Tissue | Expression Dynamics | Abbreviation |
Cervix | ![The image shows the transcriptomic changes along malignancy continuum.log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage.](images/deg_images/Cervix/ROBO1_pca_on_diff_genes.png) | CC: Cervix cancer |
HSIL_HPV: HPV-infected high-grade squamous intraepithelial lesions |
N_HPV: HPV-infected normal cervix |
Esophagus | ![The image shows the transcriptomic changes along malignancy continuum.log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage.](images/deg_images/Esophagus/ROBO1_pca_on_diff_genes.png) | ESCC: Esophageal squamous cell carcinoma |
HGIN: High-grade intraepithelial neoplasias |
LGIN: Low-grade intraepithelial neoplasias |
Liver | ![The image shows the transcriptomic changes along malignancy continuum.log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage.](images/deg_images/Liver/ROBO1_pca_on_diff_genes.png) | HCC: Hepatocellular carcinoma |
NAFLD: Non-alcoholic fatty liver disease |
Oral Cavity | ![The image shows the transcriptomic changes along malignancy continuum.log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage.](images/deg_images/OralCavity/ROBO1_pca_on_diff_genes.png) | EOLP: Erosive Oral lichen planus |
LP: leukoplakia |
NEOLP: Non-erosive oral lichen planus |
OSCC: Oral squamous cell carcinoma |
Prostate | ![The image shows the transcriptomic changes along malignancy continuum.log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage.](images/deg_images/Prostate/ROBO1_pca_on_diff_genes.png) | BPH: Benign Prostatic Hyperplasia |
Skin | ![The image shows the transcriptomic changes along malignancy continuum.log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage.](images/deg_images/Skin/ROBO1_pca_on_diff_genes.png) | AK: Actinic keratosis |
cSCC: Cutaneous squamous cell carcinoma |
SCCIS:squamous cell carcinoma in situ |
GO ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | Count |
GO:005076721 | Oral cavity | NEOLP | regulation of neurogenesis | 62/2005 | 364/18723 | 1.50e-04 | 1.71e-03 | 62 |
GO:003134631 | Oral cavity | NEOLP | positive regulation of cell projection organization | 60/2005 | 353/18723 | 2.01e-04 | 2.17e-03 | 60 |
GO:00032312 | Oral cavity | NEOLP | cardiac ventricle development | 27/2005 | 123/18723 | 2.14e-04 | 2.27e-03 | 27 |
GO:00350238 | Oral cavity | NEOLP | regulation of Rho protein signal transduction | 21/2005 | 86/18723 | 2.26e-04 | 2.37e-03 | 21 |
GO:0001960 | Oral cavity | NEOLP | negative regulation of cytokine-mediated signaling pathway | 20/2005 | 81/18723 | 2.69e-04 | 2.71e-03 | 20 |
GO:0060840 | Oral cavity | NEOLP | artery development | 23/2005 | 100/18723 | 3.00e-04 | 2.97e-03 | 23 |
GO:004657815 | Oral cavity | NEOLP | regulation of Ras protein signal transduction | 36/2005 | 189/18723 | 4.30e-04 | 3.92e-03 | 36 |
GO:004586024 | Oral cavity | NEOLP | positive regulation of protein kinase activity | 63/2005 | 386/18723 | 4.41e-04 | 3.99e-03 | 63 |
GO:00607611 | Oral cavity | NEOLP | negative regulation of response to cytokine stimulus | 20/2005 | 86/18723 | 6.22e-04 | 5.33e-03 | 20 |
GO:007190222 | Oral cavity | NEOLP | positive regulation of protein serine/threonine kinase activity | 37/2005 | 200/18723 | 6.45e-04 | 5.47e-03 | 37 |
GO:005196212 | Oral cavity | NEOLP | positive regulation of nervous system development | 47/2005 | 272/18723 | 6.49e-04 | 5.47e-03 | 47 |
GO:00032064 | Oral cavity | NEOLP | cardiac chamber morphogenesis | 25/2005 | 121/18723 | 9.29e-04 | 7.20e-03 | 25 |
GO:00032814 | Oral cavity | NEOLP | ventricular septum development | 17/2005 | 71/18723 | 1.10e-03 | 8.28e-03 | 17 |
GO:000317011 | Oral cavity | NEOLP | heart valve development | 16/2005 | 65/18723 | 1.11e-03 | 8.33e-03 | 16 |
GO:00031761 | Oral cavity | NEOLP | aortic valve development | 11/2005 | 37/18723 | 1.26e-03 | 9.21e-03 | 11 |
GO:001095032 | Oral cavity | NEOLP | positive regulation of endopeptidase activity | 33/2005 | 179/18723 | 1.30e-03 | 9.46e-03 | 33 |
GO:000721921 | Oral cavity | NEOLP | Notch signaling pathway | 32/2005 | 172/18723 | 1.31e-03 | 9.48e-03 | 32 |
GO:005196012 | Oral cavity | NEOLP | regulation of nervous system development | 68/2005 | 443/18723 | 1.46e-03 | 1.03e-02 | 68 |
GO:005077221 | Oral cavity | NEOLP | positive regulation of axonogenesis | 18/2005 | 79/18723 | 1.46e-03 | 1.03e-02 | 18 |
GO:00032053 | Oral cavity | NEOLP | cardiac chamber development | 30/2005 | 161/18723 | 1.78e-03 | 1.22e-02 | 30 |
Hugo Symbol | Variant Class | Variant Classification | dbSNP RS | HGVSc | HGVSp | HGVSp Short | SWISSPROT | BIOTYPE | SIFT | PolyPhen | Tumor Sample Barcode | Tissue | Histology | Sex | Age | Stage | Therapy Types | Drugs | Outcome |
ROBO1 | SNV | Missense_Mutation | rs770056315 | c.3778N>C | p.Thr1260Pro | p.T1260P | Q9Y6N7 | protein_coding | deleterious(0) | probably_damaging(0.947) | TCGA-A2-A04Q-01 | Breast | breast invasive carcinoma | Female | <65 | I/II | Chemotherapy | adriamycin | SD |
ROBO1 | SNV | Missense_Mutation | novel | c.2958C>A | p.Asn986Lys | p.N986K | Q9Y6N7 | protein_coding | tolerated(0.19) | benign(0.066) | TCGA-A2-A04V-01 | Breast | breast invasive carcinoma | Female | <65 | I/II | Chemotherapy | cytoxan | PD |
ROBO1 | SNV | Missense_Mutation | novel | c.1409N>C | p.Gly470Ala | p.G470A | Q9Y6N7 | protein_coding | tolerated(0.3) | possibly_damaging(0.703) | TCGA-A2-A0CV-01 | Breast | breast invasive carcinoma | Female | <65 | I/II | Chemotherapy | cytoxan | SD |
ROBO1 | SNV | Missense_Mutation | novel | c.3740N>T | p.Ala1247Val | p.A1247V | Q9Y6N7 | protein_coding | tolerated(0.08) | benign(0.074) | TCGA-AC-A5EH-01 | Breast | breast invasive carcinoma | Female | >=65 | I/II | Unknown | Unknown | SD |
ROBO1 | SNV | Missense_Mutation | | c.4874N>T | p.Arg1625Ile | p.R1625I | Q9Y6N7 | protein_coding | deleterious_low_confidence(0) | benign(0.355) | TCGA-AN-A046-01 | Breast | breast invasive carcinoma | Female | >=65 | I/II | Unknown | Unknown | SD |
ROBO1 | SNV | Missense_Mutation | rs372853961 | c.3730N>T | p.Arg1244Trp | p.R1244W | Q9Y6N7 | protein_coding | deleterious(0) | probably_damaging(0.987) | TCGA-AN-A046-01 | Breast | breast invasive carcinoma | Female | >=65 | I/II | Unknown | Unknown | SD |
ROBO1 | SNV | Missense_Mutation | rs756411742 | c.2295N>G | p.Ile765Met | p.I765M | Q9Y6N7 | protein_coding | tolerated(0.13) | benign(0.007) | TCGA-AN-A0XW-01 | Breast | breast invasive carcinoma | Female | <65 | III/IV | Unknown | Unknown | SD |
ROBO1 | SNV | Missense_Mutation | | c.440N>A | p.Cys147Tyr | p.C147Y | Q9Y6N7 | protein_coding | deleterious(0) | probably_damaging(1) | TCGA-AQ-A1H2-01 | Breast | breast invasive carcinoma | Female | >=65 | III/IV | Chemotherapy | herceptin | SD |
ROBO1 | SNV | Missense_Mutation | | c.1287N>T | p.Gln429His | p.Q429H | Q9Y6N7 | protein_coding | deleterious(0) | probably_damaging(1) | TCGA-AR-A0TU-01 | Breast | breast invasive carcinoma | Female | <65 | I/II | Unspecific | Doxorubicin | SD |
ROBO1 | SNV | Missense_Mutation | rs770056315 | c.3778A>C | p.Thr1260Pro | p.T1260P | Q9Y6N7 | protein_coding | deleterious(0) | probably_damaging(0.947) | TCGA-B6-A0I5-01 | Breast | breast invasive carcinoma | Female | <65 | I/II | Unknown | Unknown | SD |