![]() |
|||||
|
![]() | |
![]() | |
![]() | |
![]() | |
![]() | |
![]() | |
![]() |
Gene: CHMP1A |
Gene summary for CHMP1A |
![]() |
Gene information | Species | Human | Gene symbol | CHMP1A | Gene ID | 5119 |
Gene name | charged multivesicular body protein 1A | |
Gene Alias | CHMP1 | |
Cytomap | 16q24.3 | |
Gene Type | protein-coding | GO ID | GO:0000070 | UniProtAcc | Q9HD42 |
Top |
Malignant transformation analysis |
![]() |
![]() |
Entrez ID | Symbol | Replicates | Species | Organ | Tissue | Adj P-value | Log2FC | Malignancy |
5119 | CHMP1A | HTA11_2487_2000001011 | Human | Colorectum | SER | 1.88e-09 | 4.32e-01 | -0.1808 |
5119 | CHMP1A | HTA11_1938_2000001011 | Human | Colorectum | AD | 1.17e-04 | 2.92e-01 | -0.0811 |
5119 | CHMP1A | HTA11_347_2000001011 | Human | Colorectum | AD | 2.08e-04 | 1.90e-01 | -0.1954 |
5119 | CHMP1A | HTA11_411_2000001011 | Human | Colorectum | SER | 1.24e-04 | 6.71e-01 | -0.2602 |
5119 | CHMP1A | HTA11_2112_2000001011 | Human | Colorectum | SER | 6.66e-05 | 5.53e-01 | -0.2196 |
5119 | CHMP1A | HTA11_3361_2000001011 | Human | Colorectum | AD | 6.10e-08 | 4.08e-01 | -0.1207 |
5119 | CHMP1A | HTA11_696_2000001011 | Human | Colorectum | AD | 6.47e-08 | 2.72e-01 | -0.1464 |
5119 | CHMP1A | HTA11_1391_2000001011 | Human | Colorectum | AD | 1.85e-07 | 2.80e-01 | -0.059 |
5119 | CHMP1A | HTA11_2992_2000001011 | Human | Colorectum | SER | 4.15e-02 | 2.49e-01 | -0.1706 |
5119 | CHMP1A | HTA11_5212_2000001011 | Human | Colorectum | AD | 3.53e-02 | 2.33e-01 | -0.2061 |
5119 | CHMP1A | HTA11_5216_2000001011 | Human | Colorectum | SER | 4.54e-03 | 3.11e-01 | -0.1462 |
5119 | CHMP1A | HTA11_866_3004761011 | Human | Colorectum | AD | 9.96e-06 | 1.47e-01 | 0.096 |
5119 | CHMP1A | HTA11_10623_2000001011 | Human | Colorectum | AD | 6.89e-04 | 3.56e-01 | -0.0177 |
5119 | CHMP1A | HTA11_7696_3000711011 | Human | Colorectum | AD | 4.60e-07 | 2.44e-01 | 0.0674 |
5119 | CHMP1A | HTA11_99999970781_79442 | Human | Colorectum | MSS | 3.52e-03 | 1.21e-01 | 0.294 |
5119 | CHMP1A | HTA11_99999965104_69814 | Human | Colorectum | MSS | 1.89e-02 | 1.80e-01 | 0.281 |
5119 | CHMP1A | HTA11_99999971662_82457 | Human | Colorectum | MSS | 1.13e-10 | 3.63e-01 | 0.3859 |
5119 | CHMP1A | LZE2T | Human | Esophagus | ESCC | 6.62e-04 | 5.96e-01 | 0.082 |
5119 | CHMP1A | LZE4T | Human | Esophagus | ESCC | 3.78e-10 | 3.41e-01 | 0.0811 |
5119 | CHMP1A | LZE7T | Human | Esophagus | ESCC | 2.00e-04 | 3.47e-01 | 0.0667 |
Page: 1 2 3 4 5 6 7 |
![]() |
∗log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage. |
Top |
Malignant transformation related pathway analysis |
![]() |
![]() |
Tissue | Disease Stage | Enriched GO biological Processes |
Colorectum | AD | ![]() |
Colorectum | SER | ![]() |
Colorectum | MSS | ![]() |
Colorectum | MSI-H | ![]() |
Colorectum | FAP | ![]() |
∗Top 15 enriched GO BP terms are showed in the bar plot of each disease state in each tissue. Each row represents a significant GO biological process which is colored according to the -log10(p.adjust). |
Page: 1 2 3 4 5 6 7 8 9 |
![]() |
GO ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | Count |
GO:0031023 | Liver | HCC | microtubule organizing center organization | 82/7958 | 143/18723 | 2.38e-04 | 1.79e-03 | 82 |
GO:0051310 | Liver | HCC | metaphase plate congression | 42/7958 | 65/18723 | 2.63e-04 | 1.94e-03 | 42 |
GO:009030711 | Liver | HCC | mitotic spindle assembly | 42/7958 | 65/18723 | 2.63e-04 | 1.94e-03 | 42 |
GO:006164011 | Liver | HCC | cytoskeleton-dependent cytokinesis | 60/7958 | 100/18723 | 3.09e-04 | 2.20e-03 | 60 |
GO:0007098 | Liver | HCC | centrosome cycle | 75/7958 | 130/18723 | 3.33e-04 | 2.34e-03 | 75 |
GO:003970211 | Liver | HCC | viral budding via host ESCRT complex | 17/7958 | 21/18723 | 3.71e-04 | 2.56e-03 | 17 |
GO:004675511 | Liver | HCC | viral budding | 20/7958 | 26/18723 | 3.82e-04 | 2.61e-03 | 20 |
GO:0000280 | Liver | HCC | nuclear division | 220/7958 | 439/18723 | 6.90e-04 | 4.25e-03 | 220 |
GO:009016911 | Liver | HCC | regulation of spindle assembly | 19/7958 | 25/18723 | 7.01e-04 | 4.31e-03 | 19 |
GO:006195211 | Liver | HCC | midbody abscission | 14/7958 | 17/18723 | 9.39e-04 | 5.47e-03 | 14 |
GO:0050000 | Liver | HCC | chromosome localization | 49/7958 | 82/18723 | 1.20e-03 | 6.68e-03 | 49 |
GO:0051303 | Liver | HCC | establishment of chromosome localization | 47/7958 | 80/18723 | 2.45e-03 | 1.19e-02 | 47 |
GO:190167312 | Liver | HCC | regulation of mitotic spindle assembly | 14/7958 | 18/18723 | 2.57e-03 | 1.23e-02 | 14 |
GO:190489611 | Liver | HCC | ESCRT complex disassembly | 9/7958 | 10/18723 | 2.79e-03 | 1.31e-02 | 9 |
GO:190490311 | Liver | HCC | ESCRT III complex disassembly | 9/7958 | 10/18723 | 2.79e-03 | 1.31e-02 | 9 |
GO:0032886 | Liver | HCC | regulation of microtubule-based process | 123/7958 | 240/18723 | 3.69e-03 | 1.64e-02 | 123 |
GO:00466052 | Liver | HCC | regulation of centrosome cycle | 30/7958 | 49/18723 | 6.31e-03 | 2.57e-02 | 30 |
GO:001603220 | Oral cavity | OSCC | viral process | 274/7305 | 415/18723 | 2.42e-29 | 1.70e-26 | 274 |
GO:002241119 | Oral cavity | OSCC | cellular component disassembly | 283/7305 | 443/18723 | 9.57e-27 | 3.37e-24 | 283 |
GO:001905820 | Oral cavity | OSCC | viral life cycle | 208/7305 | 317/18723 | 4.59e-22 | 1.00e-19 | 208 |
Page: 1 2 3 4 5 6 7 8 9 10 11 12 13 14 15 16 17 18 19 20 21 22 23 24 25 26 27 28 |
![]() |
Pathway ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | qvalue | Count |
hsa04144 | Colorectum | AD | Endocytosis | 111/2092 | 251/8465 | 5.95e-12 | 1.42e-10 | 9.08e-11 | 111 |
hsa041441 | Colorectum | AD | Endocytosis | 111/2092 | 251/8465 | 5.95e-12 | 1.42e-10 | 9.08e-11 | 111 |
hsa041442 | Colorectum | SER | Endocytosis | 81/1580 | 251/8465 | 1.14e-07 | 2.36e-06 | 1.71e-06 | 81 |
hsa04217 | Colorectum | SER | Necroptosis | 47/1580 | 159/8465 | 5.21e-04 | 4.44e-03 | 3.22e-03 | 47 |
hsa041443 | Colorectum | SER | Endocytosis | 81/1580 | 251/8465 | 1.14e-07 | 2.36e-06 | 1.71e-06 | 81 |
hsa042171 | Colorectum | SER | Necroptosis | 47/1580 | 159/8465 | 5.21e-04 | 4.44e-03 | 3.22e-03 | 47 |
hsa041444 | Colorectum | MSS | Endocytosis | 102/1875 | 251/8465 | 1.85e-11 | 4.43e-10 | 2.71e-10 | 102 |
hsa041445 | Colorectum | MSS | Endocytosis | 102/1875 | 251/8465 | 1.85e-11 | 4.43e-10 | 2.71e-10 | 102 |
hsa04144210 | Esophagus | ESCC | Endocytosis | 186/4205 | 251/8465 | 9.74e-16 | 4.66e-14 | 2.39e-14 | 186 |
hsa0414437 | Esophagus | ESCC | Endocytosis | 186/4205 | 251/8465 | 9.74e-16 | 4.66e-14 | 2.39e-14 | 186 |
hsa0414412 | Liver | Cirrhotic | Endocytosis | 119/2530 | 251/8465 | 2.33e-09 | 4.56e-08 | 2.81e-08 | 119 |
hsa0414413 | Liver | Cirrhotic | Endocytosis | 119/2530 | 251/8465 | 2.33e-09 | 4.56e-08 | 2.81e-08 | 119 |
hsa0414422 | Liver | HCC | Endocytosis | 178/4020 | 251/8465 | 2.03e-14 | 5.22e-13 | 2.91e-13 | 178 |
hsa0414432 | Liver | HCC | Endocytosis | 178/4020 | 251/8465 | 2.03e-14 | 5.22e-13 | 2.91e-13 | 178 |
hsa0414427 | Oral cavity | OSCC | Endocytosis | 174/3704 | 251/8465 | 9.42e-17 | 4.51e-15 | 2.29e-15 | 174 |
hsa04144112 | Oral cavity | OSCC | Endocytosis | 174/3704 | 251/8465 | 9.42e-17 | 4.51e-15 | 2.29e-15 | 174 |
hsa0414428 | Oral cavity | LP | Endocytosis | 121/2418 | 251/8465 | 1.89e-11 | 3.70e-10 | 2.38e-10 | 121 |
hsa0421714 | Oral cavity | LP | Necroptosis | 59/2418 | 159/8465 | 1.15e-02 | 3.91e-02 | 2.52e-02 | 59 |
hsa0414436 | Oral cavity | LP | Endocytosis | 121/2418 | 251/8465 | 1.89e-11 | 3.70e-10 | 2.38e-10 | 121 |
hsa0421715 | Oral cavity | LP | Necroptosis | 59/2418 | 159/8465 | 1.15e-02 | 3.91e-02 | 2.52e-02 | 59 |
Page: 1 |
Top |
Cell-cell communication analysis |
![]() |
Ligand | Receptor | LRpair | Pathway | Tissue | Disease Stage |
Page: 1 |
Top |
Single-cell gene regulatory network inference analysis |
![]() |
TF | Cell Type | Tissue | Disease Stage | Target Gene | RSS | Regulon Activity |
∗The dot plots of a searched regulon are shown for all cell subpopulations in each disease state of each tissue based on the regulon specific score inferred using pySCENIC and by calculating the average expression. |
Page: 1 |
Top |
Somatic mutation of malignant transformation related genes |
![]() |
Hugo Symbol | Variant Class | Variant Classification | dbSNP RS | HGVSc | HGVSp | HGVSp Short | SWISSPROT | BIOTYPE | SIFT | PolyPhen | Tumor Sample Barcode | Tissue | Histology | Sex | Age | Stage | Therapy Types | Drugs | Outcome |
CHMP1A | SNV | Missense_Mutation | c.133N>A | p.Ala45Thr | p.A45T | Q9HD42 | protein_coding | deleterious(0) | benign(0.229) | TCGA-A6-2686-01 | Colorectum | colon adenocarcinoma | Female | >=65 | I/II | Unknown | Unknown | SD | |
CHMP1A | SNV | Missense_Mutation | c.224N>C | p.Lys75Thr | p.K75T | Q9HD42 | protein_coding | deleterious(0) | possibly_damaging(0.516) | TCGA-AD-6889-01 | Colorectum | colon adenocarcinoma | Male | >=65 | I/II | Chemotherapy | xeloda | PD | |
CHMP1A | SNV | Missense_Mutation | rs767659184 | c.197C>T | p.Ala66Val | p.A66V | Q9HD42 | protein_coding | deleterious(0) | possibly_damaging(0.581) | TCGA-CK-4951-01 | Colorectum | colon adenocarcinoma | Female | >=65 | I/II | Unknown | Unknown | PD |
CHMP1A | SNV | Missense_Mutation | c.211N>A | p.Ala71Thr | p.A71T | Q9HD42 | protein_coding | deleterious(0) | benign(0.164) | TCGA-CM-6162-01 | Colorectum | colon adenocarcinoma | Female | <65 | III/IV | Chemotherapy | oxaliplatin | SD | |
CHMP1A | SNV | Missense_Mutation | rs764268997 | c.565N>T | p.Arg189Trp | p.R189W | Q9HD42 | protein_coding | deleterious(0) | probably_damaging(0.936) | TCGA-DM-A0X9-01 | Colorectum | colon adenocarcinoma | Female | >=65 | I/II | Unknown | Unknown | SD |
CHMP1A | SNV | Missense_Mutation | novel | c.425N>T | p.Pro142Leu | p.P142L | Q9HD42 | protein_coding | deleterious(0) | probably_damaging(1) | TCGA-A5-A2K3-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | >=65 | I/II | Chemotherapy | carboplatin | SD |
CHMP1A | SNV | Missense_Mutation | rs771909969 | c.514N>A | p.Ala172Thr | p.A172T | Q9HD42 | protein_coding | tolerated(0.67) | benign(0.009) | TCGA-AP-A0LS-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | <65 | I/II | Unknown | Unknown | SD |
CHMP1A | SNV | Missense_Mutation | rs771909969 | c.514G>A | p.Ala172Thr | p.A172T | Q9HD42 | protein_coding | tolerated(0.67) | benign(0.009) | TCGA-AP-A1DV-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | <65 | I/II | Unknown | Unknown | SD |
CHMP1A | SNV | Missense_Mutation | novel | c.236N>A | p.Ala79Asp | p.A79D | Q9HD42 | protein_coding | deleterious(0) | probably_damaging(0.989) | TCGA-AX-A0J1-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | >=65 | I/II | Unknown | Unknown | SD |
CHMP1A | SNV | Missense_Mutation | novel | c.35N>T | p.Ala12Val | p.A12V | Q9HD42 | protein_coding | tolerated(0.09) | benign(0.005) | TCGA-B5-A3FC-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | <65 | I/II | Unknown | Unknown | SD |
Page: 1 2 |
Top |
Related drugs of malignant transformation related genes |
![]() |
(DGIdb 4.0) |
Entrez ID | Symbol | Category | Interaction Types | Drug Claim Name | Drug Name | PMIDs |
Page: 1 |