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Gene: ACTR3 |
Gene summary for ACTR3 |
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Gene information | Species | Human | Gene symbol | ACTR3 | Gene ID | 10096 |
Gene name | actin related protein 3 | |
Gene Alias | ARP3 | |
Cytomap | 2q14.1 | |
Gene Type | protein-coding | GO ID | GO:0000003 | UniProtAcc | B4DXW1 |
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Malignant transformation analysis |
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Entrez ID | Symbol | Replicates | Species | Organ | Tissue | Adj P-value | Log2FC | Malignancy |
10096 | ACTR3 | HTA11_3410_2000001011 | Human | Colorectum | AD | 2.88e-10 | -4.69e-01 | 0.0155 |
10096 | ACTR3 | HTA11_696_2000001011 | Human | Colorectum | AD | 2.35e-03 | -2.43e-01 | -0.1464 |
10096 | ACTR3 | HTA11_866_3004761011 | Human | Colorectum | AD | 1.15e-04 | -3.96e-01 | 0.096 |
10096 | ACTR3 | HTA11_10711_2000001011 | Human | Colorectum | AD | 7.16e-04 | -4.44e-01 | 0.0338 |
10096 | ACTR3 | HTA11_7696_3000711011 | Human | Colorectum | AD | 1.25e-07 | -3.91e-01 | 0.0674 |
10096 | ACTR3 | HTA11_99999974143_84620 | Human | Colorectum | MSS | 1.93e-03 | -3.18e-01 | 0.3005 |
10096 | ACTR3 | A015-C-203 | Human | Colorectum | FAP | 1.16e-19 | -3.89e-01 | -0.1294 |
10096 | ACTR3 | A015-C-204 | Human | Colorectum | FAP | 7.67e-04 | -2.72e-01 | -0.0228 |
10096 | ACTR3 | A014-C-040 | Human | Colorectum | FAP | 3.13e-02 | -3.85e-01 | -0.1184 |
10096 | ACTR3 | A002-C-201 | Human | Colorectum | FAP | 9.53e-09 | -2.83e-01 | 0.0324 |
10096 | ACTR3 | A002-C-203 | Human | Colorectum | FAP | 3.70e-02 | -9.83e-02 | 0.2786 |
10096 | ACTR3 | A001-C-119 | Human | Colorectum | FAP | 2.90e-11 | -5.42e-01 | -0.1557 |
10096 | ACTR3 | A001-C-108 | Human | Colorectum | FAP | 2.01e-09 | -2.57e-01 | -0.0272 |
10096 | ACTR3 | A002-C-205 | Human | Colorectum | FAP | 2.32e-19 | -5.11e-01 | -0.1236 |
10096 | ACTR3 | A001-C-104 | Human | Colorectum | FAP | 2.64e-03 | -2.25e-01 | 0.0184 |
10096 | ACTR3 | A015-C-006 | Human | Colorectum | FAP | 2.21e-11 | -4.56e-01 | -0.0994 |
10096 | ACTR3 | A015-C-106 | Human | Colorectum | FAP | 6.74e-10 | -3.03e-01 | -0.0511 |
10096 | ACTR3 | A002-C-114 | Human | Colorectum | FAP | 5.36e-12 | -3.29e-01 | -0.1561 |
10096 | ACTR3 | A015-C-104 | Human | Colorectum | FAP | 2.52e-23 | -5.07e-01 | -0.1899 |
10096 | ACTR3 | A001-C-014 | Human | Colorectum | FAP | 1.44e-10 | -2.97e-01 | 0.0135 |
Page: 1 2 3 4 5 6 7 8 9 10 |
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∗log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage. |
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Malignant transformation related pathway analysis |
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Tissue | Disease Stage | Enriched GO biological Processes |
Colorectum | AD | ![]() |
Colorectum | SER | ![]() |
Colorectum | MSS | ![]() |
Colorectum | MSI-H | ![]() |
Colorectum | FAP | ![]() |
∗Top 15 enriched GO BP terms are showed in the bar plot of each disease state in each tissue. Each row represents a significant GO biological process which is colored according to the -log10(p.adjust). |
Page: 1 2 3 4 5 6 7 8 9 |
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GO ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | Count |
GO:190274321 | Liver | HCC | regulation of lamellipodium organization | 36/7958 | 54/18723 | 2.88e-04 | 2.07e-03 | 36 |
GO:006164011 | Liver | HCC | cytoskeleton-dependent cytokinesis | 60/7958 | 100/18723 | 3.09e-04 | 2.20e-03 | 60 |
GO:0000280 | Liver | HCC | nuclear division | 220/7958 | 439/18723 | 6.90e-04 | 4.25e-03 | 220 |
GO:001059221 | Liver | HCC | positive regulation of lamellipodium assembly | 21/7958 | 29/18723 | 1.07e-03 | 6.16e-03 | 21 |
GO:003003221 | Liver | HCC | lamellipodium assembly | 44/7958 | 72/18723 | 1.10e-03 | 6.32e-03 | 44 |
GO:0050000 | Liver | HCC | chromosome localization | 49/7958 | 82/18723 | 1.20e-03 | 6.68e-03 | 49 |
GO:006049112 | Liver | HCC | regulation of cell projection assembly | 101/7958 | 188/18723 | 1.20e-03 | 6.69e-03 | 101 |
GO:012003212 | Liver | HCC | regulation of plasma membrane bounded cell projection assembly | 100/7958 | 186/18723 | 1.23e-03 | 6.81e-03 | 100 |
GO:0051303 | Liver | HCC | establishment of chromosome localization | 47/7958 | 80/18723 | 2.45e-03 | 1.19e-02 | 47 |
GO:01200344 | Liver | HCC | positive regulation of plasma membrane bounded cell projection assembly | 58/7958 | 105/18723 | 5.66e-03 | 2.36e-02 | 58 |
GO:001059111 | Liver | HCC | regulation of lamellipodium assembly | 26/7958 | 42/18723 | 8.76e-03 | 3.41e-02 | 26 |
GO:005165610 | Oral cavity | OSCC | establishment of organelle localization | 239/7305 | 390/18723 | 2.46e-19 | 3.31e-17 | 239 |
GO:004325420 | Oral cavity | OSCC | regulation of protein-containing complex assembly | 255/7305 | 428/18723 | 2.94e-18 | 3.15e-16 | 255 |
GO:003133420 | Oral cavity | OSCC | positive regulation of protein-containing complex assembly | 153/7305 | 237/18723 | 1.18e-15 | 8.33e-14 | 153 |
GO:00070592 | Oral cavity | OSCC | chromosome segregation | 206/7305 | 346/18723 | 5.82e-15 | 3.76e-13 | 206 |
GO:190290520 | Oral cavity | OSCC | positive regulation of supramolecular fiber organization | 131/7305 | 209/18723 | 3.18e-12 | 1.27e-10 | 131 |
GO:00482852 | Oral cavity | OSCC | organelle fission | 265/7305 | 488/18723 | 3.22e-12 | 1.27e-10 | 265 |
GO:190290320 | Oral cavity | OSCC | regulation of supramolecular fiber organization | 211/7305 | 383/18723 | 9.45e-11 | 2.88e-09 | 211 |
GO:00002801 | Oral cavity | OSCC | nuclear division | 237/7305 | 439/18723 | 9.62e-11 | 2.90e-09 | 237 |
GO:00988132 | Oral cavity | OSCC | nuclear chromosome segregation | 162/7305 | 281/18723 | 1.56e-10 | 4.56e-09 | 162 |
Page: 1 2 3 4 5 6 7 8 9 10 11 12 13 14 15 16 17 18 19 20 21 22 23 24 25 26 27 28 29 30 |
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Pathway ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | qvalue | Count |
hsa04144 | Colorectum | AD | Endocytosis | 111/2092 | 251/8465 | 5.95e-12 | 1.42e-10 | 9.08e-11 | 111 |
hsa05131 | Colorectum | AD | Shigellosis | 109/2092 | 247/8465 | 1.09e-11 | 2.44e-10 | 1.55e-10 | 109 |
hsa05100 | Colorectum | AD | Bacterial invasion of epithelial cells | 44/2092 | 77/8465 | 1.13e-09 | 2.22e-08 | 1.42e-08 | 44 |
hsa04530 | Colorectum | AD | Tight junction | 76/2092 | 169/8465 | 5.49e-09 | 9.69e-08 | 6.18e-08 | 76 |
hsa05132 | Colorectum | AD | Salmonella infection | 102/2092 | 249/8465 | 7.65e-09 | 1.28e-07 | 8.17e-08 | 102 |
hsa05130 | Colorectum | AD | Pathogenic Escherichia coli infection | 79/2092 | 197/8465 | 1.05e-06 | 1.36e-05 | 8.65e-06 | 79 |
hsa05135 | Colorectum | AD | Yersinia infection | 58/2092 | 137/8465 | 3.90e-06 | 4.35e-05 | 2.78e-05 | 58 |
hsa04810 | Colorectum | AD | Regulation of actin cytoskeleton | 75/2092 | 229/8465 | 3.36e-03 | 1.76e-02 | 1.12e-02 | 75 |
hsa041441 | Colorectum | AD | Endocytosis | 111/2092 | 251/8465 | 5.95e-12 | 1.42e-10 | 9.08e-11 | 111 |
hsa051311 | Colorectum | AD | Shigellosis | 109/2092 | 247/8465 | 1.09e-11 | 2.44e-10 | 1.55e-10 | 109 |
hsa051001 | Colorectum | AD | Bacterial invasion of epithelial cells | 44/2092 | 77/8465 | 1.13e-09 | 2.22e-08 | 1.42e-08 | 44 |
hsa045301 | Colorectum | AD | Tight junction | 76/2092 | 169/8465 | 5.49e-09 | 9.69e-08 | 6.18e-08 | 76 |
hsa051321 | Colorectum | AD | Salmonella infection | 102/2092 | 249/8465 | 7.65e-09 | 1.28e-07 | 8.17e-08 | 102 |
hsa051301 | Colorectum | AD | Pathogenic Escherichia coli infection | 79/2092 | 197/8465 | 1.05e-06 | 1.36e-05 | 8.65e-06 | 79 |
hsa051351 | Colorectum | AD | Yersinia infection | 58/2092 | 137/8465 | 3.90e-06 | 4.35e-05 | 2.78e-05 | 58 |
hsa048101 | Colorectum | AD | Regulation of actin cytoskeleton | 75/2092 | 229/8465 | 3.36e-03 | 1.76e-02 | 1.12e-02 | 75 |
hsa041444 | Colorectum | MSS | Endocytosis | 102/1875 | 251/8465 | 1.85e-11 | 4.43e-10 | 2.71e-10 | 102 |
hsa051314 | Colorectum | MSS | Shigellosis | 94/1875 | 247/8465 | 6.82e-09 | 1.34e-07 | 8.23e-08 | 94 |
hsa051324 | Colorectum | MSS | Salmonella infection | 92/1875 | 249/8465 | 5.23e-08 | 9.74e-07 | 5.97e-07 | 92 |
hsa046664 | Colorectum | MSS | Fc gamma R-mediated phagocytosis | 45/1875 | 97/8465 | 9.30e-08 | 1.56e-06 | 9.55e-07 | 45 |
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Cell-cell communication analysis |
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Ligand | Receptor | LRpair | Pathway | Tissue | Disease Stage |
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Single-cell gene regulatory network inference analysis |
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TF | Cell Type | Tissue | Disease Stage | Target Gene | RSS | Regulon Activity |
∗The dot plots of a searched regulon are shown for all cell subpopulations in each disease state of each tissue based on the regulon specific score inferred using pySCENIC and by calculating the average expression. |
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Somatic mutation of malignant transformation related genes |
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Hugo Symbol | Variant Class | Variant Classification | dbSNP RS | HGVSc | HGVSp | HGVSp Short | SWISSPROT | BIOTYPE | SIFT | PolyPhen | Tumor Sample Barcode | Tissue | Histology | Sex | Age | Stage | Therapy Types | Drugs | Outcome |
ACTR3 | SNV | Missense_Mutation | c.439N>G | p.Leu147Val | p.L147V | P61158 | protein_coding | deleterious(0) | possibly_damaging(0.829) | TCGA-AC-A23H-01 | Breast | breast invasive carcinoma | Female | >=65 | I/II | Unknown | Unknown | PD | |
ACTR3 | insertion | Nonsense_Mutation | novel | c.777_778insCAATAA | p.Ile259_Asn260insGlnTer | p.I259_N260insQ* | P61158 | protein_coding | TCGA-AC-A3QQ-01 | Breast | breast invasive carcinoma | Female | <65 | I/II | Unknown | Unknown | SD | ||
ACTR3 | deletion | Frame_Shift_Del | novel | c.1110delN | p.His371ThrfsTer64 | p.H371Tfs*64 | P61158 | protein_coding | TCGA-EW-A2FV-01 | Breast | breast invasive carcinoma | Female | <65 | III/IV | Chemotherapy | docetaxel | SD | ||
ACTR3 | SNV | Missense_Mutation | novel | c.1001G>A | p.Arg334His | p.R334H | P61158 | protein_coding | deleterious(0.02) | benign(0.357) | TCGA-2W-A8YY-01 | Cervix | cervical & endocervical cancer | Female | <65 | I/II | Chemotherapy | cisplatin | CR |
ACTR3 | SNV | Missense_Mutation | rs760969306 | c.808G>A | p.Asp270Asn | p.D270N | P61158 | protein_coding | deleterious(0.01) | possibly_damaging(0.69) | TCGA-AA-3984-01 | Colorectum | colon adenocarcinoma | Female | <65 | I/II | Unknown | Unknown | SD |
ACTR3 | SNV | Missense_Mutation | c.841N>C | p.Ile281Leu | p.I281L | P61158 | protein_coding | tolerated(0.17) | probably_damaging(0.999) | TCGA-AA-A010-01 | Colorectum | colon adenocarcinoma | Female | <65 | I/II | Chemotherapy | folinic | CR | |
ACTR3 | SNV | Missense_Mutation | novel | c.657N>C | p.Gln219His | p.Q219H | P61158 | protein_coding | deleterious(0.04) | probably_damaging(0.968) | TCGA-CA-6717-01 | Colorectum | colon adenocarcinoma | Male | <65 | I/II | Chemotherapy | oxaliplatin | CR |
ACTR3 | SNV | Missense_Mutation | c.923C>A | p.Pro308His | p.P308H | P61158 | protein_coding | deleterious(0) | probably_damaging(1) | TCGA-CK-5916-01 | Colorectum | colon adenocarcinoma | Female | >=65 | I/II | Unknown | Unknown | PD | |
ACTR3 | SNV | Missense_Mutation | novel | c.1191N>C | p.Lys397Asn | p.K397N | P61158 | protein_coding | deleterious(0) | probably_damaging(1) | TCGA-AG-A002-01 | Colorectum | rectum adenocarcinoma | Male | <65 | I/II | Unknown | Unknown | SD |
ACTR3 | SNV | Missense_Mutation | rs200071930 | c.688C>T | p.Arg230Cys | p.R230C | P61158 | protein_coding | deleterious(0) | probably_damaging(0.92) | TCGA-EI-6507-01 | Colorectum | rectum adenocarcinoma | Male | <65 | I/II | Unknown | Unknown | SD |
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Related drugs of malignant transformation related genes |
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(DGIdb 4.0) |
Entrez ID | Symbol | Category | Interaction Types | Drug Claim Name | Drug Name | PMIDs |
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