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Gene: SORBS1 |
Gene summary for SORBS1 |
 Gene summary. |
| Gene information | Species | Human | Gene symbol | SORBS1 | Gene ID | 10580 |
| Gene name | sorbin and SH3 domain containing 1 | |
| Gene Alias | CAP | |
| Cytomap | 10q24.1 | |
| Gene Type | protein-coding | GO ID | GO:0000271 | UniProtAcc | Q9BX66 |
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Malignant transformation analysis |
| Identification of the aberrant gene expression in precancerous and cancerous lesions by comparing the gene expression of stem-like cells in diseased tissues with normal stem cells |
| Malignant transformation involving gene list. |
| Entrez ID | Symbol | Replicates | Species | Organ | Tissue | Adj P-value | Log2FC | Malignancy |
| 10580 | SORBS1 | HTA11_3410_2000001011 | Human | Colorectum | AD | 5.37e-03 | -3.21e-01 | 0.0155 |
| 10580 | SORBS1 | HTA11_866_3004761011 | Human | Colorectum | AD | 8.51e-03 | 3.61e-01 | 0.096 |
| 10580 | SORBS1 | HTA11_99999971662_82457 | Human | Colorectum | MSS | 2.23e-20 | 1.24e+00 | 0.3859 |
| 10580 | SORBS1 | HTA11_99999973899_84307 | Human | Colorectum | MSS | 9.34e-10 | 8.81e-01 | 0.2585 |
| 10580 | SORBS1 | A001-C-207 | Human | Colorectum | FAP | 3.94e-02 | -2.92e-01 | 0.1278 |
| 10580 | SORBS1 | A015-C-203 | Human | Colorectum | FAP | 3.26e-08 | -2.33e-02 | -0.1294 |
| 10580 | SORBS1 | A002-C-201 | Human | Colorectum | FAP | 1.40e-06 | -3.52e-01 | 0.0324 |
| 10580 | SORBS1 | A002-C-203 | Human | Colorectum | FAP | 2.17e-09 | -3.64e-01 | 0.2786 |
| 10580 | SORBS1 | A001-C-108 | Human | Colorectum | FAP | 8.19e-08 | -2.84e-01 | -0.0272 |
| 10580 | SORBS1 | A002-C-205 | Human | Colorectum | FAP | 2.81e-08 | -2.49e-01 | -0.1236 |
| 10580 | SORBS1 | A015-C-006 | Human | Colorectum | FAP | 1.46e-07 | -4.19e-01 | -0.0994 |
| 10580 | SORBS1 | A015-C-106 | Human | Colorectum | FAP | 4.37e-03 | -1.48e-01 | -0.0511 |
| 10580 | SORBS1 | A002-C-114 | Human | Colorectum | FAP | 4.22e-08 | -3.78e-01 | -0.1561 |
| 10580 | SORBS1 | A015-C-104 | Human | Colorectum | FAP | 1.91e-12 | -2.35e-01 | -0.1899 |
| 10580 | SORBS1 | A001-C-014 | Human | Colorectum | FAP | 2.35e-05 | -2.34e-01 | 0.0135 |
| 10580 | SORBS1 | A002-C-016 | Human | Colorectum | FAP | 2.40e-11 | -2.83e-01 | 0.0521 |
| 10580 | SORBS1 | A015-C-002 | Human | Colorectum | FAP | 2.11e-04 | -3.50e-01 | -0.0763 |
| 10580 | SORBS1 | A001-C-203 | Human | Colorectum | FAP | 3.27e-02 | 2.59e-02 | -0.0481 |
| 10580 | SORBS1 | A002-C-116 | Human | Colorectum | FAP | 3.83e-15 | -2.54e-01 | -0.0452 |
| 10580 | SORBS1 | A014-C-008 | Human | Colorectum | FAP | 7.90e-03 | -1.60e-01 | -0.191 |
| Page: 1 2 3 4 |
| Transcriptomic changes along malignancy continuum. |
| Tissue | Expression Dynamics | Abbreviation |
| Colorectum (GSE201348) |  | FAP: Familial adenomatous polyposis |
| CRC: Colorectal cancer | ||
| Colorectum (HTA11) |  | AD: Adenomas |
| SER: Sessile serrated lesions | ||
| MSI-H: Microsatellite-high colorectal cancer | ||
| MSS: Microsatellite stable colorectal cancer | ||
| Endometrium |  | AEH: Atypical endometrial hyperplasia |
| EEC: Endometrioid Cancer | ||
| Esophagus |  | ESCC: Esophageal squamous cell carcinoma |
| HGIN: High-grade intraepithelial neoplasias | ||
| LGIN: Low-grade intraepithelial neoplasias | ||
| Liver |  | HCC: Hepatocellular carcinoma |
| NAFLD: Non-alcoholic fatty liver disease | ||
| Lung |  | AAH: Atypical adenomatous hyperplasia |
| AIS: Adenocarcinoma in situ | ||
| IAC: Invasive lung adenocarcinoma | ||
| MIA: Minimally invasive adenocarcinoma | ||
| Prostate |  | BPH: Benign Prostatic Hyperplasia |
| ∗log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage. |
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Malignant transformation related pathway analysis |
| Find out the enriched GO biological processes and KEGG pathways involved in transition from healthy to precancer to cancer |
| Figure of enriched GO biological processes. |
| Tissue | Disease Stage | Enriched GO biological Processes |
| Colorectum | AD |  |
| Colorectum | SER |  |
| Colorectum | MSS |  |
| Colorectum | MSI-H |  |
| Colorectum | FAP |  |
| ∗Top 15 enriched GO BP terms are showed in the bar plot of each disease state in each tissue. Each row represents a significant GO biological process which is colored according to the -log10(p.adjust). |
| Page: 1 2 3 4 5 6 7 8 9 |
| Enriched GO biological processes. |
| GO ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | Count |
| GO:190437719 | Esophagus | ESCC | positive regulation of protein localization to cell periphery | 47/8552 | 69/18723 | 1.37e-04 | 9.27e-04 | 47 |
| GO:190307817 | Esophagus | ESCC | positive regulation of protein localization to plasma membrane | 43/8552 | 62/18723 | 1.38e-04 | 9.35e-04 | 43 |
| GO:00442626 | Esophagus | ESCC | cellular carbohydrate metabolic process | 160/8552 | 283/18723 | 1.43e-04 | 9.66e-04 | 160 |
| GO:003003820 | Esophagus | ESCC | contractile actin filament bundle assembly | 67/8552 | 106/18723 | 2.03e-04 | 1.28e-03 | 67 |
| GO:004314920 | Esophagus | ESCC | stress fiber assembly | 67/8552 | 106/18723 | 2.03e-04 | 1.28e-03 | 67 |
| GO:00160514 | Esophagus | ESCC | carbohydrate biosynthetic process | 117/8552 | 202/18723 | 2.96e-04 | 1.79e-03 | 117 |
| GO:003432918 | Esophagus | ESCC | cell junction assembly | 227/8552 | 420/18723 | 3.06e-04 | 1.83e-03 | 227 |
| GO:00620129 | Esophagus | ESCC | regulation of small molecule metabolic process | 184/8552 | 334/18723 | 3.11e-04 | 1.85e-03 | 184 |
| GO:00109065 | Esophagus | ESCC | regulation of glucose metabolic process | 71/8552 | 119/18723 | 1.46e-03 | 6.92e-03 | 71 |
| GO:00061096 | Esophagus | ESCC | regulation of carbohydrate metabolic process | 101/8552 | 178/18723 | 1.89e-03 | 8.52e-03 | 101 |
| GO:00106755 | Esophagus | ESCC | regulation of cellular carbohydrate metabolic process | 83/8552 | 146/18723 | 4.24e-03 | 1.69e-02 | 83 |
| GO:003103219 | Esophagus | ESCC | actomyosin structure organization | 108/8552 | 196/18723 | 4.86e-03 | 1.88e-02 | 108 |
| GO:00082869 | Esophagus | ESCC | insulin receptor signaling pathway | 66/8552 | 116/18723 | 9.76e-03 | 3.37e-02 | 66 |
| GO:00192168 | Esophagus | ESCC | regulation of lipid metabolic process | 172/8552 | 331/18723 | 1.20e-02 | 4.02e-02 | 172 |
| GO:00346372 | Esophagus | ESCC | cellular carbohydrate biosynthetic process | 46/8552 | 78/18723 | 1.24e-02 | 4.13e-02 | 46 |
| GO:00713755 | Liver | NAFLD | cellular response to peptide hormone stimulus | 65/1882 | 290/18723 | 3.95e-10 | 9.62e-08 | 65 |
| GO:19016536 | Liver | NAFLD | cellular response to peptide | 71/1882 | 359/18723 | 1.82e-08 | 2.09e-06 | 71 |
| GO:00070446 | Liver | NAFLD | cell-substrate junction assembly | 29/1882 | 95/18723 | 2.71e-08 | 2.86e-06 | 29 |
| GO:01501156 | Liver | NAFLD | cell-substrate junction organization | 30/1882 | 101/18723 | 3.15e-08 | 3.23e-06 | 30 |
| GO:00328695 | Liver | NAFLD | cellular response to insulin stimulus | 47/1882 | 203/18723 | 3.60e-08 | 3.63e-06 | 47 |
| Page: 1 2 3 4 5 6 7 8 9 10 11 12 13 14 15 16 17 18 19 20 21 22 23 24 25 26 27 28 |
| Enriched KEGG pathways. |
| Pathway ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | qvalue | Count |
| hsa04520 | Colorectum | AD | Adherens junction | 50/2092 | 93/8465 | 1.52e-09 | 2.83e-08 | 1.81e-08 | 50 |
| hsa045201 | Colorectum | AD | Adherens junction | 50/2092 | 93/8465 | 1.52e-09 | 2.83e-08 | 1.81e-08 | 50 |
| hsa045204 | Colorectum | MSS | Adherens junction | 42/1875 | 93/8465 | 6.18e-07 | 9.01e-06 | 5.52e-06 | 42 |
| hsa04910 | Colorectum | MSS | Insulin signaling pathway | 43/1875 | 137/8465 | 7.37e-03 | 2.84e-02 | 1.74e-02 | 43 |
| hsa045205 | Colorectum | MSS | Adherens junction | 42/1875 | 93/8465 | 6.18e-07 | 9.01e-06 | 5.52e-06 | 42 |
| hsa049101 | Colorectum | MSS | Insulin signaling pathway | 43/1875 | 137/8465 | 7.37e-03 | 2.84e-02 | 1.74e-02 | 43 |
| hsa045208 | Colorectum | FAP | Adherens junction | 45/1404 | 93/8465 | 8.66e-13 | 2.89e-10 | 1.76e-10 | 45 |
| hsa049102 | Colorectum | FAP | Insulin signaling pathway | 36/1404 | 137/8465 | 2.51e-03 | 1.18e-02 | 7.18e-03 | 36 |
| hsa045209 | Colorectum | FAP | Adherens junction | 45/1404 | 93/8465 | 8.66e-13 | 2.89e-10 | 1.76e-10 | 45 |
| hsa049103 | Colorectum | FAP | Insulin signaling pathway | 36/1404 | 137/8465 | 2.51e-03 | 1.18e-02 | 7.18e-03 | 36 |
| hsa0452010 | Colorectum | CRC | Adherens junction | 37/1091 | 93/8465 | 5.72e-11 | 6.37e-09 | 4.32e-09 | 37 |
| hsa0452011 | Colorectum | CRC | Adherens junction | 37/1091 | 93/8465 | 5.72e-11 | 6.37e-09 | 4.32e-09 | 37 |
| hsa0452025 | Endometrium | AEH | Adherens junction | 36/1197 | 93/8465 | 3.49e-09 | 5.98e-08 | 4.37e-08 | 36 |
| hsa04520111 | Endometrium | AEH | Adherens junction | 36/1197 | 93/8465 | 3.49e-09 | 5.98e-08 | 4.37e-08 | 36 |
| hsa0452026 | Endometrium | EEC | Adherens junction | 36/1237 | 93/8465 | 8.57e-09 | 1.48e-07 | 1.11e-07 | 36 |
| hsa0452035 | Endometrium | EEC | Adherens junction | 36/1237 | 93/8465 | 8.57e-09 | 1.48e-07 | 1.11e-07 | 36 |
| hsa0452030 | Esophagus | ESCC | Adherens junction | 69/4205 | 93/8465 | 1.08e-06 | 6.83e-06 | 3.50e-06 | 69 |
| hsa049109 | Esophagus | ESCC | Insulin signaling pathway | 89/4205 | 137/8465 | 1.97e-04 | 7.32e-04 | 3.75e-04 | 89 |
| hsa04520114 | Esophagus | ESCC | Adherens junction | 69/4205 | 93/8465 | 1.08e-06 | 6.83e-06 | 3.50e-06 | 69 |
| hsa0491014 | Esophagus | ESCC | Insulin signaling pathway | 89/4205 | 137/8465 | 1.97e-04 | 7.32e-04 | 3.75e-04 | 89 |
| Page: 1 2 3 |
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Cell-cell communication analysis |
| Identification of potential cell-cell interactions between two cell types and their ligand-receptor pairs for different disease states |
| Ligand | Receptor | LRpair | Pathway | Tissue | Disease Stage |
| Page: 1 |
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Single-cell gene regulatory network inference analysis |
| Find out the significant the regulons (TFs) and the target genes of each regulon across cell types for different disease states |
| TF | Cell Type | Tissue | Disease Stage | Target Gene | RSS | Regulon Activity |
| ∗The dot plots of a searched regulon are shown for all cell subpopulations in each disease state of each tissue based on the regulon specific score inferred using pySCENIC and by calculating the average expression. |
| Page: 1 |
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Somatic mutation of malignant transformation related genes |
| Annotation of somatic variants for genes involved in malignant transformation |
| Hugo Symbol | Variant Class | Variant Classification | dbSNP RS | HGVSc | HGVSp | HGVSp Short | SWISSPROT | BIOTYPE | SIFT | PolyPhen | Tumor Sample Barcode | Tissue | Histology | Sex | Age | Stage | Therapy Types | Drugs | Outcome |
| SORBS1 | SNV | Missense_Mutation | c.1105N>G | p.Ser369Gly | p.S369G | Q9BX66 | protein_coding | tolerated_low_confidence(0.05) | probably_damaging(0.981) | TCGA-A8-A08F-01 | Breast | breast invasive carcinoma | Female | <65 | III/IV | Chemotherapy | 5-fluorouracil | CR | |
| SORBS1 | SNV | Missense_Mutation | c.2548C>G | p.Leu850Val | p.L850V | Q9BX66 | protein_coding | deleterious(0.03) | benign(0.127) | TCGA-AC-A23H-01 | Breast | breast invasive carcinoma | Female | >=65 | I/II | Unknown | Unknown | PD | |
| SORBS1 | SNV | Missense_Mutation | rs764678128 | c.3127N>T | p.Arg1043Cys | p.R1043C | Q9BX66 | protein_coding | tolerated_low_confidence(0.17) | benign(0.232) | TCGA-AN-A046-01 | Breast | breast invasive carcinoma | Female | >=65 | I/II | Unknown | Unknown | SD |
| SORBS1 | SNV | Missense_Mutation | c.1558N>A | p.Asp520Asn | p.D520N | Q9BX66 | protein_coding | deleterious(0) | probably_damaging(0.999) | TCGA-BH-A0B4-01 | Breast | breast invasive carcinoma | Male | >=65 | III/IV | Hormone Therapy | tamoxiphen | SD | |
| SORBS1 | SNV | Missense_Mutation | c.1177N>A | p.Asp393Asn | p.D393N | Q9BX66 | protein_coding | deleterious(0) | probably_damaging(1) | TCGA-C8-A132-01 | Breast | breast invasive carcinoma | Female | <65 | I/II | Unknown | Unknown | SD | |
| SORBS1 | SNV | Missense_Mutation | rs542297924 | c.995N>T | p.Ser332Leu | p.S332L | Q9BX66 | protein_coding | deleterious_low_confidence(0.03) | benign(0.131) | TCGA-C8-A8HQ-01 | Breast | breast invasive carcinoma | Female | <65 | I/II | Unknown | Unknown | SD |
| SORBS1 | SNV | Missense_Mutation | c.2032N>A | p.Glu678Lys | p.E678K | Q9BX66 | protein_coding | deleterious(0) | probably_damaging(0.995) | TCGA-D8-A27G-01 | Breast | breast invasive carcinoma | Female | >=65 | I/II | Unknown | Unknown | SD | |
| SORBS1 | SNV | Missense_Mutation | c.2380N>A | p.Glu794Lys | p.E794K | Q9BX66 | protein_coding | deleterious(0.02) | possibly_damaging(0.613) | TCGA-EW-A1J5-01 | Breast | breast invasive carcinoma | Female | <65 | I/II | Chemotherapy | adriamycin | SD | |
| SORBS1 | SNV | Missense_Mutation | rs368416628 | c.3622N>T | p.Arg1208Trp | p.R1208W | Q9BX66 | protein_coding | tolerated_low_confidence(0.18) | benign(0.17) | TCGA-LL-A441-01 | Breast | breast invasive carcinoma | Female | <65 | I/II | Chemotherapy | taxotere | CR |
| SORBS1 | insertion | Frame_Shift_Ins | novel | c.548_549insAGTGACA | p.Gly184ValfsTer28 | p.G184Vfs*28 | Q9BX66 | protein_coding | TCGA-BH-A0H6-01 | Breast | breast invasive carcinoma | Female | >=65 | I/II | Unknown | Unknown | SD |
| Page: 1 2 3 4 5 6 7 8 9 10 11 12 13 14 |
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Related drugs of malignant transformation related genes |
| Identification of chemicals and drugs interact with genes involved in malignant transfromation |
| (DGIdb 4.0) |
| Entrez ID | Symbol | Category | Interaction Types | Drug Claim Name | Drug Name | PMIDs |
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