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Gene: LAMP1 |
Gene summary for LAMP1 |
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Gene information | Species | Human | Gene symbol | LAMP1 | Gene ID | 3916 |
Gene name | lysosomal associated membrane protein 1 | |
Gene Alias | CD107a | |
Cytomap | 13q34 | |
Gene Type | protein-coding | GO ID | GO:0001775 | UniProtAcc | A0A024RDY3 |
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Malignant transformation analysis |
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Entrez ID | Symbol | Replicates | Species | Organ | Tissue | Adj P-value | Log2FC | Malignancy |
3916 | LAMP1 | HTA11_3410_2000001011 | Human | Colorectum | AD | 3.61e-08 | 3.28e-01 | 0.0155 |
3916 | LAMP1 | HTA11_2487_2000001011 | Human | Colorectum | SER | 1.36e-16 | 8.99e-01 | -0.1808 |
3916 | LAMP1 | HTA11_1938_2000001011 | Human | Colorectum | AD | 5.90e-25 | 1.08e+00 | -0.0811 |
3916 | LAMP1 | HTA11_78_2000001011 | Human | Colorectum | AD | 1.97e-14 | 7.22e-01 | -0.1088 |
3916 | LAMP1 | HTA11_347_2000001011 | Human | Colorectum | AD | 1.61e-40 | 1.02e+00 | -0.1954 |
3916 | LAMP1 | HTA11_411_2000001011 | Human | Colorectum | SER | 3.83e-11 | 1.57e+00 | -0.2602 |
3916 | LAMP1 | HTA11_2112_2000001011 | Human | Colorectum | SER | 4.60e-09 | 1.14e+00 | -0.2196 |
3916 | LAMP1 | HTA11_3361_2000001011 | Human | Colorectum | AD | 8.14e-04 | 5.64e-01 | -0.1207 |
3916 | LAMP1 | HTA11_83_2000001011 | Human | Colorectum | SER | 3.84e-16 | 1.02e+00 | -0.1526 |
3916 | LAMP1 | HTA11_696_2000001011 | Human | Colorectum | AD | 3.35e-41 | 1.03e+00 | -0.1464 |
3916 | LAMP1 | HTA11_866_2000001011 | Human | Colorectum | AD | 7.18e-18 | 5.52e-01 | -0.1001 |
3916 | LAMP1 | HTA11_1391_2000001011 | Human | Colorectum | AD | 1.08e-24 | 1.15e+00 | -0.059 |
3916 | LAMP1 | HTA11_2992_2000001011 | Human | Colorectum | SER | 2.22e-09 | 1.09e+00 | -0.1706 |
3916 | LAMP1 | HTA11_5212_2000001011 | Human | Colorectum | AD | 1.73e-17 | 1.38e+00 | -0.2061 |
3916 | LAMP1 | HTA11_546_2000001011 | Human | Colorectum | AD | 4.52e-06 | 5.69e-01 | -0.0842 |
3916 | LAMP1 | HTA11_7862_2000001011 | Human | Colorectum | AD | 3.11e-10 | 7.90e-01 | -0.0179 |
3916 | LAMP1 | HTA11_866_3004761011 | Human | Colorectum | AD | 7.89e-24 | 9.08e-01 | 0.096 |
3916 | LAMP1 | HTA11_4255_2000001011 | Human | Colorectum | SER | 6.61e-03 | 6.99e-01 | 0.0446 |
3916 | LAMP1 | HTA11_8622_2000001021 | Human | Colorectum | SER | 1.72e-07 | 7.32e-01 | 0.0528 |
3916 | LAMP1 | HTA11_7663_2000001011 | Human | Colorectum | SER | 7.50e-07 | 9.32e-01 | 0.0131 |
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∗log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage. |
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Malignant transformation related pathway analysis |
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Tissue | Disease Stage | Enriched GO biological Processes |
Colorectum | AD | ![]() |
Colorectum | SER | ![]() |
Colorectum | MSS | ![]() |
Colorectum | MSI-H | ![]() |
Colorectum | FAP | ![]() |
∗Top 15 enriched GO BP terms are showed in the bar plot of each disease state in each tissue. Each row represents a significant GO biological process which is colored according to the -log10(p.adjust). |
Page: 1 2 3 4 5 6 7 8 9 |
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GO ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | Count |
GO:00109706 | Oral cavity | OSCC | transport along microtubule | 88/7305 | 155/18723 | 5.35e-06 | 6.02e-05 | 88 |
GO:004440920 | Oral cavity | OSCC | entry into host | 86/7305 | 151/18723 | 5.74e-06 | 6.37e-05 | 86 |
GO:00723845 | Oral cavity | OSCC | organelle transport along microtubule | 53/7305 | 85/18723 | 1.10e-05 | 1.14e-04 | 53 |
GO:00450884 | Oral cavity | OSCC | regulation of innate immune response | 116/7305 | 218/18723 | 1.36e-05 | 1.37e-04 | 116 |
GO:004671820 | Oral cavity | OSCC | viral entry into host cell | 81/7305 | 144/18723 | 1.98e-05 | 1.89e-04 | 81 |
GO:00321037 | Oral cavity | OSCC | positive regulation of response to external stimulus | 203/7305 | 427/18723 | 1.79e-04 | 1.22e-03 | 203 |
GO:00991113 | Oral cavity | OSCC | microtubule-based transport | 96/7305 | 190/18723 | 7.92e-04 | 4.27e-03 | 96 |
GO:00328863 | Oral cavity | OSCC | regulation of microtubule-based process | 115/7305 | 240/18723 | 2.95e-03 | 1.28e-02 | 115 |
GO:00481022 | Oral cavity | OSCC | autophagic cell death | 9/7305 | 11/18723 | 4.85e-03 | 1.92e-02 | 9 |
GO:00068962 | Oral cavity | OSCC | Golgi to vacuole transport | 14/7305 | 20/18723 | 4.95e-03 | 1.94e-02 | 14 |
GO:00313495 | Oral cavity | OSCC | positive regulation of defense response | 127/7305 | 278/18723 | 1.32e-02 | 4.39e-02 | 127 |
GO:0016032110 | Oral cavity | LP | viral process | 211/4623 | 415/18723 | 4.06e-31 | 3.18e-28 | 211 |
GO:007259419 | Oral cavity | LP | establishment of protein localization to organelle | 205/4623 | 422/18723 | 6.76e-27 | 3.85e-24 | 205 |
GO:0019058110 | Oral cavity | LP | viral life cycle | 161/4623 | 317/18723 | 5.99e-24 | 2.21e-21 | 161 |
GO:004819316 | Oral cavity | LP | Golgi vesicle transport | 141/4623 | 296/18723 | 6.11e-18 | 1.06e-15 | 141 |
GO:0051701110 | Oral cavity | LP | biological process involved in interaction with host | 100/4623 | 203/18723 | 2.72e-14 | 3.10e-12 | 100 |
GO:0044403110 | Oral cavity | LP | biological process involved in symbiotic interaction | 130/4623 | 290/18723 | 4.23e-14 | 4.64e-12 | 130 |
GO:0031647110 | Oral cavity | LP | regulation of protein stability | 132/4623 | 298/18723 | 8.16e-14 | 7.99e-12 | 132 |
GO:003238616 | Oral cavity | LP | regulation of intracellular transport | 145/4623 | 337/18723 | 8.58e-14 | 8.27e-12 | 145 |
GO:0052126110 | Oral cavity | LP | movement in host environment | 87/4623 | 175/18723 | 6.65e-13 | 5.79e-11 | 87 |
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Pathway ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | qvalue | Count |
hsa04140 | Colorectum | AD | Autophagy - animal | 49/2092 | 141/8465 | 4.58e-03 | 2.20e-02 | 1.40e-02 | 49 |
hsa041401 | Colorectum | AD | Autophagy - animal | 49/2092 | 141/8465 | 4.58e-03 | 2.20e-02 | 1.40e-02 | 49 |
hsa04142 | Colorectum | SER | Lysosome | 38/1580 | 132/8465 | 2.87e-03 | 2.03e-02 | 1.47e-02 | 38 |
hsa041402 | Colorectum | SER | Autophagy - animal | 39/1580 | 141/8465 | 5.43e-03 | 3.28e-02 | 2.38e-02 | 39 |
hsa041421 | Colorectum | SER | Lysosome | 38/1580 | 132/8465 | 2.87e-03 | 2.03e-02 | 1.47e-02 | 38 |
hsa041403 | Colorectum | SER | Autophagy - animal | 39/1580 | 141/8465 | 5.43e-03 | 3.28e-02 | 2.38e-02 | 39 |
hsa041404 | Colorectum | MSS | Autophagy - animal | 45/1875 | 141/8465 | 4.42e-03 | 1.90e-02 | 1.16e-02 | 45 |
hsa041405 | Colorectum | MSS | Autophagy - animal | 45/1875 | 141/8465 | 4.42e-03 | 1.90e-02 | 1.16e-02 | 45 |
hsa04145 | Colorectum | MSI-H | Phagosome | 27/797 | 152/8465 | 8.74e-04 | 1.01e-02 | 8.48e-03 | 27 |
hsa041451 | Colorectum | MSI-H | Phagosome | 27/797 | 152/8465 | 8.74e-04 | 1.01e-02 | 8.48e-03 | 27 |
hsa0414524 | Endometrium | AEH | Phagosome | 41/1197 | 152/8465 | 2.12e-05 | 2.22e-04 | 1.63e-04 | 41 |
hsa04145111 | Endometrium | AEH | Phagosome | 41/1197 | 152/8465 | 2.12e-05 | 2.22e-04 | 1.63e-04 | 41 |
hsa0414525 | Endometrium | EEC | Phagosome | 42/1237 | 152/8465 | 2.01e-05 | 2.28e-04 | 1.70e-04 | 42 |
hsa0414534 | Endometrium | EEC | Phagosome | 42/1237 | 152/8465 | 2.01e-05 | 2.28e-04 | 1.70e-04 | 42 |
hsa041426 | Esophagus | HGIN | Lysosome | 33/1383 | 132/8465 | 6.65e-03 | 4.37e-02 | 3.47e-02 | 33 |
hsa0414213 | Esophagus | HGIN | Lysosome | 33/1383 | 132/8465 | 6.65e-03 | 4.37e-02 | 3.47e-02 | 33 |
hsa0414222 | Esophagus | ESCC | Lysosome | 102/4205 | 132/8465 | 5.11e-11 | 7.13e-10 | 3.65e-10 | 102 |
hsa0414010 | Esophagus | ESCC | Autophagy - animal | 101/4205 | 141/8465 | 7.60e-08 | 6.21e-07 | 3.18e-07 | 101 |
hsa0414530 | Esophagus | ESCC | Phagosome | 100/4205 | 152/8465 | 3.81e-05 | 1.72e-04 | 8.82e-05 | 100 |
hsa051527 | Esophagus | ESCC | Tuberculosis | 111/4205 | 180/8465 | 7.14e-04 | 2.32e-03 | 1.19e-03 | 111 |
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Cell-cell communication analysis |
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Ligand | Receptor | LRpair | Pathway | Tissue | Disease Stage |
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Single-cell gene regulatory network inference analysis |
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TF | Cell Type | Tissue | Disease Stage | Target Gene | RSS | Regulon Activity |
∗The dot plots of a searched regulon are shown for all cell subpopulations in each disease state of each tissue based on the regulon specific score inferred using pySCENIC and by calculating the average expression. |
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Somatic mutation of malignant transformation related genes |
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Hugo Symbol | Variant Class | Variant Classification | dbSNP RS | HGVSc | HGVSp | HGVSp Short | SWISSPROT | BIOTYPE | SIFT | PolyPhen | Tumor Sample Barcode | Tissue | Histology | Sex | Age | Stage | Therapy Types | Drugs | Outcome |
LAMP1 | SNV | Missense_Mutation | c.484N>A | p.His162Asn | p.H162N | P11279 | protein_coding | tolerated(0.51) | benign(0.009) | TCGA-C8-A1HJ-01 | Breast | breast invasive carcinoma | Female | <65 | I/II | Unknown | Unknown | SD | |
LAMP1 | insertion | Frame_Shift_Ins | novel | c.166_167insGGATTTTAAATGAAAAG | p.Thr56ArgfsTer14 | p.T56Rfs*14 | P11279 | protein_coding | TCGA-BH-A0BR-01 | Breast | breast invasive carcinoma | Female | <65 | I/II | Unknown | Unknown | SD | ||
LAMP1 | insertion | Frame_Shift_Ins | novel | c.167_168insTAAGCATCCTCTCTTT | p.Ser58HisfsTer9 | p.S58Hfs*9 | P11279 | protein_coding | TCGA-BH-A0BR-01 | Breast | breast invasive carcinoma | Female | <65 | I/II | Unknown | Unknown | SD | ||
LAMP1 | SNV | Missense_Mutation | novel | c.127A>C | p.Met43Leu | p.M43L | P11279 | protein_coding | tolerated(0.42) | benign(0.003) | TCGA-2W-A8YY-01 | Cervix | cervical & endocervical cancer | Female | <65 | I/II | Chemotherapy | cisplatin | CR |
LAMP1 | SNV | Missense_Mutation | c.1065C>G | p.Phe355Leu | p.F355L | P11279 | protein_coding | deleterious(0) | possibly_damaging(0.792) | TCGA-C5-A1M6-01 | Cervix | cervical & endocervical cancer | Female | <65 | I/II | Chemotherapy | cisplatin | PD | |
LAMP1 | SNV | Missense_Mutation | rs370286796 | c.752N>T | p.Thr251Met | p.T251M | P11279 | protein_coding | tolerated(0.24) | possibly_damaging(0.462) | TCGA-A6-2681-01 | Colorectum | colon adenocarcinoma | Female | >=65 | I/II | Unknown | Unknown | PD |
LAMP1 | SNV | Missense_Mutation | rs757618803 | c.1046N>T | p.Ala349Val | p.A349V | P11279 | protein_coding | tolerated(0.15) | benign(0.08) | TCGA-AA-3877-01 | Colorectum | colon adenocarcinoma | Female | >=65 | I/II | Unknown | Unknown | SD |
LAMP1 | SNV | Missense_Mutation | rs371034089 | c.967G>A | p.Gly323Ser | p.G323S | P11279 | protein_coding | tolerated(1) | benign(0.001) | TCGA-AD-6895-01 | Colorectum | colon adenocarcinoma | Male | >=65 | III/IV | Unknown | Unknown | SD |
LAMP1 | SNV | Missense_Mutation | rs767683537 | c.1033N>T | p.Arg345Cys | p.R345C | P11279 | protein_coding | tolerated(0.17) | possibly_damaging(0.759) | TCGA-AD-6964-01 | Colorectum | colon adenocarcinoma | Male | <65 | III/IV | Chemotherapy | folfox | PD |
LAMP1 | SNV | Missense_Mutation | c.1169N>A | p.Gly390Asp | p.G390D | P11279 | protein_coding | deleterious(0) | probably_damaging(0.98) | TCGA-F4-6570-01 | Colorectum | colon adenocarcinoma | Female | >=65 | I/II | Unknown | Unknown | SD |
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Related drugs of malignant transformation related genes |
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(DGIdb 4.0) |
Entrez ID | Symbol | Category | Interaction Types | Drug Claim Name | Drug Name | PMIDs |
3916 | LAMP1 | DRUGGABLE GENOME, EXTERNAL SIDE OF PLASMA MEMBRANE | DIMETHYL SULFOXIDE | 2243101 |
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