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Gene: FLNA |
Gene summary for FLNA |
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Gene information | Species | Human | Gene symbol | FLNA | Gene ID | 2316 |
Gene name | filamin A | |
Gene Alias | ABP-280 | |
Cytomap | Xq28 | |
Gene Type | protein-coding | GO ID | GO:0000003 | UniProtAcc | P21333 |
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Malignant transformation analysis |
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Entrez ID | Symbol | Replicates | Species | Organ | Tissue | Adj P-value | Log2FC | Malignancy |
2316 | FLNA | AEH-subject1 | Human | Endometrium | AEH | 1.82e-02 | -1.46e-01 | -0.3059 |
2316 | FLNA | AEH-subject2 | Human | Endometrium | AEH | 6.80e-05 | -1.94e-01 | -0.2525 |
2316 | FLNA | AEH-subject4 | Human | Endometrium | AEH | 1.25e-04 | -2.74e-01 | -0.2657 |
2316 | FLNA | AEH-subject5 | Human | Endometrium | AEH | 2.89e-16 | -4.67e-01 | -0.2953 |
2316 | FLNA | EEC-subject1 | Human | Endometrium | EEC | 6.22e-15 | -3.24e-01 | -0.2682 |
2316 | FLNA | EEC-subject3 | Human | Endometrium | EEC | 3.19e-25 | -3.52e-01 | -0.2525 |
2316 | FLNA | EEC-subject4 | Human | Endometrium | EEC | 9.63e-07 | -3.21e-01 | -0.2571 |
2316 | FLNA | EEC-subject5 | Human | Endometrium | EEC | 7.48e-09 | -3.19e-01 | -0.249 |
2316 | FLNA | GSM5276934 | Human | Endometrium | EEC | 2.58e-06 | -3.10e-01 | -0.0913 |
2316 | FLNA | GSM5276935 | Human | Endometrium | EEC | 8.11e-05 | -2.95e-01 | -0.123 |
2316 | FLNA | GSM5276937 | Human | Endometrium | EEC | 1.38e-02 | -2.59e-01 | -0.0897 |
2316 | FLNA | GSM6177620_NYU_UCEC1_lib1_lib1 | Human | Endometrium | EEC | 4.50e-21 | 1.36e-02 | -0.1869 |
2316 | FLNA | GSM6177620_NYU_UCEC1_lib2_lib2 | Human | Endometrium | EEC | 1.09e-16 | -1.34e-01 | -0.1875 |
2316 | FLNA | GSM6177620_NYU_UCEC1_lib3_lib3 | Human | Endometrium | EEC | 2.36e-22 | -1.39e-01 | -0.1883 |
2316 | FLNA | GSM6177621_NYU_UCEC2_lib1_lib1 | Human | Endometrium | EEC | 6.31e-17 | -1.66e-01 | -0.1934 |
2316 | FLNA | GSM6177622_NYU_UCEC3_lib1_lib1 | Human | Endometrium | EEC | 2.31e-31 | -2.35e-01 | -0.1917 |
2316 | FLNA | GSM6177622_NYU_UCEC3_lib2_lib2 | Human | Endometrium | EEC | 2.09e-33 | -2.11e-01 | -0.1916 |
2316 | FLNA | GSM6177623_NYU_UCEC3_Vis | Human | Endometrium | EEC | 4.28e-04 | -2.01e-01 | -0.1269 |
2316 | FLNA | LZE4T | Human | Esophagus | ESCC | 1.18e-15 | 6.20e-01 | 0.0811 |
2316 | FLNA | LZE7T | Human | Esophagus | ESCC | 3.13e-22 | 1.87e+00 | 0.0667 |
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∗log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage. |
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Malignant transformation related pathway analysis |
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Tissue | Disease Stage | Enriched GO biological Processes |
Colorectum | AD | ![]() |
Colorectum | SER | ![]() |
Colorectum | MSS | ![]() |
Colorectum | MSI-H | ![]() |
Colorectum | FAP | ![]() |
∗Top 15 enriched GO BP terms are showed in the bar plot of each disease state in each tissue. Each row represents a significant GO biological process which is colored according to the -log10(p.adjust). |
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GO ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | Count |
GO:00092993 | Esophagus | HGIN | mRNA transcription | 7/2587 | 16/18723 | 3.47e-03 | 3.22e-02 | 7 |
GO:190290526 | Esophagus | HGIN | positive regulation of supramolecular fiber organization | 43/2587 | 209/18723 | 4.42e-03 | 3.87e-02 | 43 |
GO:006145819 | Esophagus | HGIN | reproductive system development | 78/2587 | 427/18723 | 5.53e-03 | 4.52e-02 | 78 |
GO:0072594110 | Esophagus | ESCC | establishment of protein localization to organelle | 311/8552 | 422/18723 | 3.02e-32 | 2.13e-29 | 311 |
GO:0006913110 | Esophagus | ESCC | nucleocytoplasmic transport | 230/8552 | 301/18723 | 6.04e-28 | 2.02e-25 | 230 |
GO:0051169110 | Esophagus | ESCC | nuclear transport | 230/8552 | 301/18723 | 6.04e-28 | 2.02e-25 | 230 |
GO:014001414 | Esophagus | ESCC | mitotic nuclear division | 218/8552 | 287/18723 | 6.17e-26 | 1.78e-23 | 218 |
GO:0042176111 | Esophagus | ESCC | regulation of protein catabolic process | 280/8552 | 391/18723 | 8.65e-26 | 2.39e-23 | 280 |
GO:0031647111 | Esophagus | ESCC | regulation of protein stability | 223/8552 | 298/18723 | 5.76e-25 | 1.52e-22 | 223 |
GO:003238618 | Esophagus | ESCC | regulation of intracellular transport | 243/8552 | 337/18723 | 3.20e-23 | 7.25e-21 | 243 |
GO:003450418 | Esophagus | ESCC | protein localization to nucleus | 211/8552 | 290/18723 | 4.06e-21 | 6.60e-19 | 211 |
GO:1903829111 | Esophagus | ESCC | positive regulation of cellular protein localization | 199/8552 | 276/18723 | 2.99e-19 | 3.45e-17 | 199 |
GO:0033157110 | Esophagus | ESCC | regulation of intracellular protein transport | 169/8552 | 229/18723 | 3.31e-18 | 3.23e-16 | 169 |
GO:0032388110 | Esophagus | ESCC | positive regulation of intracellular transport | 152/8552 | 202/18723 | 7.89e-18 | 7.36e-16 | 152 |
GO:190285015 | Esophagus | ESCC | microtubule cytoskeleton organization involved in mitosis | 116/8552 | 147/18723 | 1.25e-16 | 9.91e-15 | 116 |
GO:1904951111 | Esophagus | ESCC | positive regulation of establishment of protein localization | 216/8552 | 319/18723 | 1.01e-15 | 6.86e-14 | 216 |
GO:0046822110 | Esophagus | ESCC | regulation of nucleocytoplasmic transport | 88/8552 | 106/18723 | 1.88e-15 | 1.19e-13 | 88 |
GO:000705214 | Esophagus | ESCC | mitotic spindle organization | 97/8552 | 120/18723 | 2.17e-15 | 1.33e-13 | 97 |
GO:009031617 | Esophagus | ESCC | positive regulation of intracellular protein transport | 122/8552 | 160/18723 | 2.45e-15 | 1.49e-13 | 122 |
GO:001703818 | Esophagus | ESCC | protein import | 149/8552 | 206/18723 | 5.90e-15 | 3.31e-13 | 149 |
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Pathway ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | qvalue | Count |
hsa0513226 | Endometrium | AEH | Salmonella infection | 71/1197 | 249/8465 | 1.69e-09 | 3.44e-08 | 2.52e-08 | 71 |
hsa0451015 | Endometrium | AEH | Focal adhesion | 58/1197 | 203/8465 | 4.99e-08 | 7.37e-07 | 5.39e-07 | 58 |
hsa0520518 | Endometrium | AEH | Proteoglycans in cancer | 53/1197 | 205/8465 | 5.43e-06 | 6.53e-05 | 4.78e-05 | 53 |
hsa05132112 | Endometrium | AEH | Salmonella infection | 71/1197 | 249/8465 | 1.69e-09 | 3.44e-08 | 2.52e-08 | 71 |
hsa0451016 | Endometrium | AEH | Focal adhesion | 58/1197 | 203/8465 | 4.99e-08 | 7.37e-07 | 5.39e-07 | 58 |
hsa0520519 | Endometrium | AEH | Proteoglycans in cancer | 53/1197 | 205/8465 | 5.43e-06 | 6.53e-05 | 4.78e-05 | 53 |
hsa0513227 | Endometrium | EEC | Salmonella infection | 71/1237 | 249/8465 | 7.11e-09 | 1.30e-07 | 9.69e-08 | 71 |
hsa0451024 | Endometrium | EEC | Focal adhesion | 58/1237 | 203/8465 | 1.61e-07 | 2.30e-06 | 1.71e-06 | 58 |
hsa0520524 | Endometrium | EEC | Proteoglycans in cancer | 52/1237 | 205/8465 | 3.01e-05 | 3.19e-04 | 2.38e-04 | 52 |
hsa0513236 | Endometrium | EEC | Salmonella infection | 71/1237 | 249/8465 | 7.11e-09 | 1.30e-07 | 9.69e-08 | 71 |
hsa0451034 | Endometrium | EEC | Focal adhesion | 58/1237 | 203/8465 | 1.61e-07 | 2.30e-06 | 1.71e-06 | 58 |
hsa0520534 | Endometrium | EEC | Proteoglycans in cancer | 52/1237 | 205/8465 | 3.01e-05 | 3.19e-04 | 2.38e-04 | 52 |
hsa0513239 | Esophagus | HGIN | Salmonella infection | 69/1383 | 249/8465 | 3.02e-06 | 4.47e-05 | 3.55e-05 | 69 |
hsa0520528 | Esophagus | HGIN | Proteoglycans in cancer | 47/1383 | 205/8465 | 8.23e-03 | 4.71e-02 | 3.74e-02 | 47 |
hsa05132115 | Esophagus | HGIN | Salmonella infection | 69/1383 | 249/8465 | 3.02e-06 | 4.47e-05 | 3.55e-05 | 69 |
hsa05205112 | Esophagus | HGIN | Proteoglycans in cancer | 47/1383 | 205/8465 | 8.23e-03 | 4.71e-02 | 3.74e-02 | 47 |
hsa05132211 | Esophagus | ESCC | Salmonella infection | 191/4205 | 249/8465 | 6.51e-19 | 5.45e-17 | 2.79e-17 | 191 |
hsa0520529 | Esophagus | ESCC | Proteoglycans in cancer | 138/4205 | 205/8465 | 1.79e-07 | 1.40e-06 | 7.15e-07 | 138 |
hsa0451020 | Esophagus | ESCC | Focal adhesion | 127/4205 | 203/8465 | 1.25e-04 | 4.99e-04 | 2.56e-04 | 127 |
hsa05132310 | Esophagus | ESCC | Salmonella infection | 191/4205 | 249/8465 | 6.51e-19 | 5.45e-17 | 2.79e-17 | 191 |
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Cell-cell communication analysis |
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Ligand | Receptor | LRpair | Pathway | Tissue | Disease Stage |
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Single-cell gene regulatory network inference analysis |
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TF | Cell Type | Tissue | Disease Stage | Target Gene | RSS | Regulon Activity |
∗The dot plots of a searched regulon are shown for all cell subpopulations in each disease state of each tissue based on the regulon specific score inferred using pySCENIC and by calculating the average expression. |
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Somatic mutation of malignant transformation related genes |
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Hugo Symbol | Variant Class | Variant Classification | dbSNP RS | HGVSc | HGVSp | HGVSp Short | SWISSPROT | BIOTYPE | SIFT | PolyPhen | Tumor Sample Barcode | Tissue | Histology | Sex | Age | Stage | Therapy Types | Drugs | Outcome |
FLNA | SNV | Missense_Mutation | novel | c.7115N>T | p.Ser2372Leu | p.S2372L | P21333 | protein_coding | deleterious(0.01) | probably_damaging(0.97) | TCGA-5L-AAT0-01 | Breast | breast invasive carcinoma | Female | <65 | I/II | Hormone Therapy | tamoxiphen | SD |
FLNA | SNV | Missense_Mutation | novel | c.5633N>T | p.Gly1878Val | p.G1878V | P21333 | protein_coding | deleterious(0.01) | probably_damaging(1) | TCGA-A2-A1FW-01 | Breast | breast invasive carcinoma | Female | <65 | III/IV | Chemotherapy | cytoxan | SD |
FLNA | SNV | Missense_Mutation | c.4510N>A | p.Asp1504Asn | p.D1504N | P21333 | protein_coding | tolerated(0.08) | benign(0.033) | TCGA-A7-A0DA-01 | Breast | breast invasive carcinoma | Female | <65 | I/II | Chemotherapy | adriamycin | SD | |
FLNA | SNV | Missense_Mutation | novel | c.1109N>A | p.Phe370Tyr | p.F370Y | P21333 | protein_coding | tolerated(0.08) | benign(0.168) | TCGA-A7-A4SD-01 | Breast | breast invasive carcinoma | Female | <65 | I/II | Chemotherapy | taxotere | CR |
FLNA | SNV | Missense_Mutation | rs201093148 | c.1813N>A | p.Asp605Asn | p.D605N | P21333 | protein_coding | tolerated(0.27) | benign(0.021) | TCGA-A8-A08B-01 | Breast | breast invasive carcinoma | Female | <65 | I/II | Chemotherapy | 5-fluorouracil | CR |
FLNA | SNV | Missense_Mutation | c.4711N>C | p.Asp1571His | p.D1571H | P21333 | protein_coding | deleterious(0) | probably_damaging(0.999) | TCGA-AC-A23H-01 | Breast | breast invasive carcinoma | Female | >=65 | I/II | Unknown | Unknown | PD | |
FLNA | SNV | Missense_Mutation | novel | c.4868G>T | p.Gly1623Val | p.G1623V | P21333 | protein_coding | deleterious(0) | probably_damaging(0.998) | TCGA-AN-A046-01 | Breast | breast invasive carcinoma | Female | >=65 | I/II | Unknown | Unknown | SD |
FLNA | SNV | Missense_Mutation | c.5164A>G | p.Ile1722Val | p.I1722V | P21333 | protein_coding | tolerated(0.14) | benign(0.326) | TCGA-AO-A128-01 | Breast | breast invasive carcinoma | Female | <65 | I/II | Chemotherapy | doxorubicin | SD | |
FLNA | SNV | Missense_Mutation | novel | c.4757A>G | p.Asp1586Gly | p.D1586G | P21333 | protein_coding | tolerated(0.14) | benign(0.282) | TCGA-AO-A128-01 | Breast | breast invasive carcinoma | Female | <65 | I/II | Chemotherapy | doxorubicin | SD |
FLNA | SNV | Missense_Mutation | c.7471G>T | p.Ala2491Ser | p.A2491S | P21333 | protein_coding | deleterious(0.04) | benign(0.44) | TCGA-AR-A1AO-01 | Breast | breast invasive carcinoma | Female | <65 | I/II | Chemotherapy | doxorubicin | SD |
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Related drugs of malignant transformation related genes |
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(DGIdb 4.0) |
Entrez ID | Symbol | Category | Interaction Types | Drug Claim Name | Drug Name | PMIDs |
2316 | FLNA | DRUGGABLE GENOME, TRANSPORTER | PTI-125 |
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