Schematic overview of the cellular and molecular mechanisms involved in the cancer progression, including the proposed cellular and molecular mechanisms in cancer cells trajectory. AT1: alveolar type 1 cells; AT2: alveolar type 2 cells; AAH: atypical adenomatous hyperplasia; AIS: adenocarcinoma in situ; MIA: minimally invasive adenocarcinoma; IA: invasive adenocarcinoma; EMT: epithelial-mesenchymal transition

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Center for Computational Systems Medicine
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Gene summary

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Malignant transformation analysis

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Malignant transformation related pathway analysis

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Cell-cell communication analysis

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Single-cell gene regulatory network inference analysis

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Somatic mutation of malignant transformation related genes

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Related drugs of malignant transformation related genes

Gene: SH3RF2

Gene summary for SH3RF2

check button Gene summary.

Gene informationSpeciesHuman
Gene symbol

SH3RF2

Gene ID

153769

Gene nameSH3 domain containing ring finger 2
Gene AliasHEPP1
Cytomap5q32
Gene Typeprotein-coding
GO ID

GO:0000165

UniProtAcc

Q08AM8


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Malignant transformation analysis

check button Identification of the aberrant gene expression in precancerous and cancerous lesions by comparing the gene expression of stem-like cells in diseased tissues with normal stem cells
check button Malignant transformation involving gene list.
Entrez IDSymbolReplicatesSpeciesOrganTissueAdj P-valueLog2FCMalignancy
153769SH3RF2CCI_2HumanCervixCC2.19e-067.06e-010.5249
153769SH3RF2CCI_3HumanCervixCC5.78e-148.56e-010.516
153769SH3RF2HTA11_3410_2000001011HumanColorectumAD7.43e-28-6.73e-010.0155
153769SH3RF2HTA11_2951_2000001011HumanColorectumAD2.54e-02-7.11e-010.0216
153769SH3RF2HTA11_347_2000001011HumanColorectumAD2.31e-116.13e-01-0.1954
153769SH3RF2HTA11_2112_2000001011HumanColorectumSER4.32e-02-6.82e-01-0.2196
153769SH3RF2HTA11_3361_2000001011HumanColorectumAD4.55e-09-6.54e-01-0.1207
153769SH3RF2HTA11_866_3004761011HumanColorectumAD5.11e-15-6.56e-010.096
153769SH3RF2HTA11_9408_2000001011HumanColorectumAD7.92e-03-6.47e-010.0451
153769SH3RF2HTA11_8622_2000001021HumanColorectumSER5.02e-04-6.09e-010.0528
153769SH3RF2HTA11_10711_2000001011HumanColorectumAD9.32e-03-4.90e-010.0338
153769SH3RF2HTA11_7696_3000711011HumanColorectumAD2.75e-07-4.92e-010.0674
153769SH3RF2HTA11_6818_2000001011HumanColorectumAD4.45e-06-5.01e-010.0112
153769SH3RF2HTA11_11156_2000001011HumanColorectumAD4.95e-04-9.90e-010.0397
153769SH3RF2HTA11_6818_2000001021HumanColorectumAD3.46e-03-4.80e-010.0588
153769SH3RF2HTA11_99999970781_79442HumanColorectumMSS3.17e-31-7.30e-010.294
153769SH3RF2HTA11_99999971662_82457HumanColorectumMSS5.54e-28-7.37e-010.3859
153769SH3RF2HTA11_99999973899_84307HumanColorectumMSS1.81e-05-5.82e-010.2585
153769SH3RF2HTA11_99999974143_84620HumanColorectumMSS3.68e-64-1.13e+000.3005
153769SH3RF2F007HumanColorectumFAP1.22e-12-7.49e-010.1176
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check button Transcriptomic changes along malignancy continuum.
TissueExpression DynamicsAbbreviation
CervixThe image shows the transcriptomic changes along malignancy continuum.log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage.CC: Cervix cancer
HSIL_HPV: HPV-infected high-grade squamous intraepithelial lesions
N_HPV: HPV-infected normal cervix
Colorectum (GSE201348)The image shows the transcriptomic changes along malignancy continuum.log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage.FAP: Familial adenomatous polyposis
CRC: Colorectal cancer
Colorectum (HTA11)The image shows the transcriptomic changes along malignancy continuum.log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage.AD: Adenomas
SER: Sessile serrated lesions
MSI-H: Microsatellite-high colorectal cancer
MSS: Microsatellite stable colorectal cancer
EsophagusThe image shows the transcriptomic changes along malignancy continuum.log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage.ESCC: Esophageal squamous cell carcinoma
HGIN: High-grade intraepithelial neoplasias
LGIN: Low-grade intraepithelial neoplasias
LungThe image shows the transcriptomic changes along malignancy continuum.log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage.AAH: Atypical adenomatous hyperplasia
AIS: Adenocarcinoma in situ
IAC: Invasive lung adenocarcinoma
MIA: Minimally invasive adenocarcinoma
Oral CavityThe image shows the transcriptomic changes along malignancy continuum.log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage.EOLP: Erosive Oral lichen planus
LP: leukoplakia
NEOLP: Non-erosive oral lichen planus
OSCC: Oral squamous cell carcinoma
SkinThe image shows the transcriptomic changes along malignancy continuum.log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage.AK: Actinic keratosis
cSCC: Cutaneous squamous cell carcinoma
SCCIS:squamous cell carcinoma in situ
∗log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage.

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Malignant transformation related pathway analysis

check buttonFind out the enriched GO biological processes and KEGG pathways involved in transition from healthy to precancer to cancer
check button Figure of enriched GO biological processes.
TissueDisease StageEnriched GO biological Processes
ColorectumADGO analysis - Figure of enriched GO biological processes: Top 15 enriched GO BP terms are showed in the bar plot of each disease state in each tissue. Each row represents a significant GO biological process which is colored according to the -log10(p.adjust).
ColorectumSERGO analysis - Figure of enriched GO biological processes: Top 15 enriched GO BP terms are showed in the bar plot of each disease state in each tissue. Each row represents a significant GO biological process which is colored according to the -log10(p.adjust).
ColorectumMSSGO analysis - Figure of enriched GO biological processes: Top 15 enriched GO BP terms are showed in the bar plot of each disease state in each tissue. Each row represents a significant GO biological process which is colored according to the -log10(p.adjust).
ColorectumMSI-HGO analysis - Figure of enriched GO biological processes: Top 15 enriched GO BP terms are showed in the bar plot of each disease state in each tissue. Each row represents a significant GO biological process which is colored according to the -log10(p.adjust).
ColorectumFAPGO analysis - Figure of enriched GO biological processes: Top 15 enriched GO BP terms are showed in the bar plot of each disease state in each tissue. Each row represents a significant GO biological process which is colored according to the -log10(p.adjust).
∗Top 15 enriched GO BP terms are showed in the bar plot of each disease state in each tissue. Each row represents a significant GO biological process which is colored according to the -log10(p.adjust).
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check button Enriched GO biological processes.
GO IDTissueDisease StageDescriptionGene RatioBg Ratiopvaluep.adjustCount
GO:001049813LungAISproteasomal protein catabolic process87/1849490/187234.15e-085.03e-0687
GO:003139613LungAISregulation of protein ubiquitination46/1849210/187231.71e-071.72e-0546
GO:003109813LungAISstress-activated protein kinase signaling cascade51/1849247/187232.69e-072.37e-0551
GO:190305212LungAISpositive regulation of proteolysis involved in cellular protein catabolic process33/1849133/187234.82e-073.65e-0533
GO:000725413LungAISJNK cascade38/1849167/187237.27e-075.36e-0538
GO:003243613LungAISpositive regulation of proteasomal ubiquitin-dependent protein catabolic process25/184990/187231.25e-068.19e-0525
GO:005140313LungAISstress-activated MAPK cascade48/1849239/187231.38e-068.75e-0548
GO:003243413LungAISregulation of proteasomal ubiquitin-dependent protein catabolic process32/1849134/187231.76e-061.05e-0432
GO:004340912LungAISnegative regulation of MAPK cascade39/1849180/187231.92e-061.12e-0439
GO:006113613LungAISregulation of proteasomal protein catabolic process39/1849187/187235.12e-062.47e-0439
GO:007030213LungAISregulation of stress-activated protein kinase signaling cascade40/1849195/187235.96e-062.78e-0440
GO:190332113LungAISnegative regulation of protein modification by small protein conjugation or removal24/184995/187231.22e-054.71e-0424
GO:003139713LungAISnegative regulation of protein ubiquitination22/184983/187231.22e-054.71e-0422
GO:004632812LungAISregulation of JNK cascade30/1849133/187231.24e-054.75e-0430
GO:190180013LungAISpositive regulation of proteasomal protein catabolic process27/1849114/187231.30e-054.85e-0427
GO:003287213LungAISregulation of stress-activated MAPK cascade38/1849192/187232.36e-057.81e-0438
GO:00434101LungAISpositive regulation of MAPK cascade72/1849480/187232.11e-044.32e-0372
GO:003287313LungAISnegative regulation of stress-activated MAPK cascade14/184951/187233.07e-045.62e-0314
GO:007030313LungAISnegative regulation of stress-activated protein kinase signaling cascade14/184951/187233.07e-045.62e-0314
GO:005186511LungAISprotein autoubiquitination17/184973/187236.14e-049.31e-0317
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check button Enriched KEGG pathways.
Pathway IDTissueDisease StageDescriptionGene RatioBg Ratiopvaluep.adjustqvalueCount
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Cell-cell communication analysis

check buttonIdentification of potential cell-cell interactions between two cell types and their ligand-receptor pairs for different disease states
LigandReceptorLRpairPathwayTissueDisease Stage
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Single-cell gene regulatory network inference analysis

check buttonFind out the significant the regulons (TFs) and the target genes of each regulon across cell types for different disease states
TFCell TypeTissueDisease StageTarget GeneRSSRegulon Activity
∗The dot plots of a searched regulon are shown for all cell subpopulations in each disease state of each tissue based on the regulon specific score inferred using pySCENIC and by calculating the average expression.
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Somatic mutation of malignant transformation related genes

check buttonAnnotation of somatic variants for genes involved in malignant transformation
Hugo SymbolVariant ClassVariant ClassificationdbSNP RSHGVScHGVSpHGVSp ShortSWISSPROTBIOTYPESIFTPolyPhenTumor Sample BarcodeTissueHistologySexAgeStageTherapy TypesDrugsOutcome
SH3RF2SNVMissense_Mutationc.742G>Ap.Glu248Lysp.E248KQ8TEC5protein_codingdeleterious(0.01)probably_damaging(0.994)TCGA-B6-A0RL-01Breastbreast invasive carcinomaFemale<65I/IIUnknownUnknownSD
SH3RF2SNVMissense_Mutationrs139468138c.2075N>Ap.Arg692Glnp.R692QQ8TEC5protein_codingdeleterious(0)probably_damaging(0.992)TCGA-BH-A42T-01Breastbreast invasive carcinomaFemale>=65I/IIUnknownUnknownSD
SH3RF2SNVMissense_Mutationnovelc.359T>Cp.Val120Alap.V120AQ8TEC5protein_codingtolerated(0.46)benign(0)TCGA-2W-A8YY-01Cervixcervical & endocervical cancerFemale<65I/IIChemotherapycisplatinCR
SH3RF2SNVMissense_Mutationrs747775775c.1306N>Ap.Val436Ilep.V436IQ8TEC5protein_codingdeleterious(0.02)benign(0.144)TCGA-C5-A7UE-01Cervixcervical & endocervical cancerFemale<65I/IIChemotherapycisplatinSD
SH3RF2SNVMissense_Mutationrs747678660c.1585G>Ap.Gly529Argp.G529RQ8TEC5protein_codingtolerated(0.07)benign(0.031)TCGA-C5-A7UH-01Cervixcervical & endocervical cancerFemale<65III/IVChemotherapycisplatinSD
SH3RF2SNVMissense_Mutationc.1516C>Ap.Gln506Lysp.Q506KQ8TEC5protein_codingdeleterious(0.01)benign(0.156)TCGA-DG-A2KK-01Cervixcervical & endocervical cancerFemale<65III/IVChemotherapycisplatinSD
SH3RF2SNVMissense_Mutationrs757233835c.496N>Ap.Glu166Lysp.E166KQ8TEC5protein_codingdeleterious(0.02)probably_damaging(0.936)TCGA-Q1-A73O-01Cervixcervical & endocervical cancerFemale<65I/IIChemotherapycisplatinCR
SH3RF2SNVMissense_Mutationc.2039N>Tp.Ser680Phep.S680FQ8TEC5protein_codingtolerated(0.61)benign(0.048)TCGA-AA-A00N-01Colorectumcolon adenocarcinomaMale>=65I/IIUnknownUnknownPD
SH3RF2SNVMissense_Mutationnovelc.935N>Cp.Val312Alap.V312AQ8TEC5protein_codingdeleterious(0.05)probably_damaging(0.918)TCGA-AZ-4315-01Colorectumcolon adenocarcinomaMale<65I/IIUnknownUnknownSD
SH3RF2SNVMissense_Mutationrs753470880c.1696G>Ap.Val566Metp.V566MQ8TEC5protein_codingtolerated(0.25)benign(0.005)TCGA-CM-4743-01Colorectumcolon adenocarcinomaMale>=65I/IIChemotherapycapecitabineSD
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Related drugs of malignant transformation related genes

check buttonIdentification of chemicals and drugs interact with genes involved in malignant transfromation
(DGIdb 4.0)
Entrez IDSymbolCategoryInteraction TypesDrug Claim NameDrug NamePMIDs
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