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Gene: MT1G |
Gene summary for MT1G |
Gene summary. |
Gene information | Species | Human | Gene symbol | MT1G | Gene ID | 4495 |
Gene name | metallothionein 1G | |
Gene Alias | MT1 | |
Cytomap | 16q13 | |
Gene Type | protein-coding | GO ID | GO:0001775 | UniProtAcc | P13640 |
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Malignant transformation analysis |
Identification of the aberrant gene expression in precancerous and cancerous lesions by comparing the gene expression of stem-like cells in diseased tissues with normal stem cells |
Malignant transformation involving gene list. |
Entrez ID | Symbol | Replicates | Species | Organ | Tissue | Adj P-value | Log2FC | Malignancy |
4495 | MT1G | GSM4909282 | Human | Breast | IDC | 2.37e-14 | 4.67e-01 | -0.0288 |
4495 | MT1G | GSM4909286 | Human | Breast | IDC | 2.00e-78 | 1.12e+00 | 0.1081 |
4495 | MT1G | GSM4909289 | Human | Breast | IDC | 6.90e-10 | 8.73e-01 | 0.1064 |
4495 | MT1G | GSM4909293 | Human | Breast | IDC | 2.27e-18 | 5.04e-01 | 0.1581 |
4495 | MT1G | GSM4909294 | Human | Breast | IDC | 3.78e-06 | -1.69e-01 | 0.2022 |
4495 | MT1G | GSM4909301 | Human | Breast | IDC | 7.33e-04 | -1.78e-01 | 0.1577 |
4495 | MT1G | GSM4909304 | Human | Breast | IDC | 2.45e-34 | 7.87e-01 | 0.1636 |
4495 | MT1G | GSM4909306 | Human | Breast | IDC | 1.54e-24 | 6.17e-01 | 0.1564 |
4495 | MT1G | GSM4909308 | Human | Breast | IDC | 3.00e-04 | -1.90e-01 | 0.158 |
4495 | MT1G | GSM4909309 | Human | Breast | IDC | 4.91e-06 | 3.67e-01 | 0.0483 |
4495 | MT1G | GSM4909311 | Human | Breast | IDC | 5.56e-11 | 2.66e-01 | 0.1534 |
4495 | MT1G | GSM4909315 | Human | Breast | IDC | 1.72e-05 | -1.84e-01 | 0.21 |
4495 | MT1G | GSM4909319 | Human | Breast | IDC | 8.07e-06 | -1.75e-01 | 0.1563 |
4495 | MT1G | GSM4909321 | Human | Breast | IDC | 3.78e-06 | -1.90e-01 | 0.1559 |
4495 | MT1G | NCCBC5 | Human | Breast | DCIS | 2.20e-05 | 2.77e-01 | 0.2046 |
4495 | MT1G | P1 | Human | Breast | IDC | 1.41e-03 | -1.90e-01 | 0.1527 |
4495 | MT1G | DCIS2 | Human | Breast | DCIS | 4.22e-09 | -7.81e-02 | 0.0085 |
4495 | MT1G | HTA11_3410_2000001011 | Human | Colorectum | AD | 2.19e-03 | 2.51e-01 | 0.0155 |
4495 | MT1G | HTA11_2487_2000001011 | Human | Colorectum | SER | 2.90e-34 | 1.89e+00 | -0.1808 |
4495 | MT1G | HTA11_2951_2000001011 | Human | Colorectum | AD | 3.54e-06 | 7.94e-01 | 0.0216 |
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Transcriptomic changes along malignancy continuum. |
∗log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage. |
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Malignant transformation related pathway analysis |
Find out the enriched GO biological processes and KEGG pathways involved in transition from healthy to precancer to cancer |
Figure of enriched GO biological processes. |
Tissue | Disease Stage | Enriched GO biological Processes |
Colorectum | AD | |
Colorectum | SER | |
Colorectum | MSS | |
Colorectum | MSI-H | |
Colorectum | FAP |
∗Top 15 enriched GO BP terms are showed in the bar plot of each disease state in each tissue. Each row represents a significant GO biological process which is colored according to the -log10(p.adjust). |
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Enriched GO biological processes. |
GO ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | Count |
GO:00466882 | Stomach | CSG | response to copper ion | 9/1034 | 42/18723 | 3.94e-04 | 6.42e-03 | 9 |
GO:00712482 | Stomach | CSG | cellular response to metal ion | 23/1034 | 197/18723 | 5.68e-04 | 8.32e-03 | 23 |
GO:00100432 | Stomach | CSG | response to zinc ion | 10/1034 | 58/18723 | 1.17e-03 | 1.42e-02 | 10 |
GO:00712942 | Stomach | CSG | cellular response to zinc ion | 6/1034 | 24/18723 | 1.59e-03 | 1.76e-02 | 6 |
GO:00712802 | Stomach | CSG | cellular response to copper ion | 6/1034 | 28/18723 | 3.69e-03 | 3.27e-02 | 6 |
GO:005507621 | Stomach | CSG | transition metal ion homeostasis | 16/1034 | 138/18723 | 3.97e-03 | 3.46e-02 | 16 |
GO:00025734 | Stomach | CSG | myeloid leukocyte differentiation | 21/1034 | 208/18723 | 5.63e-03 | 4.50e-02 | 21 |
GO:009875431 | Stomach | CAG | detoxification | 21/552 | 152/18723 | 4.15e-09 | 6.72e-07 | 21 |
GO:000963631 | Stomach | CAG | response to toxic substance | 28/552 | 262/18723 | 4.37e-09 | 6.72e-07 | 28 |
GO:001003831 | Stomach | CAG | response to metal ion | 34/552 | 373/18723 | 6.12e-09 | 8.53e-07 | 34 |
GO:00975013 | Stomach | CAG | stress response to metal ion | 7/552 | 19/18723 | 6.90e-07 | 4.81e-05 | 7 |
GO:00712763 | Stomach | CAG | cellular response to cadmium ion | 9/552 | 40/18723 | 1.91e-06 | 1.11e-04 | 9 |
GO:00102733 | Stomach | CAG | detoxification of copper ion | 6/552 | 15/18723 | 2.55e-06 | 1.35e-04 | 6 |
GO:19901693 | Stomach | CAG | stress response to copper ion | 6/552 | 15/18723 | 2.55e-06 | 1.35e-04 | 6 |
GO:00712413 | Stomach | CAG | cellular response to inorganic substance | 21/552 | 226/18723 | 3.70e-06 | 1.78e-04 | 21 |
GO:00466863 | Stomach | CAG | response to cadmium ion | 11/552 | 68/18723 | 4.43e-06 | 2.09e-04 | 11 |
GO:00712483 | Stomach | CAG | cellular response to metal ion | 19/552 | 197/18723 | 6.23e-06 | 2.75e-04 | 19 |
GO:00616873 | Stomach | CAG | detoxification of inorganic compound | 6/552 | 18/18723 | 8.77e-06 | 3.76e-04 | 6 |
GO:00100433 | Stomach | CAG | response to zinc ion | 9/552 | 58/18723 | 4.63e-05 | 1.45e-03 | 9 |
GO:00712943 | Stomach | CAG | cellular response to zinc ion | 6/552 | 24/18723 | 5.47e-05 | 1.60e-03 | 6 |
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Enriched KEGG pathways. |
Pathway ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | qvalue | Count |
hsa0497812 | Breast | IDC | Mineral absorption | 13/867 | 60/8465 | 6.73e-03 | 3.42e-02 | 2.56e-02 | 13 |
hsa0497813 | Breast | IDC | Mineral absorption | 13/867 | 60/8465 | 6.73e-03 | 3.42e-02 | 2.56e-02 | 13 |
hsa0497821 | Breast | DCIS | Mineral absorption | 13/846 | 60/8465 | 5.48e-03 | 2.81e-02 | 2.07e-02 | 13 |
hsa0497831 | Breast | DCIS | Mineral absorption | 13/846 | 60/8465 | 5.48e-03 | 2.81e-02 | 2.07e-02 | 13 |
hsa0497814 | Prostate | BPH | Mineral absorption | 20/1718 | 60/8465 | 1.22e-02 | 3.61e-02 | 2.23e-02 | 20 |
hsa0497815 | Prostate | BPH | Mineral absorption | 20/1718 | 60/8465 | 1.22e-02 | 3.61e-02 | 2.23e-02 | 20 |
hsa04978 | Stomach | GC | Mineral absorption | 15/708 | 60/8465 | 8.88e-05 | 9.80e-04 | 6.90e-04 | 15 |
hsa049781 | Stomach | GC | Mineral absorption | 15/708 | 60/8465 | 8.88e-05 | 9.80e-04 | 6.90e-04 | 15 |
hsa049782 | Stomach | CAG with IM | Mineral absorption | 12/640 | 60/8465 | 1.52e-03 | 1.01e-02 | 7.10e-03 | 12 |
hsa049783 | Stomach | CAG with IM | Mineral absorption | 12/640 | 60/8465 | 1.52e-03 | 1.01e-02 | 7.10e-03 | 12 |
hsa049784 | Stomach | CSG | Mineral absorption | 11/633 | 60/8465 | 4.40e-03 | 2.53e-02 | 1.82e-02 | 11 |
hsa049785 | Stomach | CSG | Mineral absorption | 11/633 | 60/8465 | 4.40e-03 | 2.53e-02 | 1.82e-02 | 11 |
hsa049786 | Stomach | CAG | Mineral absorption | 8/368 | 60/8465 | 4.18e-03 | 2.94e-02 | 2.36e-02 | 8 |
hsa049787 | Stomach | CAG | Mineral absorption | 8/368 | 60/8465 | 4.18e-03 | 2.94e-02 | 2.36e-02 | 8 |
hsa049788 | Stomach | SIM | Mineral absorption | 11/465 | 60/8465 | 3.61e-04 | 3.41e-03 | 2.74e-03 | 11 |
hsa049789 | Stomach | SIM | Mineral absorption | 11/465 | 60/8465 | 3.61e-04 | 3.41e-03 | 2.74e-03 | 11 |
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Cell-cell communication analysis |
Identification of potential cell-cell interactions between two cell types and their ligand-receptor pairs for different disease states |
Ligand | Receptor | LRpair | Pathway | Tissue | Disease Stage |
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Single-cell gene regulatory network inference analysis |
Find out the significant the regulons (TFs) and the target genes of each regulon across cell types for different disease states |
TF | Cell Type | Tissue | Disease Stage | Target Gene | RSS | Regulon Activity |
∗The dot plots of a searched regulon are shown for all cell subpopulations in each disease state of each tissue based on the regulon specific score inferred using pySCENIC and by calculating the average expression. |
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Somatic mutation of malignant transformation related genes |
Annotation of somatic variants for genes involved in malignant transformation |
Hugo Symbol | Variant Class | Variant Classification | dbSNP RS | HGVSc | HGVSp | HGVSp Short | SWISSPROT | BIOTYPE | SIFT | PolyPhen | Tumor Sample Barcode | Tissue | Histology | Sex | Age | Stage | Therapy Types | Drugs | Outcome |
MT1G | SNV | Missense_Mutation | c.185C>T | p.Ala62Val | p.A62V | P13640 | protein_coding | deleterious_low_confidence(0.02) | benign(0.399) | TCGA-AA-A01P-01 | Colorectum | colon adenocarcinoma | Female | >=65 | III/IV | Unknown | Unknown | PD | |
MT1G | SNV | Missense_Mutation | novel | c.14N>A | p.Cys5Tyr | p.C5Y | P13640 | protein_coding | deleterious_low_confidence(0.01) | probably_damaging(0.99) | TCGA-A5-A0G2-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | <65 | III/IV | Unknown | Unknown | SD |
MT1G | SNV | Missense_Mutation | novel | c.137N>T | p.Ala46Val | p.A46V | P13640 | protein_coding | deleterious(0.04) | possibly_damaging(0.463) | TCGA-AX-A0J1-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | >=65 | I/II | Unknown | Unknown | SD |
MT1G | SNV | Missense_Mutation | c.49N>T | p.Ala17Ser | p.A17S | P13640 | protein_coding | tolerated_low_confidence(0.23) | benign(0.111) | TCGA-73-4670-01 | Lung | lung adenocarcinoma | Female | >=65 | III/IV | Chemotherapy | carboplatin | SD | |
MT1G | SNV | Missense_Mutation | rs546669333 | c.164C>T | p.Ser55Leu | p.S55L | P13640 | protein_coding | tolerated(0.18) | benign(0.001) | TCGA-BR-8680-01 | Stomach | stomach adenocarcinoma | Male | <65 | III/IV | Chemotherapy | oxaliplatin | CR |
MT1G | SNV | Missense_Mutation | rs370776559 | c.49N>A | p.Ala17Thr | p.A17T | P13640 | protein_coding | tolerated_low_confidence(0.2) | benign(0.003) | TCGA-VQ-A8P2-01 | Stomach | stomach adenocarcinoma | Male | >=65 | III/IV | Unspecific | Complete Response |
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Related drugs of malignant transformation related genes |
Identification of chemicals and drugs interact with genes involved in malignant transfromation |
(DGIdb 4.0) |
Entrez ID | Symbol | Category | Interaction Types | Drug Claim Name | Drug Name | PMIDs |
4495 | MT1G | NA | BSO | 8966720 |
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