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Gene: CD47 |
Gene summary for CD47 |
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Gene information | Species | Human | Gene symbol | CD47 | Gene ID | 961 |
Gene name | CD47 molecule | |
Gene Alias | IAP | |
Cytomap | 3q13.12 | |
Gene Type | protein-coding | GO ID | GO:0001775 | UniProtAcc | Q08722 |
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Malignant transformation analysis |
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Entrez ID | Symbol | Replicates | Species | Organ | Tissue | Adj P-value | Log2FC | Malignancy |
961 | CD47 | GSM4909286 | Human | Breast | IDC | 3.35e-09 | -3.02e-01 | 0.1081 |
961 | CD47 | GSM4909287 | Human | Breast | IDC | 2.46e-08 | -4.43e-01 | 0.2057 |
961 | CD47 | GSM4909290 | Human | Breast | IDC | 8.36e-03 | -3.14e-01 | 0.2096 |
961 | CD47 | GSM4909291 | Human | Breast | IDC | 5.05e-03 | -3.77e-01 | 0.1753 |
961 | CD47 | GSM4909293 | Human | Breast | IDC | 2.14e-08 | -4.28e-01 | 0.1581 |
961 | CD47 | GSM4909294 | Human | Breast | IDC | 2.26e-19 | -5.63e-01 | 0.2022 |
961 | CD47 | GSM4909296 | Human | Breast | IDC | 5.38e-22 | -5.48e-01 | 0.1524 |
961 | CD47 | GSM4909297 | Human | Breast | IDC | 6.74e-17 | -3.44e-01 | 0.1517 |
961 | CD47 | GSM4909298 | Human | Breast | IDC | 8.09e-03 | -1.94e-01 | 0.1551 |
961 | CD47 | GSM4909301 | Human | Breast | IDC | 2.19e-20 | -5.49e-01 | 0.1577 |
961 | CD47 | GSM4909302 | Human | Breast | IDC | 3.77e-04 | -3.60e-01 | 0.1545 |
961 | CD47 | GSM4909304 | Human | Breast | IDC | 9.52e-04 | -3.57e-01 | 0.1636 |
961 | CD47 | GSM4909306 | Human | Breast | IDC | 1.94e-07 | -3.84e-01 | 0.1564 |
961 | CD47 | GSM4909307 | Human | Breast | IDC | 3.35e-19 | -5.68e-01 | 0.1569 |
961 | CD47 | GSM4909308 | Human | Breast | IDC | 4.65e-07 | -4.30e-01 | 0.158 |
961 | CD47 | GSM4909309 | Human | Breast | IDC | 1.16e-02 | -3.31e-01 | 0.0483 |
961 | CD47 | GSM4909311 | Human | Breast | IDC | 1.82e-38 | -6.43e-01 | 0.1534 |
961 | CD47 | GSM4909312 | Human | Breast | IDC | 1.37e-16 | -4.84e-01 | 0.1552 |
961 | CD47 | GSM4909313 | Human | Breast | IDC | 9.95e-04 | -3.50e-01 | 0.0391 |
961 | CD47 | GSM4909317 | Human | Breast | IDC | 9.95e-03 | -2.55e-01 | 0.1355 |
Page: 1 2 3 4 5 6 7 8 9 10 11 |
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∗log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage. |
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Malignant transformation related pathway analysis |
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Tissue | Disease Stage | Enriched GO biological Processes |
Colorectum | AD | ![]() |
Colorectum | SER | ![]() |
Colorectum | MSS | ![]() |
Colorectum | MSI-H | ![]() |
Colorectum | FAP | ![]() |
∗Top 15 enriched GO BP terms are showed in the bar plot of each disease state in each tissue. Each row represents a significant GO biological process which is colored according to the -log10(p.adjust). |
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GO ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | Count |
GO:002240723 | Cervix | N_HPV | regulation of cell-cell adhesion | 35/534 | 448/18723 | 7.85e-08 | 7.94e-06 | 35 |
GO:190303722 | Cervix | N_HPV | regulation of leukocyte cell-cell adhesion | 29/534 | 336/18723 | 1.30e-07 | 1.18e-05 | 29 |
GO:007167522 | Cervix | N_HPV | regulation of mononuclear cell migration | 16/534 | 115/18723 | 1.70e-07 | 1.43e-05 | 16 |
GO:003210322 | Cervix | N_HPV | positive regulation of response to external stimulus | 33/534 | 427/18723 | 2.38e-07 | 1.84e-05 | 33 |
GO:005090022 | Cervix | N_HPV | leukocyte migration | 30/534 | 369/18723 | 2.90e-07 | 2.13e-05 | 30 |
GO:004578525 | Cervix | N_HPV | positive regulation of cell adhesion | 33/534 | 437/18723 | 4.04e-07 | 2.67e-05 | 33 |
GO:005086322 | Cervix | N_HPV | regulation of T cell activation | 27/534 | 329/18723 | 9.51e-07 | 5.41e-05 | 27 |
GO:000268322 | Cervix | N_HPV | negative regulation of immune system process | 32/534 | 434/18723 | 1.02e-06 | 5.61e-05 | 32 |
GO:003411321 | Cervix | N_HPV | heterotypic cell-cell adhesion | 11/534 | 61/18723 | 1.05e-06 | 5.71e-05 | 11 |
GO:190303922 | Cervix | N_HPV | positive regulation of leukocyte cell-cell adhesion | 22/534 | 239/18723 | 1.48e-06 | 7.86e-05 | 22 |
GO:005125121 | Cervix | N_HPV | positive regulation of lymphocyte activation | 28/534 | 362/18723 | 1.93e-06 | 9.68e-05 | 28 |
GO:007167722 | Cervix | N_HPV | positive regulation of mononuclear cell migration | 11/534 | 65/18723 | 2.04e-06 | 9.96e-05 | 11 |
GO:005072721 | Cervix | N_HPV | regulation of inflammatory response | 29/534 | 386/18723 | 2.27e-06 | 1.07e-04 | 29 |
GO:003434112 | Cervix | N_HPV | response to interferon-gamma | 16/534 | 141/18723 | 2.76e-06 | 1.21e-04 | 16 |
GO:005072921 | Cervix | N_HPV | positive regulation of inflammatory response | 16/534 | 142/18723 | 3.03e-06 | 1.28e-04 | 16 |
GO:007167422 | Cervix | N_HPV | mononuclear cell migration | 19/534 | 196/18723 | 3.59e-06 | 1.46e-04 | 19 |
GO:005087022 | Cervix | N_HPV | positive regulation of T cell activation | 20/534 | 216/18723 | 4.05e-06 | 1.60e-04 | 20 |
GO:002240922 | Cervix | N_HPV | positive regulation of cell-cell adhesion | 23/534 | 284/18723 | 7.53e-06 | 2.66e-04 | 23 |
GO:190290325 | Cervix | N_HPV | regulation of supramolecular fiber organization | 27/534 | 383/18723 | 1.61e-05 | 4.86e-04 | 27 |
GO:000701525 | Cervix | N_HPV | actin filament organization | 29/534 | 442/18723 | 3.00e-05 | 8.02e-04 | 29 |
Page: 1 2 3 4 5 6 7 8 9 10 11 12 13 14 15 16 17 18 19 20 21 22 23 24 25 26 27 28 29 30 31 32 33 34 35 36 37 38 39 40 41 42 |
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Pathway ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | qvalue | Count |
hsa045124 | Cervix | HSIL_HPV | ECM-receptor interaction | 12/459 | 89/8465 | 2.95e-03 | 1.88e-02 | 1.52e-02 | 12 |
hsa0451211 | Cervix | HSIL_HPV | ECM-receptor interaction | 12/459 | 89/8465 | 2.95e-03 | 1.88e-02 | 1.52e-02 | 12 |
hsa045125 | Prostate | BPH | ECM-receptor interaction | 28/1718 | 89/8465 | 8.33e-03 | 2.64e-02 | 1.64e-02 | 28 |
hsa0451212 | Prostate | BPH | ECM-receptor interaction | 28/1718 | 89/8465 | 8.33e-03 | 2.64e-02 | 1.64e-02 | 28 |
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Cell-cell communication analysis |
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Ligand | Receptor | LRpair | Pathway | Tissue | Disease Stage |
THBS1 | CD47 | THBS1_CD47 | THBS | Breast | ADJ |
THBS2 | CD47 | THBS2_CD47 | THBS | Breast | ADJ |
THBS1 | CD47 | THBS1_CD47 | THBS | Breast | DCIS |
THBS2 | CD47 | THBS2_CD47 | THBS | Breast | DCIS |
THBS3 | CD47 | THBS3_CD47 | THBS | Breast | DCIS |
THBS1 | CD47 | THBS1_CD47 | THBS | Breast | Healthy |
THBS2 | CD47 | THBS2_CD47 | THBS | Breast | Healthy |
THBS1 | CD47 | THBS1_CD47 | THBS | Breast | IDC |
THBS2 | CD47 | THBS2_CD47 | THBS | Breast | IDC |
COMP | CD47 | COMP_CD47 | THBS | Breast | IDC |
THBS1 | CD47 | THBS1_CD47 | THBS | Breast | Precancer |
THBS2 | CD47 | THBS2_CD47 | THBS | Breast | Precancer |
THBS1 | CD47 | THBS1_CD47 | THBS | Cervix | ADJ |
THBS2 | CD47 | THBS2_CD47 | THBS | Cervix | ADJ |
THBS1 | CD47 | THBS1_CD47 | THBS | Cervix | CC |
THBS2 | CD47 | THBS2_CD47 | THBS | Cervix | CC |
THBS1 | CD47 | THBS1_CD47 | THBS | Cervix | Healthy |
THBS2 | CD47 | THBS2_CD47 | THBS | Cervix | Healthy |
THBS1 | CD47 | THBS1_CD47 | THBS | Cervix | Precancer |
THBS2 | CD47 | THBS2_CD47 | THBS | Cervix | Precancer |
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Single-cell gene regulatory network inference analysis |
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TF | Cell Type | Tissue | Disease Stage | Target Gene | RSS | Regulon Activity |
∗The dot plots of a searched regulon are shown for all cell subpopulations in each disease state of each tissue based on the regulon specific score inferred using pySCENIC and by calculating the average expression. |
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Somatic mutation of malignant transformation related genes |
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Hugo Symbol | Variant Class | Variant Classification | dbSNP RS | HGVSc | HGVSp | HGVSp Short | SWISSPROT | BIOTYPE | SIFT | PolyPhen | Tumor Sample Barcode | Tissue | Histology | Sex | Age | Stage | Therapy Types | Drugs | Outcome |
CD47 | SNV | Missense_Mutation | c.352N>C | p.Glu118Gln | p.E118Q | Q08722 | protein_coding | deleterious(0.03) | probably_damaging(0.998) | TCGA-AC-A23H-01 | Breast | breast invasive carcinoma | Female | >=65 | I/II | Unknown | Unknown | PD | |
CD47 | SNV | Missense_Mutation | c.640N>C | p.Val214Leu | p.V214L | Q08722 | protein_coding | deleterious(0) | possibly_damaging(0.813) | TCGA-D8-A13Z-01 | Breast | breast invasive carcinoma | Female | <65 | I/II | Chemotherapy | doxorubicine | SD | |
CD47 | SNV | Missense_Mutation | novel | c.922N>A | p.Glu308Lys | p.E308K | Q08722 | protein_coding | deleterious(0.03) | probably_damaging(0.991) | TCGA-C5-A1MH-01 | Cervix | cervical & endocervical cancer | Female | >=65 | III/IV | Chemotherapy | cisplatin | PD |
CD47 | SNV | Missense_Mutation | novel | c.459N>G | p.Ile153Met | p.I153M | Q08722 | protein_coding | deleterious(0) | possibly_damaging(0.77) | TCGA-AA-3947-01 | Colorectum | colon adenocarcinoma | Female | <65 | I/II | Unknown | Unknown | SD |
CD47 | SNV | Missense_Mutation | c.643A>T | p.Thr215Ser | p.T215S | Q08722 | protein_coding | deleterious(0) | benign(0.296) | TCGA-AA-A010-01 | Colorectum | colon adenocarcinoma | Female | <65 | I/II | Chemotherapy | folinic | CR | |
CD47 | SNV | Missense_Mutation | c.942N>C | p.Lys314Asn | p.K314N | Q08722 | protein_coding | deleterious_low_confidence(0) | probably_damaging(0.996) | TCGA-AA-A022-01 | Colorectum | colon adenocarcinoma | Female | >=65 | I/II | Unknown | Unknown | SD | |
CD47 | SNV | Missense_Mutation | novel | c.71N>C | p.Lys24Thr | p.K24T | Q08722 | protein_coding | tolerated(0.59) | benign(0.021) | TCGA-CA-6717-01 | Colorectum | colon adenocarcinoma | Male | <65 | I/II | Chemotherapy | oxaliplatin | CR |
CD47 | SNV | Missense_Mutation | c.478T>C | p.Phe160Leu | p.F160L | Q08722 | protein_coding | tolerated(0.64) | benign(0.272) | TCGA-CL-4957-01 | Colorectum | rectum adenocarcinoma | Female | >=65 | III/IV | Chemotherapy | oxaliplatin | SD | |
CD47 | SNV | Missense_Mutation | novel | c.692N>T | p.Ala231Val | p.A231V | Q08722 | protein_coding | tolerated(0.71) | benign(0.185) | TCGA-A5-A0G2-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | <65 | III/IV | Unknown | Unknown | SD |
CD47 | SNV | Missense_Mutation | rs754405285 | c.785N>T | p.Ala262Val | p.A262V | Q08722 | protein_coding | tolerated(0.07) | benign(0.012) | TCGA-AP-A059-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | >=65 | I/II | Unknown | Unknown | SD |
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Related drugs of malignant transformation related genes |
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(DGIdb 4.0) |
Entrez ID | Symbol | Category | Interaction Types | Drug Claim Name | Drug Name | PMIDs |
961 | CD47 | DRUGGABLE GENOME, EXTERNAL SIDE OF PLASMA MEMBRANE, CELL SURFACE | ABT-510 | ABT-510 | ||
961 | CD47 | DRUGGABLE GENOME, EXTERNAL SIDE OF PLASMA MEMBRANE, CELL SURFACE | ALX148 | ALX-148 | ||
961 | CD47 | DRUGGABLE GENOME, EXTERNAL SIDE OF PLASMA MEMBRANE, CELL SURFACE | TTI-621 | |||
961 | CD47 | DRUGGABLE GENOME, EXTERNAL SIDE OF PLASMA MEMBRANE, CELL SURFACE | CC-90002 | |||
961 | CD47 | DRUGGABLE GENOME, EXTERNAL SIDE OF PLASMA MEMBRANE, CELL SURFACE | Hu5F9-G4 | MAGROLIMAB |
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