Tissue | Expression Dynamics | Abbreviation |
Cervix | | CC: Cervix cancer |
HSIL_HPV: HPV-infected high-grade squamous intraepithelial lesions |
N_HPV: HPV-infected normal cervix |
Colorectum (GSE201348) | | FAP: Familial adenomatous polyposis |
CRC: Colorectal cancer |
Colorectum (HTA11) | | AD: Adenomas |
SER: Sessile serrated lesions |
MSI-H: Microsatellite-high colorectal cancer |
MSS: Microsatellite stable colorectal cancer |
Esophagus | | ESCC: Esophageal squamous cell carcinoma |
HGIN: High-grade intraepithelial neoplasias |
LGIN: Low-grade intraepithelial neoplasias |
Liver | | HCC: Hepatocellular carcinoma |
NAFLD: Non-alcoholic fatty liver disease |
GO ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | Count |
GO:00003021 | Colorectum | SER | response to reactive oxygen species | 65/2897 | 222/18723 | 1.21e-07 | 7.29e-06 | 65 |
GO:00508211 | Colorectum | SER | protein stabilization | 58/2897 | 191/18723 | 1.46e-07 | 8.59e-06 | 58 |
GO:00091991 | Colorectum | SER | ribonucleoside triphosphate metabolic process | 34/2897 | 89/18723 | 1.52e-07 | 8.81e-06 | 34 |
GO:00092011 | Colorectum | SER | ribonucleoside triphosphate biosynthetic process | 30/2897 | 74/18723 | 1.76e-07 | 9.97e-06 | 30 |
GO:00106391 | Colorectum | SER | negative regulation of organelle organization | 90/2897 | 348/18723 | 3.14e-07 | 1.69e-05 | 90 |
GO:00098951 | Colorectum | SER | negative regulation of catabolic process | 84/2897 | 320/18723 | 3.93e-07 | 2.06e-05 | 84 |
GO:00091421 | Colorectum | SER | nucleoside triphosphate biosynthetic process | 32/2897 | 85/18723 | 5.16e-07 | 2.53e-05 | 32 |
GO:00621971 | Colorectum | SER | cellular response to chemical stress | 87/2897 | 337/18723 | 5.33e-07 | 2.59e-05 | 87 |
GO:00525481 | Colorectum | SER | regulation of endopeptidase activity | 103/2897 | 432/18723 | 2.86e-06 | 1.16e-04 | 103 |
GO:00513481 | Colorectum | SER | negative regulation of transferase activity | 70/2897 | 268/18723 | 4.27e-06 | 1.62e-04 | 70 |
GO:00109521 | Colorectum | SER | positive regulation of peptidase activity | 55/2897 | 197/18723 | 5.44e-06 | 2.00e-04 | 55 |
GO:00004221 | Colorectum | SER | autophagy of mitochondrion | 29/2897 | 81/18723 | 5.61e-06 | 2.01e-04 | 29 |
GO:00617261 | Colorectum | SER | mitochondrion disassembly | 29/2897 | 81/18723 | 5.61e-06 | 2.01e-04 | 29 |
GO:00108221 | Colorectum | SER | positive regulation of mitochondrion organization | 27/2897 | 74/18723 | 7.79e-06 | 2.67e-04 | 27 |
GO:00432811 | Colorectum | SER | regulation of cysteine-type endopeptidase activity involved in apoptotic process | 57/2897 | 209/18723 | 8.08e-06 | 2.74e-04 | 57 |
GO:00345991 | Colorectum | SER | cellular response to oxidative stress | 73/2897 | 288/18723 | 8.52e-06 | 2.86e-04 | 73 |
GO:00018901 | Colorectum | SER | placenta development | 43/2897 | 144/18723 | 9.10e-06 | 3.03e-04 | 43 |
GO:20001161 | Colorectum | SER | regulation of cysteine-type endopeptidase activity | 62/2897 | 235/18723 | 1.05e-05 | 3.39e-04 | 62 |
GO:19030081 | Colorectum | SER | organelle disassembly | 36/2897 | 114/18723 | 1.22e-05 | 3.89e-04 | 36 |
GO:00091521 | Colorectum | SER | purine ribonucleotide biosynthetic process | 48/2897 | 169/18723 | 1.27e-05 | 4.01e-04 | 48 |
Hugo Symbol | Variant Class | Variant Classification | dbSNP RS | HGVSc | HGVSp | HGVSp Short | SWISSPROT | BIOTYPE | SIFT | PolyPhen | Tumor Sample Barcode | Tissue | Histology | Sex | Age | Stage | Therapy Types | Drugs | Outcome |
PARG | SNV | Missense_Mutation | novel | c.2006N>T | p.Ser669Leu | p.S669L | Q86W56 | protein_coding | deleterious(0.02) | probably_damaging(0.989) | TCGA-AQ-A54N-01 | Breast | breast invasive carcinoma | Female | <65 | I/II | Unknown | Unknown | SD |
PARG | insertion | Frame_Shift_Ins | novel | c.1451_1452insCT | p.Arg485PhefsTer3 | p.R485Ffs*3 | Q86W56 | protein_coding | | | TCGA-S3-AA11-01 | Breast | breast invasive carcinoma | Female | >=65 | I/II | Hormone Therapy | letrozole | CR |
PARG | SNV | Missense_Mutation | rs4614387 | c.1453N>T | p.Arg485Trp | p.R485W | Q86W56 | protein_coding | deleterious(0) | benign(0.072) | TCGA-C5-A8YQ-01 | Cervix | cervical & endocervical cancer | Female | >=65 | I/II | Chemotherapy | cisplatin | PD |
PARG | SNV | Missense_Mutation | novel | c.517N>G | p.Gln173Glu | p.Q173E | Q86W56 | protein_coding | tolerated_low_confidence(0.16) | benign(0.001) | TCGA-C5-A8YQ-01 | Cervix | cervical & endocervical cancer | Female | >=65 | I/II | Chemotherapy | cisplatin | PD |
PARG | SNV | Missense_Mutation | novel | c.2515N>C | p.Glu839Gln | p.E839Q | Q86W56 | protein_coding | tolerated(0.06) | benign(0.312) | TCGA-EK-A3GJ-01 | Cervix | cervical & endocervical cancer | Female | <65 | I/II | Unknown | Unknown | SD |
PARG | SNV | Missense_Mutation | novel | c.815G>A | p.Gly272Asp | p.G272D | Q86W56 | protein_coding | tolerated_low_confidence(0.64) | benign(0.049) | TCGA-VS-A8EB-01 | Cervix | cervical & endocervical cancer | Female | <65 | III/IV | Unknown | Unknown | PD |
PARG | SNV | Missense_Mutation | novel | c.1199C>G | p.Ser400Cys | p.S400C | Q86W56 | protein_coding | deleterious_low_confidence(0.02) | possibly_damaging(0.628) | TCGA-VS-A8Q8-01 | Cervix | cervical & endocervical cancer | Female | <65 | I/II | Unknown | Unknown | PD |
PARG | deletion | Frame_Shift_Del | novel | c.2808delN | p.Tyr936Ter | p.Y936* | Q86W56 | protein_coding | | | TCGA-C5-A7X3-01 | Cervix | cervical & endocervical cancer | Female | >=65 | III/IV | Chemotherapy | cisplatin | SD |
PARG | SNV | Missense_Mutation | novel | c.2173N>G | p.Thr725Ala | p.T725A | Q86W56 | protein_coding | deleterious(0.02) | benign(0.359) | TCGA-A6-5661-01 | Colorectum | colon adenocarcinoma | Female | >=65 | I/II | Unknown | Unknown | SD |
PARG | SNV | Missense_Mutation | novel | c.1865C>G | p.Ser622Cys | p.S622C | Q86W56 | protein_coding | deleterious(0.02) | probably_damaging(0.995) | TCGA-AA-3662-01 | Colorectum | colon adenocarcinoma | Female | >=65 | III/IV | Chemotherapy | capecitabine | PR |