173 | AP2M1 | GSM4909301 | Human | Breast | IDC | 1.19e-07 | -2.86e-01 | 0.1577 |
1173 | AP2M1 | GSM4909304 | Human | Breast | IDC | 2.16e-10 | 4.76e-01 | 0.1636 |
1173 | AP2M1 | GSM4909311 | Human | Breast | IDC | 1.00e-34 | -1.23e-01 | 0.1534 |
1173 | AP2M1 | GSM4909312 | Human | Breast | IDC | 3.84e-16 | 1.23e-01 | 0.1552 |
1173 | AP2M1 | GSM4909316 | Human | Breast | IDC | 5.55e-04 | 3.22e-01 | 0.21 |
1173 | AP2M1 | GSM4909318 | Human | Breast | IDC | 1.88e-04 | 3.06e-01 | 0.2031 |
1173 | AP2M1 | GSM4909319 | Human | Breast | IDC | 3.33e-47 | -1.90e-01 | 0.1563 |
1173 | AP2M1 | GSM4909320 | Human | Breast | IDC | 1.89e-08 | -3.68e-01 | 0.1575 |
1173 | AP2M1 | GSM4909321 | Human | Breast | IDC | 2.18e-21 | 2.14e-01 | 0.1559 |
1173 | AP2M1 | brca2 | Human | Breast | Precancer | 1.60e-02 | 3.16e-01 | -0.024 |
1173 | AP2M1 | M2 | Human | Breast | IDC | 1.48e-08 | 5.01e-01 | 0.21 |
1173 | AP2M1 | NCCBC14 | Human | Breast | DCIS | 1.21e-11 | 2.14e-01 | 0.2021 |
Page: 1 2 3 4 5 6 7 8 9 10 11 12 |
![]() |
∗log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage. |
Top |
Malignant transformation related pathway analysis |
![]() |
![]() |
Tissue | Disease Stage | Enriched GO biological Processes |
Colorectum | AD | ![]() |
Colorectum | SER | ![]() |
Colorectum | MSS | ![]() |
Colorectum | MSI-H | ![]() |
Colorectum | FAP | ![]() |
∗Top 15 enriched GO BP terms are showed in the bar plot of each disease state in each tissue. Each row represents a significant GO biological process which is colored according to the -log10(p.adjust). |
Page: 1 2 3 4 5 6 7 8 9 |
![]() |
GO ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | Count |
GO:190307616 | Prostate | Tumor | regulation of protein localization to plasma membrane | 36/3246 | 104/18723 | 1.61e-05 | 2.16e-04 | 36 |
GO:003010015 | Prostate | Tumor | regulation of endocytosis | 60/3246 | 211/18723 | 4.05e-05 | 4.62e-04 | 60 |
GO:000689816 | Prostate | Tumor | receptor-mediated endocytosis | 66/3246 | 244/18723 | 9.25e-05 | 9.05e-04 | 66 |
GO:190437515 | Prostate | Tumor | regulation of protein localization to cell periphery | 39/3246 | 125/18723 | 1.04e-04 | 1.00e-03 | 39 |
GO:004580716 | Prostate | Tumor | positive regulation of endocytosis | 33/3246 | 100/18723 | 1.04e-04 | 1.00e-03 | 33 |
GO:190382812 | Prostate | Tumor | negative regulation of cellular protein localization | 36/3246 | 117/18723 | 2.55e-04 | 2.14e-03 | 36 |
GO:003150312 | Prostate | Tumor | protein-containing complex localization | 59/3246 | 220/18723 | 2.71e-04 | 2.24e-03 | 59 |
GO:003162313 | Prostate | Tumor | receptor internalization | 32/3246 | 113/18723 | 2.51e-03 | 1.40e-02 | 32 |
GO:009907212 | Prostate | Tumor | regulation of postsynaptic membrane neurotransmitter receptor levels | 20/3246 | 62/18723 | 3.07e-03 | 1.63e-02 | 20 |
GO:004825914 | Prostate | Tumor | regulation of receptor-mediated endocytosis | 31/3246 | 110/18723 | 3.15e-03 | 1.65e-02 | 31 |
GO:000209011 | Prostate | Tumor | regulation of receptor internalization | 17/3246 | 56/18723 | 1.17e-02 | 4.81e-02 | 17 |
GO:001605015 | Skin | cSCC | vesicle organization | 135/4864 | 300/18723 | 5.98e-13 | 3.44e-11 | 135 |
GO:000690025 | Skin | cSCC | vesicle budding from membrane | 39/4864 | 61/18723 | 5.02e-10 | 2.02e-08 | 39 |
GO:007265926 | Skin | cSCC | protein localization to plasma membrane | 118/4864 | 284/18723 | 6.43e-09 | 2.11e-07 | 118 |
GO:199077824 | Skin | cSCC | protein localization to cell periphery | 134/4864 | 333/18723 | 7.09e-09 | 2.30e-07 | 134 |
GO:003150315 | Skin | cSCC | protein-containing complex localization | 95/4864 | 220/18723 | 2.00e-08 | 5.82e-07 | 95 |
GO:190437524 | Skin | cSCC | regulation of protein localization to cell periphery | 59/4864 | 125/18723 | 2.52e-07 | 5.28e-06 | 59 |
GO:190307625 | Skin | cSCC | regulation of protein localization to plasma membrane | 49/4864 | 104/18723 | 2.71e-06 | 4.30e-05 | 49 |
GO:190547524 | Skin | cSCC | regulation of protein localization to membrane | 72/4864 | 175/18723 | 8.12e-06 | 1.09e-04 | 72 |
GO:190382822 | Skin | cSCC | negative regulation of cellular protein localization | 50/4864 | 117/18723 | 5.85e-05 | 5.77e-04 | 50 |
Page: 1 2 3 4 5 6 7 8 9 10 11 12 13 14 15 16 17 18 |
![]() |
Pathway ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | qvalue | Count |
hsa0501616 | Breast | Precancer | Huntington disease | 98/684 | 306/8465 | 2.85e-35 | 2.25e-33 | 1.72e-33 | 98 |
hsa0496110 | Breast | Precancer | Endocrine and other factor-regulated calcium reabsorption | 11/684 | 53/8465 | 2.92e-03 | 1.81e-02 | 1.39e-02 | 11 |
hsa0501617 | Breast | Precancer | Huntington disease | 98/684 | 306/8465 | 2.85e-35 | 2.25e-33 | 1.72e-33 | 98 |
hsa0496111 | Breast | Precancer | Endocrine and other factor-regulated calcium reabsorption | 11/684 | 53/8465 | 2.92e-03 | 1.81e-02 | 1.39e-02 | 11 |
hsa0501643 | Breast | DCIS | Huntington disease | 101/846 | 306/8465 | 1.54e-29 | 1.24e-27 | 9.13e-28 | 101 |
hsa0496141 | Breast | DCIS | Endocrine and other factor-regulated calcium reabsorption | 12/846 | 53/8465 | 5.17e-03 | 2.69e-02 | 1.98e-02 | 12 |
hsa0414416 | Breast | DCIS | Endocytosis | 37/846 | 251/8465 | 9.92e-03 | 4.40e-02 | 3.24e-02 | 37 |
hsa0501653 | Breast | DCIS | Huntington disease | 101/846 | 306/8465 | 1.54e-29 | 1.24e-27 | 9.13e-28 | 101 |
hsa0496151 | Breast | DCIS | Endocrine and other factor-regulated calcium reabsorption | 12/846 | 53/8465 | 5.17e-03 | 2.69e-02 | 1.98e-02 | 12 |
hsa0414417 | Breast | DCIS | Endocytosis | 37/846 | 251/8465 | 9.92e-03 | 4.40e-02 | 3.24e-02 | 37 |
hsa0501624 | Cervix | HSIL_HPV | Huntington disease | 38/459 | 306/8465 | 1.21e-06 | 2.54e-05 | 2.05e-05 | 38 |
hsa0501634 | Cervix | HSIL_HPV | Huntington disease | 38/459 | 306/8465 | 1.21e-06 | 2.54e-05 | 2.05e-05 | 38 |
hsa05016 | Colorectum | AD | Huntington disease | 147/2092 | 306/8465 | 1.93e-19 | 9.26e-18 | 5.91e-18 | 147 |
hsa04144 | Colorectum | AD | Endocytosis | 111/2092 | 251/8465 | 5.95e-12 | 1.42e-10 | 9.08e-11 | 111 |
hsa04961 | Colorectum | AD | Endocrine and other factor-regulated calcium reabsorption | 24/2092 | 53/8465 | 8.49e-04 | 5.93e-03 | 3.78e-03 | 24 |
hsa050161 | Colorectum | AD | Huntington disease | 147/2092 | 306/8465 | 1.93e-19 | 9.26e-18 | 5.91e-18 | 147 |
hsa041441 | Colorectum | AD | Endocytosis | 111/2092 | 251/8465 | 5.95e-12 | 1.42e-10 | 9.08e-11 | 111 |
hsa049611 | Colorectum | AD | Endocrine and other factor-regulated calcium reabsorption | 24/2092 | 53/8465 | 8.49e-04 | 5.93e-03 | 3.78e-03 | 24 |
hsa050162 | Colorectum | SER | Huntington disease | 127/1580 | 306/8465 | 3.29e-21 | 1.37e-19 | 9.92e-20 | 127 |
hsa041442 | Colorectum | SER | Endocytosis | 81/1580 | 251/8465 | 1.14e-07 | 2.36e-06 | 1.71e-06 | 81 |
Page: 1 2 3 4 |
Top |
Cell-cell communication analysis |
![]() |
Ligand | Receptor | LRpair | Pathway | Tissue | Disease Stage |
Page: 1 |
Top |
Single-cell gene regulatory network inference analysis |
![]() |
TF | Cell Type | Tissue | Disease Stage | Target Gene | RSS | Regulon Activity |
∗The dot plots of a searched regulon are shown for all cell subpopulations in each disease state of each tissue based on the regulon specific score inferred using pySCENIC and by calculating the average expression. |
Page: 1 |
Top |
Somatic mutation of malignant transformation related genes |
![]() |
Hugo Symbol | Variant Class | Variant Classification | dbSNP RS | HGVSc | HGVSp | HGVSp Short | SWISSPROT | BIOTYPE | SIFT | PolyPhen | Tumor Sample Barcode | Tissue | Histology | Sex | Age | Stage | Therapy Types | Drugs | Outcome |
AP2M1 | SNV | Missense_Mutation | novel | c.164N>T | p.Asp55Val | p.D55V | protein_coding | deleterious(0) | possibly_damaging(0.885) | TCGA-BH-A0EE-01 | Breast | breast invasive carcinoma | Female | >=65 | I/II | Chemotherapy | docetaxel | SD | |
AP2M1 | SNV | Missense_Mutation | c.409N>A | p.Leu137Met | p.L137M | protein_coding | deleterious(0.04) | possibly_damaging(0.607) | TCGA-E2-A14R-01 | Breast | breast invasive carcinoma | Female | <65 | I/II | Chemotherapy | doxorubicin | PD | ||
AP2M1 | insertion | In_Frame_Ins | novel | c.162_163insCCTCACTTTATTAAGGTTACATCAGCCTTAATA | p.Val54_Asp55insProHisPheIleLysValThrSerAlaLeuIle | p.V54_D55insPHFIKVTSALI | protein_coding | TCGA-BH-A0EE-01 | Breast | breast invasive carcinoma | Female | >=65 | I/II | Chemotherapy | docetaxel | SD | |||
AP2M1 | SNV | Missense_Mutation | novel | c.1355G>A | p.Arg452His | p.R452H | protein_coding | deleterious(0) | benign(0.223) | TCGA-2W-A8YY-01 | Cervix | cervical & endocervical cancer | Female | <65 | I/II | Chemotherapy | cisplatin | CR | |
AP2M1 | SNV | Missense_Mutation | novel | c.986N>T | p.Lys329Met | p.K329M | protein_coding | deleterious(0.02) | probably_damaging(0.971) | TCGA-C5-A2LZ-01 | Cervix | cervical & endocervical cancer | Female | >=65 | III/IV | Unknown | Unknown | PD | |
AP2M1 | SNV | Missense_Mutation | c.457G>A | p.Ala153Thr | p.A153T | protein_coding | tolerated(0.76) | benign(0) | TCGA-VS-A8QA-01 | Cervix | cervical & endocervical cancer | Female | <65 | I/II | Unknown | Unknown | SD | ||
AP2M1 | SNV | Missense_Mutation | c.902G>A | p.Arg301Lys | p.R301K | protein_coding | tolerated(0.54) | benign(0.014) | TCGA-AA-3672-01 | Colorectum | colon adenocarcinoma | Female | >=65 | III/IV | Unknown | Unknown | SD | ||
AP2M1 | SNV | Missense_Mutation | c.908N>A | p.Arg303His | p.R303H | protein_coding | deleterious(0.02) | possibly_damaging(0.545) | TCGA-AA-3715-01 | Colorectum | colon adenocarcinoma | Male | >=65 | I/II | Unknown | Unknown | PD | ||
AP2M1 | SNV | Missense_Mutation | novel | c.625N>T | p.Leu209Phe | p.L209F | protein_coding | deleterious(0) | probably_damaging(0.999) | TCGA-AA-3877-01 | Colorectum | colon adenocarcinoma | Female | >=65 | I/II | Unknown | Unknown | SD | |
AP2M1 | SNV | Missense_Mutation | c.431N>A | p.Gly144Asp | p.G144D | protein_coding | deleterious(0) | probably_damaging(1) | TCGA-AA-A01R-01 | Colorectum | colon adenocarcinoma | Male | <65 | III/IV | Chemotherapy | 5-fluorouracil | PD |
Page: 1 2 3 4 5 |
Top |
Related drugs of malignant transformation related genes |
![]() |
(DGIdb 4.0) |
Entrez ID | Symbol | Category | Interaction Types | Drug Claim Name | Drug Name | PMIDs |
Page: 1 |