Tissue | Expression Dynamics | Abbreviation |
Cervix | | CC: Cervix cancer |
HSIL_HPV: HPV-infected high-grade squamous intraepithelial lesions |
N_HPV: HPV-infected normal cervix |
Colorectum (GSE201348) | | FAP: Familial adenomatous polyposis |
CRC: Colorectal cancer |
Colorectum (HTA11) | | AD: Adenomas |
SER: Sessile serrated lesions |
MSI-H: Microsatellite-high colorectal cancer |
MSS: Microsatellite stable colorectal cancer |
Esophagus | | ESCC: Esophageal squamous cell carcinoma |
HGIN: High-grade intraepithelial neoplasias |
LGIN: Low-grade intraepithelial neoplasias |
Oral Cavity | | EOLP: Erosive Oral lichen planus |
LP: leukoplakia |
NEOLP: Non-erosive oral lichen planus |
OSCC: Oral squamous cell carcinoma |
Skin | | AK: Actinic keratosis |
cSCC: Cutaneous squamous cell carcinoma |
SCCIS:squamous cell carcinoma in situ |
Thyroid | | ATC: Anaplastic thyroid cancer |
HT: Hashimoto's thyroiditis |
PTC: Papillary thyroid cancer |
GO ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | Count |
GO:006104116 | Oral cavity | OSCC | regulation of wound healing | 69/7305 | 134/18723 | 2.19e-03 | 9.95e-03 | 69 |
GO:190303615 | Oral cavity | OSCC | positive regulation of response to wounding | 40/7305 | 72/18723 | 3.21e-03 | 1.38e-02 | 40 |
GO:001076918 | Oral cavity | OSCC | regulation of cell morphogenesis involved in differentiation | 51/7305 | 96/18723 | 3.43e-03 | 1.45e-02 | 51 |
GO:003087910 | Oral cavity | OSCC | mammary gland development | 69/7305 | 137/18723 | 4.43e-03 | 1.79e-02 | 69 |
GO:190274310 | Oral cavity | OSCC | regulation of lamellipodium organization | 31/7305 | 54/18723 | 4.66e-03 | 1.87e-02 | 31 |
GO:001063218 | Oral cavity | OSCC | regulation of epithelial cell migration | 136/7305 | 292/18723 | 4.82e-03 | 1.92e-02 | 136 |
GO:20003924 | Oral cavity | OSCC | regulation of lamellipodium morphogenesis | 9/7305 | 11/18723 | 4.85e-03 | 1.92e-02 | 9 |
GO:00335987 | Oral cavity | OSCC | mammary gland epithelial cell proliferation | 17/7305 | 26/18723 | 5.83e-03 | 2.23e-02 | 17 |
GO:00903039 | Oral cavity | OSCC | positive regulation of wound healing | 33/7305 | 59/18723 | 6.17e-03 | 2.33e-02 | 33 |
GO:190274510 | Oral cavity | OSCC | positive regulation of lamellipodium organization | 22/7305 | 37/18723 | 9.34e-03 | 3.34e-02 | 22 |
GO:0090335 | Oral cavity | OSCC | regulation of brown fat cell differentiation | 15/7305 | 23/18723 | 9.84e-03 | 3.46e-02 | 15 |
GO:004206026 | Oral cavity | EOLP | wound healing | 99/2218 | 422/18723 | 1.18e-11 | 1.85e-09 | 99 |
GO:003158925 | Oral cavity | EOLP | cell-substrate adhesion | 84/2218 | 363/18723 | 8.71e-10 | 6.29e-08 | 84 |
GO:004578526 | Oral cavity | EOLP | positive regulation of cell adhesion | 95/2218 | 437/18723 | 2.30e-09 | 1.47e-07 | 95 |
GO:0001667110 | Oral cavity | EOLP | ameboidal-type cell migration | 100/2218 | 475/18723 | 5.24e-09 | 2.85e-07 | 100 |
GO:001081025 | Oral cavity | EOLP | regulation of cell-substrate adhesion | 57/2218 | 221/18723 | 7.77e-09 | 3.94e-07 | 57 |
GO:001063119 | Oral cavity | EOLP | epithelial cell migration | 80/2218 | 357/18723 | 1.03e-08 | 4.97e-07 | 80 |
GO:009013219 | Oral cavity | EOLP | epithelium migration | 80/2218 | 360/18723 | 1.52e-08 | 6.97e-07 | 80 |
GO:009013019 | Oral cavity | EOLP | tissue migration | 80/2218 | 365/18723 | 2.89e-08 | 1.16e-06 | 80 |
GO:009758122 | Oral cavity | EOLP | lamellipodium organization | 30/2218 | 90/18723 | 6.89e-08 | 2.49e-06 | 30 |
Hugo Symbol | Variant Class | Variant Classification | dbSNP RS | HGVSc | HGVSp | HGVSp Short | SWISSPROT | BIOTYPE | SIFT | PolyPhen | Tumor Sample Barcode | Tissue | Histology | Sex | Age | Stage | Therapy Types | Drugs | Outcome |
RREB1 | SNV | Missense_Mutation | novel | c.4799N>C | p.Cys1600Ser | p.C1600S | Q92766 | protein_coding | deleterious(0) | probably_damaging(0.98) | TCGA-5L-AAT0-01 | Breast | breast invasive carcinoma | Female | <65 | I/II | Hormone Therapy | tamoxiphen | SD |
RREB1 | SNV | Missense_Mutation | novel | c.953G>T | p.Cys318Phe | p.C318F | Q92766 | protein_coding | deleterious(0) | probably_damaging(0.999) | TCGA-5T-A9QA-01 | Breast | breast invasive carcinoma | Female | <65 | I/II | Chemotherapy | taxol | SD |
RREB1 | SNV | Missense_Mutation | novel | c.4672G>A | p.Val1558Met | p.V1558M | Q92766 | protein_coding | tolerated(0.13) | benign(0.023) | TCGA-A2-A0CT-01 | Breast | breast invasive carcinoma | Female | >=65 | I/II | Chemotherapy | cytoxan | SD |
RREB1 | SNV | Missense_Mutation | novel | c.220N>G | p.Ile74Val | p.I74V | Q92766 | protein_coding | tolerated(0.42) | benign(0.001) | TCGA-A8-A06P-01 | Breast | breast invasive carcinoma | Female | <65 | III/IV | Unspecific | | SD |
RREB1 | SNV | Missense_Mutation | | c.4658N>G | p.Asp1553Gly | p.D1553G | Q92766 | protein_coding | tolerated(0.12) | benign(0.42) | TCGA-A8-A09Z-01 | Breast | breast invasive carcinoma | Female | >=65 | I/II | Unknown | Unknown | SD |
RREB1 | SNV | Missense_Mutation | | c.694G>A | p.Asp232Asn | p.D232N | Q92766 | protein_coding | tolerated(0.07) | possibly_damaging(0.892) | TCGA-AN-A0FY-01 | Breast | breast invasive carcinoma | Female | <65 | I/II | Unknown | Unknown | SD |
RREB1 | SNV | Missense_Mutation | | c.1636C>T | p.Pro546Ser | p.P546S | Q92766 | protein_coding | tolerated(0.11) | benign(0.037) | TCGA-B6-A0RE-01 | Breast | breast invasive carcinoma | Female | <65 | I/II | Unknown | Unknown | SD |
RREB1 | SNV | Missense_Mutation | | c.601N>A | p.Glu201Lys | p.E201K | Q92766 | protein_coding | tolerated(0.16) | benign(0.234) | TCGA-C8-A138-01 | Breast | breast invasive carcinoma | Female | <65 | III/IV | Unknown | Unknown | SD |
RREB1 | SNV | Missense_Mutation | | c.4854N>C | p.Gln1618His | p.Q1618H | Q92766 | protein_coding | deleterious(0) | probably_damaging(0.994) | TCGA-C8-A27B-01 | Breast | breast invasive carcinoma | Female | <65 | I/II | Chemotherapy | 5-fluorouracil | CR |
RREB1 | SNV | Missense_Mutation | | c.2088N>C | p.Glu696Asp | p.E696D | Q92766 | protein_coding | deleterious(0) | probably_damaging(0.984) | TCGA-D8-A1XQ-01 | Breast | breast invasive carcinoma | Female | >=65 | I/II | Unknown | Unknown | SD |