Tissue | Expression Dynamics | Abbreviation |
Endometrium | ![The image shows the transcriptomic changes along malignancy continuum.log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage.](images/deg_images/Endometrium/LIMS1_pca_on_diff_genes.png) | AEH: Atypical endometrial hyperplasia |
EEC: Endometrioid Cancer |
Esophagus | ![The image shows the transcriptomic changes along malignancy continuum.log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage.](images/deg_images/Esophagus/LIMS1_pca_on_diff_genes.png) | ESCC: Esophageal squamous cell carcinoma |
HGIN: High-grade intraepithelial neoplasias |
LGIN: Low-grade intraepithelial neoplasias |
Liver | ![The image shows the transcriptomic changes along malignancy continuum.log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage.](images/deg_images/Liver/LIMS1_pca_on_diff_genes.png) | HCC: Hepatocellular carcinoma |
NAFLD: Non-alcoholic fatty liver disease |
Lung | ![The image shows the transcriptomic changes along malignancy continuum.log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage.](images/deg_images/Lung/LIMS1_pca_on_diff_genes.png) | AAH: Atypical adenomatous hyperplasia |
AIS: Adenocarcinoma in situ |
IAC: Invasive lung adenocarcinoma |
MIA: Minimally invasive adenocarcinoma |
Oral Cavity | ![The image shows the transcriptomic changes along malignancy continuum.log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage.](images/deg_images/OralCavity/LIMS1_pca_on_diff_genes.png) | EOLP: Erosive Oral lichen planus |
LP: leukoplakia |
NEOLP: Non-erosive oral lichen planus |
OSCC: Oral squamous cell carcinoma |
Prostate | ![The image shows the transcriptomic changes along malignancy continuum.log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage.](images/deg_images/Prostate/LIMS1_pca_on_diff_genes.png) | BPH: Benign Prostatic Hyperplasia |
Skin | ![The image shows the transcriptomic changes along malignancy continuum.log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage.](images/deg_images/Skin/LIMS1_pca_on_diff_genes.png) | AK: Actinic keratosis |
cSCC: Cutaneous squamous cell carcinoma |
SCCIS:squamous cell carcinoma in situ |
Thyroid | ![The image shows the transcriptomic changes along malignancy continuum.log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage.](images/deg_images/Thyroid/LIMS1_pca_on_diff_genes.png) | ATC: Anaplastic thyroid cancer |
HT: Hashimoto's thyroiditis |
PTC: Papillary thyroid cancer |
GO ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | Count |
GO:009010931 | Lung | MIAC | regulation of cell-substrate junction assembly | 17/967 | 66/18723 | 2.64e-08 | 1.13e-05 | 17 |
GO:000195231 | Lung | MIAC | regulation of cell-matrix adhesion | 24/967 | 128/18723 | 3.46e-08 | 1.37e-05 | 24 |
GO:001081032 | Lung | MIAC | regulation of cell-substrate adhesion | 33/967 | 221/18723 | 3.79e-08 | 1.39e-05 | 33 |
GO:004804131 | Lung | MIAC | focal adhesion assembly | 19/967 | 87/18723 | 7.35e-08 | 2.36e-05 | 19 |
GO:015011631 | Lung | MIAC | regulation of cell-substrate junction organization | 17/967 | 71/18723 | 8.51e-08 | 2.57e-05 | 17 |
GO:003158931 | Lung | MIAC | cell-substrate adhesion | 44/967 | 363/18723 | 1.30e-07 | 3.56e-05 | 44 |
GO:003432931 | Lung | MIAC | cell junction assembly | 48/967 | 420/18723 | 2.13e-07 | 4.11e-05 | 48 |
GO:000704431 | Lung | MIAC | cell-substrate junction assembly | 19/967 | 95/18723 | 3.20e-07 | 5.66e-05 | 19 |
GO:002260432 | Lung | MIAC | regulation of cell morphogenesis | 38/967 | 309/18723 | 6.47e-07 | 9.76e-05 | 38 |
GO:004308721 | Lung | MIAC | regulation of GTPase activity | 41/967 | 348/18723 | 7.39e-07 | 1.08e-04 | 41 |
GO:015011531 | Lung | MIAC | cell-substrate junction organization | 19/967 | 101/18723 | 8.64e-07 | 1.23e-04 | 19 |
GO:004578523 | Lung | MIAC | positive regulation of cell adhesion | 47/967 | 437/18723 | 1.62e-06 | 2.10e-04 | 47 |
GO:004354721 | Lung | MIAC | positive regulation of GTPase activity | 31/967 | 255/18723 | 8.63e-06 | 7.38e-04 | 31 |
GO:004521623 | Lung | MIAC | cell-cell junction organization | 26/967 | 200/18723 | 1.38e-05 | 9.86e-04 | 26 |
GO:190188831 | Lung | MIAC | regulation of cell junction assembly | 25/967 | 204/18723 | 5.46e-05 | 2.75e-03 | 25 |
GO:007155922 | Lung | MIAC | response to transforming growth factor beta | 28/967 | 256/18723 | 1.51e-04 | 5.95e-03 | 28 |
GO:001081123 | Lung | MIAC | positive regulation of cell-substrate adhesion | 17/967 | 123/18723 | 1.96e-04 | 7.07e-03 | 17 |
GO:007156022 | Lung | MIAC | cellular response to transforming growth factor beta stimulus | 26/967 | 250/18723 | 5.59e-04 | 1.42e-02 | 26 |
GO:000195422 | Lung | MIAC | positive regulation of cell-matrix adhesion | 10/967 | 58/18723 | 7.02e-04 | 1.60e-02 | 10 |
GO:20010442 | Lung | MIAC | regulation of integrin-mediated signaling pathway | 5/967 | 16/18723 | 9.85e-04 | 2.04e-02 | 5 |
Hugo Symbol | Variant Class | Variant Classification | dbSNP RS | HGVSc | HGVSp | HGVSp Short | SWISSPROT | BIOTYPE | SIFT | PolyPhen | Tumor Sample Barcode | Tissue | Histology | Sex | Age | Stage | Therapy Types | Drugs | Outcome |
LIMS1 | SNV | Missense_Mutation | novel | c.61N>T | p.Arg21Cys | p.R21C | P48059 | protein_coding | deleterious_low_confidence(0.01) | benign(0.348) | TCGA-AC-A2FE-01 | Breast | breast invasive carcinoma | Female | <65 | III/IV | Chemotherapy | adriamycin | PD |
LIMS1 | SNV | Missense_Mutation | novel | c.473N>T | p.Arg158Leu | p.R158L | P48059 | protein_coding | tolerated(0.39) | benign(0.015) | TCGA-BH-A1FC-01 | Breast | breast invasive carcinoma | Female | >=65 | I/II | Unknown | Unknown | SD |
LIMS1 | SNV | Missense_Mutation | | c.1127G>T | p.Arg376Ile | p.R376I | P48059 | protein_coding | tolerated(0.06) | probably_damaging(0.991) | TCGA-D8-A1X6-01 | Breast | breast invasive carcinoma | Female | >=65 | III/IV | Hormone Therapy | tamoxiphen | SD |
LIMS1 | SNV | Missense_Mutation | rs149119038 | c.67N>A | p.Asp23Asn | p.D23N | P48059 | protein_coding | tolerated_low_confidence(0.48) | benign(0) | TCGA-EA-A3QE-01 | Cervix | cervical & endocervical cancer | Female | <65 | I/II | Unknown | Unknown | SD |
LIMS1 | SNV | Missense_Mutation | | c.247N>A | p.Glu83Lys | p.E83K | P48059 | protein_coding | deleterious(0) | probably_damaging(0.973) | TCGA-Q1-A73O-01 | Cervix | cervical & endocervical cancer | Female | <65 | I/II | Chemotherapy | cisplatin | CR |
LIMS1 | SNV | Missense_Mutation | | c.874C>T | p.Arg292Cys | p.R292C | P48059 | protein_coding | deleterious(0) | probably_damaging(0.982) | TCGA-AA-A00N-01 | Colorectum | colon adenocarcinoma | Male | >=65 | I/II | Unknown | Unknown | PD |
LIMS1 | SNV | Missense_Mutation | rs200004487 | c.220N>T | p.Arg74Cys | p.R74C | P48059 | protein_coding | deleterious(0.02) | probably_damaging(0.953) | TCGA-D5-6930-01 | Colorectum | colon adenocarcinoma | Male | >=65 | I/II | Unknown | Unknown | SD |
LIMS1 | insertion | Nonsense_Mutation | novel | c.892_893insTTTGAGACA | p.Gly298delinsValTerAspSer | p.G298delinsV*DS | P48059 | protein_coding | | | TCGA-AM-5820-01 | Colorectum | colon adenocarcinoma | Female | <65 | I/II | Unknown | Unknown | SD |
LIMS1 | SNV | Missense_Mutation | novel | c.556N>T | p.Arg186Cys | p.R186C | P48059 | protein_coding | deleterious(0.01) | possibly_damaging(0.901) | TCGA-AJ-A3EL-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | <65 | I/II | Unknown | Unknown | SD |
LIMS1 | SNV | Missense_Mutation | rs377342624 | c.794N>A | p.Arg265His | p.R265H | P48059 | protein_coding | deleterious(0.04) | probably_damaging(0.918) | TCGA-AJ-A3OK-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | >=65 | I/II | Chemotherapy | carboplatin | CR |