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Gene: TNKS |
Gene summary for TNKS |
 Gene summary. |
| Gene information | Species | Human | Gene symbol | TNKS | Gene ID | 8658 |
| Gene name | tankyrase | |
| Gene Alias | ARTD5 | |
| Cytomap | 8p23.1 | |
| Gene Type | protein-coding | GO ID | GO:0000070 | UniProtAcc | O95271 |
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Malignant transformation analysis |
| Identification of the aberrant gene expression in precancerous and cancerous lesions by comparing the gene expression of stem-like cells in diseased tissues with normal stem cells |
| Malignant transformation involving gene list. |
| Entrez ID | Symbol | Replicates | Species | Organ | Tissue | Adj P-value | Log2FC | Malignancy |
| 8658 | TNKS | CCI_1 | Human | Cervix | CC | 5.95e-03 | 5.62e-01 | 0.528 |
| 8658 | TNKS | CCI_2 | Human | Cervix | CC | 4.10e-05 | 7.83e-01 | 0.5249 |
| 8658 | TNKS | CCI_3 | Human | Cervix | CC | 1.02e-04 | 6.39e-01 | 0.516 |
| 8658 | TNKS | HTA11_3410_2000001011 | Human | Colorectum | AD | 2.16e-16 | -5.20e-01 | 0.0155 |
| 8658 | TNKS | HTA11_2487_2000001011 | Human | Colorectum | SER | 4.94e-02 | -3.20e-01 | -0.1808 |
| 8658 | TNKS | HTA11_3361_2000001011 | Human | Colorectum | AD | 1.67e-04 | -4.90e-01 | -0.1207 |
| 8658 | TNKS | HTA11_83_2000001011 | Human | Colorectum | SER | 3.17e-02 | -3.41e-01 | -0.1526 |
| 8658 | TNKS | HTA11_696_2000001011 | Human | Colorectum | AD | 8.30e-15 | -3.86e-01 | -0.1464 |
| 8658 | TNKS | HTA11_866_2000001011 | Human | Colorectum | AD | 1.00e-06 | -3.35e-01 | -0.1001 |
| 8658 | TNKS | HTA11_5212_2000001011 | Human | Colorectum | AD | 1.85e-04 | -6.03e-01 | -0.2061 |
| 8658 | TNKS | HTA11_866_3004761011 | Human | Colorectum | AD | 1.65e-05 | -4.15e-01 | 0.096 |
| 8658 | TNKS | HTA11_8622_2000001021 | Human | Colorectum | SER | 1.21e-02 | -5.33e-01 | 0.0528 |
| 8658 | TNKS | HTA11_10711_2000001011 | Human | Colorectum | AD | 6.31e-03 | -3.25e-01 | 0.0338 |
| 8658 | TNKS | HTA11_7696_3000711011 | Human | Colorectum | AD | 1.20e-09 | -3.93e-01 | 0.0674 |
| 8658 | TNKS | HTA11_99999965104_69814 | Human | Colorectum | MSS | 2.16e-08 | -5.10e-01 | 0.281 |
| 8658 | TNKS | HTA11_99999971662_82457 | Human | Colorectum | MSS | 3.75e-12 | -4.38e-01 | 0.3859 |
| 8658 | TNKS | HTA11_99999974143_84620 | Human | Colorectum | MSS | 5.19e-06 | -3.35e-01 | 0.3005 |
| 8658 | TNKS | A001-C-207 | Human | Colorectum | FAP | 3.88e-02 | -1.47e-01 | 0.1278 |
| 8658 | TNKS | A015-C-203 | Human | Colorectum | FAP | 2.42e-29 | -2.36e-01 | -0.1294 |
| 8658 | TNKS | A015-C-204 | Human | Colorectum | FAP | 5.36e-05 | -2.31e-01 | -0.0228 |
| Page: 1 2 3 4 5 6 7 8 9 |
| Transcriptomic changes along malignancy continuum. |
| Tissue | Expression Dynamics | Abbreviation |
| Cervix |  | CC: Cervix cancer |
| HSIL_HPV: HPV-infected high-grade squamous intraepithelial lesions | ||
| N_HPV: HPV-infected normal cervix | ||
| Colorectum (GSE201348) |  | FAP: Familial adenomatous polyposis |
| CRC: Colorectal cancer | ||
| Colorectum (HTA11) |  | AD: Adenomas |
| SER: Sessile serrated lesions | ||
| MSI-H: Microsatellite-high colorectal cancer | ||
| MSS: Microsatellite stable colorectal cancer | ||
| Endometrium |  | AEH: Atypical endometrial hyperplasia |
| EEC: Endometrioid Cancer | ||
| Esophagus |  | ESCC: Esophageal squamous cell carcinoma |
| HGIN: High-grade intraepithelial neoplasias | ||
| LGIN: Low-grade intraepithelial neoplasias | ||
| Liver |  | HCC: Hepatocellular carcinoma |
| NAFLD: Non-alcoholic fatty liver disease | ||
| Lung |  | AAH: Atypical adenomatous hyperplasia |
| AIS: Adenocarcinoma in situ | ||
| IAC: Invasive lung adenocarcinoma | ||
| MIA: Minimally invasive adenocarcinoma | ||
| Prostate |  | BPH: Benign Prostatic Hyperplasia |
| Thyroid |  | ATC: Anaplastic thyroid cancer |
| HT: Hashimoto's thyroiditis | ||
| PTC: Papillary thyroid cancer |
| ∗log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage. |
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Malignant transformation related pathway analysis |
| Find out the enriched GO biological processes and KEGG pathways involved in transition from healthy to precancer to cancer |
| Figure of enriched GO biological processes. |
| Tissue | Disease Stage | Enriched GO biological Processes |
| Colorectum | AD |  |
| Colorectum | SER |  |
| Colorectum | MSS |  |
| Colorectum | MSI-H |  |
| Colorectum | FAP |  |
| ∗Top 15 enriched GO BP terms are showed in the bar plot of each disease state in each tissue. Each row represents a significant GO biological process which is colored according to the -log10(p.adjust). |
| Page: 1 2 3 4 5 6 7 8 9 |
| Enriched GO biological processes. |
| GO ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | Count |
| GO:00519734 | Colorectum | CRC | positive regulation of telomerase activity | 12/2078 | 34/18723 | 1.78e-04 | 3.17e-03 | 12 |
| GO:20012525 | Colorectum | CRC | positive regulation of chromosome organization | 21/2078 | 82/18723 | 1.82e-04 | 3.20e-03 | 21 |
| GO:00182103 | Colorectum | CRC | peptidyl-threonine modification | 28/2078 | 125/18723 | 2.10e-04 | 3.55e-03 | 28 |
| GO:00070633 | Colorectum | CRC | regulation of sister chromatid cohesion | 9/2078 | 21/18723 | 2.12e-04 | 3.56e-03 | 9 |
| GO:20005735 | Colorectum | CRC | positive regulation of DNA biosynthetic process | 18/2078 | 66/18723 | 2.21e-04 | 3.69e-03 | 18 |
| GO:00330443 | Colorectum | CRC | regulation of chromosome organization | 37/2078 | 187/18723 | 3.34e-04 | 5.10e-03 | 37 |
| GO:00902633 | Colorectum | CRC | positive regulation of canonical Wnt signaling pathway | 24/2078 | 106/18723 | 4.89e-04 | 7.00e-03 | 24 |
| GO:00070623 | Colorectum | CRC | sister chromatid cohesion | 16/2078 | 62/18723 | 9.40e-04 | 1.15e-02 | 16 |
| GO:00322045 | Colorectum | CRC | regulation of telomere maintenance | 19/2078 | 80/18723 | 9.89e-04 | 1.18e-02 | 19 |
| GO:00007235 | Colorectum | CRC | telomere maintenance | 26/2078 | 131/18723 | 2.29e-03 | 2.20e-02 | 26 |
| GO:00070643 | Colorectum | CRC | mitotic sister chromatid cohesion | 9/2078 | 28/18723 | 2.43e-03 | 2.30e-02 | 9 |
| GO:00070044 | Colorectum | CRC | telomere maintenance via telomerase | 16/2078 | 69/18723 | 3.12e-03 | 2.75e-02 | 16 |
| GO:00511003 | Colorectum | CRC | negative regulation of binding | 30/2078 | 162/18723 | 3.36e-03 | 2.87e-02 | 30 |
| GO:00322065 | Colorectum | CRC | positive regulation of telomere maintenance | 13/2078 | 52/18723 | 3.71e-03 | 3.12e-02 | 13 |
| GO:00322102 | Colorectum | CRC | regulation of telomere maintenance via telomerase | 13/2078 | 53/18723 | 4.42e-03 | 3.47e-02 | 13 |
| GO:00064035 | Colorectum | CRC | RNA localization | 35/2078 | 201/18723 | 4.64e-03 | 3.61e-02 | 35 |
| GO:19043585 | Colorectum | CRC | positive regulation of telomere maintenance via telomere lengthening | 10/2078 | 37/18723 | 5.78e-03 | 4.31e-02 | 10 |
| GO:19043565 | Colorectum | CRC | regulation of telomere maintenance via telomere lengthening | 14/2078 | 61/18723 | 6.06e-03 | 4.46e-02 | 14 |
| GO:00070513 | Colorectum | CRC | spindle organization | 32/2078 | 184/18723 | 6.70e-03 | 4.77e-02 | 32 |
| GO:0034086 | Colorectum | CRC | maintenance of sister chromatid cohesion | 5/2078 | 12/18723 | 6.79e-03 | 4.77e-02 | 5 |
| Page: 1 2 3 4 5 6 7 8 9 10 11 12 13 14 15 16 17 18 19 20 21 22 23 24 25 26 27 28 29 30 31 32 33 34 35 36 37 38 39 40 41 42 43 44 45 46 47 48 49 50 51 52 53 54 55 56 |
| Enriched KEGG pathways. |
| Pathway ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | qvalue | Count |
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Cell-cell communication analysis |
| Identification of potential cell-cell interactions between two cell types and their ligand-receptor pairs for different disease states |
| Ligand | Receptor | LRpair | Pathway | Tissue | Disease Stage |
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Single-cell gene regulatory network inference analysis |
| Find out the significant the regulons (TFs) and the target genes of each regulon across cell types for different disease states |
| TF | Cell Type | Tissue | Disease Stage | Target Gene | RSS | Regulon Activity |
| ∗The dot plots of a searched regulon are shown for all cell subpopulations in each disease state of each tissue based on the regulon specific score inferred using pySCENIC and by calculating the average expression. |
| Page: 1 |
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Somatic mutation of malignant transformation related genes |
| Annotation of somatic variants for genes involved in malignant transformation |
| Hugo Symbol | Variant Class | Variant Classification | dbSNP RS | HGVSc | HGVSp | HGVSp Short | SWISSPROT | BIOTYPE | SIFT | PolyPhen | Tumor Sample Barcode | Tissue | Histology | Sex | Age | Stage | Therapy Types | Drugs | Outcome |
| TNKS | SNV | Missense_Mutation | novel | c.401C>T | p.Ser134Phe | p.S134F | O95271 | protein_coding | deleterious_low_confidence(0.01) | benign(0.248) | TCGA-A2-A0CR-01 | Breast | breast invasive carcinoma | Female | <65 | I/II | Chemotherapy | adriamycin | CR |
| TNKS | SNV | Missense_Mutation | rs767692118 | c.3854N>G | p.Asn1285Ser | p.N1285S | O95271 | protein_coding | deleterious(0.02) | benign(0.198) | TCGA-A2-A4S2-01 | Breast | breast invasive carcinoma | Female | <65 | III/IV | Chemotherapy | adriamycin | CR |
| TNKS | SNV | Missense_Mutation | rs762904486 | c.286N>G | p.Ile96Val | p.I96V | O95271 | protein_coding | deleterious_low_confidence(0.04) | benign(0) | TCGA-D8-A145-01 | Breast | breast invasive carcinoma | Female | >=65 | I/II | Hormone Therapy | tamoxiphen | SD |
| TNKS | insertion | Frame_Shift_Ins | novel | c.560_561insTTGTTGTTTTTGTGACAGGGTCTCC | p.Glu188CysfsTer62 | p.E188Cfs*62 | O95271 | protein_coding | TCGA-AN-A0FN-01 | Breast | breast invasive carcinoma | Female | <65 | I/II | Unknown | Unknown | SD | ||
| TNKS | deletion | Frame_Shift_Del | novel | c.3731delT | p.Ile1244AsnfsTer11 | p.I1244Nfs*11 | O95271 | protein_coding | TCGA-EW-A2FV-01 | Breast | breast invasive carcinoma | Female | <65 | III/IV | Chemotherapy | docetaxel | SD | ||
| TNKS | SNV | Missense_Mutation | rs753349258 | c.932N>A | p.Arg311Gln | p.R311Q | O95271 | protein_coding | tolerated(0.08) | benign(0.036) | TCGA-2W-A8YY-01 | Cervix | cervical & endocervical cancer | Female | <65 | I/II | Chemotherapy | cisplatin | CR |
| TNKS | SNV | Missense_Mutation | novel | c.2087N>A | p.Arg696His | p.R696H | O95271 | protein_coding | tolerated(0.27) | probably_damaging(0.985) | TCGA-2W-A8YY-01 | Cervix | cervical & endocervical cancer | Female | <65 | I/II | Chemotherapy | cisplatin | CR |
| TNKS | SNV | Missense_Mutation | novel | c.3482N>A | p.Arg1161Gln | p.R1161Q | O95271 | protein_coding | deleterious(0) | probably_damaging(0.976) | TCGA-2W-A8YY-01 | Cervix | cervical & endocervical cancer | Female | <65 | I/II | Chemotherapy | cisplatin | CR |
| TNKS | SNV | Missense_Mutation | c.1240N>T | p.His414Tyr | p.H414Y | O95271 | protein_coding | deleterious(0.01) | probably_damaging(0.997) | TCGA-C5-A1BF-01 | Cervix | cervical & endocervical cancer | Female | <65 | I/II | Chemotherapy | cisplatin | PD | |
| TNKS | SNV | Missense_Mutation | rs372614885 | c.3978N>C | p.Lys1326Asn | p.K1326N | O95271 | protein_coding | deleterious_low_confidence(0) | probably_damaging(0.966) | TCGA-C5-A7UI-01 | Cervix | cervical & endocervical cancer | Female | <65 | I/II | Unknown | Unknown | SD |
| Page: 1 2 3 4 5 6 7 8 9 10 11 12 13 |
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Related drugs of malignant transformation related genes |
| Identification of chemicals and drugs interact with genes involved in malignant transfromation |
| (DGIdb 4.0) |
| Entrez ID | Symbol | Category | Interaction Types | Drug Claim Name | Drug Name | PMIDs |
| 8658 | TNKS | DRUGGABLE GENOME, ENZYME | PMID27841036-Compound-37 | |||
| 8658 | TNKS | DRUGGABLE GENOME, ENZYME | 2X-121 | 2X-121 | ||
| 8658 | TNKS | DRUGGABLE GENOME, ENZYME | inhibitor | 404859121 | ||
| 8658 | TNKS | DRUGGABLE GENOME, ENZYME | inhibitor | 404859123 | ||
| 8658 | TNKS | DRUGGABLE GENOME, ENZYME | inhibitor | 404859120 | ||
| 8658 | TNKS | DRUGGABLE GENOME, ENZYME | inhibitor | 404859118 | ||
| 8658 | TNKS | DRUGGABLE GENOME, ENZYME | inhibitor | 404859119 | ||
| 8658 | TNKS | DRUGGABLE GENOME, ENZYME | BGB-290 | PAMIPARIB |
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