Tissue | Expression Dynamics | Abbreviation |
Cervix | ![The image shows the transcriptomic changes along malignancy continuum.log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage.](images/deg_images/Cervix/NDUFS7_pca_on_diff_genes.png) | CC: Cervix cancer |
HSIL_HPV: HPV-infected high-grade squamous intraepithelial lesions |
N_HPV: HPV-infected normal cervix |
Esophagus | ![The image shows the transcriptomic changes along malignancy continuum.log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage.](images/deg_images/Esophagus/NDUFS7_pca_on_diff_genes.png) | ESCC: Esophageal squamous cell carcinoma |
HGIN: High-grade intraepithelial neoplasias |
LGIN: Low-grade intraepithelial neoplasias |
GC | ![The image shows the transcriptomic changes along malignancy continuum.log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage.](images/deg_images/GC/NDUFS7_pca_on_diff_genes.png) | CAG: Chronic atrophic gastritis |
CAG with IM: Chronic atrophic gastritis with intestinal metaplasia |
CSG: Chronic superficial gastritis |
GC: Gastric cancer |
SIM: Severe intestinal metaplasia |
WIM: Wild intestinal metaplasia |
Liver | ![The image shows the transcriptomic changes along malignancy continuum.log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage.](images/deg_images/Liver/NDUFS7_pca_on_diff_genes.png) | HCC: Hepatocellular carcinoma |
NAFLD: Non-alcoholic fatty liver disease |
Oral Cavity | ![The image shows the transcriptomic changes along malignancy continuum.log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage.](images/deg_images/OralCavity/NDUFS7_pca_on_diff_genes.png) | EOLP: Erosive Oral lichen planus |
LP: leukoplakia |
NEOLP: Non-erosive oral lichen planus |
OSCC: Oral squamous cell carcinoma |
Prostate | ![The image shows the transcriptomic changes along malignancy continuum.log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage.](images/deg_images/Prostate/NDUFS7_pca_on_diff_genes.png) | BPH: Benign Prostatic Hyperplasia |
Skin | ![The image shows the transcriptomic changes along malignancy continuum.log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage.](images/deg_images/Skin/NDUFS7_pca_on_diff_genes.png) | AK: Actinic keratosis |
cSCC: Cutaneous squamous cell carcinoma |
SCCIS:squamous cell carcinoma in situ |
Thyroid | ![The image shows the transcriptomic changes along malignancy continuum.log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage.](images/deg_images/Thyroid/NDUFS7_pca_on_diff_genes.png) | ATC: Anaplastic thyroid cancer |
HT: Hashimoto's thyroiditis |
PTC: Papillary thyroid cancer |
GO ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | Count |
GO:00229045 | Stomach | SIM | respiratory electron transport chain | 28/708 | 114/18723 | 1.41e-15 | 7.40e-13 | 28 |
GO:000609151 | Stomach | SIM | generation of precursor metabolites and energy | 58/708 | 490/18723 | 1.10e-14 | 5.18e-12 | 58 |
GO:00090605 | Stomach | SIM | aerobic respiration | 32/708 | 189/18723 | 9.30e-13 | 3.37e-10 | 32 |
GO:00453335 | Stomach | SIM | cellular respiration | 34/708 | 230/18723 | 9.47e-12 | 3.19e-09 | 34 |
GO:00159805 | Stomach | SIM | energy derivation by oxidation of organic compounds | 40/708 | 318/18723 | 2.55e-11 | 7.53e-09 | 40 |
GO:00061205 | Stomach | SIM | mitochondrial electron transport, NADH to ubiquinone | 16/708 | 51/18723 | 3.08e-11 | 8.56e-09 | 16 |
GO:00102575 | Stomach | SIM | NADH dehydrogenase complex assembly | 15/708 | 57/18723 | 2.01e-09 | 2.79e-07 | 15 |
GO:00329815 | Stomach | SIM | mitochondrial respiratory chain complex I assembly | 15/708 | 57/18723 | 2.01e-09 | 2.79e-07 | 15 |
GO:00331085 | Stomach | SIM | mitochondrial respiratory chain complex assembly | 17/708 | 93/18723 | 6.41e-08 | 6.30e-06 | 17 |
GO:19026005 | Stomach | SIM | proton transmembrane transport | 17/708 | 157/18723 | 9.59e-05 | 2.37e-03 | 17 |
GO:004277327 | Thyroid | HT | ATP synthesis coupled electron transport | 37/1272 | 95/18723 | 2.53e-19 | 4.69e-16 | 37 |
GO:004277527 | Thyroid | HT | mitochondrial ATP synthesis coupled electron transport | 37/1272 | 95/18723 | 2.53e-19 | 4.69e-16 | 37 |
GO:001964627 | Thyroid | HT | aerobic electron transport chain | 35/1272 | 87/18723 | 6.82e-19 | 7.59e-16 | 35 |
GO:002290427 | Thyroid | HT | respiratory electron transport chain | 38/1272 | 114/18723 | 4.07e-17 | 2.83e-14 | 38 |
GO:000611927 | Thyroid | HT | oxidative phosphorylation | 42/1272 | 141/18723 | 9.39e-17 | 5.80e-14 | 42 |
GO:004603429 | Thyroid | HT | ATP metabolic process | 61/1272 | 277/18723 | 1.37e-16 | 7.63e-14 | 61 |
GO:000906027 | Thyroid | HT | aerobic respiration | 47/1272 | 189/18723 | 3.35e-15 | 1.10e-12 | 47 |
GO:002290027 | Thyroid | HT | electron transport chain | 44/1272 | 175/18723 | 1.67e-14 | 4.89e-12 | 44 |
GO:004533327 | Thyroid | HT | cellular respiration | 49/1272 | 230/18723 | 5.19e-13 | 1.26e-10 | 49 |
GO:001598027 | Thyroid | HT | energy derivation by oxidation of organic compounds | 57/1272 | 318/18723 | 1.27e-11 | 2.20e-09 | 57 |
Pathway ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | qvalue | Count |
hsa0520820 | Cervix | CC | Chemical carcinogenesis - reactive oxygen species | 92/1267 | 223/8465 | 4.71e-22 | 5.09e-20 | 3.01e-20 | 92 |
hsa0501220 | Cervix | CC | Parkinson disease | 102/1267 | 266/8465 | 1.81e-21 | 1.47e-19 | 8.66e-20 | 102 |
hsa0019018 | Cervix | CC | Oxidative phosphorylation | 64/1267 | 134/8465 | 1.25e-19 | 8.07e-18 | 4.77e-18 | 64 |
hsa0502018 | Cervix | CC | Prion disease | 98/1267 | 273/8465 | 2.64e-18 | 1.42e-16 | 8.42e-17 | 98 |
hsa0541520 | Cervix | CC | Diabetic cardiomyopathy | 76/1267 | 203/8465 | 1.40e-15 | 6.46e-14 | 3.82e-14 | 76 |
hsa0501018 | Cervix | CC | Alzheimer disease | 113/1267 | 384/8465 | 9.67e-14 | 3.92e-12 | 2.32e-12 | 113 |
hsa0501618 | Cervix | CC | Huntington disease | 94/1267 | 306/8465 | 8.49e-13 | 3.06e-11 | 1.81e-11 | 94 |
hsa0502218 | Cervix | CC | Pathways of neurodegeneration - multiple diseases | 128/1267 | 476/8465 | 2.87e-12 | 9.29e-11 | 5.50e-11 | 128 |
hsa0493218 | Cervix | CC | Non-alcoholic fatty liver disease | 58/1267 | 155/8465 | 3.58e-12 | 1.05e-10 | 6.23e-11 | 58 |
hsa0471420 | Cervix | CC | Thermogenesis | 76/1267 | 232/8465 | 4.29e-12 | 1.16e-10 | 6.85e-11 | 76 |
hsa0501418 | Cervix | CC | Amyotrophic lateral sclerosis | 103/1267 | 364/8465 | 1.79e-11 | 4.47e-10 | 2.64e-10 | 103 |
hsa0472318 | Cervix | CC | Retrograde endocannabinoid signaling | 42/1267 | 148/8465 | 1.79e-05 | 1.42e-04 | 8.40e-05 | 42 |
hsa05208110 | Cervix | CC | Chemical carcinogenesis - reactive oxygen species | 92/1267 | 223/8465 | 4.71e-22 | 5.09e-20 | 3.01e-20 | 92 |
hsa05012110 | Cervix | CC | Parkinson disease | 102/1267 | 266/8465 | 1.81e-21 | 1.47e-19 | 8.66e-20 | 102 |
hsa0019019 | Cervix | CC | Oxidative phosphorylation | 64/1267 | 134/8465 | 1.25e-19 | 8.07e-18 | 4.77e-18 | 64 |
hsa0502019 | Cervix | CC | Prion disease | 98/1267 | 273/8465 | 2.64e-18 | 1.42e-16 | 8.42e-17 | 98 |
hsa05415110 | Cervix | CC | Diabetic cardiomyopathy | 76/1267 | 203/8465 | 1.40e-15 | 6.46e-14 | 3.82e-14 | 76 |
hsa0501019 | Cervix | CC | Alzheimer disease | 113/1267 | 384/8465 | 9.67e-14 | 3.92e-12 | 2.32e-12 | 113 |
hsa0501619 | Cervix | CC | Huntington disease | 94/1267 | 306/8465 | 8.49e-13 | 3.06e-11 | 1.81e-11 | 94 |
hsa0502219 | Cervix | CC | Pathways of neurodegeneration - multiple diseases | 128/1267 | 476/8465 | 2.87e-12 | 9.29e-11 | 5.50e-11 | 128 |
Hugo Symbol | Variant Class | Variant Classification | dbSNP RS | HGVSc | HGVSp | HGVSp Short | SWISSPROT | BIOTYPE | SIFT | PolyPhen | Tumor Sample Barcode | Tissue | Histology | Sex | Age | Stage | Therapy Types | Drugs | Outcome |
NDUFS7 | deletion | Frame_Shift_Del | novel | c.625delN | p.Ile209SerfsTer? | p.I209Sfs*? | O75251 | protein_coding | | | TCGA-EW-A2FV-01 | Breast | breast invasive carcinoma | Female | <65 | III/IV | Chemotherapy | docetaxel | SD |
NDUFS7 | SNV | Missense_Mutation | | c.627N>G | p.Ile209Met | p.I209M | O75251 | protein_coding | tolerated_low_confidence(0.74) | benign(0.003) | TCGA-CK-4951-01 | Colorectum | colon adenocarcinoma | Female | >=65 | I/II | Unknown | Unknown | PD |
NDUFS7 | SNV | Missense_Mutation | | c.332N>A | p.Arg111His | p.R111H | O75251 | protein_coding | deleterious_low_confidence(0.03) | probably_damaging(1) | TCGA-F4-6703-01 | Colorectum | colon adenocarcinoma | Male | <65 | I/II | Unknown | Unknown | SD |
NDUFS7 | SNV | Missense_Mutation | rs778260862 | c.29N>A | p.Arg10His | p.R10H | O75251 | protein_coding | tolerated_low_confidence(0.14) | benign(0.13) | TCGA-G4-6320-01 | Colorectum | colon adenocarcinoma | Male | >=65 | III/IV | Chemotherapy | oxaliplatin | SD |
NDUFS7 | SNV | Missense_Mutation | rs769398012 | c.614N>A | p.Arg205Gln | p.R205Q | O75251 | protein_coding | tolerated_low_confidence(0.13) | benign(0.001) | TCGA-EI-6882-01 | Colorectum | rectum adenocarcinoma | Male | <65 | I/II | Unknown | Unknown | SD |
NDUFS7 | SNV | Missense_Mutation | rs745768565 | c.466N>A | p.Gly156Arg | p.G156R | O75251 | protein_coding | tolerated_low_confidence(0.06) | probably_damaging(0.999) | TCGA-AJ-A3NF-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | <65 | III/IV | Chemotherapy | chemo | CR |
NDUFS7 | SNV | Missense_Mutation | novel | c.403C>T | p.Arg135Cys | p.R135C | O75251 | protein_coding | deleterious_low_confidence(0.03) | probably_damaging(1) | TCGA-D1-A15X-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | <65 | I/II | Unknown | Unknown | SD |
NDUFS7 | SNV | Missense_Mutation | | c.530A>G | p.Asp177Gly | p.D177G | O75251 | protein_coding | tolerated_low_confidence(0.06) | probably_damaging(1) | TCGA-D1-A15X-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | <65 | I/II | Unknown | Unknown | SD |
NDUFS7 | SNV | Missense_Mutation | novel | c.479N>G | p.Tyr160Cys | p.Y160C | O75251 | protein_coding | deleterious_low_confidence(0) | probably_damaging(1) | TCGA-D1-A175-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | <65 | I/II | Chemotherapy | paclitaxel | SD |
NDUFS7 | SNV | Missense_Mutation | novel | c.550C>T | p.Pro184Ser | p.P184S | O75251 | protein_coding | deleterious_low_confidence(0) | probably_damaging(0.997) | TCGA-D1-A1NZ-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | <65 | I/II | Unknown | Unknown | SD |