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Gene: RAB11B |
Gene summary for RAB11B |
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Gene information | Species | Human | Gene symbol | RAB11B | Gene ID | 9230 |
Gene name | RAB11B, member RAS oncogene family | |
Gene Alias | H-YPT3 | |
Cytomap | 19p13.2 | |
Gene Type | protein-coding | GO ID | GO:0000041 | UniProtAcc | Q15907 |
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Malignant transformation analysis |
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Entrez ID | Symbol | Replicates | Species | Organ | Tissue | Adj P-value | Log2FC | Malignancy |
9230 | RAB11B | HTA11_3410_2000001011 | Human | Colorectum | AD | 6.16e-05 | 2.03e-01 | 0.0155 |
9230 | RAB11B | HTA11_2487_2000001011 | Human | Colorectum | SER | 2.35e-06 | 3.29e-01 | -0.1808 |
9230 | RAB11B | HTA11_1938_2000001011 | Human | Colorectum | AD | 2.97e-09 | 4.08e-01 | -0.0811 |
9230 | RAB11B | HTA11_78_2000001011 | Human | Colorectum | AD | 1.62e-04 | 2.10e-01 | -0.1088 |
9230 | RAB11B | HTA11_347_2000001011 | Human | Colorectum | AD | 3.49e-09 | 3.38e-01 | -0.1954 |
9230 | RAB11B | HTA11_411_2000001011 | Human | Colorectum | SER | 3.11e-07 | 6.37e-01 | -0.2602 |
9230 | RAB11B | HTA11_3361_2000001011 | Human | Colorectum | AD | 2.21e-03 | 3.28e-01 | -0.1207 |
9230 | RAB11B | HTA11_696_2000001011 | Human | Colorectum | AD | 1.82e-12 | 3.47e-01 | -0.1464 |
9230 | RAB11B | HTA11_866_2000001011 | Human | Colorectum | AD | 2.81e-06 | 2.35e-01 | -0.1001 |
9230 | RAB11B | HTA11_1391_2000001011 | Human | Colorectum | AD | 4.25e-17 | 5.44e-01 | -0.059 |
9230 | RAB11B | HTA11_2992_2000001011 | Human | Colorectum | SER | 1.05e-02 | 3.20e-01 | -0.1706 |
9230 | RAB11B | HTA11_5212_2000001011 | Human | Colorectum | AD | 6.33e-07 | 3.97e-01 | -0.2061 |
9230 | RAB11B | HTA11_5216_2000001011 | Human | Colorectum | SER | 3.42e-03 | 3.34e-01 | -0.1462 |
9230 | RAB11B | HTA11_866_3004761011 | Human | Colorectum | AD | 1.21e-06 | 2.49e-01 | 0.096 |
9230 | RAB11B | HTA11_7663_2000001011 | Human | Colorectum | SER | 2.43e-03 | 5.25e-01 | 0.0131 |
9230 | RAB11B | HTA11_10623_2000001011 | Human | Colorectum | AD | 3.33e-07 | 5.69e-01 | -0.0177 |
9230 | RAB11B | HTA11_6801_2000001011 | Human | Colorectum | SER | 2.43e-02 | 2.78e-01 | 0.0171 |
9230 | RAB11B | HTA11_10711_2000001011 | Human | Colorectum | AD | 1.19e-13 | 4.86e-01 | 0.0338 |
9230 | RAB11B | HTA11_7696_3000711011 | Human | Colorectum | AD | 1.30e-29 | 6.22e-01 | 0.0674 |
9230 | RAB11B | HTA11_6818_2000001021 | Human | Colorectum | AD | 1.59e-02 | 2.85e-01 | 0.0588 |
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∗log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage. |
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Malignant transformation related pathway analysis |
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Tissue | Disease Stage | Enriched GO biological Processes |
Colorectum | AD | ![]() |
Colorectum | SER | ![]() |
Colorectum | MSS | ![]() |
Colorectum | MSI-H | ![]() |
Colorectum | FAP | ![]() |
∗Top 15 enriched GO BP terms are showed in the bar plot of each disease state in each tissue. Each row represents a significant GO biological process which is colored according to the -log10(p.adjust). |
Page: 1 2 3 4 5 6 7 8 9 |
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GO ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | Count |
GO:009015026 | Thyroid | goiters | establishment of protein localization to membrane | 19/497 | 260/18723 | 7.09e-05 | 2.37e-03 | 19 |
GO:0009743210 | Thyroid | goiters | response to carbohydrate | 18/497 | 253/18723 | 1.53e-04 | 4.40e-03 | 18 |
GO:000974626 | Thyroid | goiters | response to hexose | 16/497 | 219/18723 | 2.60e-04 | 7.09e-03 | 16 |
GO:0051656110 | Thyroid | goiters | establishment of organelle localization | 23/497 | 390/18723 | 3.26e-04 | 8.37e-03 | 23 |
GO:000974924 | Thyroid | goiters | response to glucose | 15/497 | 212/18723 | 5.62e-04 | 1.35e-02 | 15 |
GO:00428864 | Thyroid | goiters | amide transport | 18/497 | 301/18723 | 1.20e-03 | 2.39e-02 | 18 |
GO:000930619 | Thyroid | goiters | protein secretion | 20/497 | 359/18723 | 1.56e-03 | 2.93e-02 | 20 |
GO:003559219 | Thyroid | goiters | establishment of protein localization to extracellular region | 20/497 | 360/18723 | 1.61e-03 | 2.99e-02 | 20 |
GO:0043112110 | Thyroid | goiters | receptor metabolic process | 12/497 | 166/18723 | 1.63e-03 | 2.99e-02 | 12 |
GO:003238623 | Thyroid | goiters | regulation of intracellular transport | 19/497 | 337/18723 | 1.76e-03 | 3.14e-02 | 19 |
GO:00158338 | Thyroid | goiters | peptide transport | 16/497 | 264/18723 | 1.93e-03 | 3.31e-02 | 16 |
GO:007169217 | Thyroid | goiters | protein localization to extracellular region | 20/497 | 368/18723 | 2.08e-03 | 3.48e-02 | 20 |
GO:00027905 | Thyroid | goiters | peptide secretion | 15/497 | 242/18723 | 2.12e-03 | 3.53e-02 | 15 |
GO:00357737 | Thyroid | goiters | insulin secretion involved in cellular response to glucose stimulus | 7/497 | 73/18723 | 3.20e-03 | 4.79e-02 | 7 |
GO:003238632 | Thyroid | ATC | regulation of intracellular transport | 203/6293 | 337/18723 | 6.16e-24 | 1.85e-21 | 203 |
GO:009015031 | Thyroid | ATC | establishment of protein localization to membrane | 150/6293 | 260/18723 | 1.05e-15 | 7.96e-14 | 150 |
GO:005165625 | Thyroid | ATC | establishment of organelle localization | 206/6293 | 390/18723 | 2.62e-15 | 1.84e-13 | 206 |
GO:001619719 | Thyroid | ATC | endosomal transport | 128/6293 | 230/18723 | 4.44e-12 | 1.75e-10 | 128 |
GO:007121427 | Thyroid | ATC | cellular response to abiotic stimulus | 169/6293 | 331/18723 | 3.24e-11 | 1.08e-09 | 169 |
GO:010400427 | Thyroid | ATC | cellular response to environmental stimulus | 169/6293 | 331/18723 | 3.24e-11 | 1.08e-09 | 169 |
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Pathway ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | qvalue | Count |
hsa04144 | Colorectum | AD | Endocytosis | 111/2092 | 251/8465 | 5.95e-12 | 1.42e-10 | 9.08e-11 | 111 |
hsa04152 | Colorectum | AD | AMPK signaling pathway | 47/2092 | 121/8465 | 3.74e-04 | 2.82e-03 | 1.80e-03 | 47 |
hsa04962 | Colorectum | AD | Vasopressin-regulated water reabsorption | 19/2092 | 44/8465 | 5.48e-03 | 2.48e-02 | 1.58e-02 | 19 |
hsa041441 | Colorectum | AD | Endocytosis | 111/2092 | 251/8465 | 5.95e-12 | 1.42e-10 | 9.08e-11 | 111 |
hsa041521 | Colorectum | AD | AMPK signaling pathway | 47/2092 | 121/8465 | 3.74e-04 | 2.82e-03 | 1.80e-03 | 47 |
hsa049621 | Colorectum | AD | Vasopressin-regulated water reabsorption | 19/2092 | 44/8465 | 5.48e-03 | 2.48e-02 | 1.58e-02 | 19 |
hsa041442 | Colorectum | SER | Endocytosis | 81/1580 | 251/8465 | 1.14e-07 | 2.36e-06 | 1.71e-06 | 81 |
hsa041443 | Colorectum | SER | Endocytosis | 81/1580 | 251/8465 | 1.14e-07 | 2.36e-06 | 1.71e-06 | 81 |
hsa041444 | Colorectum | MSS | Endocytosis | 102/1875 | 251/8465 | 1.85e-11 | 4.43e-10 | 2.71e-10 | 102 |
hsa041522 | Colorectum | MSS | AMPK signaling pathway | 41/1875 | 121/8465 | 1.91e-03 | 9.83e-03 | 6.03e-03 | 41 |
hsa049622 | Colorectum | MSS | Vasopressin-regulated water reabsorption | 17/1875 | 44/8465 | 9.76e-03 | 3.55e-02 | 2.18e-02 | 17 |
hsa041445 | Colorectum | MSS | Endocytosis | 102/1875 | 251/8465 | 1.85e-11 | 4.43e-10 | 2.71e-10 | 102 |
hsa041523 | Colorectum | MSS | AMPK signaling pathway | 41/1875 | 121/8465 | 1.91e-03 | 9.83e-03 | 6.03e-03 | 41 |
hsa049623 | Colorectum | MSS | Vasopressin-regulated water reabsorption | 17/1875 | 44/8465 | 9.76e-03 | 3.55e-02 | 2.18e-02 | 17 |
hsa0414429 | Esophagus | HGIN | Endocytosis | 76/1383 | 251/8465 | 1.74e-08 | 3.34e-07 | 2.65e-07 | 76 |
hsa0516420 | Esophagus | HGIN | Influenza A | 42/1383 | 171/8465 | 3.41e-03 | 2.54e-02 | 2.02e-02 | 42 |
hsa049627 | Esophagus | HGIN | Vasopressin-regulated water reabsorption | 14/1383 | 44/8465 | 8.21e-03 | 4.71e-02 | 3.74e-02 | 14 |
hsa04144113 | Esophagus | HGIN | Endocytosis | 76/1383 | 251/8465 | 1.74e-08 | 3.34e-07 | 2.65e-07 | 76 |
hsa05164110 | Esophagus | HGIN | Influenza A | 42/1383 | 171/8465 | 3.41e-03 | 2.54e-02 | 2.02e-02 | 42 |
hsa0496214 | Esophagus | HGIN | Vasopressin-regulated water reabsorption | 14/1383 | 44/8465 | 8.21e-03 | 4.71e-02 | 3.74e-02 | 14 |
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Cell-cell communication analysis |
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Ligand | Receptor | LRpair | Pathway | Tissue | Disease Stage |
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Single-cell gene regulatory network inference analysis |
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TF | Cell Type | Tissue | Disease Stage | Target Gene | RSS | Regulon Activity |
∗The dot plots of a searched regulon are shown for all cell subpopulations in each disease state of each tissue based on the regulon specific score inferred using pySCENIC and by calculating the average expression. |
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Somatic mutation of malignant transformation related genes |
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Hugo Symbol | Variant Class | Variant Classification | dbSNP RS | HGVSc | HGVSp | HGVSp Short | SWISSPROT | BIOTYPE | SIFT | PolyPhen | Tumor Sample Barcode | Tissue | Histology | Sex | Age | Stage | Therapy Types | Drugs | Outcome |
RAB11B | SNV | Missense_Mutation | novel | c.152G>A | p.Arg51His | p.R51H | Q15907 | protein_coding | deleterious_low_confidence(0) | probably_damaging(0.982) | TCGA-IR-A3L7-01 | Cervix | cervical & endocervical cancer | Female | <65 | I/II | Chemotherapy | cisplatin | CR |
RAB11B | SNV | Missense_Mutation | c.136N>A | p.Val46Met | p.V46M | Q15907 | protein_coding | deleterious_low_confidence(0.02) | probably_damaging(0.984) | TCGA-AA-3664-01 | Colorectum | colon adenocarcinoma | Female | >=65 | I/II | Unknown | Unknown | SD | |
RAB11B | SNV | Missense_Mutation | novel | c.142T>G | p.Phe48Val | p.F48V | Q15907 | protein_coding | deleterious_low_confidence(0) | probably_damaging(0.997) | TCGA-AA-A010-01 | Colorectum | colon adenocarcinoma | Female | <65 | I/II | Chemotherapy | folinic | CR |
RAB11B | SNV | Missense_Mutation | c.245N>A | p.Arg82His | p.R82H | Q15907 | protein_coding | deleterious_low_confidence(0) | possibly_damaging(0.83) | TCGA-D5-6928-01 | Colorectum | colon adenocarcinoma | Male | >=65 | I/II | Unknown | Unknown | SD | |
RAB11B | SNV | Missense_Mutation | c.382N>A | p.Leu128Met | p.L128M | Q15907 | protein_coding | deleterious_low_confidence(0) | probably_damaging(0.991) | TCGA-G4-6302-01 | Colorectum | colon adenocarcinoma | Female | >=65 | I/II | Unknown | Unknown | SD | |
RAB11B | SNV | Missense_Mutation | novel | c.422C>T | p.Ala141Val | p.A141V | Q15907 | protein_coding | tolerated_low_confidence(0.06) | benign(0.014) | TCGA-AP-A1DK-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | <65 | I/II | Unknown | Unknown | SD |
RAB11B | SNV | Missense_Mutation | c.98N>A | p.Arg33His | p.R33H | Q15907 | protein_coding | deleterious_low_confidence(0.02) | possibly_damaging(0.559) | TCGA-AP-A1DV-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | <65 | I/II | Unknown | Unknown | SD | |
RAB11B | SNV | Missense_Mutation | rs747366868 | c.418C>T | p.Arg140Cys | p.R140C | Q15907 | protein_coding | deleterious_low_confidence(0.02) | benign(0.02) | TCGA-B5-A3FC-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | <65 | I/II | Unknown | Unknown | SD |
RAB11B | SNV | Missense_Mutation | rs377033835 | c.611C>T | p.Thr204Met | p.T204M | Q15907 | protein_coding | tolerated_low_confidence(0.08) | benign(0.018) | TCGA-EO-A22U-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | >=65 | I/II | Unknown | Unknown | SD |
RAB11B | SNV | Missense_Mutation | novel | c.435N>T | p.Lys145Asn | p.K145N | Q15907 | protein_coding | tolerated_low_confidence(0.06) | benign(0.03) | TCGA-EO-A3B0-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | <65 | III/IV | Unknown | Unknown | SD |
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Related drugs of malignant transformation related genes |
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(DGIdb 4.0) |
Entrez ID | Symbol | Category | Interaction Types | Drug Claim Name | Drug Name | PMIDs |
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