Schematic overview of the cellular and molecular mechanisms involved in the cancer progression, including the proposed cellular and molecular mechanisms in cancer cells trajectory. AT1: alveolar type 1 cells; AT2: alveolar type 2 cells; AAH: atypical adenomatous hyperplasia; AIS: adenocarcinoma in situ; MIA: minimally invasive adenocarcinoma; IA: invasive adenocarcinoma; EMT: epithelial-mesenchymal transition

Home

Download

Statistics

Help

Contact
Center for Computational Systems Medicine
leaf

Gene summary

leaf

Malignant transformation analysis

leaf

Malignant transformation related pathway analysis

leaf

Cell-cell communication analysis

leaf

Single-cell gene regulatory network inference analysis

leaf

Somatic mutation of malignant transformation related genes

leaf

Related drugs of malignant transformation related genes

Gene: ANK2

Gene summary for ANK2

check button Gene summary.

Gene informationSpeciesHuman
Gene symbol

ANK2

Gene ID

287

Gene nameankyrin 2
Gene AliasANK-2
Cytomap4q25-q26
Gene Typeprotein-coding
GO ID

GO:0001508

UniProtAcc

Q01484


Top

Malignant transformation analysis

check button Identification of the aberrant gene expression in precancerous and cancerous lesions by comparing the gene expression of stem-like cells in diseased tissues with normal stem cells
check button Malignant transformation involving gene list.
Entrez IDSymbolReplicatesSpeciesOrganTissueAdj P-valueLog2FCMalignancy
287ANK2ATC13HumanThyroidATC2.28e-367.42e-010.34
287ANK2ATC5HumanThyroidATC7.88e-388.07e-010.34
Page: 1 

check button Transcriptomic changes along malignancy continuum.
TissueExpression DynamicsAbbreviation
ThyroidThe image shows the transcriptomic changes along malignancy continuum.log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage.ATC: Anaplastic thyroid cancer
HT: Hashimoto's thyroiditis
PTC: Papillary thyroid cancer
∗log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage.

Top

Malignant transformation related pathway analysis

check buttonFind out the enriched GO biological processes and KEGG pathways involved in transition from healthy to precancer to cancer
check button Figure of enriched GO biological processes.
TissueDisease StageEnriched GO biological Processes
ColorectumADGO analysis - Figure of enriched GO biological processes: Top 15 enriched GO BP terms are showed in the bar plot of each disease state in each tissue. Each row represents a significant GO biological process which is colored according to the -log10(p.adjust).
ColorectumSERGO analysis - Figure of enriched GO biological processes: Top 15 enriched GO BP terms are showed in the bar plot of each disease state in each tissue. Each row represents a significant GO biological process which is colored according to the -log10(p.adjust).
ColorectumMSSGO analysis - Figure of enriched GO biological processes: Top 15 enriched GO BP terms are showed in the bar plot of each disease state in each tissue. Each row represents a significant GO biological process which is colored according to the -log10(p.adjust).
ColorectumMSI-HGO analysis - Figure of enriched GO biological processes: Top 15 enriched GO BP terms are showed in the bar plot of each disease state in each tissue. Each row represents a significant GO biological process which is colored according to the -log10(p.adjust).
ColorectumFAPGO analysis - Figure of enriched GO biological processes: Top 15 enriched GO BP terms are showed in the bar plot of each disease state in each tissue. Each row represents a significant GO biological process which is colored according to the -log10(p.adjust).
∗Top 15 enriched GO BP terms are showed in the bar plot of each disease state in each tissue. Each row represents a significant GO biological process which is colored according to the -log10(p.adjust).
Page: 1 2 3 4 5 6 7 8 9 

check button Enriched GO biological processes.
GO IDTissueDisease StageDescriptionGene RatioBg Ratiopvaluep.adjustCount
GO:007252128ThyroidATCpurine-containing compound metabolic process189/6293416/187232.83e-074.29e-06189
GO:007138328ThyroidATCcellular response to steroid hormone stimulus103/6293204/187234.32e-076.30e-06103
GO:000008216ThyroidATCG1/S transition of mitotic cell cycle107/6293214/187234.83e-076.99e-06107
GO:003051826ThyroidATCintracellular steroid hormone receptor signaling pathway65/6293116/187235.58e-077.93e-0665
GO:0006753111ThyroidATCnucleoside phosphate metabolic process219/6293497/187235.92e-078.29e-06219
GO:005123532ThyroidATCmaintenance of location152/6293327/187237.84e-071.04e-05152
GO:0009117112ThyroidATCnucleotide metabolic process215/6293489/187239.09e-071.20e-05215
GO:005105618ThyroidATCregulation of small GTPase mediated signal transduction141/6293302/187231.43e-061.77e-05141
GO:000726619ThyroidATCRho protein signal transduction73/6293137/187231.58e-061.93e-0573
GO:003432924ThyroidATCcell junction assembly187/6293420/187231.71e-062.08e-05187
GO:005165133ThyroidATCmaintenance of location in cell105/6293214/187231.92e-062.31e-05105
GO:004521629ThyroidATCcell-cell junction organization99/6293200/187232.26e-062.68e-0599
GO:000616328ThyroidATCpurine nucleotide metabolic process177/6293396/187232.39e-062.82e-05177
GO:004657818ThyroidATCregulation of Ras protein signal transduction94/6293189/187233.12e-063.55e-0594
GO:0051881110ThyroidATCregulation of mitochondrial membrane potential44/629374/187234.51e-064.94e-0544
GO:0043401111ThyroidATCsteroid hormone mediated signaling pathway71/6293136/187235.72e-066.07e-0571
GO:000915225ThyroidATCpurine ribonucleotide biosynthetic process84/6293169/187231.05e-051.04e-0484
GO:000327912ThyroidATCcardiac septum development56/6293103/187231.14e-051.11e-0456
GO:001094813ThyroidATCnegative regulation of cell cycle process134/6293294/187231.19e-051.15e-04134
GO:003314316ThyroidATCregulation of intracellular steroid hormone receptor signaling pathway43/629374/187231.30e-051.25e-0443
Page: 1 2 3 4 5 6 7 8 9 10 11 12 13 14 15 16 17 

check button Enriched KEGG pathways.
Pathway IDTissueDisease StageDescriptionGene RatioBg Ratiopvaluep.adjustqvalueCount
Page: 1 

Top

Cell-cell communication analysis

check buttonIdentification of potential cell-cell interactions between two cell types and their ligand-receptor pairs for different disease states
LigandReceptorLRpairPathwayTissueDisease Stage
Page: 1 

Top

Single-cell gene regulatory network inference analysis

check buttonFind out the significant the regulons (TFs) and the target genes of each regulon across cell types for different disease states
TFCell TypeTissueDisease StageTarget GeneRSSRegulon Activity
∗The dot plots of a searched regulon are shown for all cell subpopulations in each disease state of each tissue based on the regulon specific score inferred using pySCENIC and by calculating the average expression.
Page: 1 

Top

Somatic mutation of malignant transformation related genes

check buttonAnnotation of somatic variants for genes involved in malignant transformation
Hugo SymbolVariant ClassVariant ClassificationdbSNP RSHGVScHGVSpHGVSp ShortSWISSPROTBIOTYPESIFTPolyPhenTumor Sample BarcodeTissueHistologySexAgeStageTherapy TypesDrugsOutcome
ANK2SNVMissense_Mutationrs775323997c.3094N>Ap.Glu1032Lysp.E1032KQ01484protein_codingdeleterious(0)probably_damaging(0.962)TCGA-5L-AAT1-01Breastbreast invasive carcinomaFemale<65III/IVHormone TherapyletrozolSD
ANK2SNVMissense_Mutationnovelc.6349N>Ap.Asp2117Asnp.D2117NQ01484protein_codingdeleterious_low_confidence(0)possibly_damaging(0.642)TCGA-5L-AAT1-01Breastbreast invasive carcinomaFemale<65III/IVHormone TherapyletrozolSD
ANK2SNVMissense_Mutationc.2728C>Gp.Leu910Valp.L910VQ01484protein_codingtolerated(0.07)benign(0.135)TCGA-A2-A0CT-01Breastbreast invasive carcinomaFemale>=65I/IIChemotherapycytoxanSD
ANK2SNVMissense_Mutationrs754722115c.4280N>Ap.Arg1427Glnp.R1427QQ01484protein_codingdeleterious(0)probably_damaging(0.999)TCGA-A7-A4SC-01Breastbreast invasive carcinomaFemale<65I/IIHormone TherapytamoxiphenSD
ANK2SNVMissense_Mutationrs367592943c.5827G>Ap.Gly1943Argp.G1943RQ01484protein_codingdeleterious_low_confidence(0.01)possibly_damaging(0.506)TCGA-A8-A06T-01Breastbreast invasive carcinomaFemale>=65III/IVHormone TherapyanastrozoleSD
ANK2SNVMissense_Mutationc.4222N>Ap.Glu1408Lysp.E1408KQ01484protein_codingdeleterious(0)probably_damaging(0.999)TCGA-AC-A23H-01Breastbreast invasive carcinomaFemale>=65I/IIUnknownUnknownPD
ANK2SNVMissense_Mutationc.7868N>Ap.Ser2623Tyrp.S2623YQ01484protein_codingtolerated_low_confidence(0.83)possibly_damaging(0.66)TCGA-AC-A23H-01Breastbreast invasive carcinomaFemale>=65I/IIUnknownUnknownPD
ANK2SNVMissense_Mutationnovelc.6215C>Ap.Ser2072Tyrp.S2072YQ01484protein_codingtolerated_low_confidence(0.07)benign(0.367)TCGA-AN-A046-01Breastbreast invasive carcinomaFemale>=65I/IIUnknownUnknownSD
ANK2SNVMissense_Mutationnovelc.7594G>Tp.Gly2532Trpp.G2532WQ01484protein_codingdeleterious(0)probably_damaging(1)TCGA-AN-A046-01Breastbreast invasive carcinomaFemale>=65I/IIUnknownUnknownSD
ANK2SNVMissense_Mutationnovelc.8177C>Ap.Thr2726Asnp.T2726NQ01484protein_codingtolerated_low_confidence(0.51)benign(0)TCGA-AN-A046-01Breastbreast invasive carcinomaFemale>=65I/IIUnknownUnknownSD
Page: 1 2 3 4 5 6 7 8 9 10 11 12 13 14 15 16 17 18 19 20 21 22 23 24 25 26 27 28 29 30 31 32 33 34 35 36 37 38 39 40 41 42 43 44 45 46 47 48 49 50 51 52 53 54 55 56 57 58 59 60 61 

Top

Related drugs of malignant transformation related genes

check buttonIdentification of chemicals and drugs interact with genes involved in malignant transfromation
(DGIdb 4.0)
Entrez IDSymbolCategoryInteraction TypesDrug Claim NameDrug NamePMIDs
Page: 1