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Gene: HIP1R |
Gene summary for HIP1R |
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Gene information | Species | Human | Gene symbol | HIP1R | Gene ID | 9026 |
Gene name | huntingtin interacting protein 1 related | |
Gene Alias | HIP12 | |
Cytomap | 12q24.31 | |
Gene Type | protein-coding | GO ID | GO:0001696 | UniProtAcc | B3KQW8 |
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Malignant transformation analysis |
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Entrez ID | Symbol | Replicates | Species | Organ | Tissue | Adj P-value | Log2FC | Malignancy |
9026 | HIP1R | LZE5T | Human | Esophagus | ESCC | 7.82e-03 | 3.46e-01 | 0.0514 |
9026 | HIP1R | LZE7T | Human | Esophagus | ESCC | 4.47e-04 | 2.75e-01 | 0.0667 |
9026 | HIP1R | LZE20T | Human | Esophagus | ESCC | 3.71e-06 | 1.65e-01 | 0.0662 |
9026 | HIP1R | LZE24T | Human | Esophagus | ESCC | 2.89e-14 | 3.54e-01 | 0.0596 |
9026 | HIP1R | LZE21T | Human | Esophagus | ESCC | 1.13e-04 | 3.65e-01 | 0.0655 |
9026 | HIP1R | P1T-E | Human | Esophagus | ESCC | 2.93e-13 | 5.13e-01 | 0.0875 |
9026 | HIP1R | P2T-E | Human | Esophagus | ESCC | 5.73e-26 | 5.53e-01 | 0.1177 |
9026 | HIP1R | P4T-E | Human | Esophagus | ESCC | 1.92e-10 | 2.49e-01 | 0.1323 |
9026 | HIP1R | P5T-E | Human | Esophagus | ESCC | 1.69e-18 | 4.14e-01 | 0.1327 |
9026 | HIP1R | P8T-E | Human | Esophagus | ESCC | 4.42e-24 | 4.96e-01 | 0.0889 |
9026 | HIP1R | P9T-E | Human | Esophagus | ESCC | 1.65e-03 | 1.39e-01 | 0.1131 |
9026 | HIP1R | P10T-E | Human | Esophagus | ESCC | 4.44e-08 | 1.23e-01 | 0.116 |
9026 | HIP1R | P11T-E | Human | Esophagus | ESCC | 2.26e-07 | 3.98e-01 | 0.1426 |
9026 | HIP1R | P12T-E | Human | Esophagus | ESCC | 2.81e-16 | 3.20e-01 | 0.1122 |
9026 | HIP1R | P15T-E | Human | Esophagus | ESCC | 1.40e-14 | 3.38e-01 | 0.1149 |
9026 | HIP1R | P16T-E | Human | Esophagus | ESCC | 3.26e-15 | 2.36e-01 | 0.1153 |
9026 | HIP1R | P17T-E | Human | Esophagus | ESCC | 7.22e-10 | 4.00e-01 | 0.1278 |
9026 | HIP1R | P20T-E | Human | Esophagus | ESCC | 3.11e-09 | 2.71e-01 | 0.1124 |
9026 | HIP1R | P21T-E | Human | Esophagus | ESCC | 3.24e-28 | 5.04e-01 | 0.1617 |
9026 | HIP1R | P22T-E | Human | Esophagus | ESCC | 5.12e-05 | 1.10e-01 | 0.1236 |
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∗log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage. |
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Malignant transformation related pathway analysis |
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Tissue | Disease Stage | Enriched GO biological Processes |
Colorectum | AD | ![]() |
Colorectum | SER | ![]() |
Colorectum | MSS | ![]() |
Colorectum | MSI-H | ![]() |
Colorectum | FAP | ![]() |
∗Top 15 enriched GO BP terms are showed in the bar plot of each disease state in each tissue. Each row represents a significant GO biological process which is colored according to the -log10(p.adjust). |
Page: 1 2 3 4 5 6 7 8 9 |
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GO ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | Count |
GO:00357947 | Oral cavity | OSCC | positive regulation of mitochondrial membrane permeability | 31/7305 | 43/18723 | 1.10e-05 | 1.14e-04 | 31 |
GO:003004118 | Oral cavity | OSCC | actin filament polymerization | 103/7305 | 191/18723 | 1.94e-05 | 1.87e-04 | 103 |
GO:00420587 | Oral cavity | OSCC | regulation of epidermal growth factor receptor signaling pathway | 46/7305 | 73/18723 | 2.80e-05 | 2.59e-04 | 46 |
GO:003133318 | Oral cavity | OSCC | negative regulation of protein-containing complex assembly | 79/7305 | 141/18723 | 3.01e-05 | 2.76e-04 | 79 |
GO:00973459 | Oral cavity | OSCC | mitochondrial outer membrane permeabilization | 24/7305 | 32/18723 | 3.83e-05 | 3.37e-04 | 24 |
GO:000689810 | Oral cavity | OSCC | receptor-mediated endocytosis | 125/7305 | 244/18723 | 6.56e-05 | 5.32e-04 | 125 |
GO:19026868 | Oral cavity | OSCC | mitochondrial outer membrane permeabilization involved in programmed cell death | 28/7305 | 40/18723 | 7.00e-05 | 5.60e-04 | 28 |
GO:19057107 | Oral cavity | OSCC | positive regulation of membrane permeability | 32/7305 | 48/18723 | 9.60e-05 | 7.25e-04 | 32 |
GO:00069196 | Oral cavity | OSCC | activation of cysteine-type endopeptidase activity involved in apoptotic process | 47/7305 | 78/18723 | 1.16e-04 | 8.42e-04 | 47 |
GO:19021107 | Oral cavity | OSCC | positive regulation of mitochondrial membrane permeability involved in apoptotic process | 26/7305 | 38/18723 | 2.29e-04 | 1.49e-03 | 26 |
GO:19021085 | Oral cavity | OSCC | regulation of mitochondrial membrane permeability involved in apoptotic process | 29/7305 | 45/18723 | 4.85e-04 | 2.86e-03 | 29 |
GO:00725838 | Oral cavity | OSCC | clathrin-dependent endocytosis | 30/7305 | 47/18723 | 4.96e-04 | 2.92e-03 | 30 |
GO:19010288 | Oral cavity | OSCC | regulation of mitochondrial outer membrane permeabilization involved in apoptotic signaling pathway | 16/7305 | 21/18723 | 5.99e-04 | 3.39e-03 | 16 |
GO:00480086 | Oral cavity | OSCC | platelet-derived growth factor receptor signaling pathway | 34/7305 | 56/18723 | 8.17e-04 | 4.35e-03 | 34 |
GO:003431410 | Oral cavity | OSCC | Arp2/3 complex-mediated actin nucleation | 25/7305 | 39/18723 | 1.32e-03 | 6.57e-03 | 25 |
GO:004825910 | Oral cavity | OSCC | regulation of receptor-mediated endocytosis | 58/7305 | 110/18723 | 2.37e-03 | 1.05e-02 | 58 |
GO:19010303 | Oral cavity | OSCC | positive regulation of mitochondrial outer membrane permeabilization involved in apoptotic signaling pathway | 9/7305 | 11/18723 | 4.85e-03 | 1.92e-02 | 9 |
GO:190290417 | Oral cavity | OSCC | negative regulation of supramolecular fiber organization | 81/7305 | 167/18723 | 7.70e-03 | 2.82e-02 | 81 |
GO:00343155 | Oral cavity | OSCC | regulation of Arp2/3 complex-mediated actin nucleation | 14/7305 | 21/18723 | 9.54e-03 | 3.39e-02 | 14 |
GO:00450107 | Oral cavity | OSCC | actin nucleation | 29/7305 | 52/18723 | 1.05e-02 | 3.57e-02 | 29 |
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Pathway ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | qvalue | Count |
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Cell-cell communication analysis |
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Ligand | Receptor | LRpair | Pathway | Tissue | Disease Stage |
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Single-cell gene regulatory network inference analysis |
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TF | Cell Type | Tissue | Disease Stage | Target Gene | RSS | Regulon Activity |
∗The dot plots of a searched regulon are shown for all cell subpopulations in each disease state of each tissue based on the regulon specific score inferred using pySCENIC and by calculating the average expression. |
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Somatic mutation of malignant transformation related genes |
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Hugo Symbol | Variant Class | Variant Classification | dbSNP RS | HGVSc | HGVSp | HGVSp Short | SWISSPROT | BIOTYPE | SIFT | PolyPhen | Tumor Sample Barcode | Tissue | Histology | Sex | Age | Stage | Therapy Types | Drugs | Outcome |
HIP1R | SNV | Missense_Mutation | rs771199833 | c.2192N>T | p.Arg731Leu | p.R731L | O75146 | protein_coding | deleterious(0.02) | benign(0.001) | TCGA-A7-A3RF-01 | Breast | breast invasive carcinoma | Female | >=65 | I/II | Hormone Therapy | anastrozole | PD |
HIP1R | SNV | Missense_Mutation | c.2901T>G | p.Asp967Glu | p.D967E | O75146 | protein_coding | deleterious(0.03) | probably_damaging(0.998) | TCGA-E2-A1B4-01 | Breast | breast invasive carcinoma | Female | >=65 | III/IV | Hormone Therapy | arimidex | SD | |
HIP1R | SNV | Missense_Mutation | rs749155510 | c.1696N>T | p.Arg566Trp | p.R566W | O75146 | protein_coding | deleterious(0.01) | possibly_damaging(0.677) | TCGA-2W-A8YY-01 | Cervix | cervical & endocervical cancer | Female | <65 | I/II | Chemotherapy | cisplatin | CR |
HIP1R | insertion | Frame_Shift_Ins | novel | c.2349_2350insCTGG | p.Asp784LeufsTer13 | p.D784Lfs*13 | O75146 | protein_coding | TCGA-DS-A1OA-01 | Cervix | cervical & endocervical cancer | Female | >=65 | I/II | Chemotherapy | carboplatin | PD | ||
HIP1R | insertion | Frame_Shift_Ins | novel | c.2351_2352insAAGC | p.Asp784GlufsTer13 | p.D784Efs*13 | O75146 | protein_coding | TCGA-DS-A1OA-01 | Cervix | cervical & endocervical cancer | Female | >=65 | I/II | Chemotherapy | carboplatin | PD | ||
HIP1R | SNV | Missense_Mutation | rs375128048 | c.374N>A | p.Arg125His | p.R125H | O75146 | protein_coding | tolerated(0.08) | possibly_damaging(0.708) | TCGA-5M-AAT6-01 | Colorectum | colon adenocarcinoma | Female | <65 | III/IV | Unknown | Unknown | PD |
HIP1R | SNV | Missense_Mutation | rs752398981 | c.1888G>A | p.Glu630Lys | p.E630K | O75146 | protein_coding | deleterious(0.01) | possibly_damaging(0.701) | TCGA-AA-3492-01 | Colorectum | colon adenocarcinoma | Female | >=65 | I/II | Unknown | Unknown | SD |
HIP1R | SNV | Missense_Mutation | rs185463143 | c.1801C>T | p.Arg601Trp | p.R601W | O75146 | protein_coding | deleterious(0.02) | possibly_damaging(0.462) | TCGA-AA-3663-01 | Colorectum | colon adenocarcinoma | Male | <65 | I/II | Unknown | Unknown | SD |
HIP1R | SNV | Missense_Mutation | rs756668419 | c.842G>A | p.Arg281Gln | p.R281Q | O75146 | protein_coding | tolerated(1) | benign(0.013) | TCGA-AA-3947-01 | Colorectum | colon adenocarcinoma | Female | <65 | I/II | Unknown | Unknown | SD |
HIP1R | SNV | Missense_Mutation | rs140673904 | c.3068C>T | p.Ala1023Val | p.A1023V | O75146 | protein_coding | tolerated(0.27) | benign(0.013) | TCGA-AA-3947-01 | Colorectum | colon adenocarcinoma | Female | <65 | I/II | Unknown | Unknown | SD |
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Related drugs of malignant transformation related genes |
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(DGIdb 4.0) |
Entrez ID | Symbol | Category | Interaction Types | Drug Claim Name | Drug Name | PMIDs |
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