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Gene: MICA |
Gene summary for MICA |
 Gene summary. |
| Gene information | Species | Human | Gene symbol | MICA | Gene ID | 100507436 |
| Gene name | MHC class I polypeptide-related sequence A | |
| Gene Alias | MIC-A | |
| Cytomap | 6p21.33 | |
| Gene Type | protein-coding | GO ID | GO:0001775 | UniProtAcc | Q29983 |
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Malignant transformation analysis |
| Identification of the aberrant gene expression in precancerous and cancerous lesions by comparing the gene expression of stem-like cells in diseased tissues with normal stem cells |
| Malignant transformation involving gene list. |
| Entrez ID | Symbol | Replicates | Species | Organ | Tissue | Adj P-value | Log2FC | Malignancy |
| 100507436 | MICA | LZE4T | Human | Esophagus | ESCC | 8.03e-12 | 3.00e-01 | 0.0811 |
| 100507436 | MICA | LZE7T | Human | Esophagus | ESCC | 3.10e-04 | 2.55e-01 | 0.0667 |
| 100507436 | MICA | LZE20T | Human | Esophagus | ESCC | 6.46e-04 | 1.02e-01 | 0.0662 |
| 100507436 | MICA | LZE24T | Human | Esophagus | ESCC | 1.06e-08 | 2.36e-01 | 0.0596 |
| 100507436 | MICA | LZE6T | Human | Esophagus | ESCC | 7.69e-06 | 4.79e-01 | 0.0845 |
| 100507436 | MICA | P1T-E | Human | Esophagus | ESCC | 1.82e-07 | 4.01e-01 | 0.0875 |
| 100507436 | MICA | P2T-E | Human | Esophagus | ESCC | 1.42e-19 | 2.92e-01 | 0.1177 |
| 100507436 | MICA | P4T-E | Human | Esophagus | ESCC | 2.68e-27 | 6.57e-01 | 0.1323 |
| 100507436 | MICA | P5T-E | Human | Esophagus | ESCC | 3.82e-18 | 4.93e-01 | 0.1327 |
| 100507436 | MICA | P8T-E | Human | Esophagus | ESCC | 2.40e-07 | 1.59e-01 | 0.0889 |
| 100507436 | MICA | P9T-E | Human | Esophagus | ESCC | 3.55e-02 | 1.20e-01 | 0.1131 |
| 100507436 | MICA | P10T-E | Human | Esophagus | ESCC | 6.24e-16 | 2.59e-01 | 0.116 |
| 100507436 | MICA | P11T-E | Human | Esophagus | ESCC | 3.38e-26 | 7.15e-01 | 0.1426 |
| 100507436 | MICA | P12T-E | Human | Esophagus | ESCC | 2.04e-11 | 2.48e-01 | 0.1122 |
| 100507436 | MICA | P15T-E | Human | Esophagus | ESCC | 3.00e-12 | 2.94e-01 | 0.1149 |
| 100507436 | MICA | P16T-E | Human | Esophagus | ESCC | 9.04e-14 | 2.33e-01 | 0.1153 |
| 100507436 | MICA | P17T-E | Human | Esophagus | ESCC | 1.07e-07 | 3.53e-01 | 0.1278 |
| 100507436 | MICA | P19T-E | Human | Esophagus | ESCC | 6.99e-04 | 3.13e-01 | 0.1662 |
| 100507436 | MICA | P20T-E | Human | Esophagus | ESCC | 3.46e-10 | 2.51e-01 | 0.1124 |
| 100507436 | MICA | P21T-E | Human | Esophagus | ESCC | 8.03e-20 | 5.56e-01 | 0.1617 |
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| Transcriptomic changes along malignancy continuum. |
| Tissue | Expression Dynamics | Abbreviation |
| Esophagus |  | ESCC: Esophageal squamous cell carcinoma |
| HGIN: High-grade intraepithelial neoplasias | ||
| LGIN: Low-grade intraepithelial neoplasias | ||
| Liver |  | HCC: Hepatocellular carcinoma |
| NAFLD: Non-alcoholic fatty liver disease | ||
| Oral Cavity |  | EOLP: Erosive Oral lichen planus |
| LP: leukoplakia | ||
| NEOLP: Non-erosive oral lichen planus | ||
| OSCC: Oral squamous cell carcinoma |
| ∗log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage. |
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Malignant transformation related pathway analysis |
| Find out the enriched GO biological processes and KEGG pathways involved in transition from healthy to precancer to cancer |
| Figure of enriched GO biological processes. |
| Tissue | Disease Stage | Enriched GO biological Processes |
| Colorectum | AD |  |
| Colorectum | SER |  |
| Colorectum | MSS |  |
| Colorectum | MSI-H |  |
| Colorectum | FAP |  |
| ∗Top 15 enriched GO BP terms are showed in the bar plot of each disease state in each tissue. Each row represents a significant GO biological process which is colored according to the -log10(p.adjust). |
| Page: 1 2 3 4 5 6 7 8 9 |
| Enriched GO biological processes. |
| GO ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | Count |
| GO:190374711 | Liver | HCC | regulation of establishment of protein localization to mitochondrion | 41/7958 | 50/18723 | 1.14e-08 | 2.83e-07 | 41 |
| GO:000940811 | Liver | HCC | response to heat | 76/7958 | 110/18723 | 1.48e-08 | 3.58e-07 | 76 |
| GO:190321411 | Liver | HCC | regulation of protein targeting to mitochondrion | 36/7958 | 44/18723 | 1.02e-07 | 1.98e-06 | 36 |
| GO:000815422 | Liver | HCC | actin polymerization or depolymerization | 130/7958 | 218/18723 | 2.31e-07 | 4.14e-06 | 130 |
| GO:003004122 | Liver | HCC | actin filament polymerization | 116/7958 | 191/18723 | 2.66e-07 | 4.68e-06 | 116 |
| GO:00516071 | Liver | HCC | defense response to virus | 151/7958 | 265/18723 | 1.27e-06 | 1.85e-05 | 151 |
| GO:01405461 | Liver | HCC | defense response to symbiont | 151/7958 | 265/18723 | 1.27e-06 | 1.85e-05 | 151 |
| GO:003444622 | Liver | HCC | substrate adhesion-dependent cell spreading | 67/7958 | 108/18723 | 3.24e-05 | 3.28e-04 | 67 |
| GO:00324562 | Liver | HCC | endocytic recycling | 48/7958 | 73/18723 | 5.07e-05 | 4.83e-04 | 48 |
| GO:00028321 | Liver | HCC | negative regulation of response to biotic stimulus | 66/7958 | 108/18723 | 7.24e-05 | 6.50e-04 | 66 |
| GO:000926611 | Liver | HCC | response to temperature stimulus | 101/7958 | 178/18723 | 8.55e-05 | 7.48e-04 | 101 |
| GO:00028312 | Liver | HCC | regulation of response to biotic stimulus | 173/7958 | 327/18723 | 8.55e-05 | 7.48e-04 | 173 |
| GO:003158922 | Liver | HCC | cell-substrate adhesion | 188/7958 | 363/18723 | 2.00e-04 | 1.55e-03 | 188 |
| GO:004521622 | Liver | HCC | cell-cell junction organization | 107/7958 | 200/18723 | 1.06e-03 | 6.11e-03 | 107 |
| GO:00450881 | Liver | HCC | regulation of innate immune response | 113/7958 | 218/18723 | 3.27e-03 | 1.50e-02 | 113 |
| GO:00458241 | Liver | HCC | negative regulation of innate immune response | 42/7958 | 71/18723 | 3.41e-03 | 1.55e-02 | 42 |
| GO:0050777 | Liver | HCC | negative regulation of immune response | 101/7958 | 194/18723 | 4.40e-03 | 1.90e-02 | 101 |
| GO:004329712 | Liver | HCC | apical junction assembly | 45/7958 | 78/18723 | 4.83e-03 | 2.03e-02 | 45 |
| GO:003153212 | Liver | HCC | actin cytoskeleton reorganization | 59/7958 | 107/18723 | 5.57e-03 | 2.32e-02 | 59 |
| GO:01201935 | Liver | HCC | tight junction organization | 45/7958 | 80/18723 | 9.02e-03 | 3.48e-02 | 45 |
| Page: 1 2 3 4 5 6 7 8 9 10 11 12 13 14 15 16 17 18 19 20 21 22 23 24 25 26 27 28 29 |
| Enriched KEGG pathways. |
| Pathway ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | qvalue | Count |
| hsa05167211 | Esophagus | ESCC | Kaposi sarcoma-associated herpesvirus infection | 136/4205 | 194/8465 | 4.28e-09 | 4.22e-08 | 2.16e-08 | 136 |
| hsa0516738 | Esophagus | ESCC | Kaposi sarcoma-associated herpesvirus infection | 136/4205 | 194/8465 | 4.28e-09 | 4.22e-08 | 2.16e-08 | 136 |
| hsa0516721 | Liver | HCC | Kaposi sarcoma-associated herpesvirus infection | 111/4020 | 194/8465 | 3.78e-03 | 1.16e-02 | 6.45e-03 | 111 |
| hsa0516731 | Liver | HCC | Kaposi sarcoma-associated herpesvirus infection | 111/4020 | 194/8465 | 3.78e-03 | 1.16e-02 | 6.45e-03 | 111 |
| hsa0516729 | Oral cavity | OSCC | Kaposi sarcoma-associated herpesvirus infection | 125/3704 | 194/8465 | 3.67e-09 | 3.84e-08 | 1.96e-08 | 125 |
| hsa05167113 | Oral cavity | OSCC | Kaposi sarcoma-associated herpesvirus infection | 125/3704 | 194/8465 | 3.67e-09 | 3.84e-08 | 1.96e-08 | 125 |
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Cell-cell communication analysis |
| Identification of potential cell-cell interactions between two cell types and their ligand-receptor pairs for different disease states |
| Ligand | Receptor | LRpair | Pathway | Tissue | Disease Stage |
| Page: 1 |
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Single-cell gene regulatory network inference analysis |
| Find out the significant the regulons (TFs) and the target genes of each regulon across cell types for different disease states |
| TF | Cell Type | Tissue | Disease Stage | Target Gene | RSS | Regulon Activity |
| ∗The dot plots of a searched regulon are shown for all cell subpopulations in each disease state of each tissue based on the regulon specific score inferred using pySCENIC and by calculating the average expression. |
| Page: 1 |
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Somatic mutation of malignant transformation related genes |
| Annotation of somatic variants for genes involved in malignant transformation |
| Hugo Symbol | Variant Class | Variant Classification | dbSNP RS | HGVSc | HGVSp | HGVSp Short | SWISSPROT | BIOTYPE | SIFT | PolyPhen | Tumor Sample Barcode | Tissue | Histology | Sex | Age | Stage | Therapy Types | Drugs | Outcome |
| MICA | SNV | Missense_Mutation | rs746669979 | c.173G>A | p.Arg58His | p.R58H | protein_coding | tolerated(1) | benign(0.009) | TCGA-A2-A1FW-01 | Breast | breast invasive carcinoma | Female | <65 | III/IV | Chemotherapy | cytoxan | SD | |
| MICA | SNV | Missense_Mutation | c.507G>C | p.Leu169Phe | p.L169F | protein_coding | tolerated(0.06) | possibly_damaging(0.624) | TCGA-AC-A23H-01 | Breast | breast invasive carcinoma | Female | >=65 | I/II | Unknown | Unknown | PD | ||
| MICA | insertion | Frame_Shift_Ins | novel | c.517_518insGAGAAGT | p.Ala173GlyfsTer89 | p.A173Gfs*89 | protein_coding | TCGA-AQ-A04J-01 | Breast | breast invasive carcinoma | Female | <65 | I/II | Chemotherapy | cytoxan | SD | |||
| MICA | insertion | Frame_Shift_Ins | novel | c.518_519insACTGCTGGGTGGGGGCAGGCTTG | p.Met174LeufsTer9 | p.M174Lfs*9 | protein_coding | TCGA-AQ-A04J-01 | Breast | breast invasive carcinoma | Female | <65 | I/II | Chemotherapy | cytoxan | SD | |||
| MICA | SNV | Missense_Mutation | c.360N>C | p.Glu120Asp | p.E120D | protein_coding | tolerated(0.05) | possibly_damaging(0.835) | TCGA-DG-A2KM-01 | Cervix | cervical & endocervical cancer | Female | <65 | I/II | Chemotherapy | cisplatin | SD | ||
| MICA | SNV | Missense_Mutation | novel | c.73N>T | p.Pro25Ser | p.P25S | protein_coding | tolerated(0.55) | possibly_damaging(0.887) | TCGA-AG-3892-01 | Colorectum | rectum adenocarcinoma | Female | <65 | I/II | Unknown | Unknown | SD | |
| MICA | SNV | Missense_Mutation | novel | c.982C>A | p.Leu328Ile | p.L328I | protein_coding | tolerated_low_confidence(0.13) | benign(0.052) | TCGA-F5-6814-01 | Colorectum | rectum adenocarcinoma | Male | <65 | I/II | Unknown | Unknown | SD | |
| MICA | SNV | Missense_Mutation | novel | c.98N>T | p.Thr33Met | p.T33M | protein_coding | deleterious(0.04) | benign(0.11) | TCGA-A5-A0G2-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | <65 | III/IV | Unknown | Unknown | SD | |
| MICA | SNV | Missense_Mutation | novel | c.545N>A | p.Ala182Asp | p.A182D | protein_coding | tolerated(0.25) | possibly_damaging(0.887) | TCGA-AJ-A3BH-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | Unknown | I/II | Unknown | Unknown | SD | |
| MICA | SNV | Missense_Mutation | novel | c.82C>T | p.Leu28Phe | p.L28F | protein_coding | deleterious(0.05) | probably_damaging(0.999) | TCGA-AJ-A3EK-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | <65 | I/II | Chemotherapy | carboplatin | CR |
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Related drugs of malignant transformation related genes |
| Identification of chemicals and drugs interact with genes involved in malignant transfromation |
| (DGIdb 4.0) |
| Entrez ID | Symbol | Category | Interaction Types | Drug Claim Name | Drug Name | PMIDs |
| 100507436 | MICA | EXTERNAL SIDE OF PLASMA MEMBRANE, CELL SURFACE | HSP70 | 17911639 |
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