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Gene: CDH3 |
Gene summary for CDH3 |
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Gene information | Species | Human | Gene symbol | CDH3 | Gene ID | 1001 |
Gene name | cadherin 3 | |
Gene Alias | CDHP | |
Cytomap | 16q22.1 | |
Gene Type | protein-coding | GO ID | GO:0001816 | UniProtAcc | P22223 |
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Malignant transformation analysis |
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Entrez ID | Symbol | Replicates | Species | Organ | Tissue | Adj P-value | Log2FC | Malignancy |
1001 | CDH3 | CA_HPV_1 | Human | Cervix | CC | 1.61e-02 | -1.28e-01 | 0.0264 |
1001 | CDH3 | CCI_2 | Human | Cervix | CC | 5.84e-19 | 1.42e+00 | 0.5249 |
1001 | CDH3 | CCI_3 | Human | Cervix | CC | 1.11e-13 | 9.86e-01 | 0.516 |
1001 | CDH3 | Tumor | Human | Cervix | CC | 7.73e-34 | 6.46e-01 | 0.1241 |
1001 | CDH3 | sample3 | Human | Cervix | CC | 1.34e-38 | 6.93e-01 | 0.1387 |
1001 | CDH3 | T3 | Human | Cervix | CC | 2.09e-45 | 6.99e-01 | 0.1389 |
1001 | CDH3 | HTA11_3410_2000001011 | Human | Colorectum | AD | 4.86e-10 | 2.41e-01 | 0.0155 |
1001 | CDH3 | HTA11_2487_2000001011 | Human | Colorectum | SER | 2.87e-03 | 2.08e-01 | -0.1808 |
1001 | CDH3 | HTA11_1938_2000001011 | Human | Colorectum | AD | 1.13e-16 | 4.17e-01 | -0.0811 |
1001 | CDH3 | HTA11_78_2000001011 | Human | Colorectum | AD | 6.08e-09 | 3.48e-01 | -0.1088 |
1001 | CDH3 | HTA11_411_2000001011 | Human | Colorectum | SER | 1.64e-03 | 4.81e-01 | -0.2602 |
1001 | CDH3 | HTA11_1391_2000001011 | Human | Colorectum | AD | 1.18e-17 | 5.54e-01 | -0.059 |
1001 | CDH3 | HTA11_866_3004761011 | Human | Colorectum | AD | 5.89e-08 | 2.42e-01 | 0.096 |
1001 | CDH3 | HTA11_10711_2000001011 | Human | Colorectum | AD | 1.68e-04 | 1.40e-01 | 0.0338 |
1001 | CDH3 | HTA11_7696_3000711011 | Human | Colorectum | AD | 6.00e-23 | 5.42e-01 | 0.0674 |
1001 | CDH3 | HTA11_11156_2000001011 | Human | Colorectum | AD | 4.10e-02 | 2.47e-01 | 0.0397 |
1001 | CDH3 | HTA11_6818_2000001021 | Human | Colorectum | AD | 4.84e-09 | 3.09e-01 | 0.0588 |
1001 | CDH3 | HTA11_99999970781_79442 | Human | Colorectum | MSS | 1.03e-30 | 7.11e-01 | 0.294 |
1001 | CDH3 | HTA11_99999965104_69814 | Human | Colorectum | MSS | 2.34e-06 | 3.26e-01 | 0.281 |
1001 | CDH3 | HTA11_99999971662_82457 | Human | Colorectum | MSS | 9.88e-32 | 8.59e-01 | 0.3859 |
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∗log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage. |
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Malignant transformation related pathway analysis |
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Tissue | Disease Stage | Enriched GO biological Processes |
Colorectum | AD | ![]() |
Colorectum | SER | ![]() |
Colorectum | MSS | ![]() |
Colorectum | MSI-H | ![]() |
Colorectum | FAP | ![]() |
∗Top 15 enriched GO BP terms are showed in the bar plot of each disease state in each tissue. Each row represents a significant GO biological process which is colored according to the -log10(p.adjust). |
Page: 1 2 3 4 5 6 7 8 9 |
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GO ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | Count |
GO:005165019 | Thyroid | PTC | establishment of vesicle localization | 89/5968 | 161/18723 | 6.38e-10 | 1.97e-08 | 89 |
GO:005164817 | Thyroid | PTC | vesicle localization | 94/5968 | 177/18723 | 3.54e-09 | 9.45e-08 | 94 |
GO:0042060112 | Thyroid | PTC | wound healing | 190/5968 | 422/18723 | 7.72e-09 | 1.92e-07 | 190 |
GO:0060828110 | Thyroid | PTC | regulation of canonical Wnt signaling pathway | 123/5968 | 253/18723 | 1.83e-08 | 4.26e-07 | 123 |
GO:0060070110 | Thyroid | PTC | canonical Wnt signaling pathway | 141/5968 | 303/18723 | 5.71e-08 | 1.21e-06 | 141 |
GO:003017719 | Thyroid | PTC | positive regulation of Wnt signaling pathway | 72/5968 | 140/18723 | 1.16e-06 | 1.69e-05 | 72 |
GO:009026319 | Thyroid | PTC | positive regulation of canonical Wnt signaling pathway | 55/5968 | 106/18723 | 1.45e-05 | 1.55e-04 | 55 |
GO:007163512 | Thyroid | PTC | negative regulation of transforming growth factor beta production | 10/5968 | 12/18723 | 3.59e-04 | 2.44e-03 | 10 |
GO:007160415 | Thyroid | PTC | transforming growth factor beta production | 23/5968 | 43/18723 | 2.66e-03 | 1.35e-02 | 23 |
GO:007163415 | Thyroid | PTC | regulation of transforming growth factor beta production | 22/5968 | 41/18723 | 3.11e-03 | 1.53e-02 | 22 |
GO:0009410111 | Thyroid | PTC | response to xenobiotic stimulus | 171/5968 | 462/18723 | 1.00e-02 | 4.07e-02 | 171 |
GO:00480095 | Thyroid | PTC | insulin-like growth factor receptor signaling pathway | 19/5968 | 37/18723 | 1.07e-02 | 4.29e-02 | 19 |
GO:001605525 | Thyroid | ATC | Wnt signaling pathway | 234/6293 | 444/18723 | 4.64e-17 | 4.31e-15 | 234 |
GO:019873825 | Thyroid | ATC | cell-cell signaling by wnt | 234/6293 | 446/18723 | 9.26e-17 | 8.25e-15 | 234 |
GO:005165625 | Thyroid | ATC | establishment of organelle localization | 206/6293 | 390/18723 | 2.62e-15 | 1.84e-13 | 206 |
GO:003011125 | Thyroid | ATC | regulation of Wnt signaling pathway | 177/6293 | 328/18723 | 1.83e-14 | 1.05e-12 | 177 |
GO:004206034 | Thyroid | ATC | wound healing | 210/6293 | 422/18723 | 3.33e-12 | 1.37e-10 | 210 |
GO:006082825 | Thyroid | ATC | regulation of canonical Wnt signaling pathway | 134/6293 | 253/18723 | 1.49e-10 | 4.56e-09 | 134 |
GO:006007025 | Thyroid | ATC | canonical Wnt signaling pathway | 154/6293 | 303/18723 | 3.68e-10 | 1.02e-08 | 154 |
GO:0030177110 | Thyroid | ATC | positive regulation of Wnt signaling pathway | 80/6293 | 140/18723 | 8.75e-09 | 1.86e-07 | 80 |
Page: 1 2 3 4 5 6 7 8 9 10 11 12 13 14 15 |
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Pathway ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | qvalue | Count |
hsa045147 | Cervix | CC | Cell adhesion molecules | 36/1267 | 157/8465 | 4.94e-03 | 1.67e-02 | 9.86e-03 | 36 |
hsa0451412 | Cervix | CC | Cell adhesion molecules | 36/1267 | 157/8465 | 4.94e-03 | 1.67e-02 | 9.86e-03 | 36 |
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Cell-cell communication analysis |
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Ligand | Receptor | LRpair | Pathway | Tissue | Disease Stage |
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Single-cell gene regulatory network inference analysis |
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TF | Cell Type | Tissue | Disease Stage | Target Gene | RSS | Regulon Activity |
∗The dot plots of a searched regulon are shown for all cell subpopulations in each disease state of each tissue based on the regulon specific score inferred using pySCENIC and by calculating the average expression. |
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Somatic mutation of malignant transformation related genes |
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Hugo Symbol | Variant Class | Variant Classification | dbSNP RS | HGVSc | HGVSp | HGVSp Short | SWISSPROT | BIOTYPE | SIFT | PolyPhen | Tumor Sample Barcode | Tissue | Histology | Sex | Age | Stage | Therapy Types | Drugs | Outcome |
CDH3 | SNV | Missense_Mutation | rs144117679 | c.2395N>A | p.Ala799Thr | p.A799T | P22223 | protein_coding | tolerated(0.06) | benign(0.009) | TCGA-D8-A1XY-01 | Breast | breast invasive carcinoma | Female | >=65 | I/II | Chemotherapy | tamoxiphen | SD |
CDH3 | deletion | In_Frame_Del | novel | c.959_964delNNNNNN | p.Ala321_Asn322del | p.A321_N322del | P22223 | protein_coding | TCGA-A7-A5ZX-01 | Breast | breast invasive carcinoma | Female | <65 | III/IV | Chemotherapy | doxorubicin | CR | ||
CDH3 | insertion | Nonsense_Mutation | novel | c.1348_1349insCCCATTAGATGTGCACTCAGGAAACACGGGAGTGTTTATGTTACAG | p.Gln450ProfsTer3 | p.Q450Pfs*3 | P22223 | protein_coding | TCGA-B6-A0IK-01 | Breast | breast invasive carcinoma | Female | <65 | III/IV | Unknown | Unknown | PD | ||
CDH3 | insertion | Nonsense_Mutation | novel | c.2447_2448insTATTCATTTATTCAACACATATAGCAGTTGAATA | p.Lys817IlefsTer10 | p.K817Ifs*10 | P22223 | protein_coding | TCGA-BH-A0EE-01 | Breast | breast invasive carcinoma | Female | >=65 | I/II | Chemotherapy | docetaxel | SD | ||
CDH3 | SNV | Missense_Mutation | rs371492322 | c.2177C>T | p.Pro726Leu | p.P726L | P22223 | protein_coding | deleterious(0) | probably_damaging(0.999) | TCGA-2W-A8YY-01 | Cervix | cervical & endocervical cancer | Female | <65 | I/II | Chemotherapy | cisplatin | CR |
CDH3 | SNV | Missense_Mutation | novel | c.1601N>C | p.Leu534Pro | p.L534P | P22223 | protein_coding | deleterious(0) | probably_damaging(1) | TCGA-A6-6651-01 | Colorectum | colon adenocarcinoma | Female | <65 | III/IV | Ancillary | leucovorin | SD |
CDH3 | SNV | Missense_Mutation | c.1182N>T | p.Lys394Asn | p.K394N | P22223 | protein_coding | deleterious(0) | probably_damaging(0.952) | TCGA-AA-3663-01 | Colorectum | colon adenocarcinoma | Male | <65 | I/II | Unknown | Unknown | SD | |
CDH3 | SNV | Missense_Mutation | rs200463078 | c.437N>T | p.Thr146Met | p.T146M | P22223 | protein_coding | deleterious(0) | probably_damaging(0.999) | TCGA-AA-3679-01 | Colorectum | colon adenocarcinoma | Male | <65 | III/IV | Chemotherapy | folinic | SD |
CDH3 | SNV | Missense_Mutation | c.1093N>C | p.Thr365Pro | p.T365P | P22223 | protein_coding | deleterious(0.03) | possibly_damaging(0.511) | TCGA-AA-3930-01 | Colorectum | colon adenocarcinoma | Male | >=65 | III/IV | Chemotherapy | capecitabine | PD | |
CDH3 | SNV | Missense_Mutation | rs868118578 | c.1621N>A | p.Val541Ile | p.V541I | P22223 | protein_coding | tolerated(0.39) | benign(0.001) | TCGA-AA-A00N-01 | Colorectum | colon adenocarcinoma | Male | >=65 | I/II | Unknown | Unknown | PD |
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Related drugs of malignant transformation related genes |
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(DGIdb 4.0) |
Entrez ID | Symbol | Category | Interaction Types | Drug Claim Name | Drug Name | PMIDs |
1001 | CDH3 | DRUGGABLE GENOME | PF-3732010 | |||
1001 | CDH3 | DRUGGABLE GENOME | PF-06671008 | PF-06671008 |
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