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Gene: RBPJ |
Gene summary for RBPJ |
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Gene information | Species | Human | Gene symbol | RBPJ | Gene ID | 3516 |
Gene name | recombination signal binding protein for immunoglobulin kappa J region | |
Gene Alias | AOS3 | |
Cytomap | 4p15.2 | |
Gene Type | protein-coding | GO ID | GO:0000003 | UniProtAcc | Q06330 |
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Malignant transformation analysis |
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Entrez ID | Symbol | Replicates | Species | Organ | Tissue | Adj P-value | Log2FC | Malignancy |
3516 | RBPJ | LZE2T | Human | Esophagus | ESCC | 1.28e-12 | 4.94e-01 | 0.082 |
3516 | RBPJ | LZE3D | Human | Esophagus | HGIN | 4.44e-04 | 4.43e-01 | 0.0668 |
3516 | RBPJ | LZE4T | Human | Esophagus | ESCC | 1.15e-04 | 2.85e-01 | 0.0811 |
3516 | RBPJ | LZE7T | Human | Esophagus | ESCC | 1.37e-03 | 5.57e-01 | 0.0667 |
3516 | RBPJ | LZE8T | Human | Esophagus | ESCC | 1.34e-07 | 2.53e-01 | 0.067 |
3516 | RBPJ | LZE20T | Human | Esophagus | ESCC | 2.16e-07 | 1.59e-01 | 0.0662 |
3516 | RBPJ | LZE22D1 | Human | Esophagus | HGIN | 5.77e-04 | 2.03e-02 | 0.0595 |
3516 | RBPJ | LZE22T | Human | Esophagus | ESCC | 2.45e-02 | 3.96e-02 | 0.068 |
3516 | RBPJ | LZE24T | Human | Esophagus | ESCC | 3.44e-13 | 2.17e-01 | 0.0596 |
3516 | RBPJ | LZE21T | Human | Esophagus | ESCC | 7.37e-04 | 1.26e-01 | 0.0655 |
3516 | RBPJ | LZE6T | Human | Esophagus | ESCC | 6.25e-08 | 2.68e-01 | 0.0845 |
3516 | RBPJ | P1T-E | Human | Esophagus | ESCC | 7.56e-07 | 1.87e-01 | 0.0875 |
3516 | RBPJ | P2T-E | Human | Esophagus | ESCC | 5.84e-26 | 5.97e-01 | 0.1177 |
3516 | RBPJ | P4T-E | Human | Esophagus | ESCC | 1.93e-20 | 5.60e-01 | 0.1323 |
3516 | RBPJ | P5T-E | Human | Esophagus | ESCC | 5.96e-20 | 1.18e-01 | 0.1327 |
3516 | RBPJ | P8T-E | Human | Esophagus | ESCC | 1.06e-21 | 7.23e-01 | 0.0889 |
3516 | RBPJ | P9T-E | Human | Esophagus | ESCC | 6.13e-13 | 2.29e-01 | 0.1131 |
3516 | RBPJ | P10T-E | Human | Esophagus | ESCC | 7.18e-26 | 6.12e-01 | 0.116 |
3516 | RBPJ | P11T-E | Human | Esophagus | ESCC | 1.96e-14 | 6.07e-01 | 0.1426 |
3516 | RBPJ | P12T-E | Human | Esophagus | ESCC | 3.10e-16 | 5.14e-01 | 0.1122 |
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∗log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage. |
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Malignant transformation related pathway analysis |
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Tissue | Disease Stage | Enriched GO biological Processes |
Colorectum | AD | ![]() |
Colorectum | SER | ![]() |
Colorectum | MSS | ![]() |
Colorectum | MSI-H | ![]() |
Colorectum | FAP | ![]() |
∗Top 15 enriched GO BP terms are showed in the bar plot of each disease state in each tissue. Each row represents a significant GO biological process which is colored according to the -log10(p.adjust). |
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GO ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | Count |
GO:004592710 | Oral cavity | OSCC | positive regulation of growth | 125/7305 | 259/18723 | 1.44e-03 | 6.97e-03 | 125 |
GO:00605416 | Oral cavity | OSCC | respiratory system development | 100/7305 | 203/18723 | 1.83e-03 | 8.60e-03 | 100 |
GO:00071789 | Oral cavity | OSCC | transmembrane receptor protein serine/threonine kinase signaling pathway | 165/7305 | 355/18723 | 2.31e-03 | 1.02e-02 | 165 |
GO:00454453 | Oral cavity | OSCC | myoblast differentiation | 46/7305 | 84/18723 | 2.43e-03 | 1.07e-02 | 46 |
GO:00605378 | Oral cavity | OSCC | muscle tissue development | 185/7305 | 403/18723 | 2.60e-03 | 1.14e-02 | 185 |
GO:00454469 | Oral cavity | OSCC | endothelial cell differentiation | 61/7305 | 118/18723 | 3.40e-03 | 1.44e-02 | 61 |
GO:00426927 | Oral cavity | OSCC | muscle cell differentiation | 175/7305 | 384/18723 | 4.79e-03 | 1.92e-02 | 175 |
GO:0048820 | Oral cavity | OSCC | hair follicle maturation | 10/7305 | 13/18723 | 6.32e-03 | 2.35e-02 | 10 |
GO:00147067 | Oral cavity | OSCC | striated muscle tissue development | 174/7305 | 384/18723 | 6.45e-03 | 2.40e-02 | 174 |
GO:00605629 | Oral cavity | OSCC | epithelial tube morphogenesis | 149/7305 | 325/18723 | 6.73e-03 | 2.50e-02 | 149 |
GO:00480132 | Oral cavity | OSCC | ephrin receptor signaling pathway | 29/7305 | 51/18723 | 7.33e-03 | 2.71e-02 | 29 |
GO:01061065 | Oral cavity | OSCC | cold-induced thermogenesis | 71/7305 | 144/18723 | 7.51e-03 | 2.75e-02 | 71 |
GO:01201615 | Oral cavity | OSCC | regulation of cold-induced thermogenesis | 71/7305 | 144/18723 | 7.51e-03 | 2.75e-02 | 71 |
GO:00016594 | Oral cavity | OSCC | temperature homeostasis | 84/7305 | 174/18723 | 7.84e-03 | 2.87e-02 | 84 |
GO:00487713 | Oral cavity | OSCC | tissue remodeling | 84/7305 | 175/18723 | 9.39e-03 | 3.36e-02 | 84 |
GO:19908454 | Oral cavity | OSCC | adaptive thermogenesis | 76/7305 | 157/18723 | 1.02e-02 | 3.52e-02 | 76 |
GO:00330024 | Oral cavity | OSCC | muscle cell proliferation | 115/7305 | 248/18723 | 1.05e-02 | 3.58e-02 | 115 |
GO:00487627 | Oral cavity | OSCC | mesenchymal cell differentiation | 109/7305 | 236/18723 | 1.43e-02 | 4.69e-02 | 109 |
GO:00488637 | Oral cavity | OSCC | stem cell differentiation | 96/7305 | 206/18723 | 1.55e-02 | 4.99e-02 | 96 |
GO:000170117 | Oral cavity | LP | in utero embryonic development | 142/4623 | 367/18723 | 1.48e-09 | 6.75e-08 | 142 |
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Pathway ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | qvalue | Count |
hsa0501727 | Esophagus | HGIN | Spinocerebellar ataxia | 43/1383 | 143/8465 | 2.68e-05 | 3.64e-04 | 2.89e-04 | 43 |
hsa0516930 | Esophagus | HGIN | Epstein-Barr virus infection | 55/1383 | 202/8465 | 5.13e-05 | 6.19e-04 | 4.92e-04 | 55 |
hsa052039 | Esophagus | HGIN | Viral carcinogenesis | 53/1383 | 204/8465 | 2.58e-04 | 2.71e-03 | 2.15e-03 | 53 |
hsa05017112 | Esophagus | HGIN | Spinocerebellar ataxia | 43/1383 | 143/8465 | 2.68e-05 | 3.64e-04 | 2.89e-04 | 43 |
hsa05169114 | Esophagus | HGIN | Epstein-Barr virus infection | 55/1383 | 202/8465 | 5.13e-05 | 6.19e-04 | 4.92e-04 | 55 |
hsa0520315 | Esophagus | HGIN | Viral carcinogenesis | 53/1383 | 204/8465 | 2.58e-04 | 2.71e-03 | 2.15e-03 | 53 |
hsa05169210 | Esophagus | ESCC | Epstein-Barr virus infection | 151/4205 | 202/8465 | 1.55e-13 | 3.45e-12 | 1.77e-12 | 151 |
hsa0516510 | Esophagus | ESCC | Human papillomavirus infection | 215/4205 | 331/8465 | 7.86e-09 | 7.12e-08 | 3.65e-08 | 215 |
hsa0520325 | Esophagus | ESCC | Viral carcinogenesis | 137/4205 | 204/8465 | 2.47e-07 | 1.88e-06 | 9.62e-07 | 137 |
hsa0501728 | Esophagus | ESCC | Spinocerebellar ataxia | 94/4205 | 143/8465 | 6.77e-05 | 2.90e-04 | 1.48e-04 | 94 |
hsa043306 | Esophagus | ESCC | Notch signaling pathway | 42/4205 | 62/8465 | 2.97e-03 | 7.97e-03 | 4.08e-03 | 42 |
hsa046585 | Esophagus | ESCC | Th1 and Th2 cell differentiation | 58/4205 | 92/8465 | 6.49e-03 | 1.60e-02 | 8.19e-03 | 58 |
hsa0516937 | Esophagus | ESCC | Epstein-Barr virus infection | 151/4205 | 202/8465 | 1.55e-13 | 3.45e-12 | 1.77e-12 | 151 |
hsa0516515 | Esophagus | ESCC | Human papillomavirus infection | 215/4205 | 331/8465 | 7.86e-09 | 7.12e-08 | 3.65e-08 | 215 |
hsa0520335 | Esophagus | ESCC | Viral carcinogenesis | 137/4205 | 204/8465 | 2.47e-07 | 1.88e-06 | 9.62e-07 | 137 |
hsa0501736 | Esophagus | ESCC | Spinocerebellar ataxia | 94/4205 | 143/8465 | 6.77e-05 | 2.90e-04 | 1.48e-04 | 94 |
hsa0433013 | Esophagus | ESCC | Notch signaling pathway | 42/4205 | 62/8465 | 2.97e-03 | 7.97e-03 | 4.08e-03 | 42 |
hsa0465812 | Esophagus | ESCC | Th1 and Th2 cell differentiation | 58/4205 | 92/8465 | 6.49e-03 | 1.60e-02 | 8.19e-03 | 58 |
hsa0501710 | Liver | Cirrhotic | Spinocerebellar ataxia | 66/2530 | 143/8465 | 2.58e-05 | 2.15e-04 | 1.32e-04 | 66 |
hsa05165 | Liver | Cirrhotic | Human papillomavirus infection | 124/2530 | 331/8465 | 1.55e-03 | 7.83e-03 | 4.83e-03 | 124 |
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Cell-cell communication analysis |
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Ligand | Receptor | LRpair | Pathway | Tissue | Disease Stage |
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Single-cell gene regulatory network inference analysis |
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∗The dot plots of a searched regulon are shown for all cell subpopulations in each disease state of each tissue based on the regulon specific score inferred using pySCENIC and by calculating the average expression. |
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Somatic mutation of malignant transformation related genes |
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Hugo Symbol | Variant Class | Variant Classification | dbSNP RS | HGVSc | HGVSp | HGVSp Short | SWISSPROT | BIOTYPE | SIFT | PolyPhen | Tumor Sample Barcode | Tissue | Histology | Sex | Age | Stage | Therapy Types | Drugs | Outcome |
RBPJ | SNV | Missense_Mutation | c.1118N>C | p.Leu373Pro | p.L373P | Q06330 | protein_coding | deleterious(0.03) | probably_damaging(0.99) | TCGA-BH-A0E9-01 | Breast | breast invasive carcinoma | Female | <65 | I/II | Chemotherapy | taxotere | CR | |
RBPJ | SNV | Missense_Mutation | rs141690523 | c.110G>A | p.Arg37Gln | p.R37Q | Q06330 | protein_coding | tolerated(0.22) | benign(0.006) | TCGA-A6-6141-01 | Colorectum | colon adenocarcinoma | Male | <65 | I/II | Chemotherapy | 5-fu | SD |
RBPJ | SNV | Missense_Mutation | rs750670227 | c.31G>A | p.Glu11Lys | p.E11K | Q06330 | protein_coding | tolerated_low_confidence(0.48) | benign(0.001) | TCGA-AZ-6599-01 | Colorectum | colon adenocarcinoma | Male | >=65 | I/II | Unknown | Unknown | SD |
RBPJ | SNV | Missense_Mutation | c.149N>G | p.Ile50Ser | p.I50S | Q06330 | protein_coding | deleterious(0) | probably_damaging(0.988) | TCGA-CA-6717-01 | Colorectum | colon adenocarcinoma | Male | <65 | I/II | Chemotherapy | oxaliplatin | CR | |
RBPJ | SNV | Missense_Mutation | rs141690523 | c.110G>A | p.Arg37Gln | p.R37Q | Q06330 | protein_coding | tolerated(0.22) | benign(0.006) | TCGA-CA-6718-01 | Colorectum | colon adenocarcinoma | Male | <65 | I/II | Unknown | Unknown | PD |
RBPJ | SNV | Missense_Mutation | rs141690523 | c.110G>A | p.Arg37Gln | p.R37Q | Q06330 | protein_coding | tolerated(0.22) | benign(0.006) | TCGA-AG-3892-01 | Colorectum | rectum adenocarcinoma | Female | <65 | I/II | Unknown | Unknown | SD |
RBPJ | SNV | Missense_Mutation | c.965T>C | p.Ile322Thr | p.I322T | Q06330 | protein_coding | deleterious(0) | probably_damaging(0.944) | TCGA-AG-3892-01 | Colorectum | rectum adenocarcinoma | Female | <65 | I/II | Unknown | Unknown | SD | |
RBPJ | SNV | Missense_Mutation | novel | c.455N>G | p.Asp152Gly | p.D152G | Q06330 | protein_coding | deleterious(0.01) | possibly_damaging(0.615) | TCGA-AG-A002-01 | Colorectum | rectum adenocarcinoma | Male | <65 | I/II | Unknown | Unknown | SD |
RBPJ | SNV | Missense_Mutation | novel | c.746N>C | p.Lys249Thr | p.K249T | Q06330 | protein_coding | tolerated(0.06) | probably_damaging(1) | TCGA-AG-A002-01 | Colorectum | rectum adenocarcinoma | Male | <65 | I/II | Unknown | Unknown | SD |
RBPJ | SNV | Missense_Mutation | novel | c.790A>C | p.Ile264Leu | p.I264L | Q06330 | protein_coding | deleterious(0) | possibly_damaging(0.875) | TCGA-F5-6814-01 | Colorectum | rectum adenocarcinoma | Male | <65 | I/II | Unknown | Unknown | SD |
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Related drugs of malignant transformation related genes |
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(DGIdb 4.0) |
Entrez ID | Symbol | Category | Interaction Types | Drug Claim Name | Drug Name | PMIDs |
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