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Gene: RUVBL2 |
Gene summary for RUVBL2 |
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Gene information | Species | Human | Gene symbol | RUVBL2 | Gene ID | 10856 |
Gene name | RuvB like AAA ATPase 2 | |
Gene Alias | CGI-46 | |
Cytomap | 19q13.33 | |
Gene Type | protein-coding | GO ID | GO:0000491 | UniProtAcc | B3KNL2 |
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Malignant transformation analysis |
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Entrez ID | Symbol | Replicates | Species | Organ | Tissue | Adj P-value | Log2FC | Malignancy |
10856 | RUVBL2 | LZE2T | Human | Esophagus | ESCC | 2.79e-04 | 7.88e-01 | 0.082 |
10856 | RUVBL2 | LZE4T | Human | Esophagus | ESCC | 1.04e-18 | 5.46e-01 | 0.0811 |
10856 | RUVBL2 | LZE5T | Human | Esophagus | ESCC | 8.00e-08 | 4.66e-01 | 0.0514 |
10856 | RUVBL2 | LZE7T | Human | Esophagus | ESCC | 6.05e-19 | 6.92e-01 | 0.0667 |
10856 | RUVBL2 | LZE8T | Human | Esophagus | ESCC | 2.18e-12 | 4.43e-01 | 0.067 |
10856 | RUVBL2 | LZE20T | Human | Esophagus | ESCC | 4.86e-11 | 3.58e-01 | 0.0662 |
10856 | RUVBL2 | LZE22D1 | Human | Esophagus | HGIN | 1.97e-02 | 1.14e-01 | 0.0595 |
10856 | RUVBL2 | LZE22T | Human | Esophagus | ESCC | 8.64e-07 | 6.56e-01 | 0.068 |
10856 | RUVBL2 | LZE24T | Human | Esophagus | ESCC | 6.25e-37 | 8.43e-01 | 0.0596 |
10856 | RUVBL2 | LZE21T | Human | Esophagus | ESCC | 3.38e-12 | 6.17e-01 | 0.0655 |
10856 | RUVBL2 | LZE6T | Human | Esophagus | ESCC | 5.14e-10 | 4.97e-01 | 0.0845 |
10856 | RUVBL2 | P1T-E | Human | Esophagus | ESCC | 1.39e-19 | 6.47e-01 | 0.0875 |
10856 | RUVBL2 | P2T-E | Human | Esophagus | ESCC | 3.44e-40 | 8.03e-01 | 0.1177 |
10856 | RUVBL2 | P4T-E | Human | Esophagus | ESCC | 2.49e-49 | 1.13e+00 | 0.1323 |
10856 | RUVBL2 | P5T-E | Human | Esophagus | ESCC | 1.36e-38 | 8.04e-01 | 0.1327 |
10856 | RUVBL2 | P8T-E | Human | Esophagus | ESCC | 1.73e-77 | 1.47e+00 | 0.0889 |
10856 | RUVBL2 | P9T-E | Human | Esophagus | ESCC | 4.15e-29 | 5.09e-01 | 0.1131 |
10856 | RUVBL2 | P10T-E | Human | Esophagus | ESCC | 2.78e-61 | 1.20e+00 | 0.116 |
10856 | RUVBL2 | P11T-E | Human | Esophagus | ESCC | 5.88e-32 | 9.09e-01 | 0.1426 |
10856 | RUVBL2 | P12T-E | Human | Esophagus | ESCC | 2.01e-51 | 1.01e+00 | 0.1122 |
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∗log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage. |
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Malignant transformation related pathway analysis |
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Tissue | Disease Stage | Enriched GO biological Processes |
Colorectum | AD | ![]() |
Colorectum | SER | ![]() |
Colorectum | MSS | ![]() |
Colorectum | MSI-H | ![]() |
Colorectum | FAP | ![]() |
∗Top 15 enriched GO BP terms are showed in the bar plot of each disease state in each tissue. Each row represents a significant GO biological process which is colored according to the -log10(p.adjust). |
Page: 1 2 3 4 5 6 7 8 9 |
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GO ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | Count |
GO:001657312 | Oral cavity | LP | histone acetylation | 60/4623 | 152/18723 | 3.80e-05 | 5.61e-04 | 60 |
GO:001657014 | Oral cavity | LP | histone modification | 152/4623 | 463/18723 | 4.04e-05 | 5.90e-04 | 152 |
GO:004396711 | Oral cavity | LP | histone H4 acetylation | 31/4623 | 67/18723 | 9.80e-05 | 1.22e-03 | 31 |
GO:001605515 | Oral cavity | LP | Wnt signaling pathway | 140/4623 | 444/18723 | 5.80e-04 | 5.35e-03 | 140 |
GO:019873815 | Oral cavity | LP | cell-cell signaling by wnt | 140/4623 | 446/18723 | 7.12e-04 | 6.38e-03 | 140 |
GO:007019913 | Oral cavity | LP | establishment of protein localization to chromosome | 14/4623 | 25/18723 | 7.95e-04 | 7.01e-03 | 14 |
GO:003235516 | Oral cavity | LP | response to estradiol | 52/4623 | 141/18723 | 8.28e-04 | 7.24e-03 | 52 |
GO:003105613 | Oral cavity | LP | regulation of histone modification | 55/4623 | 152/18723 | 1.01e-03 | 8.48e-03 | 55 |
GO:00310581 | Oral cavity | LP | positive regulation of histone modification | 36/4623 | 92/18723 | 1.51e-03 | 1.18e-02 | 36 |
GO:190198312 | Oral cavity | LP | regulation of protein acetylation | 31/4623 | 77/18723 | 1.83e-03 | 1.38e-02 | 31 |
GO:200075612 | Oral cavity | LP | regulation of peptidyl-lysine acetylation | 26/4623 | 63/18723 | 2.75e-03 | 1.93e-02 | 26 |
GO:006082815 | Oral cavity | LP | regulation of canonical Wnt signaling pathway | 82/4623 | 253/18723 | 3.23e-03 | 2.18e-02 | 82 |
GO:00004921 | Oral cavity | LP | box C/D snoRNP assembly | 7/4623 | 10/18723 | 3.24e-03 | 2.18e-02 | 7 |
GO:003011115 | Oral cavity | LP | regulation of Wnt signaling pathway | 103/4623 | 328/18723 | 3.29e-03 | 2.21e-02 | 103 |
GO:006007015 | Oral cavity | LP | canonical Wnt signaling pathway | 94/4623 | 303/18723 | 6.97e-03 | 3.96e-02 | 94 |
GO:003239213 | Oral cavity | LP | DNA geometric change | 33/4623 | 90/18723 | 7.51e-03 | 4.15e-02 | 33 |
GO:007259425 | Oral cavity | EOLP | establishment of protein localization to organelle | 108/2218 | 422/18723 | 2.91e-15 | 1.45e-12 | 108 |
GO:007182626 | Oral cavity | EOLP | ribonucleoprotein complex subunit organization | 62/2218 | 227/18723 | 1.42e-10 | 1.52e-08 | 62 |
GO:000640323 | Oral cavity | EOLP | RNA localization | 57/2218 | 201/18723 | 1.62e-10 | 1.68e-08 | 57 |
GO:000645725 | Oral cavity | EOLP | protein folding | 59/2218 | 212/18723 | 1.76e-10 | 1.79e-08 | 59 |
Page: 1 2 3 4 5 6 7 8 9 10 11 12 13 14 15 16 17 18 19 20 21 22 |
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Pathway ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | qvalue | Count |
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Cell-cell communication analysis |
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Ligand | Receptor | LRpair | Pathway | Tissue | Disease Stage |
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Single-cell gene regulatory network inference analysis |
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TF | Cell Type | Tissue | Disease Stage | Target Gene | RSS | Regulon Activity |
∗The dot plots of a searched regulon are shown for all cell subpopulations in each disease state of each tissue based on the regulon specific score inferred using pySCENIC and by calculating the average expression. |
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Somatic mutation of malignant transformation related genes |
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Hugo Symbol | Variant Class | Variant Classification | dbSNP RS | HGVSc | HGVSp | HGVSp Short | SWISSPROT | BIOTYPE | SIFT | PolyPhen | Tumor Sample Barcode | Tissue | Histology | Sex | Age | Stage | Therapy Types | Drugs | Outcome |
RUVBL2 | SNV | Missense_Mutation | c.634N>A | p.Ala212Thr | p.A212T | Q9Y230 | protein_coding | deleterious(0.03) | benign(0.125) | TCGA-AN-A0AK-01 | Breast | breast invasive carcinoma | Female | >=65 | I/II | Unknown | Unknown | SD | |
RUVBL2 | deletion | Frame_Shift_Del | novel | c.71delN | p.His25ThrfsTer38 | p.H25Tfs*38 | Q9Y230 | protein_coding | TCGA-D8-A27V-01 | Breast | breast invasive carcinoma | Female | <65 | I/II | Hormone Therapy | tamoxiphen | SD | ||
RUVBL2 | SNV | Missense_Mutation | c.388N>T | p.Arg130Cys | p.R130C | Q9Y230 | protein_coding | deleterious(0) | probably_damaging(0.986) | TCGA-2W-A8YY-01 | Cervix | cervical & endocervical cancer | Female | <65 | I/II | Chemotherapy | cisplatin | CR | |
RUVBL2 | SNV | Missense_Mutation | c.1054N>A | p.Asp352Asn | p.D352N | Q9Y230 | protein_coding | deleterious(0) | probably_damaging(0.989) | TCGA-AA-3660-01 | Colorectum | colon adenocarcinoma | Female | <65 | I/II | Unknown | Unknown | SD | |
RUVBL2 | SNV | Missense_Mutation | c.1006C>T | p.Arg336Trp | p.R336W | Q9Y230 | protein_coding | deleterious(0) | probably_damaging(1) | TCGA-AA-3864-01 | Colorectum | colon adenocarcinoma | Male | >=65 | I/II | Unknown | Unknown | SD | |
RUVBL2 | SNV | Missense_Mutation | c.634G>A | p.Ala212Thr | p.A212T | Q9Y230 | protein_coding | deleterious(0.03) | benign(0.125) | TCGA-AA-A010-01 | Colorectum | colon adenocarcinoma | Female | <65 | I/II | Chemotherapy | folinic | CR | |
RUVBL2 | SNV | Missense_Mutation | rs767467214 | c.1198N>T | p.Arg400Cys | p.R400C | Q9Y230 | protein_coding | deleterious(0) | probably_damaging(1) | TCGA-CK-4951-01 | Colorectum | colon adenocarcinoma | Female | >=65 | I/II | Unknown | Unknown | PD |
RUVBL2 | SNV | Missense_Mutation | c.599N>T | p.Gly200Val | p.G200V | Q9Y230 | protein_coding | deleterious(0) | probably_damaging(0.998) | TCGA-G4-6304-01 | Colorectum | colon adenocarcinoma | Female | >=65 | I/II | Chemotherapy | fluorouracil | PD | |
RUVBL2 | SNV | Missense_Mutation | rs761782658 | c.272N>T | p.Ala91Val | p.A91V | Q9Y230 | protein_coding | deleterious(0) | probably_damaging(0.976) | TCGA-EI-6507-01 | Colorectum | rectum adenocarcinoma | Male | <65 | I/II | Unknown | Unknown | SD |
RUVBL2 | SNV | Missense_Mutation | c.517N>A | p.Asp173Asn | p.D173N | Q9Y230 | protein_coding | tolerated(0.05) | probably_damaging(0.986) | TCGA-EI-6507-01 | Colorectum | rectum adenocarcinoma | Male | <65 | I/II | Unknown | Unknown | SD |
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Related drugs of malignant transformation related genes |
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(DGIdb 4.0) |
Entrez ID | Symbol | Category | Interaction Types | Drug Claim Name | Drug Name | PMIDs |
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