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Gene: TNFRSF1A |
Gene summary for TNFRSF1A |
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Gene information | Species | Human | Gene symbol | TNFRSF1A | Gene ID | 7132 |
Gene name | TNF receptor superfamily member 1A | |
Gene Alias | CD120a | |
Cytomap | 12p13.31 | |
Gene Type | protein-coding | GO ID | GO:0001885 | UniProtAcc | P19438 |
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Malignant transformation analysis |
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Entrez ID | Symbol | Replicates | Species | Organ | Tissue | Adj P-value | Log2FC | Malignancy |
7132 | TNFRSF1A | HTA11_2487_2000001011 | Human | Colorectum | SER | 7.09e-05 | 4.40e-01 | -0.1808 |
7132 | TNFRSF1A | HTA11_347_2000001011 | Human | Colorectum | AD | 2.09e-05 | 3.28e-01 | -0.1954 |
7132 | TNFRSF1A | HTA11_411_2000001011 | Human | Colorectum | SER | 4.81e-02 | 8.89e-01 | -0.2602 |
7132 | TNFRSF1A | HTA11_696_2000001011 | Human | Colorectum | AD | 2.23e-05 | 3.82e-01 | -0.1464 |
7132 | TNFRSF1A | HTA11_1391_2000001011 | Human | Colorectum | AD | 9.65e-07 | 4.56e-01 | -0.059 |
7132 | TNFRSF1A | HTA11_7696_3000711011 | Human | Colorectum | AD | 4.38e-03 | 1.37e-01 | 0.0674 |
7132 | TNFRSF1A | HTA11_99999971662_82457 | Human | Colorectum | MSS | 7.03e-04 | 2.34e-01 | 0.3859 |
7132 | TNFRSF1A | A015-C-203 | Human | Colorectum | FAP | 8.20e-03 | -1.17e-01 | -0.1294 |
7132 | TNFRSF1A | A002-C-205 | Human | Colorectum | FAP | 4.05e-02 | -1.45e-01 | -0.1236 |
7132 | TNFRSF1A | A002-C-016 | Human | Colorectum | FAP | 4.45e-04 | -1.44e-01 | 0.0521 |
7132 | TNFRSF1A | A002-C-116 | Human | Colorectum | FAP | 5.45e-03 | -1.57e-01 | -0.0452 |
7132 | TNFRSF1A | F034 | Human | Colorectum | FAP | 3.81e-02 | -1.41e-01 | -0.0665 |
7132 | TNFRSF1A | CRC-3-11773 | Human | Colorectum | CRC | 2.19e-02 | -8.51e-02 | 0.2564 |
7132 | TNFRSF1A | LZE2T | Human | Esophagus | ESCC | 4.29e-03 | 3.71e-02 | 0.082 |
7132 | TNFRSF1A | LZE3D | Human | Esophagus | HGIN | 5.58e-03 | 4.70e-01 | 0.0668 |
7132 | TNFRSF1A | LZE4T | Human | Esophagus | ESCC | 5.99e-16 | 2.96e-01 | 0.0811 |
7132 | TNFRSF1A | LZE5T | Human | Esophagus | ESCC | 1.41e-02 | 2.52e-01 | 0.0514 |
7132 | TNFRSF1A | LZE8T | Human | Esophagus | ESCC | 1.37e-05 | 3.36e-01 | 0.067 |
7132 | TNFRSF1A | LZE20T | Human | Esophagus | ESCC | 7.22e-09 | 2.15e-01 | 0.0662 |
7132 | TNFRSF1A | LZE22D1 | Human | Esophagus | HGIN | 3.91e-05 | 9.52e-02 | 0.0595 |
Page: 1 2 3 4 5 6 7 8 9 |
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∗log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage. |
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Malignant transformation related pathway analysis |
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Tissue | Disease Stage | Enriched GO biological Processes |
Colorectum | AD | ![]() |
Colorectum | SER | ![]() |
Colorectum | MSS | ![]() |
Colorectum | MSI-H | ![]() |
Colorectum | FAP | ![]() |
∗Top 15 enriched GO BP terms are showed in the bar plot of each disease state in each tissue. Each row represents a significant GO biological process which is colored according to the -log10(p.adjust). |
Page: 1 2 3 4 5 6 7 8 9 |
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GO ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | Count |
GO:003320913 | Oral cavity | LP | tumor necrosis factor-mediated signaling pathway | 38/4623 | 99/18723 | 1.72e-03 | 1.31e-02 | 38 |
GO:003461219 | Oral cavity | LP | response to tumor necrosis factor | 83/4623 | 253/18723 | 2.10e-03 | 1.54e-02 | 83 |
GO:007135619 | Oral cavity | LP | cellular response to tumor necrosis factor | 76/4623 | 229/18723 | 2.24e-03 | 1.62e-02 | 76 |
GO:009719334 | Oral cavity | NEOLP | intrinsic apoptotic signaling pathway | 79/2005 | 288/18723 | 1.41e-15 | 6.97e-13 | 79 |
GO:009719133 | Oral cavity | NEOLP | extrinsic apoptotic signaling pathway | 55/2005 | 219/18723 | 1.07e-09 | 7.82e-08 | 55 |
GO:004312231 | Oral cavity | NEOLP | regulation of I-kappaB kinase/NF-kappaB signaling | 58/2005 | 249/18723 | 7.81e-09 | 4.09e-07 | 58 |
GO:000724931 | Oral cavity | NEOLP | I-kappaB kinase/NF-kappaB signaling | 62/2005 | 281/18723 | 2.16e-08 | 9.59e-07 | 62 |
GO:00301982 | Oral cavity | NEOLP | extracellular matrix organization | 64/2005 | 301/18723 | 5.66e-08 | 2.24e-06 | 64 |
GO:00430622 | Oral cavity | NEOLP | extracellular structure organization | 64/2005 | 302/18723 | 6.44e-08 | 2.50e-06 | 64 |
GO:00452292 | Oral cavity | NEOLP | external encapsulating structure organization | 64/2005 | 304/18723 | 8.33e-08 | 3.17e-06 | 64 |
GO:001922122 | Oral cavity | NEOLP | cytokine-mediated signaling pathway | 88/2005 | 472/18723 | 1.37e-07 | 4.80e-06 | 88 |
GO:003210323 | Oral cavity | NEOLP | positive regulation of response to external stimulus | 81/2005 | 427/18723 | 2.04e-07 | 6.74e-06 | 81 |
GO:003461231 | Oral cavity | NEOLP | response to tumor necrosis factor | 55/2005 | 253/18723 | 2.23e-07 | 7.28e-06 | 55 |
GO:007135631 | Oral cavity | NEOLP | cellular response to tumor necrosis factor | 50/2005 | 229/18723 | 6.79e-07 | 1.93e-05 | 50 |
GO:004312331 | Oral cavity | NEOLP | positive regulation of I-kappaB kinase/NF-kappaB signaling | 43/2005 | 186/18723 | 8.08e-07 | 2.21e-05 | 43 |
GO:003320931 | Oral cavity | NEOLP | tumor necrosis factor-mediated signaling pathway | 27/2005 | 99/18723 | 3.40e-06 | 7.60e-05 | 27 |
GO:007265931 | Oral cavity | NEOLP | protein localization to plasma membrane | 56/2005 | 284/18723 | 4.51e-06 | 9.60e-05 | 56 |
GO:000315823 | Oral cavity | NEOLP | endothelium development | 33/2005 | 136/18723 | 4.94e-06 | 1.04e-04 | 33 |
GO:199077831 | Oral cavity | NEOLP | protein localization to cell periphery | 62/2005 | 333/18723 | 9.84e-06 | 1.86e-04 | 62 |
GO:000862531 | Oral cavity | NEOLP | extrinsic apoptotic signaling pathway via death domain receptors | 23/2005 | 82/18723 | 1.07e-05 | 1.98e-04 | 23 |
Page: 1 2 3 4 5 6 7 8 9 10 11 12 13 14 15 16 17 18 19 20 21 22 23 24 25 26 27 |
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Pathway ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | qvalue | Count |
hsa05010 | Colorectum | AD | Alzheimer disease | 174/2092 | 384/8465 | 1.82e-19 | 9.26e-18 | 5.91e-18 | 174 |
hsa04932 | Colorectum | AD | Non-alcoholic fatty liver disease | 90/2092 | 155/8465 | 4.83e-19 | 1.80e-17 | 1.15e-17 | 90 |
hsa05014 | Colorectum | AD | Amyotrophic lateral sclerosis | 164/2092 | 364/8465 | 4.28e-18 | 1.27e-16 | 8.09e-17 | 164 |
hsa05022 | Colorectum | AD | Pathways of neurodegeneration - multiple diseases | 201/2092 | 476/8465 | 4.54e-18 | 1.27e-16 | 8.09e-17 | 201 |
hsa05171 | Colorectum | AD | Coronavirus disease - COVID-19 | 113/2092 | 232/8465 | 9.90e-16 | 2.55e-14 | 1.63e-14 | 113 |
hsa05131 | Colorectum | AD | Shigellosis | 109/2092 | 247/8465 | 1.09e-11 | 2.44e-10 | 1.55e-10 | 109 |
hsa05132 | Colorectum | AD | Salmonella infection | 102/2092 | 249/8465 | 7.65e-09 | 1.28e-07 | 8.17e-08 | 102 |
hsa05417 | Colorectum | AD | Lipid and atherosclerosis | 73/2092 | 215/8465 | 1.31e-03 | 8.27e-03 | 5.27e-03 | 73 |
hsa05170 | Colorectum | AD | Human immunodeficiency virus 1 infection | 72/2092 | 212/8465 | 1.40e-03 | 8.46e-03 | 5.39e-03 | 72 |
hsa05163 | Colorectum | AD | Human cytomegalovirus infection | 75/2092 | 225/8465 | 2.00e-03 | 1.10e-02 | 7.01e-03 | 75 |
hsa05160 | Colorectum | AD | Hepatitis C | 54/2092 | 157/8465 | 3.87e-03 | 1.96e-02 | 1.25e-02 | 54 |
hsa05166 | Colorectum | AD | Human T-cell leukemia virus 1 infection | 72/2092 | 222/8465 | 5.24e-03 | 2.44e-02 | 1.55e-02 | 72 |
hsa050101 | Colorectum | AD | Alzheimer disease | 174/2092 | 384/8465 | 1.82e-19 | 9.26e-18 | 5.91e-18 | 174 |
hsa049321 | Colorectum | AD | Non-alcoholic fatty liver disease | 90/2092 | 155/8465 | 4.83e-19 | 1.80e-17 | 1.15e-17 | 90 |
hsa050141 | Colorectum | AD | Amyotrophic lateral sclerosis | 164/2092 | 364/8465 | 4.28e-18 | 1.27e-16 | 8.09e-17 | 164 |
hsa050221 | Colorectum | AD | Pathways of neurodegeneration - multiple diseases | 201/2092 | 476/8465 | 4.54e-18 | 1.27e-16 | 8.09e-17 | 201 |
hsa051711 | Colorectum | AD | Coronavirus disease - COVID-19 | 113/2092 | 232/8465 | 9.90e-16 | 2.55e-14 | 1.63e-14 | 113 |
hsa051311 | Colorectum | AD | Shigellosis | 109/2092 | 247/8465 | 1.09e-11 | 2.44e-10 | 1.55e-10 | 109 |
hsa051321 | Colorectum | AD | Salmonella infection | 102/2092 | 249/8465 | 7.65e-09 | 1.28e-07 | 8.17e-08 | 102 |
hsa054171 | Colorectum | AD | Lipid and atherosclerosis | 73/2092 | 215/8465 | 1.31e-03 | 8.27e-03 | 5.27e-03 | 73 |
Page: 1 2 3 4 5 6 7 8 9 10 11 12 13 14 15 16 17 18 19 20 21 22 23 24 25 26 27 28 29 30 |
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Cell-cell communication analysis |
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Ligand | Receptor | LRpair | Pathway | Tissue | Disease Stage |
TNF | TNFRSF1A | TNF_TNFRSF1A | TNF | Breast | ADJ |
TNF | TNFRSF1A | TNF_TNFRSF1A | TNF | Breast | DCIS |
TNF | TNFRSF1A | TNF_TNFRSF1A | TNF | Breast | Healthy |
LTA | TNFRSF1A | LTA_TNFRSF1A | LT | Cervix | ADJ |
TNF | TNFRSF1A | TNF_TNFRSF1A | TNF | Cervix | CC |
TNF | TNFRSF1A | TNF_TNFRSF1A | TNF | Cervix | Healthy |
TNF | TNFRSF1A | TNF_TNFRSF1A | TNF | Cervix | Precancer |
TNF | TNFRSF1A | TNF_TNFRSF1A | TNF | Endometrium | ADJ |
TNF | TNFRSF1A | TNF_TNFRSF1A | TNF | Endometrium | AEH |
TNF | TNFRSF1A | TNF_TNFRSF1A | TNF | Endometrium | EEC |
TNF | TNFRSF1A | TNF_TNFRSF1A | TNF | Endometrium | Healthy |
LTA | TNFRSF1A | LTA_TNFRSF1A | LT | Esophagus | ESCC |
TNF | TNFRSF1A | TNF_TNFRSF1A | TNF | GC | ADJ |
TNF | TNFRSF1A | TNF_TNFRSF1A | TNF | HNSCC | ADJ |
TNF | TNFRSF1A | TNF_TNFRSF1A | TNF | HNSCC | OSCC |
TNF | TNFRSF1A | TNF_TNFRSF1A | TNF | HNSCC | Precancer |
TNF | TNFRSF1A | TNF_TNFRSF1A | TNF | Liver | Healthy |
TNF | TNFRSF1A | TNF_TNFRSF1A | TNF | Liver | Precancer |
TNF | TNFRSF1A | TNF_TNFRSF1A | TNF | Lung | AAH |
TNF | TNFRSF1A | TNF_TNFRSF1A | TNF | Lung | ADJ |
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Single-cell gene regulatory network inference analysis |
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TF | Cell Type | Tissue | Disease Stage | Target Gene | RSS | Regulon Activity |
∗The dot plots of a searched regulon are shown for all cell subpopulations in each disease state of each tissue based on the regulon specific score inferred using pySCENIC and by calculating the average expression. |
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Somatic mutation of malignant transformation related genes |
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Hugo Symbol | Variant Class | Variant Classification | dbSNP RS | HGVSc | HGVSp | HGVSp Short | SWISSPROT | BIOTYPE | SIFT | PolyPhen | Tumor Sample Barcode | Tissue | Histology | Sex | Age | Stage | Therapy Types | Drugs | Outcome |
TNFRSF1A | SNV | Missense_Mutation | rs199961053 | c.167N>T | p.Ser56Leu | p.S56L | P19438 | protein_coding | deleterious(0) | possibly_damaging(0.591) | TCGA-AN-A046-01 | Breast | breast invasive carcinoma | Female | >=65 | I/II | Unknown | Unknown | SD |
TNFRSF1A | SNV | Missense_Mutation | novel | c.829N>G | p.Pro277Ala | p.P277A | P19438 | protein_coding | tolerated(0.24) | benign(0) | TCGA-BH-A0B6-01 | Breast | breast invasive carcinoma | Female | <65 | I/II | Unknown | Unknown | SD |
TNFRSF1A | SNV | Missense_Mutation | rs104895245 | c.265N>C | p.Phe89Leu | p.F89L | P19438 | protein_coding | deleterious(0.01) | possibly_damaging(0.898) | TCGA-BH-A1FN-01 | Breast | breast invasive carcinoma | Female | <65 | I/II | Unknown | Unknown | PD |
TNFRSF1A | SNV | Missense_Mutation | c.74C>T | p.Ser25Leu | p.S25L | P19438 | protein_coding | tolerated(0.36) | benign(0.003) | TCGA-C8-A274-01 | Breast | breast invasive carcinoma | Female | <65 | I/II | Hormone Therapy | tamoxiphen | SD | |
TNFRSF1A | SNV | Missense_Mutation | novel | c.977N>T | p.Ala326Val | p.A326V | P19438 | protein_coding | tolerated(0.5) | benign(0.028) | TCGA-2W-A8YY-01 | Cervix | cervical & endocervical cancer | Female | <65 | I/II | Chemotherapy | cisplatin | CR |
TNFRSF1A | SNV | Missense_Mutation | c.364N>T | p.Asp122Tyr | p.D122Y | P19438 | protein_coding | deleterious(0) | probably_damaging(0.998) | TCGA-2W-A8YY-01 | Cervix | cervical & endocervical cancer | Female | <65 | I/II | Chemotherapy | cisplatin | CR | |
TNFRSF1A | SNV | Missense_Mutation | rs201794033 | c.928N>T | p.Pro310Ser | p.P310S | P19438 | protein_coding | tolerated(0.13) | possibly_damaging(0.902) | TCGA-C5-A2LX-01 | Cervix | cervical & endocervical cancer | Female | <65 | I/II | Chemotherapy | cisplatin | SD |
TNFRSF1A | SNV | Missense_Mutation | rs768168665 | c.1267N>T | p.Arg423Cys | p.R423C | P19438 | protein_coding | tolerated(0.15) | benign(0.153) | TCGA-5M-AAT6-01 | Colorectum | colon adenocarcinoma | Female | <65 | III/IV | Unknown | Unknown | PD |
TNFRSF1A | SNV | Missense_Mutation | c.47N>C | p.Leu16Pro | p.L16P | P19438 | protein_coding | tolerated(0.14) | benign(0.026) | TCGA-AA-A022-01 | Colorectum | colon adenocarcinoma | Female | >=65 | I/II | Unknown | Unknown | SD | |
TNFRSF1A | SNV | Missense_Mutation | rs199961053 | c.167N>T | p.Ser56Leu | p.S56L | P19438 | protein_coding | deleterious(0) | possibly_damaging(0.591) | TCGA-AZ-4315-01 | Colorectum | colon adenocarcinoma | Male | <65 | I/II | Unknown | Unknown | SD |
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Related drugs of malignant transformation related genes |
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(DGIdb 4.0) |
Entrez ID | Symbol | Category | Interaction Types | Drug Claim Name | Drug Name | PMIDs |
7132 | TNFRSF1A | CELL SURFACE, DRUGGABLE GENOME | UVB | 9754576 | ||
7132 | TNFRSF1A | CELL SURFACE, DRUGGABLE GENOME | CYCLOPHOSPHAMIDE | CYCLOPHOSPHAMIDE | 9894568 | |
7132 | TNFRSF1A | CELL SURFACE, DRUGGABLE GENOME | infliximab | INFLIXIMAB | 22480748 | |
7132 | TNFRSF1A | CELL SURFACE, DRUGGABLE GENOME | Tumor necrosis factor alpha (TNF-alpha) inhibitors | 22480748,24776844,25311255 | ||
7132 | TNFRSF1A | CELL SURFACE, DRUGGABLE GENOME | 178101767 | |||
7132 | TNFRSF1A | CELL SURFACE, DRUGGABLE GENOME | 178101757 | |||
7132 | TNFRSF1A | CELL SURFACE, DRUGGABLE GENOME | adalimumab | ADALIMUMAB | 22480748 | |
7132 | TNFRSF1A | CELL SURFACE, DRUGGABLE GENOME | 178101766 | |||
7132 | TNFRSF1A | CELL SURFACE, DRUGGABLE GENOME | etanercept | ETANERCEPT | 22480748 | |
7132 | TNFRSF1A | CELL SURFACE, DRUGGABLE GENOME | CYT-6091 |
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