GO ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | Count |
GO:0045785112 | Thyroid | PTC | positive regulation of cell adhesion | 176/5968 | 437/18723 | 1.10e-04 | 8.83e-04 | 176 |
GO:00603486 | Thyroid | PTC | bone development | 90/5968 | 205/18723 | 1.89e-04 | 1.42e-03 | 90 |
GO:004560015 | Thyroid | PTC | positive regulation of fat cell differentiation | 33/5968 | 66/18723 | 1.63e-03 | 9.01e-03 | 33 |
GO:00302785 | Thyroid | PTC | regulation of ossification | 51/5968 | 115/18723 | 3.30e-03 | 1.61e-02 | 51 |
GO:004559814 | Thyroid | PTC | regulation of fat cell differentiation | 59/5968 | 139/18723 | 5.50e-03 | 2.50e-02 | 59 |
GO:000182313 | Thyroid | PTC | mesonephros development | 42/5968 | 96/18723 | 9.53e-03 | 3.91e-02 | 42 |
GO:00171452 | Thyroid | PTC | stem cell division | 16/5968 | 30/18723 | 1.19e-02 | 4.69e-02 | 16 |
GO:003450423 | Thyroid | ATC | protein localization to nucleus | 175/6293 | 290/18723 | 6.23e-21 | 1.23e-18 | 175 |
GO:000150332 | Thyroid | ATC | ossification | 206/6293 | 408/18723 | 9.23e-13 | 3.95e-11 | 206 |
GO:000182222 | Thyroid | ATC | kidney development | 146/6293 | 293/18723 | 5.81e-09 | 1.28e-07 | 146 |
GO:000165522 | Thyroid | ATC | urogenital system development | 164/6293 | 338/18723 | 7.92e-09 | 1.70e-07 | 164 |
GO:007200122 | Thyroid | ATC | renal system development | 149/6293 | 302/18723 | 9.48e-09 | 1.99e-07 | 149 |
GO:006034813 | Thyroid | ATC | bone development | 102/6293 | 205/18723 | 1.18e-06 | 1.52e-05 | 102 |
GO:0045785210 | Thyroid | ATC | positive regulation of cell adhesion | 194/6293 | 437/18723 | 1.40e-06 | 1.75e-05 | 194 |
GO:003009933 | Thyroid | ATC | myeloid cell differentiation | 170/6293 | 381/18723 | 4.26e-06 | 4.68e-05 | 170 |
GO:003027813 | Thyroid | ATC | regulation of ossification | 60/6293 | 115/18723 | 3.01e-05 | 2.51e-04 | 60 |
GO:004544423 | Thyroid | ATC | fat cell differentiation | 105/6293 | 229/18723 | 7.42e-05 | 5.62e-04 | 105 |
GO:00020624 | Thyroid | ATC | chondrocyte differentiation | 54/6293 | 106/18723 | 1.67e-04 | 1.14e-03 | 54 |
GO:00614484 | Thyroid | ATC | connective tissue development | 112/6293 | 252/18723 | 2.08e-04 | 1.38e-03 | 112 |
GO:000182321 | Thyroid | ATC | mesonephros development | 49/6293 | 96/18723 | 3.08e-04 | 1.94e-03 | 49 |
TF | Cell Type | Tissue | Disease Stage | Target Gene | RSS | Regulon Activity |
ZBTB1 | MSC | Breast | ADJ | HK2,REL,RBBP6, etc. | 6.65e-03 | |
ZBTB1 | CAF | Breast | DCIS | HK2,REL,RBBP6, etc. | 5.85e-02 | |
ZBTB1 | MSC | Breast | Healthy | HK2,REL,RBBP6, etc. | 7.45e-02 | |
ZBTB1 | MSC | Breast | Precancer | HK2,REL,RBBP6, etc. | 2.37e-01 | |
ZBTB1 | TREG | Cervix | ADJ | CCL4L2,AKAP5,ZC3H18, etc. | 1.49e-02 | |
ZBTB1 | ICAF | Colorectum | SER | COL4A5,CTSK,C16orf87, etc. | 3.86e-01 | |
ZBTB1 | INCAF | Endometrium | ADJ | FAM156B,ZNF101,GDF7, etc. | 6.05e-01 | |
ZBTB1 | FIB | Endometrium | ADJ | FAM156B,ZNF101,GDF7, etc. | 1.39e-02 | |
ZBTB1 | INCAF | Endometrium | AEH | FAM156B,ZNF101,GDF7, etc. | 6.02e-01 | |
ZBTB1 | ICAF | Endometrium | AEH | FAM156B,ZNF101,GDF7, etc. | 7.24e-03 | |
Hugo Symbol | Variant Class | Variant Classification | dbSNP RS | HGVSc | HGVSp | HGVSp Short | SWISSPROT | BIOTYPE | SIFT | PolyPhen | Tumor Sample Barcode | Tissue | Histology | Sex | Age | Stage | Therapy Types | Drugs | Outcome |
ZBTB1 | SNV | Missense_Mutation | | c.1458G>C | p.Glu486Asp | p.E486D | Q9Y2K1 | protein_coding | tolerated(0.6) | benign(0.16) | TCGA-5L-AAT1-01 | Breast | breast invasive carcinoma | Female | <65 | III/IV | Hormone Therapy | letrozol | SD |
ZBTB1 | SNV | Missense_Mutation | | c.204N>A | p.Met68Ile | p.M68I | Q9Y2K1 | protein_coding | tolerated(0.08) | benign(0.031) | TCGA-AC-A23H-01 | Breast | breast invasive carcinoma | Female | >=65 | I/II | Unknown | Unknown | PD |
ZBTB1 | SNV | Missense_Mutation | rs148266968 | c.961N>A | p.Glu321Lys | p.E321K | Q9Y2K1 | protein_coding | tolerated(0.5) | benign(0.092) | TCGA-AC-A23H-01 | Breast | breast invasive carcinoma | Female | >=65 | I/II | Unknown | Unknown | PD |
ZBTB1 | SNV | Missense_Mutation | novel | c.1898G>A | p.Arg633Lys | p.R633K | Q9Y2K1 | protein_coding | tolerated(0.11) | probably_damaging(0.935) | TCGA-BH-A0C0-01 | Breast | breast invasive carcinoma | Female | <65 | I/II | Chemotherapy | carboplatin | SD |
ZBTB1 | insertion | Nonsense_Mutation | novel | c.1901_1902insATGAGA | p.Tyr634delinsTer | p.Y634delins* | Q9Y2K1 | protein_coding | | | TCGA-A8-A096-01 | Breast | breast invasive carcinoma | Female | >=65 | I/II | Unknown | Unknown | SD |
ZBTB1 | deletion | Frame_Shift_Del | rs747075448 | c.1140delN | p.Ser383ValfsTer6 | p.S383Vfs*6 | Q9Y2K1 | protein_coding | | | TCGA-AN-A0AK-01 | Breast | breast invasive carcinoma | Female | >=65 | I/II | Unknown | Unknown | SD |
ZBTB1 | insertion | Frame_Shift_Ins | novel | c.687_688insCTGGAGGGAGC | p.Leu231GlufsTer5 | p.L231Efs*5 | Q9Y2K1 | protein_coding | | | TCGA-AR-A0TU-01 | Breast | breast invasive carcinoma | Female | <65 | I/II | Unspecific | Doxorubicin | SD |
ZBTB1 | deletion | Frame_Shift_Del | novel | c.1885delN | p.Gly630AlafsTer24 | p.G630Afs*24 | Q9Y2K1 | protein_coding | | | TCGA-D8-A27V-01 | Breast | breast invasive carcinoma | Female | <65 | I/II | Hormone Therapy | tamoxiphen | SD |
ZBTB1 | SNV | Missense_Mutation | rs143630259 | c.1406N>A | p.Arg469Gln | p.R469Q | Q9Y2K1 | protein_coding | deleterious(0.03) | benign(0.232) | TCGA-EK-A2RC-01 | Cervix | cervical & endocervical cancer | Female | <65 | I/II | Unknown | Unknown | SD |
ZBTB1 | SNV | Missense_Mutation | | c.1476G>C | p.Glu492Asp | p.E492D | Q9Y2K1 | protein_coding | tolerated(0.42) | benign(0.428) | TCGA-IR-A3LK-01 | Cervix | cervical & endocervical cancer | Female | >=65 | I/II | Chemotherapy | cisplatin | PD |