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Gene: PTTG1IP |
Gene summary for PTTG1IP |
Gene summary. |
Gene information | Species | Human | Gene symbol | PTTG1IP | Gene ID | 754 |
Gene name | PTTG1 interacting protein | |
Gene Alias | C21orf1 | |
Cytomap | 21q22.3 | |
Gene Type | protein-coding | GO ID | GO:0006464 | UniProtAcc | B4DPZ0 |
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Malignant transformation analysis |
Identification of the aberrant gene expression in precancerous and cancerous lesions by comparing the gene expression of stem-like cells in diseased tissues with normal stem cells |
Malignant transformation involving gene list. |
Entrez ID | Symbol | Replicates | Species | Organ | Tissue | Adj P-value | Log2FC | Malignancy |
754 | PTTG1IP | HTA11_3410_2000001011 | Human | Colorectum | AD | 6.70e-11 | 3.40e-01 | 0.0155 |
754 | PTTG1IP | HTA11_2487_2000001011 | Human | Colorectum | SER | 7.71e-17 | 1.11e+00 | -0.1808 |
754 | PTTG1IP | HTA11_1938_2000001011 | Human | Colorectum | AD | 2.07e-12 | 8.12e-01 | -0.0811 |
754 | PTTG1IP | HTA11_78_2000001011 | Human | Colorectum | AD | 9.33e-07 | 5.33e-01 | -0.1088 |
754 | PTTG1IP | HTA11_347_2000001011 | Human | Colorectum | AD | 2.47e-42 | 1.18e+00 | -0.1954 |
754 | PTTG1IP | HTA11_411_2000001011 | Human | Colorectum | SER | 1.99e-10 | 2.12e+00 | -0.2602 |
754 | PTTG1IP | HTA11_2112_2000001011 | Human | Colorectum | SER | 2.06e-07 | 1.24e+00 | -0.2196 |
754 | PTTG1IP | HTA11_83_2000001011 | Human | Colorectum | SER | 3.75e-08 | 7.48e-01 | -0.1526 |
754 | PTTG1IP | HTA11_696_2000001011 | Human | Colorectum | AD | 7.73e-21 | 6.78e-01 | -0.1464 |
754 | PTTG1IP | HTA11_866_2000001011 | Human | Colorectum | AD | 1.92e-05 | 3.82e-01 | -0.1001 |
754 | PTTG1IP | HTA11_1391_2000001011 | Human | Colorectum | AD | 1.02e-12 | 8.25e-01 | -0.059 |
754 | PTTG1IP | HTA11_2992_2000001011 | Human | Colorectum | SER | 1.11e-05 | 8.04e-01 | -0.1706 |
754 | PTTG1IP | HTA11_5212_2000001011 | Human | Colorectum | AD | 3.25e-17 | 1.55e+00 | -0.2061 |
754 | PTTG1IP | HTA11_546_2000001011 | Human | Colorectum | AD | 1.20e-03 | 4.63e-01 | -0.0842 |
754 | PTTG1IP | HTA11_7862_2000001011 | Human | Colorectum | AD | 2.15e-03 | 5.43e-01 | -0.0179 |
754 | PTTG1IP | HTA11_866_3004761011 | Human | Colorectum | AD | 2.14e-06 | 3.92e-01 | 0.096 |
754 | PTTG1IP | HTA11_4255_2000001011 | Human | Colorectum | SER | 2.95e-02 | 4.43e-01 | 0.0446 |
754 | PTTG1IP | HTA11_7663_2000001011 | Human | Colorectum | SER | 8.29e-03 | 3.94e-01 | 0.0131 |
754 | PTTG1IP | HTA11_7696_3000711011 | Human | Colorectum | AD | 2.52e-04 | 3.30e-01 | 0.0674 |
754 | PTTG1IP | HTA11_7469_2000001011 | Human | Colorectum | AD | 1.21e-05 | 1.14e+00 | -0.0124 |
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Transcriptomic changes along malignancy continuum. |
∗log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage. |
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Malignant transformation related pathway analysis |
Find out the enriched GO biological processes and KEGG pathways involved in transition from healthy to precancer to cancer |
Figure of enriched GO biological processes. |
Tissue | Disease Stage | Enriched GO biological Processes |
Colorectum | AD | |
Colorectum | SER | |
Colorectum | MSS | |
Colorectum | MSI-H | |
Colorectum | FAP |
∗Top 15 enriched GO BP terms are showed in the bar plot of each disease state in each tissue. Each row represents a significant GO biological process which is colored according to the -log10(p.adjust). |
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Enriched GO biological processes. |
GO ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | Count |
GO:20012437 | Liver | Cirrhotic | negative regulation of intrinsic apoptotic signaling pathway | 47/4634 | 98/18723 | 5.26e-07 | 1.17e-05 | 47 |
GO:007233112 | Liver | Cirrhotic | signal transduction by p53 class mediator | 69/4634 | 163/18723 | 5.97e-07 | 1.30e-05 | 69 |
GO:00723326 | Liver | Cirrhotic | intrinsic apoptotic signaling pathway by p53 class mediator | 38/4634 | 76/18723 | 1.75e-06 | 3.32e-05 | 38 |
GO:00170387 | Liver | Cirrhotic | protein import | 77/4634 | 206/18723 | 3.56e-05 | 4.32e-04 | 77 |
GO:19033222 | Liver | Cirrhotic | positive regulation of protein modification by small protein conjugation or removal | 52/4634 | 138/18723 | 4.91e-04 | 3.94e-03 | 52 |
GO:003033012 | Liver | Cirrhotic | DNA damage response, signal transduction by p53 class mediator | 31/4634 | 72/18723 | 5.03e-04 | 4.00e-03 | 31 |
GO:190179612 | Liver | Cirrhotic | regulation of signal transduction by p53 class mediator | 37/4634 | 93/18723 | 9.58e-04 | 6.78e-03 | 37 |
GO:200102011 | Liver | Cirrhotic | regulation of response to DNA damage stimulus | 75/4634 | 219/18723 | 9.75e-04 | 6.89e-03 | 75 |
GO:0031398 | Liver | Cirrhotic | positive regulation of protein ubiquitination | 44/4634 | 119/18723 | 1.98e-03 | 1.23e-02 | 44 |
GO:00427701 | Liver | Cirrhotic | signal transduction in response to DNA damage | 58/4634 | 172/18723 | 5.00e-03 | 2.59e-02 | 58 |
GO:19022535 | Liver | Cirrhotic | regulation of intrinsic apoptotic signaling pathway by p53 class mediator | 14/4634 | 29/18723 | 5.09e-03 | 2.62e-02 | 14 |
GO:00511706 | Liver | Cirrhotic | import into nucleus | 54/4634 | 159/18723 | 5.59e-03 | 2.83e-02 | 54 |
GO:007259422 | Liver | HCC | establishment of protein localization to organelle | 299/7958 | 422/18723 | 1.06e-32 | 6.10e-30 | 299 |
GO:000989622 | Liver | HCC | positive regulation of catabolic process | 335/7958 | 492/18723 | 3.83e-31 | 1.87e-28 | 335 |
GO:003133122 | Liver | HCC | positive regulation of cellular catabolic process | 295/7958 | 427/18723 | 3.20e-29 | 1.45e-26 | 295 |
GO:004217622 | Liver | HCC | regulation of protein catabolic process | 267/7958 | 391/18723 | 2.45e-25 | 7.38e-23 | 267 |
GO:000691322 | Liver | HCC | nucleocytoplasmic transport | 208/7958 | 301/18723 | 5.51e-21 | 8.12e-19 | 208 |
GO:005116922 | Liver | HCC | nuclear transport | 208/7958 | 301/18723 | 5.51e-21 | 8.12e-19 | 208 |
GO:190336222 | Liver | HCC | regulation of cellular protein catabolic process | 182/7958 | 255/18723 | 5.91e-21 | 8.52e-19 | 182 |
GO:004573222 | Liver | HCC | positive regulation of protein catabolic process | 163/7958 | 231/18723 | 4.00e-18 | 4.69e-16 | 163 |
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Enriched KEGG pathways. |
Pathway ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | qvalue | Count |
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Cell-cell communication analysis |
Identification of potential cell-cell interactions between two cell types and their ligand-receptor pairs for different disease states |
Ligand | Receptor | LRpair | Pathway | Tissue | Disease Stage |
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Single-cell gene regulatory network inference analysis |
Find out the significant the regulons (TFs) and the target genes of each regulon across cell types for different disease states |
TF | Cell Type | Tissue | Disease Stage | Target Gene | RSS | Regulon Activity |
∗The dot plots of a searched regulon are shown for all cell subpopulations in each disease state of each tissue based on the regulon specific score inferred using pySCENIC and by calculating the average expression. |
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Somatic mutation of malignant transformation related genes |
Annotation of somatic variants for genes involved in malignant transformation |
Hugo Symbol | Variant Class | Variant Classification | dbSNP RS | HGVSc | HGVSp | HGVSp Short | SWISSPROT | BIOTYPE | SIFT | PolyPhen | Tumor Sample Barcode | Tissue | Histology | Sex | Age | Stage | Therapy Types | Drugs | Outcome |
PTTG1IP | SNV | Missense_Mutation | novel | c.457N>A | p.Glu153Lys | p.E153K | P53801 | protein_coding | deleterious(0) | probably_damaging(0.997) | TCGA-A8-A0A7-01 | Breast | breast invasive carcinoma | Female | <65 | I/II | Unknown | Unknown | SD |
PTTG1IP | SNV | Missense_Mutation | c.124N>G | p.Gln42Glu | p.Q42E | P53801 | protein_coding | tolerated(1) | benign(0.003) | TCGA-JW-A5VL-01 | Cervix | cervical & endocervical cancer | Female | <65 | I/II | Unknown | Unknown | SD | |
PTTG1IP | SNV | Missense_Mutation | rs138357182 | c.308N>T | p.Ser103Leu | p.S103L | P53801 | protein_coding | deleterious(0) | probably_damaging(0.997) | TCGA-AA-3510-01 | Colorectum | colon adenocarcinoma | Male | >=65 | I/II | Unknown | Unknown | SD |
PTTG1IP | SNV | Missense_Mutation | rs758698293 | c.151N>C | p.Cys51Arg | p.C51R | P53801 | protein_coding | deleterious(0) | benign(0.332) | TCGA-G4-6304-01 | Colorectum | colon adenocarcinoma | Female | >=65 | I/II | Chemotherapy | fluorouracil | PD |
PTTG1IP | SNV | Missense_Mutation | rs374480622 | c.418N>T | p.Arg140Trp | p.R140W | P53801 | protein_coding | deleterious(0) | possibly_damaging(0.855) | TCGA-G4-6588-01 | Colorectum | colon adenocarcinoma | Female | <65 | I/II | Unknown | Unknown | SD |
PTTG1IP | SNV | Missense_Mutation | c.259N>T | p.Arg87Cys | p.R87C | P53801 | protein_coding | deleterious(0) | probably_damaging(0.917) | TCGA-G4-6588-01 | Colorectum | colon adenocarcinoma | Female | <65 | I/II | Unknown | Unknown | SD | |
PTTG1IP | SNV | Missense_Mutation | rs778141805 | c.449G>A | p.Arg150Gln | p.R150Q | P53801 | protein_coding | deleterious(0) | probably_damaging(0.997) | TCGA-AP-A1DK-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | <65 | I/II | Unknown | Unknown | SD |
PTTG1IP | SNV | Missense_Mutation | novel | c.466A>T | p.Thr156Ser | p.T156S | P53801 | protein_coding | tolerated(0.43) | benign(0.005) | TCGA-B5-A3FC-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | <65 | I/II | Unknown | Unknown | SD |
PTTG1IP | SNV | Missense_Mutation | novel | c.130A>G | p.Thr44Ala | p.T44A | P53801 | protein_coding | deleterious(0.01) | benign(0.005) | TCGA-EO-A22U-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | >=65 | I/II | Unknown | Unknown | SD |
PTTG1IP | SNV | Missense_Mutation | c.177N>C | p.Trp59Cys | p.W59C | P53801 | protein_coding | deleterious(0) | probably_damaging(0.999) | TCGA-69-7979-01 | Lung | lung adenocarcinoma | Female | >=65 | I/II | Unknown | Unknown | SD |
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Related drugs of malignant transformation related genes |
Identification of chemicals and drugs interact with genes involved in malignant transfromation |
(DGIdb 4.0) |
Entrez ID | Symbol | Category | Interaction Types | Drug Claim Name | Drug Name | PMIDs |
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