GO ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | Count |
GO:003027811 | Prostate | Tumor | regulation of ossification | 32/3246 | 115/18723 | 3.39e-03 | 1.75e-02 | 32 |
GO:190210712 | Prostate | Tumor | positive regulation of leukocyte differentiation | 41/3246 | 157/18723 | 3.63e-03 | 1.86e-02 | 41 |
GO:190370812 | Prostate | Tumor | positive regulation of hemopoiesis | 41/3246 | 157/18723 | 3.63e-03 | 1.86e-02 | 41 |
GO:000941111 | Prostate | Tumor | response to UV | 39/3246 | 149/18723 | 4.29e-03 | 2.14e-02 | 39 |
GO:00456381 | Prostate | Tumor | negative regulation of myeloid cell differentiation | 26/3246 | 90/18723 | 4.54e-03 | 2.24e-02 | 26 |
GO:003021711 | Prostate | Tumor | T cell differentiation | 61/3246 | 257/18723 | 5.30e-03 | 2.54e-02 | 61 |
GO:0042789 | Prostate | Tumor | mRNA transcription by RNA polymerase II | 6/3246 | 11/18723 | 5.63e-03 | 2.63e-02 | 6 |
GO:000182312 | Prostate | Tumor | mesonephros development | 27/3246 | 96/18723 | 5.77e-03 | 2.68e-02 | 27 |
GO:190303914 | Prostate | Tumor | positive regulation of leukocyte cell-cell adhesion | 57/3246 | 239/18723 | 6.17e-03 | 2.86e-02 | 57 |
GO:006034811 | Prostate | Tumor | bone development | 50/3246 | 205/18723 | 6.30e-03 | 2.89e-02 | 50 |
GO:00023201 | Prostate | Tumor | lymphoid progenitor cell differentiation | 9/3246 | 22/18723 | 7.96e-03 | 3.52e-02 | 9 |
GO:004558011 | Prostate | Tumor | regulation of T cell differentiation | 37/3246 | 146/18723 | 9.18e-03 | 3.95e-02 | 37 |
GO:000245614 | Prostate | Tumor | T cell mediated immunity | 29/3246 | 109/18723 | 9.93e-03 | 4.20e-02 | 29 |
GO:0034504111 | Thyroid | PTC | protein localization to nucleus | 170/5968 | 290/18723 | 3.34e-21 | 6.38e-19 | 170 |
GO:000182215 | Thyroid | PTC | kidney development | 133/5968 | 293/18723 | 7.57e-07 | 1.18e-05 | 133 |
GO:0001503110 | Thyroid | PTC | ossification | 176/5968 | 408/18723 | 9.26e-07 | 1.40e-05 | 176 |
GO:000165517 | Thyroid | PTC | urogenital system development | 149/5968 | 338/18723 | 1.41e-06 | 2.01e-05 | 149 |
GO:007200114 | Thyroid | PTC | renal system development | 135/5968 | 302/18723 | 1.76e-06 | 2.43e-05 | 135 |
GO:0030099113 | Thyroid | PTC | myeloid cell differentiation | 160/5968 | 381/18723 | 1.75e-05 | 1.82e-04 | 160 |
GO:004544418 | Thyroid | PTC | fat cell differentiation | 102/5968 | 229/18723 | 3.66e-05 | 3.40e-04 | 102 |
TF | Cell Type | Tissue | Disease Stage | Target Gene | RSS | Regulon Activity |
ZBTB1 | MSC | Breast | ADJ | HK2,REL,RBBP6, etc. | 6.65e-03 | ![The dot plots of a searched regulon are shown for all cell subpopulations in each disease state of each tissue based on the regulon specific score inferred using pySCENIC and by calculating the average expression.](images/gene_regulatory/Breast/Str/TF_ADJ/regulons_activity_in_dotplot.png) |
ZBTB1 | CAF | Breast | DCIS | HK2,REL,RBBP6, etc. | 5.85e-02 | ![The dot plots of a searched regulon are shown for all cell subpopulations in each disease state of each tissue based on the regulon specific score inferred using pySCENIC and by calculating the average expression.](images/gene_regulatory/Breast/Str/TF_DCIS/regulons_activity_in_dotplot.png) |
ZBTB1 | MSC | Breast | Healthy | HK2,REL,RBBP6, etc. | 7.45e-02 | ![The dot plots of a searched regulon are shown for all cell subpopulations in each disease state of each tissue based on the regulon specific score inferred using pySCENIC and by calculating the average expression.](images/gene_regulatory/Breast/Str/TF_Healthy/regulons_activity_in_dotplot.png) |
ZBTB1 | MSC | Breast | Precancer | HK2,REL,RBBP6, etc. | 2.37e-01 | ![The dot plots of a searched regulon are shown for all cell subpopulations in each disease state of each tissue based on the regulon specific score inferred using pySCENIC and by calculating the average expression.](images/gene_regulatory/Breast/Str/TF_Precancer/regulons_activity_in_dotplot.png) |
ZBTB1 | TREG | Cervix | ADJ | CCL4L2,AKAP5,ZC3H18, etc. | 1.49e-02 | ![The dot plots of a searched regulon are shown for all cell subpopulations in each disease state of each tissue based on the regulon specific score inferred using pySCENIC and by calculating the average expression.](images/gene_regulatory/Cervix/Str/TF_ADJ/regulons_activity_in_dotplot.png) |
ZBTB1 | ICAF | Colorectum | SER | COL4A5,CTSK,C16orf87, etc. | 3.86e-01 | ![The dot plots of a searched regulon are shown for all cell subpopulations in each disease state of each tissue based on the regulon specific score inferred using pySCENIC and by calculating the average expression.](images/gene_regulatory/Colorectum/Str/TF_SER/regulons_activity_in_dotplot.png) |
ZBTB1 | INCAF | Endometrium | ADJ | FAM156B,ZNF101,GDF7, etc. | 6.05e-01 | ![The dot plots of a searched regulon are shown for all cell subpopulations in each disease state of each tissue based on the regulon specific score inferred using pySCENIC and by calculating the average expression.](images/gene_regulatory/Endometrium/Str/TF_ADJ/regulons_activity_in_dotplot.png) |
ZBTB1 | FIB | Endometrium | ADJ | FAM156B,ZNF101,GDF7, etc. | 1.39e-02 | ![The dot plots of a searched regulon are shown for all cell subpopulations in each disease state of each tissue based on the regulon specific score inferred using pySCENIC and by calculating the average expression.](images/gene_regulatory/Endometrium/Str/TF_ADJ/regulons_activity_in_dotplot.png) |
ZBTB1 | INCAF | Endometrium | AEH | FAM156B,ZNF101,GDF7, etc. | 6.02e-01 | ![The dot plots of a searched regulon are shown for all cell subpopulations in each disease state of each tissue based on the regulon specific score inferred using pySCENIC and by calculating the average expression.](images/gene_regulatory/Endometrium/Str/TF_AEH/regulons_activity_in_dotplot.png) |
ZBTB1 | ICAF | Endometrium | AEH | FAM156B,ZNF101,GDF7, etc. | 7.24e-03 | ![The dot plots of a searched regulon are shown for all cell subpopulations in each disease state of each tissue based on the regulon specific score inferred using pySCENIC and by calculating the average expression.](images/gene_regulatory/Endometrium/Str/TF_AEH/regulons_activity_in_dotplot.png) |
Hugo Symbol | Variant Class | Variant Classification | dbSNP RS | HGVSc | HGVSp | HGVSp Short | SWISSPROT | BIOTYPE | SIFT | PolyPhen | Tumor Sample Barcode | Tissue | Histology | Sex | Age | Stage | Therapy Types | Drugs | Outcome |
ZBTB1 | SNV | Missense_Mutation | | c.1458G>C | p.Glu486Asp | p.E486D | Q9Y2K1 | protein_coding | tolerated(0.6) | benign(0.16) | TCGA-5L-AAT1-01 | Breast | breast invasive carcinoma | Female | <65 | III/IV | Hormone Therapy | letrozol | SD |
ZBTB1 | SNV | Missense_Mutation | | c.204N>A | p.Met68Ile | p.M68I | Q9Y2K1 | protein_coding | tolerated(0.08) | benign(0.031) | TCGA-AC-A23H-01 | Breast | breast invasive carcinoma | Female | >=65 | I/II | Unknown | Unknown | PD |
ZBTB1 | SNV | Missense_Mutation | rs148266968 | c.961N>A | p.Glu321Lys | p.E321K | Q9Y2K1 | protein_coding | tolerated(0.5) | benign(0.092) | TCGA-AC-A23H-01 | Breast | breast invasive carcinoma | Female | >=65 | I/II | Unknown | Unknown | PD |
ZBTB1 | SNV | Missense_Mutation | novel | c.1898G>A | p.Arg633Lys | p.R633K | Q9Y2K1 | protein_coding | tolerated(0.11) | probably_damaging(0.935) | TCGA-BH-A0C0-01 | Breast | breast invasive carcinoma | Female | <65 | I/II | Chemotherapy | carboplatin | SD |
ZBTB1 | insertion | Nonsense_Mutation | novel | c.1901_1902insATGAGA | p.Tyr634delinsTer | p.Y634delins* | Q9Y2K1 | protein_coding | | | TCGA-A8-A096-01 | Breast | breast invasive carcinoma | Female | >=65 | I/II | Unknown | Unknown | SD |
ZBTB1 | deletion | Frame_Shift_Del | rs747075448 | c.1140delN | p.Ser383ValfsTer6 | p.S383Vfs*6 | Q9Y2K1 | protein_coding | | | TCGA-AN-A0AK-01 | Breast | breast invasive carcinoma | Female | >=65 | I/II | Unknown | Unknown | SD |
ZBTB1 | insertion | Frame_Shift_Ins | novel | c.687_688insCTGGAGGGAGC | p.Leu231GlufsTer5 | p.L231Efs*5 | Q9Y2K1 | protein_coding | | | TCGA-AR-A0TU-01 | Breast | breast invasive carcinoma | Female | <65 | I/II | Unspecific | Doxorubicin | SD |
ZBTB1 | deletion | Frame_Shift_Del | novel | c.1885delN | p.Gly630AlafsTer24 | p.G630Afs*24 | Q9Y2K1 | protein_coding | | | TCGA-D8-A27V-01 | Breast | breast invasive carcinoma | Female | <65 | I/II | Hormone Therapy | tamoxiphen | SD |
ZBTB1 | SNV | Missense_Mutation | rs143630259 | c.1406N>A | p.Arg469Gln | p.R469Q | Q9Y2K1 | protein_coding | deleterious(0.03) | benign(0.232) | TCGA-EK-A2RC-01 | Cervix | cervical & endocervical cancer | Female | <65 | I/II | Unknown | Unknown | SD |
ZBTB1 | SNV | Missense_Mutation | | c.1476G>C | p.Glu492Asp | p.E492D | Q9Y2K1 | protein_coding | tolerated(0.42) | benign(0.428) | TCGA-IR-A3LK-01 | Cervix | cervical & endocervical cancer | Female | >=65 | I/II | Chemotherapy | cisplatin | PD |