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Gene: CDC42 |
Gene summary for CDC42 |
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Gene information | Species | Human | Gene symbol | CDC42 | Gene ID | 998 |
Gene name | cell division cycle 42 | |
Gene Alias | CDC42Hs | |
Cytomap | 1p36.12 | |
Gene Type | protein-coding | GO ID | GO:0000165 | UniProtAcc | A0A024RAE4 |
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Malignant transformation analysis |
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Entrez ID | Symbol | Replicates | Species | Organ | Tissue | Adj P-value | Log2FC | Malignancy |
998 | CDC42 | GSM4909285 | Human | Breast | IDC | 2.21e-18 | -5.83e-01 | 0.21 |
998 | CDC42 | GSM4909286 | Human | Breast | IDC | 3.63e-12 | -4.65e-01 | 0.1081 |
998 | CDC42 | GSM4909294 | Human | Breast | IDC | 1.64e-11 | 1.58e-01 | 0.2022 |
998 | CDC42 | GSM4909296 | Human | Breast | IDC | 1.08e-13 | -3.28e-01 | 0.1524 |
998 | CDC42 | GSM4909297 | Human | Breast | IDC | 1.54e-34 | 3.48e-01 | 0.1517 |
998 | CDC42 | GSM4909301 | Human | Breast | IDC | 3.06e-04 | -3.66e-01 | 0.1577 |
998 | CDC42 | GSM4909304 | Human | Breast | IDC | 6.71e-09 | 3.00e-01 | 0.1636 |
998 | CDC42 | GSM4909307 | Human | Breast | IDC | 3.64e-09 | -4.78e-01 | 0.1569 |
998 | CDC42 | GSM4909309 | Human | Breast | IDC | 7.03e-06 | -3.95e-01 | 0.0483 |
998 | CDC42 | GSM4909311 | Human | Breast | IDC | 2.49e-45 | -6.70e-01 | 0.1534 |
998 | CDC42 | GSM4909312 | Human | Breast | IDC | 1.49e-14 | -2.74e-01 | 0.1552 |
998 | CDC42 | GSM4909313 | Human | Breast | IDC | 4.68e-02 | -2.87e-02 | 0.0391 |
998 | CDC42 | GSM4909315 | Human | Breast | IDC | 3.05e-11 | 3.01e-01 | 0.21 |
998 | CDC42 | GSM4909316 | Human | Breast | IDC | 5.68e-05 | 2.94e-01 | 0.21 |
998 | CDC42 | GSM4909319 | Human | Breast | IDC | 9.52e-47 | -5.80e-01 | 0.1563 |
998 | CDC42 | GSM4909320 | Human | Breast | IDC | 2.23e-12 | -6.54e-01 | 0.1575 |
998 | CDC42 | GSM4909321 | Human | Breast | IDC | 1.91e-22 | -4.40e-01 | 0.1559 |
998 | CDC42 | ctrl6 | Human | Breast | Precancer | 5.69e-03 | 3.63e-01 | -0.0061 |
998 | CDC42 | NCCBC14 | Human | Breast | DCIS | 8.35e-30 | 4.21e-01 | 0.2021 |
998 | CDC42 | NCCBC5 | Human | Breast | DCIS | 3.21e-16 | 1.10e-01 | 0.2046 |
Page: 1 2 3 4 5 6 7 8 9 10 11 12 13 14 |
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∗log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage. |
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Malignant transformation related pathway analysis |
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Tissue | Disease Stage | Enriched GO biological Processes |
Colorectum | AD | ![]() |
Colorectum | SER | ![]() |
Colorectum | MSS | ![]() |
Colorectum | MSI-H | ![]() |
Colorectum | FAP | ![]() |
∗Top 15 enriched GO BP terms are showed in the bar plot of each disease state in each tissue. Each row represents a significant GO biological process which is colored according to the -log10(p.adjust). |
Page: 1 2 3 4 5 6 7 8 9 |
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GO ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | Count |
GO:00313339 | Cervix | CC | negative regulation of protein-containing complex assembly | 35/2311 | 141/18723 | 3.41e-05 | 5.55e-04 | 35 |
GO:00301008 | Cervix | CC | regulation of endocytosis | 47/2311 | 211/18723 | 3.65e-05 | 5.82e-04 | 47 |
GO:002176210 | Cervix | CC | substantia nigra development | 16/2311 | 44/18723 | 3.81e-05 | 5.99e-04 | 16 |
GO:003223110 | Cervix | CC | regulation of actin filament bundle assembly | 28/2311 | 105/18723 | 5.19e-05 | 7.79e-04 | 28 |
GO:00107708 | Cervix | CC | positive regulation of cell morphogenesis involved in differentiation | 23/2311 | 79/18723 | 5.44e-05 | 8.04e-04 | 23 |
GO:00458077 | Cervix | CC | positive regulation of endocytosis | 27/2311 | 100/18723 | 5.55e-05 | 8.10e-04 | 27 |
GO:011002010 | Cervix | CC | regulation of actomyosin structure organization | 27/2311 | 100/18723 | 5.55e-05 | 8.10e-04 | 27 |
GO:19000269 | Cervix | CC | positive regulation of substrate adhesion-dependent cell spreading | 15/2311 | 41/18723 | 6.11e-05 | 8.76e-04 | 15 |
GO:19027457 | Cervix | CC | positive regulation of lamellipodium organization | 14/2311 | 37/18723 | 6.97e-05 | 9.81e-04 | 14 |
GO:007099710 | Cervix | CC | neuron death | 70/2311 | 361/18723 | 7.50e-05 | 1.03e-03 | 70 |
GO:005149210 | Cervix | CC | regulation of stress fiber assembly | 25/2311 | 91/18723 | 7.59e-05 | 1.04e-03 | 25 |
GO:00900685 | Cervix | CC | positive regulation of cell cycle process | 50/2311 | 236/18723 | 8.25e-05 | 1.11e-03 | 50 |
GO:190121610 | Cervix | CC | positive regulation of neuron death | 26/2311 | 97/18723 | 8.64e-05 | 1.15e-03 | 26 |
GO:00605375 | Cervix | CC | muscle tissue development | 76/2311 | 403/18723 | 9.76e-05 | 1.27e-03 | 76 |
GO:00310329 | Cervix | CC | actomyosin structure organization | 43/2311 | 196/18723 | 1.11e-04 | 1.40e-03 | 43 |
GO:00459277 | Cervix | CC | positive regulation of growth | 53/2311 | 259/18723 | 1.33e-04 | 1.64e-03 | 53 |
GO:20002493 | Cervix | CC | regulation of actin cytoskeleton reorganization | 14/2311 | 39/18723 | 1.36e-04 | 1.66e-03 | 14 |
GO:00015588 | Cervix | CC | regulation of cell growth | 77/2311 | 414/18723 | 1.40e-04 | 1.70e-03 | 77 |
GO:003003810 | Cervix | CC | contractile actin filament bundle assembly | 27/2311 | 106/18723 | 1.63e-04 | 1.94e-03 | 27 |
GO:004314910 | Cervix | CC | stress fiber assembly | 27/2311 | 106/18723 | 1.63e-04 | 1.94e-03 | 27 |
Page: 1 2 3 4 5 6 7 8 9 10 11 12 13 14 15 16 17 18 19 20 21 22 23 24 25 26 27 28 29 30 31 32 33 34 35 36 37 38 39 40 41 42 43 44 45 46 47 48 49 50 51 52 53 54 55 56 57 58 59 60 61 62 63 64 65 66 67 68 69 70 71 72 73 74 75 76 77 78 79 80 81 82 83 84 85 86 87 88 89 90 91 92 93 94 95 96 97 98 99 100 101 102 103 104 105 106 107 108 109 110 111 112 113 114 115 116 117 118 119 120 121 122 123 124 125 126 127 128 129 130 131 132 133 134 135 136 137 138 139 140 141 142 143 144 145 146 147 148 149 150 151 152 153 154 155 156 157 158 159 160 161 162 163 164 165 166 167 168 169 170 171 172 173 174 175 176 177 |
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Pathway ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | qvalue | Count |
hsa0493216 | Breast | Precancer | Non-alcoholic fatty liver disease | 48/684 | 155/8465 | 6.16e-17 | 1.50e-15 | 1.15e-15 | 48 |
hsa0513218 | Breast | Precancer | Salmonella infection | 49/684 | 249/8465 | 2.92e-09 | 6.15e-08 | 4.71e-08 | 49 |
hsa0513018 | Breast | Precancer | Pathogenic Escherichia coli infection | 38/684 | 197/8465 | 3.12e-07 | 5.81e-06 | 4.45e-06 | 38 |
hsa0513118 | Breast | Precancer | Shigellosis | 44/684 | 247/8465 | 3.91e-07 | 6.86e-06 | 5.26e-06 | 44 |
hsa0541718 | Breast | Precancer | Lipid and atherosclerosis | 37/684 | 215/8465 | 7.64e-06 | 9.29e-05 | 7.12e-05 | 37 |
hsa0453018 | Breast | Precancer | Tight junction | 31/684 | 169/8465 | 1.13e-05 | 1.26e-04 | 9.64e-05 | 31 |
hsa0510018 | Breast | Precancer | Bacterial invasion of epithelial cells | 16/684 | 77/8465 | 3.55e-04 | 2.80e-03 | 2.15e-03 | 16 |
hsa0467018 | Breast | Precancer | Leukocyte transendothelial migration | 20/684 | 114/8465 | 7.26e-04 | 5.33e-03 | 4.09e-03 | 20 |
hsa0520514 | Breast | Precancer | Proteoglycans in cancer | 30/684 | 205/8465 | 1.00e-03 | 7.18e-03 | 5.50e-03 | 30 |
hsa0452018 | Breast | Precancer | Adherens junction | 17/684 | 93/8465 | 1.11e-03 | 7.57e-03 | 5.80e-03 | 17 |
hsa051206 | Breast | Precancer | Epithelial cell signaling in Helicobacter pylori infection | 14/684 | 70/8465 | 1.21e-03 | 7.99e-03 | 6.12e-03 | 14 |
hsa052036 | Breast | Precancer | Viral carcinogenesis | 27/684 | 204/8465 | 7.19e-03 | 4.06e-02 | 3.11e-02 | 27 |
hsa0493217 | Breast | Precancer | Non-alcoholic fatty liver disease | 48/684 | 155/8465 | 6.16e-17 | 1.50e-15 | 1.15e-15 | 48 |
hsa0513219 | Breast | Precancer | Salmonella infection | 49/684 | 249/8465 | 2.92e-09 | 6.15e-08 | 4.71e-08 | 49 |
hsa0513019 | Breast | Precancer | Pathogenic Escherichia coli infection | 38/684 | 197/8465 | 3.12e-07 | 5.81e-06 | 4.45e-06 | 38 |
hsa0513119 | Breast | Precancer | Shigellosis | 44/684 | 247/8465 | 3.91e-07 | 6.86e-06 | 5.26e-06 | 44 |
hsa0541719 | Breast | Precancer | Lipid and atherosclerosis | 37/684 | 215/8465 | 7.64e-06 | 9.29e-05 | 7.12e-05 | 37 |
hsa0453019 | Breast | Precancer | Tight junction | 31/684 | 169/8465 | 1.13e-05 | 1.26e-04 | 9.64e-05 | 31 |
hsa0510019 | Breast | Precancer | Bacterial invasion of epithelial cells | 16/684 | 77/8465 | 3.55e-04 | 2.80e-03 | 2.15e-03 | 16 |
hsa0467019 | Breast | Precancer | Leukocyte transendothelial migration | 20/684 | 114/8465 | 7.26e-04 | 5.33e-03 | 4.09e-03 | 20 |
Page: 1 2 3 4 5 6 7 8 9 10 11 12 13 14 15 16 17 18 19 20 21 22 23 24 25 26 27 28 29 30 31 32 33 34 35 36 37 38 39 40 41 42 43 44 45 46 |
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Cell-cell communication analysis |
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Ligand | Receptor | LRpair | Pathway | Tissue | Disease Stage |
Page: 1 |
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Single-cell gene regulatory network inference analysis |
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TF | Cell Type | Tissue | Disease Stage | Target Gene | RSS | Regulon Activity |
∗The dot plots of a searched regulon are shown for all cell subpopulations in each disease state of each tissue based on the regulon specific score inferred using pySCENIC and by calculating the average expression. |
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Somatic mutation of malignant transformation related genes |
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Hugo Symbol | Variant Class | Variant Classification | dbSNP RS | HGVSc | HGVSp | HGVSp Short | SWISSPROT | BIOTYPE | SIFT | PolyPhen | Tumor Sample Barcode | Tissue | Histology | Sex | Age | Stage | Therapy Types | Drugs | Outcome |
CDC42 | SNV | Missense_Mutation | novel | c.560G>T | p.Arg187Met | p.R187M | P60953 | protein_coding | deleterious_low_confidence(0.01) | benign(0.102) | TCGA-2W-A8YY-01 | Cervix | cervical & endocervical cancer | Female | <65 | I/II | Chemotherapy | cisplatin | CR |
CDC42 | SNV | Missense_Mutation | c.248N>T | p.Ser83Leu | p.S83L | P60953 | protein_coding | deleterious(0.02) | probably_damaging(0.98) | TCGA-C5-A1BQ-01 | Cervix | cervical & endocervical cancer | Female | >=65 | III/IV | Chemotherapy | cisplatin | CR | |
CDC42 | SNV | Missense_Mutation | c.498N>T | p.Lys166Asn | p.K166N | P60953 | protein_coding | deleterious(0.01) | benign(0.288) | TCGA-A6-6141-01 | Colorectum | colon adenocarcinoma | Male | <65 | I/II | Chemotherapy | 5-fu | SD | |
CDC42 | SNV | Missense_Mutation | c.511N>A | p.Glu171Lys | p.E171K | P60953 | protein_coding | deleterious(0.03) | probably_damaging(0.976) | TCGA-AA-3663-01 | Colorectum | colon adenocarcinoma | Male | <65 | I/II | Unknown | Unknown | SD | |
CDC42 | SNV | Missense_Mutation | c.498G>T | p.Lys166Asn | p.K166N | P60953 | protein_coding | deleterious(0.01) | benign(0.288) | TCGA-AZ-4315-01 | Colorectum | colon adenocarcinoma | Male | <65 | I/II | Unknown | Unknown | SD | |
CDC42 | SNV | Missense_Mutation | rs756680625 | c.557G>A | p.Arg186His | p.R186H | P60953 | protein_coding | tolerated(0.15) | benign(0) | TCGA-AG-A002-01 | Colorectum | rectum adenocarcinoma | Male | <65 | I/II | Unknown | Unknown | SD |
CDC42 | SNV | Missense_Mutation | novel | c.80A>C | p.Lys27Thr | p.K27T | P60953 | protein_coding | tolerated(0.11) | benign(0.281) | TCGA-F5-6814-01 | Colorectum | rectum adenocarcinoma | Male | <65 | I/II | Unknown | Unknown | SD |
CDC42 | SNV | Missense_Mutation | rs756680625 | c.557G>A | p.Arg186His | p.R186H | P60953 | protein_coding | tolerated(0.15) | benign(0) | TCGA-F5-6814-01 | Colorectum | rectum adenocarcinoma | Male | <65 | I/II | Unknown | Unknown | SD |
CDC42 | SNV | Missense_Mutation | c.498N>T | p.Lys166Asn | p.K166N | P60953 | protein_coding | deleterious(0.01) | benign(0.288) | TCGA-AJ-A3EL-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | <65 | I/II | Unknown | Unknown | SD | |
CDC42 | SNV | Missense_Mutation | c.450G>T | p.Lys150Asn | p.K150N | P60953 | protein_coding | tolerated(0.15) | benign(0.068) | TCGA-AP-A051-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | >=65 | I/II | Unknown | Unknown | SD |
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Related drugs of malignant transformation related genes |
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(DGIdb 4.0) |
Entrez ID | Symbol | Category | Interaction Types | Drug Claim Name | Drug Name | PMIDs |
998 | CDC42 | DRUGGABLE GENOME | SECRAMINE B | SECRAMINE B | 16408091 | |
998 | CDC42 | DRUGGABLE GENOME | SECRAMINE A | SECRAMINE A | 16408091 | |
998 | CDC42 | DRUGGABLE GENOME | ZU-0073945 | CHEMBL563777 | 19527032 | |
998 | CDC42 | DRUGGABLE GENOME | GNRH | GONADORELIN ACETATE | 9626657 | |
998 | CDC42 | DRUGGABLE GENOME | ZU-4194738 | CHEMBL554475 | 19527032 | |
998 | CDC42 | DRUGGABLE GENOME | ZU-3594419 | CHEMBL562095 | 19527032 |
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