Tissue | Expression Dynamics | Abbreviation |
Colorectum (GSE201348) | ![The image shows the transcriptomic changes along malignancy continuum.log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage.](images/deg_images/Colorectum/Becker/VIL1_pca_on_diff_genes.png) | FAP: Familial adenomatous polyposis |
CRC: Colorectal cancer |
Colorectum (HTA11) | ![The image shows the transcriptomic changes along malignancy continuum.log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage.](images/deg_images/Colorectum/Chen/VIL1_pca_on_diff_genes.png) | AD: Adenomas |
SER: Sessile serrated lesions |
MSI-H: Microsatellite-high colorectal cancer |
MSS: Microsatellite stable colorectal cancer |
GC | ![The image shows the transcriptomic changes along malignancy continuum.log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage.](images/deg_images/GC/VIL1_pca_on_diff_genes.png) | CAG: Chronic atrophic gastritis |
CAG with IM: Chronic atrophic gastritis with intestinal metaplasia |
CSG: Chronic superficial gastritis |
GC: Gastric cancer |
SIM: Severe intestinal metaplasia |
WIM: Wild intestinal metaplasia |
Liver | ![The image shows the transcriptomic changes along malignancy continuum.log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage.](images/deg_images/Liver/VIL1_pca_on_diff_genes.png) | HCC: Hepatocellular carcinoma |
NAFLD: Non-alcoholic fatty liver disease |
GO ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | Count |
GO:00106322 | Colorectum | MSS | regulation of epithelial cell migration | 77/3467 | 292/18723 | 5.39e-04 | 6.04e-03 | 77 |
GO:00901302 | Colorectum | MSS | tissue migration | 93/3467 | 365/18723 | 5.42e-04 | 6.06e-03 | 93 |
GO:00508921 | Colorectum | MSS | intestinal absorption | 17/3467 | 41/18723 | 5.48e-04 | 6.10e-03 | 17 |
GO:20001172 | Colorectum | MSS | negative regulation of cysteine-type endopeptidase activity | 29/3467 | 86/18723 | 5.53e-04 | 6.14e-03 | 29 |
GO:00713642 | Colorectum | MSS | cellular response to epidermal growth factor stimulus | 18/3467 | 45/18723 | 6.38e-04 | 6.99e-03 | 18 |
GO:00514942 | Colorectum | MSS | negative regulation of cytoskeleton organization | 47/3467 | 163/18723 | 8.45e-04 | 8.71e-03 | 47 |
GO:00106342 | Colorectum | MSS | positive regulation of epithelial cell migration | 50/3467 | 176/18723 | 8.50e-04 | 8.75e-03 | 50 |
GO:00486381 | Colorectum | MSS | regulation of developmental growth | 84/3467 | 330/18723 | 1.01e-03 | 1.01e-02 | 84 |
GO:00308342 | Colorectum | MSS | regulation of actin filament depolymerization | 20/3467 | 54/18723 | 1.04e-03 | 1.03e-02 | 20 |
GO:00510162 | Colorectum | MSS | barbed-end actin filament capping | 12/3467 | 26/18723 | 1.16e-03 | 1.12e-02 | 12 |
GO:00486391 | Colorectum | MSS | positive regulation of developmental growth | 49/3467 | 174/18723 | 1.17e-03 | 1.13e-02 | 49 |
GO:00459272 | Colorectum | MSS | positive regulation of growth | 68/3467 | 259/18723 | 1.24e-03 | 1.19e-02 | 68 |
GO:00513461 | Colorectum | MSS | negative regulation of hydrolase activity | 92/3467 | 379/18723 | 2.85e-03 | 2.22e-02 | 92 |
GO:00226001 | Colorectum | MSS | digestive system process | 31/3467 | 104/18723 | 3.46e-03 | 2.59e-02 | 31 |
GO:00510142 | Colorectum | MSS | actin filament severing | 8/3467 | 16/18723 | 4.27e-03 | 3.04e-02 | 8 |
GO:0070252 | Colorectum | MSS | actin-mediated cell contraction | 29/3467 | 97/18723 | 4.38e-03 | 3.10e-02 | 29 |
GO:0035264 | Colorectum | MSS | multicellular organism growth | 37/3467 | 132/18723 | 4.77e-03 | 3.34e-02 | 37 |
GO:00516932 | Colorectum | MSS | actin filament capping | 15/3467 | 41/18723 | 4.88e-03 | 3.40e-02 | 15 |
GO:00511252 | Colorectum | MSS | regulation of actin nucleation | 12/3467 | 30/18723 | 5.00e-03 | 3.46e-02 | 12 |
GO:00308352 | Colorectum | MSS | negative regulation of actin filament depolymerization | 16/3467 | 45/18723 | 5.12e-03 | 3.51e-02 | 16 |
Hugo Symbol | Variant Class | Variant Classification | dbSNP RS | HGVSc | HGVSp | HGVSp Short | SWISSPROT | BIOTYPE | SIFT | PolyPhen | Tumor Sample Barcode | Tissue | Histology | Sex | Age | Stage | Therapy Types | Drugs | Outcome |
VIL1 | SNV | Missense_Mutation | rs762246582 | c.2020N>A | p.Ala674Thr | p.A674T | P09327 | protein_coding | deleterious(0.04) | possibly_damaging(0.57) | TCGA-A2-A3Y0-01 | Breast | breast invasive carcinoma | Female | <65 | I/II | Chemotherapy | adriamycin | CR |
VIL1 | SNV | Missense_Mutation | | c.1473N>G | p.Ile491Met | p.I491M | P09327 | protein_coding | tolerated(0.14) | benign(0.196) | TCGA-AC-A23H-01 | Breast | breast invasive carcinoma | Female | >=65 | I/II | Unknown | Unknown | PD |
VIL1 | SNV | Missense_Mutation | | c.2065N>A | p.Arg689Ser | p.R689S | P09327 | protein_coding | deleterious(0.01) | probably_damaging(1) | TCGA-B6-A0X4-01 | Breast | breast invasive carcinoma | Female | <65 | I/II | Unknown | Unknown | PD |
VIL1 | SNV | Missense_Mutation | rs370604646 | c.2065C>T | p.Arg689Cys | p.R689C | P09327 | protein_coding | deleterious(0) | probably_damaging(1) | TCGA-BH-A18G-01 | Breast | breast invasive carcinoma | Female | >=65 | I/II | Unknown | Unknown | SD |
VIL1 | SNV | Missense_Mutation | rs750796385 | c.1333N>A | p.Val445Ile | p.V445I | P09327 | protein_coding | tolerated(0.94) | benign(0) | TCGA-D8-A1JF-01 | Breast | breast invasive carcinoma | Female | >=65 | III/IV | Unknown | Unknown | SD |
VIL1 | insertion | Frame_Shift_Ins | novel | c.2478_2479insAAACAACAAAAAACAATGGCCAGGCATGGTGGCTCATGCC | p.Phe827LysfsTer74 | p.F827Kfs*74 | P09327 | protein_coding | | | TCGA-A2-A0CP-01 | Breast | breast invasive carcinoma | Female | <65 | I/II | Chemotherapy | cytoxan | SD |
VIL1 | insertion | Frame_Shift_Ins | novel | c.1639_1640insT | p.Leu548ProfsTer16 | p.L548Pfs*16 | P09327 | protein_coding | | | TCGA-A8-A09Z-01 | Breast | breast invasive carcinoma | Female | >=65 | I/II | Unknown | Unknown | SD |
VIL1 | insertion | In_Frame_Ins | novel | c.1641_1642insTTCATAGGAGACTACCCTGGAGGTTCTATCACCTATGTGGAA | p.Val547_Leu548insPheIleGlyAspTyrProGlyGlySerIleThrTyrValGlu | p.V547_L548insFIGDYPGGSITYVE | P09327 | protein_coding | | | TCGA-A8-A09Z-01 | Breast | breast invasive carcinoma | Female | >=65 | I/II | Unknown | Unknown | SD |
VIL1 | insertion | Nonsense_Mutation | novel | c.68_69insTCACCTCCCAAAAGGCAGAAAATAAA | p.Arg23SerfsTer9 | p.R23Sfs*9 | P09327 | protein_coding | | | TCGA-AO-A0JF-01 | Breast | breast invasive carcinoma | Female | >=65 | I/II | Chemotherapy | doxorubicin | SD |
VIL1 | deletion | Frame_Shift_Del | | c.1858delC | p.Arg620GlyfsTer33 | p.R620Gfs*33 | P09327 | protein_coding | | | TCGA-BH-A0HA-01 | Breast | breast invasive carcinoma | Female | <65 | I/II | Unknown | Unknown | SD |