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Gene: NEK6 |
Gene summary for NEK6 |
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Gene information | Species | Human | Gene symbol | NEK6 | Gene ID | 10783 |
Gene name | NIMA related kinase 6 | |
Gene Alias | SID6-1512 | |
Cytomap | 9q33.3 | |
Gene Type | protein-coding | GO ID | GO:0000070 | UniProtAcc | Q9HC98 |
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Malignant transformation analysis |
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Entrez ID | Symbol | Replicates | Species | Organ | Tissue | Adj P-value | Log2FC | Malignancy |
10783 | NEK6 | LZE4T | Human | Esophagus | ESCC | 1.68e-05 | 1.13e-01 | 0.0811 |
10783 | NEK6 | LZE8T | Human | Esophagus | ESCC | 2.63e-03 | 9.52e-02 | 0.067 |
10783 | NEK6 | LZE20T | Human | Esophagus | ESCC | 2.27e-07 | 3.69e-01 | 0.0662 |
10783 | NEK6 | P1T-E | Human | Esophagus | ESCC | 2.61e-05 | 4.46e-01 | 0.0875 |
10783 | NEK6 | P2T-E | Human | Esophagus | ESCC | 3.64e-15 | 3.06e-01 | 0.1177 |
10783 | NEK6 | P4T-E | Human | Esophagus | ESCC | 1.68e-17 | 3.71e-01 | 0.1323 |
10783 | NEK6 | P5T-E | Human | Esophagus | ESCC | 1.50e-14 | 2.09e-01 | 0.1327 |
10783 | NEK6 | P8T-E | Human | Esophagus | ESCC | 6.81e-63 | 1.15e+00 | 0.0889 |
10783 | NEK6 | P9T-E | Human | Esophagus | ESCC | 6.68e-06 | 1.91e-01 | 0.1131 |
10783 | NEK6 | P10T-E | Human | Esophagus | ESCC | 5.84e-22 | 3.50e-01 | 0.116 |
10783 | NEK6 | P11T-E | Human | Esophagus | ESCC | 1.91e-27 | 9.59e-01 | 0.1426 |
10783 | NEK6 | P12T-E | Human | Esophagus | ESCC | 4.51e-20 | 2.95e-01 | 0.1122 |
10783 | NEK6 | P15T-E | Human | Esophagus | ESCC | 8.56e-17 | 4.50e-01 | 0.1149 |
10783 | NEK6 | P16T-E | Human | Esophagus | ESCC | 4.77e-17 | 2.43e-01 | 0.1153 |
10783 | NEK6 | P17T-E | Human | Esophagus | ESCC | 4.10e-06 | 4.86e-01 | 0.1278 |
10783 | NEK6 | P19T-E | Human | Esophagus | ESCC | 4.93e-13 | 9.11e-01 | 0.1662 |
10783 | NEK6 | P21T-E | Human | Esophagus | ESCC | 2.03e-44 | 8.62e-01 | 0.1617 |
10783 | NEK6 | P22T-E | Human | Esophagus | ESCC | 4.65e-15 | 2.42e-01 | 0.1236 |
10783 | NEK6 | P23T-E | Human | Esophagus | ESCC | 4.80e-07 | 2.41e-01 | 0.108 |
10783 | NEK6 | P24T-E | Human | Esophagus | ESCC | 4.74e-18 | 3.12e-01 | 0.1287 |
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∗log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage. |
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Malignant transformation related pathway analysis |
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Tissue | Disease Stage | Enriched GO biological Processes |
Colorectum | AD | ![]() |
Colorectum | SER | ![]() |
Colorectum | MSS | ![]() |
Colorectum | MSI-H | ![]() |
Colorectum | FAP | ![]() |
∗Top 15 enriched GO BP terms are showed in the bar plot of each disease state in each tissue. Each row represents a significant GO biological process which is colored according to the -log10(p.adjust). |
Page: 1 2 3 4 5 6 7 8 9 |
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GO ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | Count |
GO:00510815 | Thyroid | ATC | nuclear envelope disassembly | 8/6293 | 11/18723 | 9.31e-03 | 3.44e-02 | 8 |
Page: 1 2 3 4 5 6 7 8 9 10 11 12 13 14 |
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Pathway ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | qvalue | Count |
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Cell-cell communication analysis |
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Ligand | Receptor | LRpair | Pathway | Tissue | Disease Stage |
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Single-cell gene regulatory network inference analysis |
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TF | Cell Type | Tissue | Disease Stage | Target Gene | RSS | Regulon Activity |
∗The dot plots of a searched regulon are shown for all cell subpopulations in each disease state of each tissue based on the regulon specific score inferred using pySCENIC and by calculating the average expression. |
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Somatic mutation of malignant transformation related genes |
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Hugo Symbol | Variant Class | Variant Classification | dbSNP RS | HGVSc | HGVSp | HGVSp Short | SWISSPROT | BIOTYPE | SIFT | PolyPhen | Tumor Sample Barcode | Tissue | Histology | Sex | Age | Stage | Therapy Types | Drugs | Outcome |
NEK6 | SNV | Missense_Mutation | c.469N>C | p.Glu157Gln | p.E157Q | Q9HC98 | protein_coding | deleterious(0.01) | probably_damaging(0.997) | TCGA-AC-A23H-01 | Breast | breast invasive carcinoma | Female | >=65 | I/II | Unknown | Unknown | PD | |
NEK6 | SNV | Missense_Mutation | novel | c.686N>A | p.Arg229His | p.R229H | Q9HC98 | protein_coding | deleterious(0) | probably_damaging(0.996) | TCGA-BH-A18L-01 | Breast | breast invasive carcinoma | Female | <65 | III/IV | Unknown | Unknown | SD |
NEK6 | SNV | Missense_Mutation | c.808N>G | p.Leu270Val | p.L270V | Q9HC98 | protein_coding | tolerated(0.11) | possibly_damaging(0.664) | TCGA-D8-A27G-01 | Breast | breast invasive carcinoma | Female | >=65 | I/II | Unknown | Unknown | SD | |
NEK6 | insertion | Frame_Shift_Ins | novel | c.607_608insCTGATGCCCGTTGGAAC | p.Met203ThrfsTer24 | p.M203Tfs*24 | Q9HC98 | protein_coding | TCGA-A8-A08H-01 | Breast | breast invasive carcinoma | Female | >=65 | I/II | Unknown | Unknown | SD | ||
NEK6 | SNV | Missense_Mutation | rs879292381 | c.577N>A | p.Ala193Thr | p.A193T | Q9HC98 | protein_coding | deleterious(0) | probably_damaging(0.989) | TCGA-2W-A8YY-01 | Cervix | cervical & endocervical cancer | Female | <65 | I/II | Chemotherapy | cisplatin | CR |
NEK6 | SNV | Missense_Mutation | c.341N>T | p.Glu114Val | p.E114V | Q9HC98 | protein_coding | deleterious(0.01) | possibly_damaging(0.886) | TCGA-C5-A1MI-01 | Cervix | cervical & endocervical cancer | Female | <65 | I/II | Chemotherapy | cisplatin | PD | |
NEK6 | SNV | Missense_Mutation | rs750746819 | c.217N>T | p.Arg73Cys | p.R73C | Q9HC98 | protein_coding | tolerated_low_confidence(0.11) | benign(0.006) | TCGA-MA-AA3W-01 | Cervix | cervical & endocervical cancer | Female | <65 | I/II | Chemotherapy | cisplatin | CR |
NEK6 | SNV | Missense_Mutation | c.959N>C | p.Ile320Thr | p.I320T | Q9HC98 | protein_coding | deleterious(0) | probably_damaging(0.972) | TCGA-AA-3811-01 | Colorectum | colon adenocarcinoma | Female | >=65 | III/IV | Unknown | Unknown | PD | |
NEK6 | SNV | Missense_Mutation | c.661N>C | p.Lys221Gln | p.K221Q | Q9HC98 | protein_coding | deleterious(0.03) | probably_damaging(0.999) | TCGA-AA-3966-01 | Colorectum | colon adenocarcinoma | Female | >=65 | I/II | Unknown | Unknown | SD | |
NEK6 | SNV | Missense_Mutation | rs183673274 | c.230N>T | p.Ala77Val | p.A77V | Q9HC98 | protein_coding | tolerated(0.1) | benign(0.051) | TCGA-AD-A5EJ-01 | Colorectum | colon adenocarcinoma | Female | >=65 | I/II | Unknown | Unknown | SD |
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Related drugs of malignant transformation related genes |
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(DGIdb 4.0) |
Entrez ID | Symbol | Category | Interaction Types | Drug Claim Name | Drug Name | PMIDs |
10783 | NEK6 | DRUGGABLE GENOME, KINASE, ENZYME, SERINE THREONINE KINASE | inhibitor | 249565885 |
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