GO ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | Count |
GO:000724913 | Lung | AIS | I-kappaB kinase/NF-kappaB signaling | 45/1849 | 281/18723 | 7.90e-04 | 1.11e-02 | 45 |
GO:00987321 | Lung | AIS | macromolecule deacylation | 23/1849 | 116/18723 | 8.77e-04 | 1.19e-02 | 23 |
GO:00510921 | Lung | AIS | positive regulation of NF-kappaB transcription factor activity | 28/1849 | 152/18723 | 8.81e-04 | 1.19e-02 | 28 |
GO:005109011 | Lung | AIS | regulation of DNA-binding transcription factor activity | 64/1849 | 440/18723 | 1.04e-03 | 1.36e-02 | 64 |
GO:19049518 | Lung | AIS | positive regulation of establishment of protein localization | 49/1849 | 319/18723 | 1.21e-03 | 1.54e-02 | 49 |
GO:004819312 | Lung | AIS | Golgi vesicle transport | 46/1849 | 296/18723 | 1.32e-03 | 1.64e-02 | 46 |
GO:004682212 | Lung | AIS | regulation of nucleocytoplasmic transport | 21/1849 | 106/18723 | 1.45e-03 | 1.77e-02 | 21 |
GO:190382913 | Lung | AIS | positive regulation of cellular protein localization | 43/1849 | 276/18723 | 1.77e-03 | 2.01e-02 | 43 |
GO:005109111 | Lung | AIS | positive regulation of DNA-binding transcription factor activity | 41/1849 | 260/18723 | 1.77e-03 | 2.01e-02 | 41 |
GO:003166913 | Lung | AIS | cellular response to nutrient levels | 35/1849 | 215/18723 | 2.15e-03 | 2.31e-02 | 35 |
GO:001050812 | Lung | AIS | positive regulation of autophagy | 23/1849 | 124/18723 | 2.22e-03 | 2.37e-02 | 23 |
GO:005067312 | Lung | AIS | epithelial cell proliferation | 62/1849 | 437/18723 | 2.26e-03 | 2.39e-02 | 62 |
GO:001095912 | Lung | AIS | regulation of metal ion transport | 58/1849 | 406/18723 | 2.63e-03 | 2.67e-02 | 58 |
GO:003238812 | Lung | AIS | positive regulation of intracellular transport | 33/1849 | 202/18723 | 2.67e-03 | 2.70e-02 | 33 |
GO:001063412 | Lung | AIS | positive regulation of epithelial cell migration | 29/1849 | 176/18723 | 4.12e-03 | 3.68e-02 | 29 |
GO:001083712 | Lung | AIS | regulation of keratinocyte proliferation | 9/1849 | 35/18723 | 5.76e-03 | 4.81e-02 | 9 |
GO:0006816 | Lung | AIS | calcium ion transport | 58/1849 | 422/18723 | 6.08e-03 | 4.98e-02 | 58 |
GO:003166713 | Lung | AIS | response to nutrient levels | 64/1849 | 474/18723 | 6.13e-03 | 4.98e-02 | 64 |
GO:00903111 | Lung | AIS | regulation of protein deacetylation | 11/1849 | 48/18723 | 6.14e-03 | 4.98e-02 | 11 |
GO:007259416 | Prostate | BPH | establishment of protein localization to organelle | 142/3107 | 422/18723 | 4.01e-18 | 1.31e-15 | 142 |
Pathway ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | qvalue | Count |
hsa0520826 | Endometrium | AEH | Chemical carcinogenesis - reactive oxygen species | 91/1197 | 223/8465 | 3.28e-23 | 1.33e-21 | 9.76e-22 | 91 |
hsa0401514 | Endometrium | AEH | Rap1 signaling pathway | 49/1197 | 210/8465 | 2.03e-04 | 1.78e-03 | 1.30e-03 | 49 |
hsa05208112 | Endometrium | AEH | Chemical carcinogenesis - reactive oxygen species | 91/1197 | 223/8465 | 3.28e-23 | 1.33e-21 | 9.76e-22 | 91 |
hsa0401515 | Endometrium | AEH | Rap1 signaling pathway | 49/1197 | 210/8465 | 2.03e-04 | 1.78e-03 | 1.30e-03 | 49 |
hsa0520827 | Endometrium | EEC | Chemical carcinogenesis - reactive oxygen species | 94/1237 | 223/8465 | 4.11e-24 | 1.93e-22 | 1.44e-22 | 94 |
hsa0401522 | Endometrium | EEC | Rap1 signaling pathway | 49/1237 | 210/8465 | 4.45e-04 | 3.47e-03 | 2.59e-03 | 49 |
hsa0520836 | Endometrium | EEC | Chemical carcinogenesis - reactive oxygen species | 94/1237 | 223/8465 | 4.11e-24 | 1.93e-22 | 1.44e-22 | 94 |
hsa0401532 | Endometrium | EEC | Rap1 signaling pathway | 49/1237 | 210/8465 | 4.45e-04 | 3.47e-03 | 2.59e-03 | 49 |
hsa0520816 | Lung | IAC | Chemical carcinogenesis - reactive oxygen species | 51/1053 | 223/8465 | 8.45e-06 | 2.14e-04 | 1.42e-04 | 51 |
hsa0401510 | Lung | IAC | Rap1 signaling pathway | 41/1053 | 210/8465 | 2.01e-03 | 1.07e-02 | 7.10e-03 | 41 |
hsa0520817 | Lung | IAC | Chemical carcinogenesis - reactive oxygen species | 51/1053 | 223/8465 | 8.45e-06 | 2.14e-04 | 1.42e-04 | 51 |
hsa0401511 | Lung | IAC | Rap1 signaling pathway | 41/1053 | 210/8465 | 2.01e-03 | 1.07e-02 | 7.10e-03 | 41 |
hsa0520823 | Lung | AIS | Chemical carcinogenesis - reactive oxygen species | 47/961 | 223/8465 | 1.63e-05 | 3.77e-04 | 2.41e-04 | 47 |
hsa0401521 | Lung | AIS | Rap1 signaling pathway | 41/961 | 210/8465 | 3.23e-04 | 3.38e-03 | 2.16e-03 | 41 |
hsa0520833 | Lung | AIS | Chemical carcinogenesis - reactive oxygen species | 47/961 | 223/8465 | 1.63e-05 | 3.77e-04 | 2.41e-04 | 47 |
hsa0401531 | Lung | AIS | Rap1 signaling pathway | 41/961 | 210/8465 | 3.23e-04 | 3.38e-03 | 2.16e-03 | 41 |
hsa0520828 | Prostate | BPH | Chemical carcinogenesis - reactive oxygen species | 114/1718 | 223/8465 | 3.05e-25 | 1.44e-23 | 8.91e-24 | 114 |
hsa0401516 | Prostate | BPH | Rap1 signaling pathway | 61/1718 | 210/8465 | 1.40e-03 | 5.85e-03 | 3.62e-03 | 61 |
hsa05208113 | Prostate | BPH | Chemical carcinogenesis - reactive oxygen species | 114/1718 | 223/8465 | 3.05e-25 | 1.44e-23 | 8.91e-24 | 114 |
hsa0401517 | Prostate | BPH | Rap1 signaling pathway | 61/1718 | 210/8465 | 1.40e-03 | 5.85e-03 | 3.62e-03 | 61 |
Hugo Symbol | Variant Class | Variant Classification | dbSNP RS | HGVSc | HGVSp | HGVSp Short | SWISSPROT | BIOTYPE | SIFT | PolyPhen | Tumor Sample Barcode | Tissue | Histology | Sex | Age | Stage | Therapy Types | Drugs | Outcome |
PRKD1 | SNV | Missense_Mutation | novel | c.865C>T | p.Pro289Ser | p.P289S | | protein_coding | deleterious(0) | probably_damaging(0.995) | TCGA-AC-A6IX-01 | Breast | breast invasive carcinoma | Female | <65 | III/IV | Unknown | Unknown | SD |
PRKD1 | SNV | Missense_Mutation | | c.1780N>C | p.Asp594His | p.D594H | | protein_coding | deleterious(0) | probably_damaging(0.916) | TCGA-AR-A1AI-01 | Breast | breast invasive carcinoma | Female | <65 | I/II | Chemotherapy | cytoxan | PD |
PRKD1 | SNV | Missense_Mutation | novel | c.1466N>T | p.Ala489Val | p.A489V | | protein_coding | tolerated(0.18) | benign(0.009) | TCGA-BH-A0HF-01 | Breast | breast invasive carcinoma | Female | >=65 | I/II | Hormone Therapy | arimidex | SD |
PRKD1 | SNV | Missense_Mutation | novel | c.950A>G | p.His317Arg | p.H317R | | protein_coding | deleterious(0.01) | probably_damaging(0.998) | TCGA-BH-A8FY-01 | Breast | breast invasive carcinoma | Female | >=65 | I/II | Unknown | Unknown | SD |
PRKD1 | SNV | Missense_Mutation | rs368595371 | c.314N>A | p.Arg105His | p.R105H | | protein_coding | deleterious(0.02) | benign(0.349) | TCGA-D8-A1XQ-01 | Breast | breast invasive carcinoma | Female | >=65 | I/II | Unknown | Unknown | SD |
PRKD1 | SNV | Missense_Mutation | | c.766A>G | p.Asn256Asp | p.N256D | | protein_coding | tolerated(0.33) | benign(0.022) | TCGA-GM-A2DB-01 | Breast | breast invasive carcinoma | Female | <65 | I/II | Chemotherapy | taxol | CR |
PRKD1 | SNV | Missense_Mutation | novel | c.2488N>T | p.Val830Leu | p.V830L | | protein_coding | deleterious(0) | benign(0.272) | TCGA-LL-A6FQ-01 | Breast | breast invasive carcinoma | Female | >=65 | III/IV | Unknown | Unknown | SD |
PRKD1 | insertion | Nonsense_Mutation | novel | c.2582_2583insTTCTGTTTGGTGTGTCCCATTGGTGTTGTCATTGTAAA | p.Lys862SerfsTer12 | p.K862Sfs*12 | | protein_coding | | | TCGA-A2-A0EY-01 | Breast | breast invasive carcinoma | Female | <65 | I/II | Chemotherapy | adriamycin | SD |
PRKD1 | insertion | Nonsense_Mutation | novel | c.2356_2357insCTTACAGCTGATAGAGCTCTAAAACAAT | p.Ser786ThrfsTer4 | p.S786Tfs*4 | | protein_coding | | | TCGA-AN-A04A-01 | Breast | breast invasive carcinoma | Female | <65 | III/IV | Unknown | Unknown | SD |
PRKD1 | SNV | Missense_Mutation | | c.2710N>A | p.Glu904Lys | p.E904K | | protein_coding | tolerated_low_confidence(0.66) | benign(0.015) | TCGA-DG-A2KK-01 | Cervix | cervical & endocervical cancer | Female | <65 | III/IV | Chemotherapy | cisplatin | SD |
Entrez ID | Symbol | Category | Interaction Types | Drug Claim Name | Drug Name | PMIDs |
5587 | PRKD1 | DRUGGABLE GENOME, KINASE, ENZYME, TRANSCRIPTION FACTOR, SERINE THREONINE KINASE | inhibitor | 178102596 | | |
5587 | PRKD1 | DRUGGABLE GENOME, KINASE, ENZYME, TRANSCRIPTION FACTOR, SERINE THREONINE KINASE | inhibitor | SOPHORETIN | QUERCETIN | |
5587 | PRKD1 | DRUGGABLE GENOME, KINASE, ENZYME, TRANSCRIPTION FACTOR, SERINE THREONINE KINASE | inhibitor | 249565728 | | |
5587 | PRKD1 | DRUGGABLE GENOME, KINASE, ENZYME, TRANSCRIPTION FACTOR, SERINE THREONINE KINASE | inhibitor | 328083472 | | |
5587 | PRKD1 | DRUGGABLE GENOME, KINASE, ENZYME, TRANSCRIPTION FACTOR, SERINE THREONINE KINASE | | RESVERATROL | RESVERATROL | 11008129 |
5587 | PRKD1 | DRUGGABLE GENOME, KINASE, ENZYME, TRANSCRIPTION FACTOR, SERINE THREONINE KINASE | inhibitor | CHEMBL494089 | GSK-690693 | |
5587 | PRKD1 | DRUGGABLE GENOME, KINASE, ENZYME, TRANSCRIPTION FACTOR, SERINE THREONINE KINASE | inhibitor | 348353640 | | |
5587 | PRKD1 | DRUGGABLE GENOME, KINASE, ENZYME, TRANSCRIPTION FACTOR, SERINE THREONINE KINASE | | VASOPRESSIN | VASOPRESSIN | 11514571 |
5587 | PRKD1 | DRUGGABLE GENOME, KINASE, ENZYME, TRANSCRIPTION FACTOR, SERINE THREONINE KINASE | inhibitor | CHEMBL608533 | MIDOSTAURIN | |
5587 | PRKD1 | DRUGGABLE GENOME, KINASE, ENZYME, TRANSCRIPTION FACTOR, SERINE THREONINE KINASE | inhibitor | 328083471 | | |