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Gene: LYPLA1 |
Gene summary for LYPLA1 |
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Gene information | Species | Human | Gene symbol | LYPLA1 | Gene ID | 10434 |
Gene name | lysophospholipase 1 | |
Gene Alias | APT-1 | |
Cytomap | 8q11.23 | |
Gene Type | protein-coding | GO ID | GO:0002084 | UniProtAcc | B4DP64 |
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Malignant transformation analysis |
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Entrez ID | Symbol | Replicates | Species | Organ | Tissue | Adj P-value | Log2FC | Malignancy |
10434 | LYPLA1 | GSM4909286 | Human | Breast | IDC | 1.94e-02 | 8.49e-02 | 0.1081 |
10434 | LYPLA1 | GSM4909291 | Human | Breast | IDC | 6.20e-10 | 4.85e-01 | 0.1753 |
10434 | LYPLA1 | GSM4909293 | Human | Breast | IDC | 1.81e-08 | 4.37e-01 | 0.1581 |
10434 | LYPLA1 | GSM4909295 | Human | Breast | IDC | 1.87e-02 | 3.44e-01 | 0.0898 |
10434 | LYPLA1 | GSM4909296 | Human | Breast | IDC | 1.45e-03 | -1.20e-01 | 0.1524 |
10434 | LYPLA1 | GSM4909297 | Human | Breast | IDC | 1.28e-08 | 5.11e-02 | 0.1517 |
10434 | LYPLA1 | GSM4909304 | Human | Breast | IDC | 7.19e-06 | 3.38e-01 | 0.1636 |
10434 | LYPLA1 | GSM4909305 | Human | Breast | IDC | 4.21e-04 | 3.39e-01 | 0.0436 |
10434 | LYPLA1 | GSM4909306 | Human | Breast | IDC | 7.73e-08 | 4.20e-01 | 0.1564 |
10434 | LYPLA1 | GSM4909308 | Human | Breast | IDC | 5.86e-10 | 3.69e-01 | 0.158 |
10434 | LYPLA1 | GSM4909311 | Human | Breast | IDC | 2.71e-16 | 1.37e-02 | 0.1534 |
10434 | LYPLA1 | GSM4909312 | Human | Breast | IDC | 7.29e-35 | 8.07e-01 | 0.1552 |
10434 | LYPLA1 | GSM4909317 | Human | Breast | IDC | 8.61e-70 | 1.20e+00 | 0.1355 |
10434 | LYPLA1 | GSM4909318 | Human | Breast | IDC | 4.99e-38 | 1.41e+00 | 0.2031 |
10434 | LYPLA1 | GSM4909319 | Human | Breast | IDC | 1.45e-21 | -1.85e-01 | 0.1563 |
10434 | LYPLA1 | GSM4909321 | Human | Breast | IDC | 1.21e-10 | 2.24e-01 | 0.1559 |
10434 | LYPLA1 | NCCBC11 | Human | Breast | DCIS | 1.94e-02 | 3.60e-01 | 0.1232 |
10434 | LYPLA1 | NCCBC14 | Human | Breast | DCIS | 7.79e-03 | 2.64e-02 | 0.2021 |
10434 | LYPLA1 | NCCBC2 | Human | Breast | DCIS | 2.28e-02 | 1.37e-01 | 0.1554 |
10434 | LYPLA1 | NCCBC5 | Human | Breast | DCIS | 2.83e-03 | -2.91e-02 | 0.2046 |
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∗log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage. |
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Malignant transformation related pathway analysis |
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Tissue | Disease Stage | Enriched GO biological Processes |
Colorectum | AD | ![]() |
Colorectum | SER | ![]() |
Colorectum | MSS | ![]() |
Colorectum | MSI-H | ![]() |
Colorectum | FAP | ![]() |
∗Top 15 enriched GO BP terms are showed in the bar plot of each disease state in each tissue. Each row represents a significant GO biological process which is colored according to the -log10(p.adjust). |
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GO ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | Count |
GO:190307625 | Skin | cSCC | regulation of protein localization to plasma membrane | 49/4864 | 104/18723 | 2.71e-06 | 4.30e-05 | 49 |
GO:009887617 | Skin | cSCC | vesicle-mediated transport to the plasma membrane | 59/4864 | 136/18723 | 7.60e-06 | 1.04e-04 | 59 |
GO:190547524 | Skin | cSCC | regulation of protein localization to membrane | 72/4864 | 175/18723 | 8.12e-06 | 1.09e-04 | 72 |
GO:00356016 | Skin | cSCC | protein deacylation | 50/4864 | 112/18723 | 1.42e-05 | 1.77e-04 | 50 |
GO:00987326 | Skin | cSCC | macromolecule deacylation | 50/4864 | 116/18723 | 4.47e-05 | 4.69e-04 | 50 |
GO:000689316 | Skin | cSCC | Golgi to plasma membrane transport | 30/4864 | 60/18723 | 5.67e-05 | 5.67e-04 | 30 |
GO:006195122 | Skin | cSCC | establishment of protein localization to plasma membrane | 30/4864 | 60/18723 | 5.67e-05 | 5.67e-04 | 30 |
GO:190382822 | Skin | cSCC | negative regulation of cellular protein localization | 50/4864 | 117/18723 | 5.85e-05 | 5.77e-04 | 50 |
GO:004300115 | Skin | cSCC | Golgi to plasma membrane protein transport | 22/4864 | 40/18723 | 8.93e-05 | 8.37e-04 | 22 |
GO:19049506 | Skin | cSCC | negative regulation of establishment of protein localization | 52/4864 | 131/18723 | 3.95e-04 | 3.09e-03 | 52 |
GO:00512245 | Skin | cSCC | negative regulation of protein transport | 50/4864 | 127/18723 | 6.32e-04 | 4.55e-03 | 50 |
GO:19043766 | Skin | cSCC | negative regulation of protein localization to cell periphery | 14/4864 | 26/18723 | 2.26e-03 | 1.32e-02 | 14 |
GO:19030779 | Skin | cSCC | negative regulation of protein localization to plasma membrane | 13/4864 | 24/18723 | 3.02e-03 | 1.67e-02 | 13 |
GO:19054765 | Skin | cSCC | negative regulation of protein localization to membrane | 15/4864 | 32/18723 | 8.65e-03 | 4.00e-02 | 15 |
GO:004819320 | Thyroid | PTC | Golgi vesicle transport | 186/5968 | 296/18723 | 3.09e-28 | 1.22e-25 | 186 |
GO:0090150112 | Thyroid | PTC | establishment of protein localization to membrane | 149/5968 | 260/18723 | 1.64e-17 | 1.59e-15 | 149 |
GO:0072659112 | Thyroid | PTC | protein localization to plasma membrane | 153/5968 | 284/18723 | 9.90e-15 | 6.50e-13 | 153 |
GO:1990778111 | Thyroid | PTC | protein localization to cell periphery | 172/5968 | 333/18723 | 3.71e-14 | 2.30e-12 | 172 |
GO:000689218 | Thyroid | PTC | post-Golgi vesicle-mediated transport | 66/5968 | 104/18723 | 3.36e-11 | 1.24e-09 | 66 |
GO:000689317 | Thyroid | PTC | Golgi to plasma membrane transport | 41/5968 | 60/18723 | 7.26e-09 | 1.82e-07 | 41 |
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Pathway ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | qvalue | Count |
hsa05231 | Colorectum | MSS | Choline metabolism in cancer | 34/1875 | 98/8465 | 2.90e-03 | 1.39e-02 | 8.50e-03 | 34 |
hsa052311 | Colorectum | MSS | Choline metabolism in cancer | 34/1875 | 98/8465 | 2.90e-03 | 1.39e-02 | 8.50e-03 | 34 |
hsa052312 | Colorectum | FAP | Choline metabolism in cancer | 29/1404 | 98/8465 | 9.03e-04 | 5.20e-03 | 3.16e-03 | 29 |
hsa052313 | Colorectum | FAP | Choline metabolism in cancer | 29/1404 | 98/8465 | 9.03e-04 | 5.20e-03 | 3.16e-03 | 29 |
hsa052314 | Colorectum | CRC | Choline metabolism in cancer | 24/1091 | 98/8465 | 1.21e-03 | 9.84e-03 | 6.67e-03 | 24 |
hsa052315 | Colorectum | CRC | Choline metabolism in cancer | 24/1091 | 98/8465 | 1.21e-03 | 9.84e-03 | 6.67e-03 | 24 |
hsa052319 | Esophagus | ESCC | Choline metabolism in cancer | 61/4205 | 98/8465 | 7.97e-03 | 1.92e-02 | 9.84e-03 | 61 |
hsa0523114 | Esophagus | ESCC | Choline metabolism in cancer | 61/4205 | 98/8465 | 7.97e-03 | 1.92e-02 | 9.84e-03 | 61 |
hsa052316 | Liver | HCC | Choline metabolism in cancer | 57/4020 | 98/8465 | 2.14e-02 | 4.90e-02 | 2.72e-02 | 57 |
hsa0523111 | Liver | HCC | Choline metabolism in cancer | 57/4020 | 98/8465 | 2.14e-02 | 4.90e-02 | 2.72e-02 | 57 |
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Cell-cell communication analysis |
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Ligand | Receptor | LRpair | Pathway | Tissue | Disease Stage |
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Single-cell gene regulatory network inference analysis |
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TF | Cell Type | Tissue | Disease Stage | Target Gene | RSS | Regulon Activity |
∗The dot plots of a searched regulon are shown for all cell subpopulations in each disease state of each tissue based on the regulon specific score inferred using pySCENIC and by calculating the average expression. |
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Somatic mutation of malignant transformation related genes |
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Hugo Symbol | Variant Class | Variant Classification | dbSNP RS | HGVSc | HGVSp | HGVSp Short | SWISSPROT | BIOTYPE | SIFT | PolyPhen | Tumor Sample Barcode | Tissue | Histology | Sex | Age | Stage | Therapy Types | Drugs | Outcome |
LYPLA1 | SNV | Missense_Mutation | novel | c.494N>T | p.Ser165Phe | p.S165F | O75608 | protein_coding | deleterious(0) | possibly_damaging(0.722) | TCGA-C5-A2LZ-01 | Cervix | cervical & endocervical cancer | Female | >=65 | III/IV | Unknown | Unknown | PD |
LYPLA1 | SNV | Missense_Mutation | c.229N>T | p.Gly77Trp | p.G77W | O75608 | protein_coding | deleterious(0) | probably_damaging(0.998) | TCGA-AA-3811-01 | Colorectum | colon adenocarcinoma | Female | >=65 | III/IV | Unknown | Unknown | PD | |
LYPLA1 | SNV | Missense_Mutation | novel | c.335N>T | p.Arg112Ile | p.R112I | O75608 | protein_coding | deleterious(0) | probably_damaging(0.994) | TCGA-CA-6717-01 | Colorectum | colon adenocarcinoma | Male | <65 | I/II | Chemotherapy | oxaliplatin | CR |
LYPLA1 | SNV | Missense_Mutation | c.260N>T | p.Ser87Phe | p.S87F | O75608 | protein_coding | deleterious(0.04) | benign(0.365) | TCGA-CA-6717-01 | Colorectum | colon adenocarcinoma | Male | <65 | I/II | Chemotherapy | oxaliplatin | CR | |
LYPLA1 | SNV | Missense_Mutation | rs767257936 | c.554N>T | p.Thr185Met | p.T185M | O75608 | protein_coding | deleterious(0.01) | possibly_damaging(0.681) | TCGA-QG-A5Z2-01 | Colorectum | colon adenocarcinoma | Male | <65 | I/II | Unknown | Unknown | SD |
LYPLA1 | SNV | Missense_Mutation | novel | c.259N>C | p.Ser87Pro | p.S87P | O75608 | protein_coding | tolerated(0.34) | benign(0) | TCGA-AX-A06F-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | <65 | III/IV | Chemotherapy | carboplatin | SD |
LYPLA1 | SNV | Missense_Mutation | rs371316608 | c.629N>T | p.Ser210Leu | p.S210L | O75608 | protein_coding | deleterious(0.02) | possibly_damaging(0.676) | TCGA-D1-A17Q-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | <65 | I/II | Unknown | Unknown | SD |
LYPLA1 | SNV | Missense_Mutation | novel | c.362N>T | p.Gly121Val | p.G121V | O75608 | protein_coding | deleterious(0.01) | probably_damaging(1) | TCGA-DF-A2KU-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | Unknown | I/II | Unknown | Unknown | SD |
LYPLA1 | SNV | Missense_Mutation | novel | c.20C>T | p.Ser7Leu | p.S7L | O75608 | protein_coding | deleterious(0) | benign(0.095) | TCGA-DD-AAD5-01 | Liver | liver hepatocellular carcinoma | Male | <65 | I/II | Unknown | Unknown | PD |
LYPLA1 | SNV | Missense_Mutation | c.346N>C | p.Gly116Arg | p.G116R | O75608 | protein_coding | deleterious(0.01) | probably_damaging(1) | TCGA-33-4582-01 | Lung | lung squamous cell carcinoma | Male | <65 | I/II | Unknown | Unknown | PD |
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Related drugs of malignant transformation related genes |
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(DGIdb 4.0) |
Entrez ID | Symbol | Category | Interaction Types | Drug Claim Name | Drug Name | PMIDs |
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