GO ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | Count |
GO:00108221 | Colorectum | SER | positive regulation of mitochondrion organization | 27/2897 | 74/18723 | 7.79e-06 | 2.67e-04 | 27 |
GO:00510171 | Colorectum | SER | actin filament bundle assembly | 46/2897 | 157/18723 | 7.88e-06 | 2.69e-04 | 46 |
GO:00432811 | Colorectum | SER | regulation of cysteine-type endopeptidase activity involved in apoptotic process | 57/2897 | 209/18723 | 8.08e-06 | 2.74e-04 | 57 |
GO:20001161 | Colorectum | SER | regulation of cysteine-type endopeptidase activity | 62/2897 | 235/18723 | 1.05e-05 | 3.39e-04 | 62 |
GO:00971911 | Colorectum | SER | extrinsic apoptotic signaling pathway | 58/2897 | 219/18723 | 1.76e-05 | 5.22e-04 | 58 |
GO:00328681 | Colorectum | SER | response to insulin | 65/2897 | 264/18723 | 6.70e-05 | 1.53e-03 | 65 |
GO:00434341 | Colorectum | SER | response to peptide hormone | 93/2897 | 414/18723 | 9.61e-05 | 2.04e-03 | 93 |
GO:00018361 | Colorectum | SER | release of cytochrome c from mitochondria | 21/2897 | 59/18723 | 1.17e-04 | 2.44e-03 | 21 |
GO:20012351 | Colorectum | SER | positive regulation of apoptotic signaling pathway | 36/2897 | 126/18723 | 1.29e-04 | 2.63e-03 | 36 |
GO:00109501 | Colorectum | SER | positive regulation of endopeptidase activity | 47/2897 | 179/18723 | 1.32e-04 | 2.66e-03 | 47 |
GO:2001236 | Colorectum | SER | regulation of extrinsic apoptotic signaling pathway | 39/2897 | 151/18723 | 6.67e-04 | 8.94e-03 | 39 |
GO:00322311 | Colorectum | SER | regulation of actin filament bundle assembly | 29/2897 | 105/18723 | 1.01e-03 | 1.20e-02 | 29 |
GO:00300381 | Colorectum | SER | contractile actin filament bundle assembly | 29/2897 | 106/18723 | 1.19e-03 | 1.36e-02 | 29 |
GO:00431491 | Colorectum | SER | stress fiber assembly | 29/2897 | 106/18723 | 1.19e-03 | 1.36e-02 | 29 |
GO:00901991 | Colorectum | SER | regulation of release of cytochrome c from mitochondria | 16/2897 | 48/18723 | 1.65e-03 | 1.72e-02 | 16 |
GO:00432801 | Colorectum | SER | positive regulation of cysteine-type endopeptidase activity involved in apoptotic process | 33/2897 | 129/18723 | 1.97e-03 | 1.97e-02 | 33 |
GO:00514921 | Colorectum | SER | regulation of stress fiber assembly | 25/2897 | 91/18723 | 2.36e-03 | 2.25e-02 | 25 |
GO:00322331 | Colorectum | SER | positive regulation of actin filament bundle assembly | 19/2897 | 63/18723 | 2.41e-03 | 2.29e-02 | 19 |
GO:00069841 | Colorectum | SER | ER-nucleus signaling pathway | 15/2897 | 46/18723 | 2.92e-03 | 2.59e-02 | 15 |
GO:20010561 | Colorectum | SER | positive regulation of cysteine-type endopeptidase activity | 36/2897 | 148/18723 | 3.21e-03 | 2.76e-02 | 36 |
Hugo Symbol | Variant Class | Variant Classification | dbSNP RS | HGVSc | HGVSp | HGVSp Short | SWISSPROT | BIOTYPE | SIFT | PolyPhen | Tumor Sample Barcode | Tissue | Histology | Sex | Age | Stage | Therapy Types | Drugs | Outcome |
F10 | SNV | Missense_Mutation | novel | c.260N>T | p.Gly87Val | p.G87V | P00742 | protein_coding | deleterious(0) | probably_damaging(0.996) | TCGA-A2-A25A-01 | Breast | breast invasive carcinoma | Female | <65 | I/II | Unspecific | Cytoxan | SD |
F10 | SNV | Missense_Mutation | novel | c.240N>A | p.Phe80Leu | p.F80L | P00742 | protein_coding | deleterious(0) | probably_damaging(0.927) | TCGA-AN-A046-01 | Breast | breast invasive carcinoma | Female | >=65 | I/II | Unknown | Unknown | SD |
F10 | SNV | Missense_Mutation | rs121964941 | c.1120T>C | p.Ser374Pro | p.S374P | P00742 | protein_coding | deleterious(0.03) | possibly_damaging(0.511) | TCGA-AO-A128-01 | Breast | breast invasive carcinoma | Female | <65 | I/II | Chemotherapy | doxorubicin | SD |
F10 | SNV | Missense_Mutation | | c.8N>A | p.Arg3His | p.R3H | P00742 | protein_coding | tolerated_low_confidence(0.16) | benign(0) | TCGA-BH-A18G-01 | Breast | breast invasive carcinoma | Female | >=65 | I/II | Unknown | Unknown | SD |
F10 | SNV | Missense_Mutation | | c.860N>T | p.Arg287Met | p.R287M | P00742 | protein_coding | tolerated(0.11) | probably_damaging(0.95) | TCGA-BH-A18G-01 | Breast | breast invasive carcinoma | Female | >=65 | I/II | Unknown | Unknown | SD |
F10 | insertion | Frame_Shift_Ins | novel | c.950_951insCAGCCTGTTGAGGTTTGCGATTCTTGTTTCCTGGTTCGAGTCTT | p.Glu317AspfsTer16 | p.E317Dfs*16 | P00742 | protein_coding | | | TCGA-A2-A04Q-01 | Breast | breast invasive carcinoma | Female | <65 | I/II | Chemotherapy | adriamycin | SD |
F10 | insertion | In_Frame_Ins | novel | c.958_959insGGCCTC | p.Asp320delinsGlyProHis | p.D320delinsGPH | P00742 | protein_coding | | | TCGA-BH-A0E2-01 | Breast | breast invasive carcinoma | Female | <65 | III/IV | Chemotherapy | doxorubicin | SD |
F10 | insertion | Nonsense_Mutation | novel | c.959_960insTCTGCATCTTTAGGAAGAATGGTTGGTGTTCGTGT | p.Phe321LeufsTer4 | p.F321Lfs*4 | P00742 | protein_coding | | | TCGA-BH-A0E2-01 | Breast | breast invasive carcinoma | Female | <65 | III/IV | Chemotherapy | doxorubicin | SD |
F10 | insertion | Nonsense_Mutation | novel | c.987_988insTATACATTTTAAAATATAAA | p.Thr330TyrfsTer4 | p.T330Yfs*4 | P00742 | protein_coding | | | TCGA-E9-A1NC-01 | Breast | breast invasive carcinoma | Female | <65 | I/II | Chemotherapy | doxorubicin | CR |
F10 | SNV | Missense_Mutation | rs201675411 | c.1016C>T | p.Ala339Val | p.A339V | P00742 | protein_coding | tolerated(1) | benign(0.147) | TCGA-2W-A8YY-01 | Cervix | cervical & endocervical cancer | Female | <65 | I/II | Chemotherapy | cisplatin | CR |
Entrez ID | Symbol | Category | Interaction Types | Drug Claim Name | Drug Name | PMIDs |
2159 | F10 | DRUGGABLE GENOME, PROTEASE, ENZYME | | Apixaban | APIXABAN | |
2159 | F10 | DRUGGABLE GENOME, PROTEASE, ENZYME | | BIBT986 | TANOGITRAN | |
2159 | F10 | DRUGGABLE GENOME, PROTEASE, ENZYME | | Trimidox | TRIMETHOPRIM/SULFADOXINE | |
2159 | F10 | DRUGGABLE GENOME, PROTEASE, ENZYME | | Emicizumab | EMICIZUMAB | |
2159 | F10 | DRUGGABLE GENOME, PROTEASE, ENZYME | | PRT4445 | | |
2159 | F10 | DRUGGABLE GENOME, PROTEASE, ENZYME | inhibitor | 405067325 | OTAMIXABAN | |
2159 | F10 | DRUGGABLE GENOME, PROTEASE, ENZYME | | SR-123781A | | |
2159 | F10 | DRUGGABLE GENOME, PROTEASE, ENZYME | inhibitor | CHEMBL1908371 | IDRAPARINUX SODIUM | |
2159 | F10 | DRUGGABLE GENOME, PROTEASE, ENZYME | | FACTOR IX | | |
2159 | F10 | DRUGGABLE GENOME, PROTEASE, ENZYME | | ANTITHROMBIN | | |