Tissue | Expression Dynamics | Abbreviation |
Esophagus | ![The image shows the transcriptomic changes along malignancy continuum.log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage.](images/deg_images/Esophagus/KDM1A_pca_on_diff_genes.png) | ESCC: Esophageal squamous cell carcinoma |
HGIN: High-grade intraepithelial neoplasias |
LGIN: Low-grade intraepithelial neoplasias |
Liver | ![The image shows the transcriptomic changes along malignancy continuum.log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage.](images/deg_images/Liver/KDM1A_pca_on_diff_genes.png) | HCC: Hepatocellular carcinoma |
NAFLD: Non-alcoholic fatty liver disease |
Lung | ![The image shows the transcriptomic changes along malignancy continuum.log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage.](images/deg_images/Lung/KDM1A_pca_on_diff_genes.png) | AAH: Atypical adenomatous hyperplasia |
AIS: Adenocarcinoma in situ |
IAC: Invasive lung adenocarcinoma |
MIA: Minimally invasive adenocarcinoma |
Oral Cavity | ![The image shows the transcriptomic changes along malignancy continuum.log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage.](images/deg_images/OralCavity/KDM1A_pca_on_diff_genes.png) | EOLP: Erosive Oral lichen planus |
LP: leukoplakia |
NEOLP: Non-erosive oral lichen planus |
OSCC: Oral squamous cell carcinoma |
Prostate | ![The image shows the transcriptomic changes along malignancy continuum.log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage.](images/deg_images/Prostate/KDM1A_pca_on_diff_genes.png) | BPH: Benign Prostatic Hyperplasia |
Skin | ![The image shows the transcriptomic changes along malignancy continuum.log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage.](images/deg_images/Skin/KDM1A_pca_on_diff_genes.png) | AK: Actinic keratosis |
cSCC: Cutaneous squamous cell carcinoma |
SCCIS:squamous cell carcinoma in situ |
Thyroid | ![The image shows the transcriptomic changes along malignancy continuum.log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage.](images/deg_images/Thyroid/KDM1A_pca_on_diff_genes.png) | ATC: Anaplastic thyroid cancer |
HT: Hashimoto's thyroiditis |
PTC: Papillary thyroid cancer |
GO ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | Count |
GO:00515918 | Lung | IAC | response to cAMP | 21/2061 | 93/18723 | 9.98e-04 | 1.19e-02 | 21 |
GO:00310564 | Lung | IAC | regulation of histone modification | 30/2061 | 152/18723 | 1.07e-03 | 1.26e-02 | 30 |
GO:0043392 | Lung | IAC | negative regulation of DNA binding | 14/2061 | 52/18723 | 1.14e-03 | 1.33e-02 | 14 |
GO:00064794 | Lung | IAC | protein methylation | 34/2061 | 181/18723 | 1.28e-03 | 1.45e-02 | 34 |
GO:00082134 | Lung | IAC | protein alkylation | 34/2061 | 181/18723 | 1.28e-03 | 1.45e-02 | 34 |
GO:00714804 | Lung | IAC | cellular response to gamma radiation | 10/2061 | 31/18723 | 1.28e-03 | 1.45e-02 | 10 |
GO:00713206 | Lung | IAC | cellular response to cAMP | 14/2061 | 53/18723 | 1.39e-03 | 1.53e-02 | 14 |
GO:00165714 | Lung | IAC | histone methylation | 28/2061 | 141/18723 | 1.39e-03 | 1.53e-02 | 28 |
GO:00309002 | Lung | IAC | forebrain development | 61/2061 | 379/18723 | 1.52e-03 | 1.61e-02 | 61 |
GO:00083615 | Lung | IAC | regulation of cell size | 33/2061 | 181/18723 | 2.47e-03 | 2.33e-02 | 33 |
GO:00003778 | Lung | IAC | RNA splicing, via transesterification reactions with bulged adenosine as nucleophile | 52/2061 | 320/18723 | 2.64e-03 | 2.44e-02 | 52 |
GO:00003988 | Lung | IAC | mRNA splicing, via spliceosome | 52/2061 | 320/18723 | 2.64e-03 | 2.44e-02 | 52 |
GO:0055001 | Lung | IAC | muscle cell development | 33/2061 | 184/18723 | 3.24e-03 | 2.79e-02 | 33 |
GO:00003758 | Lung | IAC | RNA splicing, via transesterification reactions | 52/2061 | 324/18723 | 3.43e-03 | 2.93e-02 | 52 |
GO:0043518 | Lung | IAC | negative regulation of DNA damage response, signal transduction by p53 class mediator | 6/2061 | 15/18723 | 3.67e-03 | 3.07e-02 | 6 |
GO:00507675 | Lung | IAC | regulation of neurogenesis | 57/2061 | 364/18723 | 3.92e-03 | 3.24e-02 | 57 |
GO:00165744 | Lung | IAC | histone ubiquitination | 12/2061 | 47/18723 | 4.05e-03 | 3.31e-02 | 12 |
GO:0061647 | Lung | IAC | histone H3-K9 modification | 12/2061 | 48/18723 | 4.87e-03 | 3.77e-02 | 12 |
GO:1901797 | Lung | IAC | negative regulation of signal transduction by p53 class mediator | 9/2061 | 31/18723 | 4.94e-03 | 3.78e-02 | 9 |
GO:00515671 | Lung | IAC | histone H3-K9 methylation | 10/2061 | 37/18723 | 5.45e-03 | 4.08e-02 | 10 |
Hugo Symbol | Variant Class | Variant Classification | dbSNP RS | HGVSc | HGVSp | HGVSp Short | SWISSPROT | BIOTYPE | SIFT | PolyPhen | Tumor Sample Barcode | Tissue | Histology | Sex | Age | Stage | Therapy Types | Drugs | Outcome |
KDM1A | SNV | Missense_Mutation | | c.1189G>C | p.Glu397Gln | p.E397Q | O60341 | protein_coding | tolerated(0.07) | possibly_damaging(0.552) | TCGA-AC-A23H-01 | Breast | breast invasive carcinoma | Female | >=65 | I/II | Unknown | Unknown | PD |
KDM1A | SNV | Missense_Mutation | | c.812G>A | p.Arg271Gln | p.R271Q | O60341 | protein_coding | deleterious(0.04) | probably_damaging(0.941) | TCGA-AN-A046-01 | Breast | breast invasive carcinoma | Female | >=65 | I/II | Unknown | Unknown | SD |
KDM1A | SNV | Missense_Mutation | | c.2426N>G | p.Ser809Trp | p.S809W | O60341 | protein_coding | deleterious(0) | possibly_damaging(0.803) | TCGA-GM-A2D9-01 | Breast | breast invasive carcinoma | Female | >=65 | I/II | Hormone Therapy | arimidex | SD |
KDM1A | SNV | Missense_Mutation | | c.1189N>A | p.Glu397Lys | p.E397K | O60341 | protein_coding | deleterious(0.01) | benign(0.413) | TCGA-W8-A86G-01 | Breast | breast invasive carcinoma | Female | >=65 | I/II | Hormone Therapy | arimidex | SD |
KDM1A | insertion | Nonsense_Mutation | novel | c.677_678insATAGAGATGGAGAAGAATATTATTCCAAGCATACATTAATGT | p.Thr226_Gln227insTer | p.T226_Q227ins* | O60341 | protein_coding | | | TCGA-A2-A0CQ-01 | Breast | breast invasive carcinoma | Female | <65 | I/II | Chemotherapy | adriamycin | SD |
KDM1A | insertion | Nonsense_Mutation | novel | c.1919_1920insGATGACAGTTGAGGATTCTGAAGTTGAC | p.Tyr640Ter | p.Y640* | O60341 | protein_coding | | | TCGA-A8-A0A4-01 | Breast | breast invasive carcinoma | Female | >=65 | I/II | Hormone Therapy | tamoxiphen | CR |
KDM1A | insertion | Frame_Shift_Ins | novel | c.1816_1817insGAGCGTGGTGGCTCATGCCTGTAATACCAGCACTT | p.Leu606ArgfsTer13 | p.L606Rfs*13 | O60341 | protein_coding | | | TCGA-B6-A0IK-01 | Breast | breast invasive carcinoma | Female | <65 | III/IV | Unknown | Unknown | PD |
KDM1A | SNV | Missense_Mutation | | c.817C>A | p.His273Asn | p.H273N | O60341 | protein_coding | deleterious(0) | probably_damaging(0.996) | TCGA-EA-A1QS-01 | Cervix | cervical & endocervical cancer | Female | <65 | I/II | Unknown | Unknown | SD |
KDM1A | SNV | Missense_Mutation | novel | c.358T>C | p.Tyr120His | p.Y120H | O60341 | protein_coding | deleterious_low_confidence(0.03) | probably_damaging(0.991) | TCGA-EA-A3HU-01 | Cervix | cervical & endocervical cancer | Female | <65 | I/II | Unknown | Unknown | SD |
KDM1A | SNV | Missense_Mutation | novel | c.1844G>T | p.Arg615Leu | p.R615L | O60341 | protein_coding | deleterious(0.02) | possibly_damaging(0.69) | TCGA-EK-A2IP-01 | Cervix | cervical & endocervical cancer | Female | <65 | I/II | Unknown | Unknown | SD |
Entrez ID | Symbol | Category | Interaction Types | Drug Claim Name | Drug Name | PMIDs |
23028 | KDM1A | DRUGGABLE GENOME, ENZYME, CELL SURFACE, TRANSCRIPTION FACTOR COMPLEX, TRANSCRIPTION FACTOR BINDING | inhibitor | 178103603 | | |
23028 | KDM1A | DRUGGABLE GENOME, ENZYME, CELL SURFACE, TRANSCRIPTION FACTOR COMPLEX, TRANSCRIPTION FACTOR BINDING | inhibitor | 310264760 | | |
23028 | KDM1A | DRUGGABLE GENOME, ENZYME, CELL SURFACE, TRANSCRIPTION FACTOR COMPLEX, TRANSCRIPTION FACTOR BINDING | | TRANYLCYPROMINE HYDROCHLORIDE | TRANYLCYPROMINE HYDROCHLORIDE | |
23028 | KDM1A | DRUGGABLE GENOME, ENZYME, CELL SURFACE, TRANSCRIPTION FACTOR COMPLEX, TRANSCRIPTION FACTOR BINDING | | 2-[N-(PHTHALIMIDO)]ETHYL CARBAMIMIDOTHIOATE HCL | CHEMBL2182009 | 22876979 |
23028 | KDM1A | DRUGGABLE GENOME, ENZYME, CELL SURFACE, TRANSCRIPTION FACTOR COMPLEX, TRANSCRIPTION FACTOR BINDING | inhibitor | 249565921 | | |
23028 | KDM1A | DRUGGABLE GENOME, ENZYME, CELL SURFACE, TRANSCRIPTION FACTOR COMPLEX, TRANSCRIPTION FACTOR BINDING | activator | 252166601 | | |
23028 | KDM1A | DRUGGABLE GENOME, ENZYME, CELL SURFACE, TRANSCRIPTION FACTOR COMPLEX, TRANSCRIPTION FACTOR BINDING | inhibitor | 178103602 | | |
23028 | KDM1A | DRUGGABLE GENOME, ENZYME, CELL SURFACE, TRANSCRIPTION FACTOR COMPLEX, TRANSCRIPTION FACTOR BINDING | inhibitor | 178101964 | TRANYLCYPROMINE | |
23028 | KDM1A | DRUGGABLE GENOME, ENZYME, CELL SURFACE, TRANSCRIPTION FACTOR COMPLEX, TRANSCRIPTION FACTOR BINDING | | PARNATE | PARNATE | 21382717 |
23028 | KDM1A | DRUGGABLE GENOME, ENZYME, CELL SURFACE, TRANSCRIPTION FACTOR COMPLEX, TRANSCRIPTION FACTOR BINDING | | NAMOLINE | NAMOLINE | 24007511 |