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Gene: NCSTN |
Gene summary for NCSTN |
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Gene information | Species | Human | Gene symbol | NCSTN | Gene ID | 23385 |
Gene name | nicastrin | |
Gene Alias | ATAG1874 | |
Cytomap | 1q23.2 | |
Gene Type | protein-coding | GO ID | GO:0001775 | UniProtAcc | Q92542 |
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Malignant transformation analysis |
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Entrez ID | Symbol | Replicates | Species | Organ | Tissue | Adj P-value | Log2FC | Malignancy |
23385 | NCSTN | HTA11_3410_2000001011 | Human | Colorectum | AD | 5.46e-05 | 1.99e-01 | 0.0155 |
23385 | NCSTN | HTA11_2487_2000001011 | Human | Colorectum | SER | 1.53e-08 | 4.19e-01 | -0.1808 |
23385 | NCSTN | HTA11_2951_2000001011 | Human | Colorectum | AD | 2.93e-02 | 4.21e-01 | 0.0216 |
23385 | NCSTN | HTA11_1938_2000001011 | Human | Colorectum | AD | 8.14e-06 | 3.67e-01 | -0.0811 |
23385 | NCSTN | HTA11_78_2000001011 | Human | Colorectum | AD | 5.38e-05 | 2.38e-01 | -0.1088 |
23385 | NCSTN | HTA11_347_2000001011 | Human | Colorectum | AD | 1.21e-19 | 4.60e-01 | -0.1954 |
23385 | NCSTN | HTA11_411_2000001011 | Human | Colorectum | SER | 3.59e-02 | 7.59e-01 | -0.2602 |
23385 | NCSTN | HTA11_83_2000001011 | Human | Colorectum | SER | 1.61e-02 | 3.25e-01 | -0.1526 |
23385 | NCSTN | HTA11_696_2000001011 | Human | Colorectum | AD | 2.53e-10 | 3.70e-01 | -0.1464 |
23385 | NCSTN | HTA11_866_2000001011 | Human | Colorectum | AD | 5.89e-05 | 1.96e-01 | -0.1001 |
23385 | NCSTN | HTA11_1391_2000001011 | Human | Colorectum | AD | 2.89e-08 | 4.70e-01 | -0.059 |
23385 | NCSTN | HTA11_5212_2000001011 | Human | Colorectum | AD | 5.13e-06 | 4.39e-01 | -0.2061 |
23385 | NCSTN | HTA11_5216_2000001011 | Human | Colorectum | SER | 2.03e-02 | 3.21e-01 | -0.1462 |
23385 | NCSTN | HTA11_866_3004761011 | Human | Colorectum | AD | 3.81e-06 | 3.41e-01 | 0.096 |
23385 | NCSTN | HTA11_8622_2000001021 | Human | Colorectum | SER | 8.19e-03 | 3.99e-01 | 0.0528 |
23385 | NCSTN | HTA11_10623_2000001011 | Human | Colorectum | AD | 7.04e-04 | 3.60e-01 | -0.0177 |
23385 | NCSTN | HTA11_6801_2000001011 | Human | Colorectum | SER | 8.81e-04 | 4.54e-01 | 0.0171 |
23385 | NCSTN | HTA11_10711_2000001011 | Human | Colorectum | AD | 1.89e-02 | 2.60e-01 | 0.0338 |
23385 | NCSTN | HTA11_7696_3000711011 | Human | Colorectum | AD | 9.46e-12 | 3.84e-01 | 0.0674 |
23385 | NCSTN | HTA11_7469_2000001011 | Human | Colorectum | AD | 4.79e-02 | 5.44e-01 | -0.0124 |
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∗log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage. |
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Malignant transformation related pathway analysis |
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Tissue | Disease Stage | Enriched GO biological Processes |
Colorectum | AD | ![]() |
Colorectum | SER | ![]() |
Colorectum | MSS | ![]() |
Colorectum | MSI-H | ![]() |
Colorectum | FAP | ![]() |
∗Top 15 enriched GO BP terms are showed in the bar plot of each disease state in each tissue. Each row represents a significant GO biological process which is colored according to the -log10(p.adjust). |
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GO ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | Count |
GO:000910011 | Thyroid | ATC | glycoprotein metabolic process | 153/6293 | 387/18723 | 7.90e-03 | 3.06e-02 | 153 |
GO:003420521 | Thyroid | ATC | amyloid-beta formation | 28/6293 | 57/18723 | 1.09e-02 | 3.94e-02 | 28 |
GO:007124823 | Thyroid | ATC | cellular response to metal ion | 82/6293 | 197/18723 | 1.11e-02 | 3.99e-02 | 82 |
GO:005043521 | Thyroid | ATC | amyloid-beta metabolic process | 32/6293 | 67/18723 | 1.13e-02 | 4.04e-02 | 32 |
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Pathway ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | qvalue | Count |
hsa05010 | Colorectum | AD | Alzheimer disease | 174/2092 | 384/8465 | 1.82e-19 | 9.26e-18 | 5.91e-18 | 174 |
hsa050101 | Colorectum | AD | Alzheimer disease | 174/2092 | 384/8465 | 1.82e-19 | 9.26e-18 | 5.91e-18 | 174 |
hsa050102 | Colorectum | SER | Alzheimer disease | 146/1580 | 384/8465 | 6.52e-20 | 2.40e-18 | 1.75e-18 | 146 |
hsa050103 | Colorectum | SER | Alzheimer disease | 146/1580 | 384/8465 | 6.52e-20 | 2.40e-18 | 1.75e-18 | 146 |
hsa050104 | Colorectum | MSS | Alzheimer disease | 169/1875 | 384/8465 | 1.21e-22 | 1.01e-20 | 6.21e-21 | 169 |
hsa050105 | Colorectum | MSS | Alzheimer disease | 169/1875 | 384/8465 | 1.21e-22 | 1.01e-20 | 6.21e-21 | 169 |
hsa05010210 | Esophagus | ESCC | Alzheimer disease | 263/4205 | 384/8465 | 1.80e-14 | 5.47e-13 | 2.80e-13 | 263 |
hsa043306 | Esophagus | ESCC | Notch signaling pathway | 42/4205 | 62/8465 | 2.97e-03 | 7.97e-03 | 4.08e-03 | 42 |
hsa0501038 | Esophagus | ESCC | Alzheimer disease | 263/4205 | 384/8465 | 1.80e-14 | 5.47e-13 | 2.80e-13 | 263 |
hsa0433013 | Esophagus | ESCC | Notch signaling pathway | 42/4205 | 62/8465 | 2.97e-03 | 7.97e-03 | 4.08e-03 | 42 |
hsa0501014 | Liver | Cirrhotic | Alzheimer disease | 180/2530 | 384/8465 | 5.52e-13 | 1.36e-11 | 8.36e-12 | 180 |
hsa0501015 | Liver | Cirrhotic | Alzheimer disease | 180/2530 | 384/8465 | 5.52e-13 | 1.36e-11 | 8.36e-12 | 180 |
hsa0501022 | Liver | HCC | Alzheimer disease | 254/4020 | 384/8465 | 3.75e-14 | 8.97e-13 | 4.99e-13 | 254 |
hsa0501032 | Liver | HCC | Alzheimer disease | 254/4020 | 384/8465 | 3.75e-14 | 8.97e-13 | 4.99e-13 | 254 |
hsa0501028 | Oral cavity | OSCC | Alzheimer disease | 244/3704 | 384/8465 | 1.18e-15 | 3.60e-14 | 1.83e-14 | 244 |
hsa043305 | Oral cavity | OSCC | Notch signaling pathway | 44/3704 | 62/8465 | 1.26e-05 | 5.55e-05 | 2.83e-05 | 44 |
hsa05010112 | Oral cavity | OSCC | Alzheimer disease | 244/3704 | 384/8465 | 1.18e-15 | 3.60e-14 | 1.83e-14 | 244 |
hsa0433012 | Oral cavity | OSCC | Notch signaling pathway | 44/3704 | 62/8465 | 1.26e-05 | 5.55e-05 | 2.83e-05 | 44 |
hsa0501029 | Oral cavity | LP | Alzheimer disease | 197/2418 | 384/8465 | 6.66e-22 | 3.69e-20 | 2.38e-20 | 197 |
hsa0501037 | Oral cavity | LP | Alzheimer disease | 197/2418 | 384/8465 | 6.66e-22 | 3.69e-20 | 2.38e-20 | 197 |
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Cell-cell communication analysis |
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Ligand | Receptor | LRpair | Pathway | Tissue | Disease Stage |
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Single-cell gene regulatory network inference analysis |
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TF | Cell Type | Tissue | Disease Stage | Target Gene | RSS | Regulon Activity |
∗The dot plots of a searched regulon are shown for all cell subpopulations in each disease state of each tissue based on the regulon specific score inferred using pySCENIC and by calculating the average expression. |
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Somatic mutation of malignant transformation related genes |
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Hugo Symbol | Variant Class | Variant Classification | dbSNP RS | HGVSc | HGVSp | HGVSp Short | SWISSPROT | BIOTYPE | SIFT | PolyPhen | Tumor Sample Barcode | Tissue | Histology | Sex | Age | Stage | Therapy Types | Drugs | Outcome |
NCSTN | SNV | Missense_Mutation | c.170N>G | p.Thr57Ser | p.T57S | Q92542 | protein_coding | deleterious(0.01) | probably_damaging(0.983) | TCGA-A7-A0DA-01 | Breast | breast invasive carcinoma | Female | <65 | I/II | Chemotherapy | adriamycin | SD | |
NCSTN | SNV | Missense_Mutation | c.1420G>C | p.Glu474Gln | p.E474Q | Q92542 | protein_coding | deleterious(0.03) | benign(0.238) | TCGA-AC-A23H-01 | Breast | breast invasive carcinoma | Female | >=65 | I/II | Unknown | Unknown | PD | |
NCSTN | SNV | Missense_Mutation | c.2070C>G | p.Ile690Met | p.I690M | Q92542 | protein_coding | tolerated(0.06) | benign(0.067) | TCGA-AC-A23H-01 | Breast | breast invasive carcinoma | Female | >=65 | I/II | Unknown | Unknown | PD | |
NCSTN | SNV | Missense_Mutation | novel | c.1715C>T | p.Ala572Val | p.A572V | Q92542 | protein_coding | deleterious(0.02) | possibly_damaging(0.787) | TCGA-E9-A3Q9-01 | Breast | breast invasive carcinoma | Female | >=65 | III/IV | Chemotherapy | cyclophosphane | CR |
NCSTN | SNV | Missense_Mutation | novel | c.1625N>C | p.Leu542Pro | p.L542P | Q92542 | protein_coding | tolerated(0.14) | possibly_damaging(0.675) | TCGA-OL-A6VO-01 | Breast | breast invasive carcinoma | Female | <65 | I/II | Chemotherapy | taxotere | CR |
NCSTN | insertion | Nonsense_Mutation | novel | c.724_725insGTCCCAAAGGATCAGGAGAGCCTACTGTCACCTAAGGCTCAC | p.Ile242delinsSerProLysGlySerGlyGluProThrValThrTerGlySerLeu | p.I242delinsSPKGSGEPTVT*GSL | Q92542 | protein_coding | TCGA-AN-A0FW-01 | Breast | breast invasive carcinoma | Female | >=65 | III/IV | Unknown | Unknown | SD | ||
NCSTN | SNV | Missense_Mutation | rs200800006 | c.892G>A | p.Ala298Thr | p.A298T | Q92542 | protein_coding | tolerated(0.54) | benign(0.121) | TCGA-2W-A8YY-01 | Cervix | cervical & endocervical cancer | Female | <65 | I/II | Chemotherapy | cisplatin | CR |
NCSTN | SNV | Missense_Mutation | c.375N>C | p.Leu125Phe | p.L125F | Q92542 | protein_coding | tolerated(0.7) | benign(0) | TCGA-C5-A1MK-01 | Cervix | cervical & endocervical cancer | Female | >=65 | III/IV | Chemotherapy | carboplatin | PD | |
NCSTN | SNV | Missense_Mutation | c.1144C>T | p.Pro382Ser | p.P382S | Q92542 | protein_coding | deleterious(0) | probably_damaging(1) | TCGA-EK-A2PG-01 | Cervix | cervical & endocervical cancer | Female | >=65 | I/II | Unknown | Unknown | SD | |
NCSTN | SNV | Missense_Mutation | c.412N>A | p.Val138Ile | p.V138I | Q92542 | protein_coding | tolerated(0.38) | benign(0.033) | TCGA-A6-2672-01 | Colorectum | colon adenocarcinoma | Female | >=65 | III/IV | Unknown | Unknown | SD |
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Related drugs of malignant transformation related genes |
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(DGIdb 4.0) |
Entrez ID | Symbol | Category | Interaction Types | Drug Claim Name | Drug Name | PMIDs |
23385 | NCSTN | DRUGGABLE GENOME, CLINICALLY ACTIONABLE | inhibitor | MK0752 | ||
23385 | NCSTN | DRUGGABLE GENOME, CLINICALLY ACTIONABLE | inhibitor | RO 4929097 | ||
23385 | NCSTN | DRUGGABLE GENOME, CLINICALLY ACTIONABLE | inhibitor | PF03084014 | ||
23385 | NCSTN | DRUGGABLE GENOME, CLINICALLY ACTIONABLE | BMS-299897 | CHEMBL247471 | ||
23385 | NCSTN | DRUGGABLE GENOME, CLINICALLY ACTIONABLE | IC261 | IC261 | 20350806 | |
23385 | NCSTN | DRUGGABLE GENOME, CLINICALLY ACTIONABLE | GSI-136 | GSI-136 | ||
23385 | NCSTN | DRUGGABLE GENOME, CLINICALLY ACTIONABLE | inhibitor | CHEMBL463981 | BEGACESTAT | |
23385 | NCSTN | DRUGGABLE GENOME, CLINICALLY ACTIONABLE | modulator | CHEMBL190083 | TARENFLURBIL | |
23385 | NCSTN | DRUGGABLE GENOME, CLINICALLY ACTIONABLE | inhibitor | CHEMBL520733 | SEMAGACESTAT | |
23385 | NCSTN | DRUGGABLE GENOME, CLINICALLY ACTIONABLE | inhibitor | MK0752 |
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