![]() |
|||||
|
![]() | |
![]() | |
![]() | |
![]() | |
![]() | |
![]() | |
![]() |
Gene: VAMP8 |
Gene summary for VAMP8 |
![]() |
Gene information | Species | Human | Gene symbol | VAMP8 | Gene ID | 8673 |
Gene name | vesicle associated membrane protein 8 | |
Gene Alias | EDB | |
Cytomap | 2p11.2 | |
Gene Type | protein-coding | GO ID | GO:0001775 | UniProtAcc | Q9BV40 |
Top |
Malignant transformation analysis |
![]() |
![]() |
Entrez ID | Symbol | Replicates | Species | Organ | Tissue | Adj P-value | Log2FC | Malignancy |
8673 | VAMP8 | CA_HPV_1 | Human | Cervix | CC | 2.02e-09 | 1.13e-01 | 0.0264 |
8673 | VAMP8 | CA_HPV_3 | Human | Cervix | CC | 1.90e-04 | 4.12e-02 | 0.0414 |
8673 | VAMP8 | CCI_1 | Human | Cervix | CC | 1.49e-11 | -9.00e-01 | 0.528 |
8673 | VAMP8 | CCI_3 | Human | Cervix | CC | 8.00e-16 | -9.31e-01 | 0.516 |
8673 | VAMP8 | CCII_1 | Human | Cervix | CC | 3.12e-24 | -9.71e-01 | 0.3249 |
8673 | VAMP8 | sample1 | Human | Cervix | CC | 4.83e-04 | -5.50e-01 | 0.0959 |
8673 | VAMP8 | sample3 | Human | Cervix | CC | 1.02e-05 | 1.36e-01 | 0.1387 |
8673 | VAMP8 | T1 | Human | Cervix | CC | 1.44e-14 | -6.21e-01 | 0.0918 |
8673 | VAMP8 | T3 | Human | Cervix | CC | 1.89e-02 | 1.42e-01 | 0.1389 |
8673 | VAMP8 | HTA11_3410_2000001011 | Human | Colorectum | AD | 3.13e-09 | 2.62e-01 | 0.0155 |
8673 | VAMP8 | HTA11_2487_2000001011 | Human | Colorectum | SER | 2.87e-37 | 1.57e+00 | -0.1808 |
8673 | VAMP8 | HTA11_2951_2000001011 | Human | Colorectum | AD | 3.40e-03 | 4.09e-01 | 0.0216 |
8673 | VAMP8 | HTA11_1938_2000001011 | Human | Colorectum | AD | 3.85e-21 | 9.68e-01 | -0.0811 |
8673 | VAMP8 | HTA11_78_2000001011 | Human | Colorectum | AD | 9.21e-05 | 2.84e-01 | -0.1088 |
8673 | VAMP8 | HTA11_347_2000001011 | Human | Colorectum | AD | 5.43e-36 | 9.15e-01 | -0.1954 |
8673 | VAMP8 | HTA11_411_2000001011 | Human | Colorectum | SER | 4.64e-20 | 2.26e+00 | -0.2602 |
8673 | VAMP8 | HTA11_2112_2000001011 | Human | Colorectum | SER | 2.76e-16 | 1.68e+00 | -0.2196 |
8673 | VAMP8 | HTA11_3361_2000001011 | Human | Colorectum | AD | 1.32e-16 | 7.48e-01 | -0.1207 |
8673 | VAMP8 | HTA11_83_2000001011 | Human | Colorectum | SER | 4.59e-20 | 1.04e+00 | -0.1526 |
8673 | VAMP8 | HTA11_696_2000001011 | Human | Colorectum | AD | 1.24e-43 | 1.16e+00 | -0.1464 |
Page: 1 2 3 4 5 6 7 8 9 10 11 |
![]() |
∗log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage. |
Top |
Malignant transformation related pathway analysis |
![]() |
![]() |
Tissue | Disease Stage | Enriched GO biological Processes |
Colorectum | AD | ![]() |
Colorectum | SER | ![]() |
Colorectum | MSS | ![]() |
Colorectum | MSI-H | ![]() |
Colorectum | FAP | ![]() |
∗Top 15 enriched GO BP terms are showed in the bar plot of each disease state in each tissue. Each row represents a significant GO biological process which is colored according to the -log10(p.adjust). |
Page: 1 2 3 4 5 6 7 8 9 |
![]() |
GO ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | Count |
GO:0022411110 | Oral cavity | LP | cellular component disassembly | 173/4623 | 443/18723 | 9.97e-12 | 7.44e-10 | 173 |
GO:007265919 | Oral cavity | LP | protein localization to plasma membrane | 119/4623 | 284/18723 | 1.11e-10 | 6.44e-09 | 119 |
GO:199077817 | Oral cavity | LP | protein localization to cell periphery | 133/4623 | 333/18723 | 4.42e-10 | 2.21e-08 | 133 |
GO:000961516 | Oral cavity | LP | response to virus | 143/4623 | 367/18723 | 7.42e-10 | 3.52e-08 | 143 |
GO:005165615 | Oral cavity | LP | establishment of organelle localization | 147/4623 | 390/18723 | 6.01e-09 | 2.46e-07 | 147 |
GO:0044409110 | Oral cavity | LP | entry into host | 68/4623 | 151/18723 | 3.72e-08 | 1.33e-06 | 68 |
GO:190547517 | Oral cavity | LP | regulation of protein localization to membrane | 74/4623 | 175/18723 | 2.26e-07 | 6.81e-06 | 74 |
GO:0046718110 | Oral cavity | LP | viral entry into host cell | 63/4623 | 144/18723 | 4.16e-07 | 1.19e-05 | 63 |
GO:190307618 | Oral cavity | LP | regulation of protein localization to plasma membrane | 48/4623 | 104/18723 | 1.51e-06 | 3.62e-05 | 48 |
GO:190437517 | Oral cavity | LP | regulation of protein localization to cell periphery | 55/4623 | 125/18723 | 1.77e-06 | 4.11e-05 | 55 |
GO:005160711 | Oral cavity | LP | defense response to virus | 97/4623 | 265/18723 | 9.31e-06 | 1.74e-04 | 97 |
GO:014054611 | Oral cavity | LP | defense response to symbiont | 97/4623 | 265/18723 | 9.31e-06 | 1.74e-04 | 97 |
GO:003298414 | Oral cavity | LP | protein-containing complex disassembly | 83/4623 | 224/18723 | 2.38e-05 | 3.86e-04 | 83 |
GO:004828412 | Oral cavity | LP | organelle fusion | 56/4623 | 141/18723 | 5.55e-05 | 7.62e-04 | 56 |
GO:002240613 | Oral cavity | LP | membrane docking | 38/4623 | 86/18723 | 5.97e-05 | 8.13e-04 | 38 |
GO:000690611 | Oral cavity | LP | vesicle fusion | 44/4623 | 106/18723 | 1.01e-04 | 1.24e-03 | 44 |
GO:009017411 | Oral cavity | LP | organelle membrane fusion | 45/4623 | 110/18723 | 1.28e-04 | 1.49e-03 | 45 |
GO:009735211 | Oral cavity | LP | autophagosome maturation | 21/4623 | 40/18723 | 1.42e-04 | 1.64e-03 | 21 |
GO:00610251 | Oral cavity | LP | membrane fusion | 58/4623 | 163/18723 | 1.19e-03 | 9.62e-03 | 58 |
GO:014005612 | Oral cavity | LP | organelle localization by membrane tethering | 31/4623 | 77/18723 | 1.83e-03 | 1.38e-02 | 31 |
Page: 1 2 3 4 5 6 7 8 9 10 11 12 13 14 15 16 17 18 19 20 21 |
![]() |
Pathway ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | qvalue | Count |
hsa046115 | Cervix | CC | Platelet activation | 28/1267 | 124/8465 | 1.50e-02 | 4.45e-02 | 2.63e-02 | 28 |
hsa0461113 | Cervix | CC | Platelet activation | 28/1267 | 124/8465 | 1.50e-02 | 4.45e-02 | 2.63e-02 | 28 |
hsa04140 | Colorectum | AD | Autophagy - animal | 49/2092 | 141/8465 | 4.58e-03 | 2.20e-02 | 1.40e-02 | 49 |
hsa041401 | Colorectum | AD | Autophagy - animal | 49/2092 | 141/8465 | 4.58e-03 | 2.20e-02 | 1.40e-02 | 49 |
hsa041402 | Colorectum | SER | Autophagy - animal | 39/1580 | 141/8465 | 5.43e-03 | 3.28e-02 | 2.38e-02 | 39 |
hsa041403 | Colorectum | SER | Autophagy - animal | 39/1580 | 141/8465 | 5.43e-03 | 3.28e-02 | 2.38e-02 | 39 |
hsa041404 | Colorectum | MSS | Autophagy - animal | 45/1875 | 141/8465 | 4.42e-03 | 1.90e-02 | 1.16e-02 | 45 |
hsa041405 | Colorectum | MSS | Autophagy - animal | 45/1875 | 141/8465 | 4.42e-03 | 1.90e-02 | 1.16e-02 | 45 |
hsa0414010 | Esophagus | ESCC | Autophagy - animal | 101/4205 | 141/8465 | 7.60e-08 | 6.21e-07 | 3.18e-07 | 101 |
hsa041305 | Esophagus | ESCC | SNARE interactions in vesicular transport | 28/4205 | 33/8465 | 2.75e-05 | 1.32e-04 | 6.75e-05 | 28 |
hsa0414015 | Esophagus | ESCC | Autophagy - animal | 101/4205 | 141/8465 | 7.60e-08 | 6.21e-07 | 3.18e-07 | 101 |
hsa0413012 | Esophagus | ESCC | SNARE interactions in vesicular transport | 28/4205 | 33/8465 | 2.75e-05 | 1.32e-04 | 6.75e-05 | 28 |
hsa041406 | Liver | Cirrhotic | Autophagy - animal | 65/2530 | 141/8465 | 3.10e-05 | 2.47e-04 | 1.52e-04 | 65 |
hsa04130 | Liver | Cirrhotic | SNARE interactions in vesicular transport | 18/2530 | 33/8465 | 2.64e-03 | 1.10e-02 | 6.76e-03 | 18 |
hsa0414011 | Liver | Cirrhotic | Autophagy - animal | 65/2530 | 141/8465 | 3.10e-05 | 2.47e-04 | 1.52e-04 | 65 |
hsa041301 | Liver | Cirrhotic | SNARE interactions in vesicular transport | 18/2530 | 33/8465 | 2.64e-03 | 1.10e-02 | 6.76e-03 | 18 |
hsa0414021 | Liver | HCC | Autophagy - animal | 99/4020 | 141/8465 | 3.08e-08 | 4.70e-07 | 2.61e-07 | 99 |
hsa046112 | Liver | HCC | Platelet activation | 71/4020 | 124/8465 | 1.77e-02 | 4.15e-02 | 2.31e-02 | 71 |
hsa0414031 | Liver | HCC | Autophagy - animal | 99/4020 | 141/8465 | 3.08e-08 | 4.70e-07 | 2.61e-07 | 99 |
hsa0461111 | Liver | HCC | Platelet activation | 71/4020 | 124/8465 | 1.77e-02 | 4.15e-02 | 2.31e-02 | 71 |
Page: 1 2 |
Top |
Cell-cell communication analysis |
![]() |
Ligand | Receptor | LRpair | Pathway | Tissue | Disease Stage |
Page: 1 |
Top |
Single-cell gene regulatory network inference analysis |
![]() |
TF | Cell Type | Tissue | Disease Stage | Target Gene | RSS | Regulon Activity |
∗The dot plots of a searched regulon are shown for all cell subpopulations in each disease state of each tissue based on the regulon specific score inferred using pySCENIC and by calculating the average expression. |
Page: 1 |
Top |
Somatic mutation of malignant transformation related genes |
![]() |
Hugo Symbol | Variant Class | Variant Classification | dbSNP RS | HGVSc | HGVSp | HGVSp Short | SWISSPROT | BIOTYPE | SIFT | PolyPhen | Tumor Sample Barcode | Tissue | Histology | Sex | Age | Stage | Therapy Types | Drugs | Outcome |
VAMP8 | SNV | Missense_Mutation | c.68N>A | p.Val23Asp | p.V23D | Q9BV40 | protein_coding | deleterious(0) | probably_damaging(1) | TCGA-AA-3994-01 | Colorectum | colon adenocarcinoma | Male | >=65 | III/IV | Chemotherapy | capecitabine | CR | |
VAMP8 | SNV | Missense_Mutation | c.286N>G | p.Thr96Ala | p.T96A | Q9BV40 | protein_coding | deleterious(0.02) | benign(0.18) | TCGA-AZ-4615-01 | Colorectum | colon adenocarcinoma | Male | >=65 | III/IV | Chemotherapy | xeloda | PD | |
VAMP8 | SNV | Missense_Mutation | novel | c.233T>C | p.Val78Ala | p.V78A | Q9BV40 | protein_coding | tolerated(0.13) | benign(0.207) | TCGA-AG-A014-01 | Colorectum | rectum adenocarcinoma | Male | >=65 | I/II | Unknown | Unknown | SD |
VAMP8 | SNV | Missense_Mutation | novel | c.235N>A | p.Leu79Ile | p.L79I | Q9BV40 | protein_coding | tolerated(0.91) | benign(0.003) | TCGA-A5-A0G2-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | <65 | III/IV | Unknown | Unknown | SD |
VAMP8 | SNV | Missense_Mutation | c.71A>C | p.Lys24Thr | p.K24T | Q9BV40 | protein_coding | tolerated(0.09) | possibly_damaging(0.721) | TCGA-AP-A0L9-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | >=65 | I/II | Unknown | Unknown | SD | |
VAMP8 | SNV | Missense_Mutation | novel | c.287C>T | p.Thr96Ile | p.T96I | Q9BV40 | protein_coding | deleterious(0) | possibly_damaging(0.792) | TCGA-AX-A0J1-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | >=65 | I/II | Unknown | Unknown | SD |
VAMP8 | SNV | Missense_Mutation | c.224N>T | p.Lys75Met | p.K75M | Q9BV40 | protein_coding | deleterious(0) | probably_damaging(0.992) | TCGA-BG-A0LX-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | <65 | I/II | Unknown | Unknown | SD | |
VAMP8 | SNV | Missense_Mutation | rs766364692 | c.220N>A | p.Val74Met | p.V74M | Q9BV40 | protein_coding | tolerated(0.08) | benign(0.053) | TCGA-EO-A22U-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | >=65 | I/II | Unknown | Unknown | SD |
VAMP8 | SNV | Missense_Mutation | novel | c.101T>C | p.Ile34Thr | p.I34T | Q9BV40 | protein_coding | tolerated(0.08) | benign(0.425) | TCGA-EY-A1GI-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | <65 | I/II | Unknown | Unknown | SD |
VAMP8 | deletion | Frame_Shift_Del | rs774807701 | c.110delN | p.Glu39LysfsTer36 | p.E39Kfs*36 | Q9BV40 | protein_coding | TCGA-D1-A1NZ-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | <65 | I/II | Unknown | Unknown | SD |
Page: 1 2 |
Top |
Related drugs of malignant transformation related genes |
![]() |
(DGIdb 4.0) |
Entrez ID | Symbol | Category | Interaction Types | Drug Claim Name | Drug Name | PMIDs |
Page: 1 |