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Gene: ICAM1 |
Gene summary for ICAM1 |
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Gene information | Species | Human | Gene symbol | ICAM1 | Gene ID | 3383 |
Gene name | intercellular adhesion molecule 1 | |
Gene Alias | BB2 | |
Cytomap | 19p13.2 | |
Gene Type | protein-coding | GO ID | GO:0000003 | UniProtAcc | P05362 |
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Malignant transformation analysis |
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Entrez ID | Symbol | Replicates | Species | Organ | Tissue | Adj P-value | Log2FC | Malignancy |
3383 | ICAM1 | AEH-subject1 | Human | Endometrium | AEH | 2.49e-02 | 2.92e-01 | -0.3059 |
3383 | ICAM1 | GSM5276934 | Human | Endometrium | EEC | 8.90e-29 | 7.93e-01 | -0.0913 |
3383 | ICAM1 | GSM5276937 | Human | Endometrium | EEC | 5.41e-16 | 6.37e-01 | -0.0897 |
3383 | ICAM1 | LZE4T | Human | Esophagus | ESCC | 1.80e-09 | 1.25e-01 | 0.0811 |
3383 | ICAM1 | P2T-E | Human | Esophagus | ESCC | 1.50e-02 | 5.82e-01 | 0.1177 |
3383 | ICAM1 | P5T-E | Human | Esophagus | ESCC | 7.13e-04 | 4.26e-01 | 0.1327 |
3383 | ICAM1 | P8T-E | Human | Esophagus | ESCC | 1.36e-41 | 1.96e+00 | 0.0889 |
3383 | ICAM1 | P9T-E | Human | Esophagus | ESCC | 4.22e-03 | 9.26e-01 | 0.1131 |
3383 | ICAM1 | P11T-E | Human | Esophagus | ESCC | 4.30e-08 | 2.03e+00 | 0.1426 |
3383 | ICAM1 | P21T-E | Human | Esophagus | ESCC | 6.22e-18 | 9.21e-01 | 0.1617 |
3383 | ICAM1 | P23T-E | Human | Esophagus | ESCC | 1.25e-12 | 1.59e+00 | 0.108 |
3383 | ICAM1 | P24T-E | Human | Esophagus | ESCC | 5.06e-16 | 8.30e-01 | 0.1287 |
3383 | ICAM1 | P26T-E | Human | Esophagus | ESCC | 3.49e-03 | 1.11e-01 | 0.1276 |
3383 | ICAM1 | P31T-E | Human | Esophagus | ESCC | 9.52e-05 | 4.19e-01 | 0.1251 |
3383 | ICAM1 | P36T-E | Human | Esophagus | ESCC | 1.80e-20 | 2.01e+00 | 0.1187 |
3383 | ICAM1 | P37T-E | Human | Esophagus | ESCC | 6.15e-37 | 1.70e+00 | 0.1371 |
3383 | ICAM1 | P40T-E | Human | Esophagus | ESCC | 1.88e-03 | 7.21e-01 | 0.109 |
3383 | ICAM1 | P42T-E | Human | Esophagus | ESCC | 7.44e-05 | 1.13e+00 | 0.1175 |
3383 | ICAM1 | P47T-E | Human | Esophagus | ESCC | 6.67e-04 | 6.01e-01 | 0.1067 |
3383 | ICAM1 | P48T-E | Human | Esophagus | ESCC | 1.35e-02 | 7.14e-01 | 0.0959 |
Page: 1 2 3 4 5 6 7 |
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∗log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage. |
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Malignant transformation related pathway analysis |
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Tissue | Disease Stage | Enriched GO biological Processes |
Colorectum | AD | ![]() |
Colorectum | SER | ![]() |
Colorectum | MSS | ![]() |
Colorectum | MSI-H | ![]() |
Colorectum | FAP | ![]() |
∗Top 15 enriched GO BP terms are showed in the bar plot of each disease state in each tissue. Each row represents a significant GO biological process which is colored according to the -log10(p.adjust). |
Page: 1 2 3 4 5 6 7 8 9 |
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GO ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | Count |
GO:005109013 | Endometrium | EEC | regulation of DNA-binding transcription factor activity | 75/2168 | 440/18723 | 3.71e-04 | 3.97e-03 | 75 |
GO:003461215 | Endometrium | EEC | response to tumor necrosis factor | 48/2168 | 253/18723 | 3.77e-04 | 4.03e-03 | 48 |
GO:001095914 | Endometrium | EEC | regulation of metal ion transport | 70/2168 | 406/18723 | 4.12e-04 | 4.35e-03 | 70 |
GO:190303713 | Endometrium | EEC | regulation of leukocyte cell-cell adhesion | 60/2168 | 336/18723 | 4.13e-04 | 4.36e-03 | 60 |
GO:00085851 | Endometrium | EEC | female gonad development | 23/2168 | 95/18723 | 4.20e-04 | 4.40e-03 | 23 |
GO:190002712 | Endometrium | EEC | regulation of ruffle assembly | 11/2168 | 31/18723 | 4.54e-04 | 4.69e-03 | 11 |
GO:006102814 | Endometrium | EEC | establishment of endothelial barrier | 14/2168 | 46/18723 | 4.90e-04 | 5.00e-03 | 14 |
GO:00466601 | Endometrium | EEC | female sex differentiation | 26/2168 | 114/18723 | 4.99e-04 | 5.05e-03 | 26 |
GO:000268513 | Endometrium | EEC | regulation of leukocyte migration | 41/2168 | 210/18723 | 5.35e-04 | 5.38e-03 | 41 |
GO:003083315 | Endometrium | EEC | regulation of actin filament polymerization | 35/2168 | 172/18723 | 6.07e-04 | 6.01e-03 | 35 |
GO:000110113 | Endometrium | EEC | response to acid chemical | 29/2168 | 135/18723 | 6.98e-04 | 6.68e-03 | 29 |
GO:008016414 | Endometrium | EEC | regulation of nitric oxide metabolic process | 17/2168 | 64/18723 | 7.49e-04 | 7.05e-03 | 17 |
GO:000806414 | Endometrium | EEC | regulation of actin polymerization or depolymerization | 37/2168 | 188/18723 | 8.33e-04 | 7.67e-03 | 37 |
GO:003166916 | Endometrium | EEC | cellular response to nutrient levels | 41/2168 | 215/18723 | 8.72e-04 | 7.97e-03 | 41 |
GO:000862513 | Endometrium | EEC | extrinsic apoptotic signaling pathway via death domain receptors | 20/2168 | 82/18723 | 8.79e-04 | 8.02e-03 | 20 |
GO:003083214 | Endometrium | EEC | regulation of actin filament length | 37/2168 | 189/18723 | 9.23e-04 | 8.32e-03 | 37 |
GO:007122213 | Endometrium | EEC | cellular response to lipopolysaccharide | 40/2168 | 209/18723 | 9.31e-04 | 8.37e-03 | 40 |
GO:190204113 | Endometrium | EEC | regulation of extrinsic apoptotic signaling pathway via death domain receptors | 14/2168 | 49/18723 | 9.88e-04 | 8.76e-03 | 14 |
GO:00075696 | Endometrium | EEC | cell aging | 28/2168 | 132/18723 | 1.05e-03 | 9.17e-03 | 28 |
GO:009717812 | Endometrium | EEC | ruffle assembly | 13/2168 | 44/18723 | 1.05e-03 | 9.17e-03 | 13 |
Page: 1 2 3 4 5 6 7 8 9 10 11 12 13 14 15 16 17 18 19 20 21 22 23 24 25 26 27 28 29 30 31 32 33 34 35 36 37 38 39 40 41 42 43 44 45 46 47 48 49 50 51 52 53 54 55 56 57 58 59 60 61 62 63 64 65 66 67 68 69 70 71 72 73 74 75 76 77 78 79 80 81 82 83 84 85 86 87 88 89 90 91 92 93 94 95 96 97 98 99 100 101 102 103 104 105 106 107 108 109 110 111 112 113 114 115 116 117 118 119 120 121 122 123 124 125 126 |
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Pathway ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | qvalue | Count |
hsa0541625 | Endometrium | AEH | Viral myocarditis | 27/1197 | 60/8465 | 6.98e-09 | 1.13e-07 | 8.30e-08 | 27 |
hsa0541826 | Endometrium | AEH | Fluid shear stress and atherosclerosis | 43/1197 | 139/8465 | 2.47e-07 | 3.49e-06 | 2.55e-06 | 43 |
hsa0467026 | Endometrium | AEH | Leukocyte transendothelial migration | 37/1197 | 114/8465 | 4.51e-07 | 6.11e-06 | 4.47e-06 | 37 |
hsa049337 | Endometrium | AEH | AGE-RAGE signaling pathway in diabetic complications | 28/1197 | 100/8465 | 2.11e-04 | 1.80e-03 | 1.32e-03 | 28 |
hsa0516626 | Endometrium | AEH | Human T-cell leukemia virus 1 infection | 50/1197 | 222/8465 | 4.30e-04 | 3.11e-03 | 2.27e-03 | 50 |
hsa0516725 | Endometrium | AEH | Kaposi sarcoma-associated herpesvirus infection | 44/1197 | 194/8465 | 7.97e-04 | 5.28e-03 | 3.87e-03 | 44 |
hsa0541726 | Endometrium | AEH | Lipid and atherosclerosis | 47/1197 | 215/8465 | 1.24e-03 | 7.62e-03 | 5.58e-03 | 47 |
hsa0532316 | Endometrium | AEH | Rheumatoid arthritis | 23/1197 | 93/8465 | 4.43e-03 | 2.46e-02 | 1.80e-02 | 23 |
hsa0516924 | Endometrium | AEH | Epstein-Barr virus infection | 42/1197 | 202/8465 | 5.72e-03 | 3.05e-02 | 2.23e-02 | 42 |
hsa05416111 | Endometrium | AEH | Viral myocarditis | 27/1197 | 60/8465 | 6.98e-09 | 1.13e-07 | 8.30e-08 | 27 |
hsa05418112 | Endometrium | AEH | Fluid shear stress and atherosclerosis | 43/1197 | 139/8465 | 2.47e-07 | 3.49e-06 | 2.55e-06 | 43 |
hsa04670111 | Endometrium | AEH | Leukocyte transendothelial migration | 37/1197 | 114/8465 | 4.51e-07 | 6.11e-06 | 4.47e-06 | 37 |
hsa0493314 | Endometrium | AEH | AGE-RAGE signaling pathway in diabetic complications | 28/1197 | 100/8465 | 2.11e-04 | 1.80e-03 | 1.32e-03 | 28 |
hsa05166111 | Endometrium | AEH | Human T-cell leukemia virus 1 infection | 50/1197 | 222/8465 | 4.30e-04 | 3.11e-03 | 2.27e-03 | 50 |
hsa05167111 | Endometrium | AEH | Kaposi sarcoma-associated herpesvirus infection | 44/1197 | 194/8465 | 7.97e-04 | 5.28e-03 | 3.87e-03 | 44 |
hsa05417111 | Endometrium | AEH | Lipid and atherosclerosis | 47/1197 | 215/8465 | 1.24e-03 | 7.62e-03 | 5.58e-03 | 47 |
hsa0532317 | Endometrium | AEH | Rheumatoid arthritis | 23/1197 | 93/8465 | 4.43e-03 | 2.46e-02 | 1.80e-02 | 23 |
hsa05169111 | Endometrium | AEH | Epstein-Barr virus infection | 42/1197 | 202/8465 | 5.72e-03 | 3.05e-02 | 2.23e-02 | 42 |
hsa0541626 | Endometrium | EEC | Viral myocarditis | 28/1237 | 60/8465 | 2.81e-09 | 5.77e-08 | 4.30e-08 | 28 |
hsa0516627 | Endometrium | EEC | Human T-cell leukemia virus 1 infection | 52/1237 | 222/8465 | 2.73e-04 | 2.36e-03 | 1.76e-03 | 52 |
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Cell-cell communication analysis |
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Ligand | Receptor | LRpair | Pathway | Tissue | Disease Stage |
ICAM1 | ITGAL_ITGB2 | ICAM1_ITGAL_ITGB2 | ICAM | Breast | ADJ |
ICAM1 | ITGAL | ICAM1_ITGAL | ICAM | Breast | ADJ |
ICAM1 | SPN | ICAM1_SPN | ICAM | Breast | ADJ |
ITGB2 | ICAM1 | ITGB2_ICAM1 | ITGB2 | Breast | ADJ |
ITGB2 | ICAM1 | ITGB2_ICAM1 | ITGB2 | Breast | DCIS |
ICAM1 | ITGAX_ITGB2 | ICAM1_ITGAX_ITGB2 | ICAM | Breast | DCIS |
ICAM1 | ITGAL_ITGB2 | ICAM1_ITGAL_ITGB2 | ICAM | Breast | DCIS |
ICAM1 | ITGAM_ITGB2 | ICAM1_ITGAM_ITGB2 | ICAM | Breast | DCIS |
ICAM1 | ITGAL | ICAM1_ITGAL | ICAM | Breast | DCIS |
ICAM1 | SPN | ICAM1_SPN | ICAM | Breast | DCIS |
ITGB2 | ICAM1 | ITGB2_ICAM1 | ITGB2 | Breast | Healthy |
ICAM1 | ITGAX_ITGB2 | ICAM1_ITGAX_ITGB2 | ICAM | Breast | Healthy |
ICAM1 | ITGAL_ITGB2 | ICAM1_ITGAL_ITGB2 | ICAM | Breast | Healthy |
ICAM1 | ITGAM_ITGB2 | ICAM1_ITGAM_ITGB2 | ICAM | Breast | Healthy |
ICAM1 | ITGAL | ICAM1_ITGAL | ICAM | Breast | Healthy |
ICAM1 | SPN | ICAM1_SPN | ICAM | Breast | Healthy |
ITGB2 | ICAM1 | ITGB2_ICAM1 | ITGB2 | Breast | IDC |
ICAM1 | ITGAX_ITGB2 | ICAM1_ITGAX_ITGB2 | ICAM | Breast | IDC |
ICAM1 | ITGAL_ITGB2 | ICAM1_ITGAL_ITGB2 | ICAM | Breast | IDC |
ICAM1 | ITGAM_ITGB2 | ICAM1_ITGAM_ITGB2 | ICAM | Breast | IDC |
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Single-cell gene regulatory network inference analysis |
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TF | Cell Type | Tissue | Disease Stage | Target Gene | RSS | Regulon Activity |
∗The dot plots of a searched regulon are shown for all cell subpopulations in each disease state of each tissue based on the regulon specific score inferred using pySCENIC and by calculating the average expression. |
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Somatic mutation of malignant transformation related genes |
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Hugo Symbol | Variant Class | Variant Classification | dbSNP RS | HGVSc | HGVSp | HGVSp Short | SWISSPROT | BIOTYPE | SIFT | PolyPhen | Tumor Sample Barcode | Tissue | Histology | Sex | Age | Stage | Therapy Types | Drugs | Outcome |
ICAM1 | SNV | Missense_Mutation | novel | c.652C>T | p.Pro218Ser | p.P218S | P05362 | protein_coding | tolerated(0.78) | benign(0.193) | TCGA-A2-A0CR-01 | Breast | breast invasive carcinoma | Female | <65 | I/II | Chemotherapy | adriamycin | CR |
ICAM1 | SNV | Missense_Mutation | rs375023616 | c.692N>T | p.Thr231Met | p.T231M | P05362 | protein_coding | deleterious(0.02) | possibly_damaging(0.782) | TCGA-A8-A09Z-01 | Breast | breast invasive carcinoma | Female | >=65 | I/II | Unknown | Unknown | SD |
ICAM1 | SNV | Missense_Mutation | rs746554151 | c.611N>T | p.Ser204Leu | p.S204L | P05362 | protein_coding | deleterious(0) | probably_damaging(1) | TCGA-AN-A046-01 | Breast | breast invasive carcinoma | Female | >=65 | I/II | Unknown | Unknown | SD |
ICAM1 | SNV | Missense_Mutation | novel | c.1087G>A | p.Glu363Lys | p.E363K | P05362 | protein_coding | tolerated(0.16) | benign(0.358) | TCGA-AN-A0FS-01 | Breast | breast invasive carcinoma | Female | <65 | I/II | Unknown | Unknown | SD |
ICAM1 | SNV | Missense_Mutation | c.601N>C | p.Glu201Gln | p.E201Q | P05362 | protein_coding | tolerated(1) | benign(0) | TCGA-EW-A1J5-01 | Breast | breast invasive carcinoma | Female | <65 | I/II | Chemotherapy | adriamycin | SD | |
ICAM1 | deletion | Frame_Shift_Del | novel | c.457delN | p.Glu154ArgfsTer4 | p.E154Rfs*4 | P05362 | protein_coding | TCGA-EW-A2FV-01 | Breast | breast invasive carcinoma | Female | <65 | III/IV | Chemotherapy | docetaxel | SD | ||
ICAM1 | SNV | Missense_Mutation | rs775418785 | c.1468N>A | p.Ala490Thr | p.A490T | P05362 | protein_coding | tolerated(0.16) | benign(0.003) | TCGA-2W-A8YY-01 | Cervix | cervical & endocervical cancer | Female | <65 | I/II | Chemotherapy | cisplatin | CR |
ICAM1 | SNV | Missense_Mutation | rs200230807 | c.1403N>A | p.Arg468His | p.R468H | P05362 | protein_coding | tolerated(0.18) | probably_damaging(0.978) | TCGA-ZJ-AAX8-01 | Cervix | cervical & endocervical cancer | Female | <65 | III/IV | Unknown | Unknown | SD |
ICAM1 | SNV | Missense_Mutation | rs775418785 | c.1468N>A | p.Ala490Thr | p.A490T | P05362 | protein_coding | tolerated(0.16) | benign(0.003) | TCGA-AA-3502-01 | Colorectum | colon adenocarcinoma | Male | >=65 | I/II | Unknown | Unknown | SD |
ICAM1 | SNV | Missense_Mutation | rs780437504 | c.1433G>A | p.Arg478Gln | p.R478Q | P05362 | protein_coding | tolerated(1) | benign(0.001) | TCGA-AA-3864-01 | Colorectum | colon adenocarcinoma | Male | >=65 | I/II | Unknown | Unknown | SD |
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Related drugs of malignant transformation related genes |
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(DGIdb 4.0) |
Entrez ID | Symbol | Category | Interaction Types | Drug Claim Name | Drug Name | PMIDs |
3383 | ICAM1 | EXTERNAL SIDE OF PLASMA MEMBRANE, CELL SURFACE, DRUGGABLE GENOME | BI-505 | BI-505 | ||
3383 | ICAM1 | EXTERNAL SIDE OF PLASMA MEMBRANE, CELL SURFACE, DRUGGABLE GENOME | COXSACKIEVIRUS TYPE A21 | |||
3383 | ICAM1 | EXTERNAL SIDE OF PLASMA MEMBRANE, CELL SURFACE, DRUGGABLE GENOME | BI-505 | BI-505 | ||
3383 | ICAM1 | EXTERNAL SIDE OF PLASMA MEMBRANE, CELL SURFACE, DRUGGABLE GENOME | Alicaforsen | ALICAFORSEN | ||
3383 | ICAM1 | EXTERNAL SIDE OF PLASMA MEMBRANE, CELL SURFACE, DRUGGABLE GENOME | antagonist | CHEMBL2108401 | ENLIMOMAB PEGOL | |
3383 | ICAM1 | EXTERNAL SIDE OF PLASMA MEMBRANE, CELL SURFACE, DRUGGABLE GENOME | lifitegrast | LIFITEGRAST | ||
3383 | ICAM1 | EXTERNAL SIDE OF PLASMA MEMBRANE, CELL SURFACE, DRUGGABLE GENOME | antagonist | CHEMBL2109482 | BI-505 | |
3383 | ICAM1 | EXTERNAL SIDE OF PLASMA MEMBRANE, CELL SURFACE, DRUGGABLE GENOME | ALICAFORSEN | ALICAFORSEN | ||
3383 | ICAM1 | EXTERNAL SIDE OF PLASMA MEMBRANE, CELL SURFACE, DRUGGABLE GENOME | SAR 1118 | |||
3383 | ICAM1 | EXTERNAL SIDE OF PLASMA MEMBRANE, CELL SURFACE, DRUGGABLE GENOME | HYALURONAN | HYALURONAN |
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