Schematic overview of the cellular and molecular mechanisms involved in the cancer progression, including the proposed cellular and molecular mechanisms in cancer cells trajectory. AT1: alveolar type 1 cells; AT2: alveolar type 2 cells; AAH: atypical adenomatous hyperplasia; AIS: adenocarcinoma in situ; MIA: minimally invasive adenocarcinoma; IA: invasive adenocarcinoma; EMT: epithelial-mesenchymal transition

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Center for Computational Systems Medicine
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Gene summary

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Malignant transformation analysis

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Malignant transformation related pathway analysis

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Cell-cell communication analysis

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Single-cell gene regulatory network inference analysis

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Somatic mutation of malignant transformation related genes

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Related drugs of malignant transformation related genes

Gene: HIP1

Gene summary for HIP1

check button Gene summary.

Gene informationSpeciesHuman
Gene symbol

HIP1

Gene ID

3092

Gene namehuntingtin interacting protein 1
Gene AliasHIP-I
Cytomap7q11.23
Gene Typeprotein-coding
GO ID

GO:0006508

UniProtAcc

B4DK46


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Malignant transformation analysis

check button Identification of the aberrant gene expression in precancerous and cancerous lesions by comparing the gene expression of stem-like cells in diseased tissues with normal stem cells
check button Malignant transformation involving gene list.
Entrez IDSymbolReplicatesSpeciesOrganTissueAdj P-valueLog2FCMalignancy
3092HIP1CCI_2HumanCervixCC7.82e-045.67e-010.5249
3092HIP1CCI_3HumanCervixCC3.04e-076.98e-010.516
3092HIP1HTA11_347_2000001011HumanColorectumAD1.12e-033.91e-01-0.1954
3092HIP1HTA11_546_2000001011HumanColorectumAD1.28e-025.12e-01-0.0842
3092HIP1HTA11_99999974143_84620HumanColorectumMSS4.20e-024.44e-010.3005
3092HIP1A001-C-119HumanColorectumFAP2.14e-045.15e-01-0.1557
3092HIP1A002-C-116HumanColorectumFAP5.09e-05-1.78e-01-0.0452
3092HIP1AEH-subject1HumanEndometriumAEH4.17e-154.55e-01-0.3059
3092HIP1AEH-subject2HumanEndometriumAEH3.72e-053.16e-01-0.2525
3092HIP1AEH-subject3HumanEndometriumAEH2.06e-052.39e-01-0.2576
3092HIP1AEH-subject4HumanEndometriumAEH2.10e-033.24e-01-0.2657
3092HIP1AEH-subject5HumanEndometriumAEH5.00e-032.89e-01-0.2953
3092HIP1EEC-subject1HumanEndometriumEEC4.51e-124.09e-01-0.2682
3092HIP1EEC-subject2HumanEndometriumEEC1.82e-073.15e-01-0.2607
3092HIP1EEC-subject3HumanEndometriumEEC1.82e-082.30e-01-0.2525
3092HIP1EEC-subject4HumanEndometriumEEC8.51e-062.52e-01-0.2571
3092HIP1GSM6177620_NYU_UCEC1_lib1_lib1HumanEndometriumEEC1.38e-057.39e-02-0.1869
3092HIP1GSM6177620_NYU_UCEC1_lib2_lib2HumanEndometriumEEC4.52e-06-5.06e-03-0.1875
3092HIP1GSM6177620_NYU_UCEC1_lib3_lib3HumanEndometriumEEC8.08e-07-2.47e-02-0.1883
3092HIP1GSM6177621_NYU_UCEC2_lib1_lib1HumanEndometriumEEC2.58e-071.41e-02-0.1934
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check button Transcriptomic changes along malignancy continuum.
TissueExpression DynamicsAbbreviation
CervixThe image shows the transcriptomic changes along malignancy continuum.log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage.CC: Cervix cancer
HSIL_HPV: HPV-infected high-grade squamous intraepithelial lesions
N_HPV: HPV-infected normal cervix
Colorectum (GSE201348)The image shows the transcriptomic changes along malignancy continuum.log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage.FAP: Familial adenomatous polyposis
CRC: Colorectal cancer
Colorectum (HTA11)The image shows the transcriptomic changes along malignancy continuum.log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage.AD: Adenomas
SER: Sessile serrated lesions
MSI-H: Microsatellite-high colorectal cancer
MSS: Microsatellite stable colorectal cancer
EndometriumThe image shows the transcriptomic changes along malignancy continuum.log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage.AEH: Atypical endometrial hyperplasia
EEC: Endometrioid Cancer
EsophagusThe image shows the transcriptomic changes along malignancy continuum.log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage.ESCC: Esophageal squamous cell carcinoma
HGIN: High-grade intraepithelial neoplasias
LGIN: Low-grade intraepithelial neoplasias
LiverThe image shows the transcriptomic changes along malignancy continuum.log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage.HCC: Hepatocellular carcinoma
NAFLD: Non-alcoholic fatty liver disease
LungThe image shows the transcriptomic changes along malignancy continuum.log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage.AAH: Atypical adenomatous hyperplasia
AIS: Adenocarcinoma in situ
IAC: Invasive lung adenocarcinoma
MIA: Minimally invasive adenocarcinoma
Oral CavityThe image shows the transcriptomic changes along malignancy continuum.log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage.EOLP: Erosive Oral lichen planus
LP: leukoplakia
NEOLP: Non-erosive oral lichen planus
OSCC: Oral squamous cell carcinoma
ProstateThe image shows the transcriptomic changes along malignancy continuum.log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage.BPH: Benign Prostatic Hyperplasia
SkinThe image shows the transcriptomic changes along malignancy continuum.log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage.AK: Actinic keratosis
cSCC: Cutaneous squamous cell carcinoma
SCCIS:squamous cell carcinoma in situ
ThyroidThe image shows the transcriptomic changes along malignancy continuum.log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage.ATC: Anaplastic thyroid cancer
HT: Hashimoto's thyroiditis
PTC: Papillary thyroid cancer
∗log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage.

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Malignant transformation related pathway analysis

check buttonFind out the enriched GO biological processes and KEGG pathways involved in transition from healthy to precancer to cancer
check button Figure of enriched GO biological processes.
TissueDisease StageEnriched GO biological Processes
ColorectumADGO analysis - Figure of enriched GO biological processes: Top 15 enriched GO BP terms are showed in the bar plot of each disease state in each tissue. Each row represents a significant GO biological process which is colored according to the -log10(p.adjust).
ColorectumSERGO analysis - Figure of enriched GO biological processes: Top 15 enriched GO BP terms are showed in the bar plot of each disease state in each tissue. Each row represents a significant GO biological process which is colored according to the -log10(p.adjust).
ColorectumMSSGO analysis - Figure of enriched GO biological processes: Top 15 enriched GO BP terms are showed in the bar plot of each disease state in each tissue. Each row represents a significant GO biological process which is colored according to the -log10(p.adjust).
ColorectumMSI-HGO analysis - Figure of enriched GO biological processes: Top 15 enriched GO BP terms are showed in the bar plot of each disease state in each tissue. Each row represents a significant GO biological process which is colored according to the -log10(p.adjust).
ColorectumFAPGO analysis - Figure of enriched GO biological processes: Top 15 enriched GO BP terms are showed in the bar plot of each disease state in each tissue. Each row represents a significant GO biological process which is colored according to the -log10(p.adjust).
∗Top 15 enriched GO BP terms are showed in the bar plot of each disease state in each tissue. Each row represents a significant GO biological process which is colored according to the -log10(p.adjust).
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check button Enriched GO biological processes.
GO IDTissueDisease StageDescriptionGene RatioBg Ratiopvaluep.adjustCount
GO:190290312LiverCirrhoticregulation of supramolecular fiber organization148/4634383/187238.85e-104.08e-08148
GO:003297012LiverCirrhoticregulation of actin filament-based process152/4634397/187231.12e-095.00e-08152
GO:00432817LiverCirrhoticregulation of cysteine-type endopeptidase activity involved in apoptotic process91/4634209/187231.91e-097.98e-0891
GO:00070065LiverCirrhoticmitochondrial membrane organization57/4634116/187231.13e-084.29e-0757
GO:003295612LiverCirrhoticregulation of actin cytoskeleton organization136/4634358/187231.47e-085.49e-07136
GO:20001167LiverCirrhoticregulation of cysteine-type endopeptidase activity97/4634235/187231.61e-085.99e-0797
GO:005125812LiverCirrhoticprotein polymerization116/4634297/187232.87e-089.78e-07116
GO:004339312LiverCirrhoticregulation of protein binding83/4634196/187234.44e-081.42e-0683
GO:00313337LiverCirrhoticnegative regulation of protein-containing complex assembly64/4634141/187237.08e-082.14e-0664
GO:011005312LiverCirrhoticregulation of actin filament organization108/4634278/187231.17e-073.32e-06108
GO:00313347LiverCirrhoticpositive regulation of protein-containing complex assembly95/4634237/187231.21e-073.39e-0695
GO:190290512LiverCirrhoticpositive regulation of supramolecular fiber organization86/4634209/187231.21e-073.39e-0686
GO:005109912LiverCirrhoticpositive regulation of binding74/4634173/187231.44e-073.87e-0674
GO:00109527LiverCirrhoticpositive regulation of peptidase activity81/4634197/187232.89e-077.03e-0681
GO:003227112LiverCirrhoticregulation of protein polymerization92/4634233/187234.25e-079.86e-0692
GO:000815412LiverCirrhoticactin polymerization or depolymerization86/4634218/187231.04e-062.13e-0586
GO:00108216LiverCirrhoticregulation of mitochondrion organization62/4634144/187231.09e-062.22e-0562
GO:003004112LiverCirrhoticactin filament polymerization77/4634191/187231.41e-062.79e-0577
GO:003209211LiverCirrhoticpositive regulation of protein binding41/463485/187232.28e-064.19e-0541
GO:003253512LiverCirrhoticregulation of cellular component size135/4634383/187232.32e-064.26e-05135
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check button Enriched KEGG pathways.
Pathway IDTissueDisease StageDescriptionGene RatioBg Ratiopvaluep.adjustqvalueCount
hsa0501618CervixCCHuntington disease94/1267306/84658.49e-133.06e-111.81e-1194
hsa0502218CervixCCPathways of neurodegeneration - multiple diseases128/1267476/84652.87e-129.29e-115.50e-11128
hsa0501619CervixCCHuntington disease94/1267306/84658.49e-133.06e-111.81e-1194
hsa0502219CervixCCPathways of neurodegeneration - multiple diseases128/1267476/84652.87e-129.29e-115.50e-11128
hsa05016ColorectumADHuntington disease147/2092306/84651.93e-199.26e-185.91e-18147
hsa05022ColorectumADPathways of neurodegeneration - multiple diseases201/2092476/84654.54e-181.27e-168.09e-17201
hsa050161ColorectumADHuntington disease147/2092306/84651.93e-199.26e-185.91e-18147
hsa050221ColorectumADPathways of neurodegeneration - multiple diseases201/2092476/84654.54e-181.27e-168.09e-17201
hsa050164ColorectumMSSHuntington disease141/1875306/84652.90e-211.62e-199.92e-20141
hsa050224ColorectumMSSPathways of neurodegeneration - multiple diseases192/1875476/84652.79e-201.04e-186.36e-19192
hsa050165ColorectumMSSHuntington disease141/1875306/84652.90e-211.62e-199.92e-20141
hsa050225ColorectumMSSPathways of neurodegeneration - multiple diseases192/1875476/84652.79e-201.04e-186.36e-19192
hsa050228ColorectumFAPPathways of neurodegeneration - multiple diseases117/1404476/84652.81e-064.47e-052.72e-05117
hsa050168ColorectumFAPHuntington disease73/1404306/84655.54e-043.93e-032.39e-0373
hsa050229ColorectumFAPPathways of neurodegeneration - multiple diseases117/1404476/84652.81e-064.47e-052.72e-05117
hsa050169ColorectumFAPHuntington disease73/1404306/84655.54e-043.93e-032.39e-0373
hsa0501620EndometriumAEHHuntington disease118/1197306/84653.00e-272.44e-251.78e-25118
hsa0502220EndometriumAEHPathways of neurodegeneration - multiple diseases137/1197476/84659.27e-182.32e-161.70e-16137
hsa05016110EndometriumAEHHuntington disease118/1197306/84653.00e-272.44e-251.78e-25118
hsa05022110EndometriumAEHPathways of neurodegeneration - multiple diseases137/1197476/84659.27e-182.32e-161.70e-16137
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Cell-cell communication analysis

check buttonIdentification of potential cell-cell interactions between two cell types and their ligand-receptor pairs for different disease states
LigandReceptorLRpairPathwayTissueDisease Stage
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Single-cell gene regulatory network inference analysis

check buttonFind out the significant the regulons (TFs) and the target genes of each regulon across cell types for different disease states
TFCell TypeTissueDisease StageTarget GeneRSSRegulon Activity
∗The dot plots of a searched regulon are shown for all cell subpopulations in each disease state of each tissue based on the regulon specific score inferred using pySCENIC and by calculating the average expression.
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Somatic mutation of malignant transformation related genes

check buttonAnnotation of somatic variants for genes involved in malignant transformation
Hugo SymbolVariant ClassVariant ClassificationdbSNP RSHGVScHGVSpHGVSp ShortSWISSPROTBIOTYPESIFTPolyPhenTumor Sample BarcodeTissueHistologySexAgeStageTherapy TypesDrugsOutcome
HIP1SNVMissense_Mutationnovelc.341N>Ap.Ser114Tyrp.S114YO00291protein_codingtolerated(0.28)possibly_damaging(0.883)TCGA-A2-A0EV-01Breastbreast invasive carcinomaFemale>=65I/IIUnknownUnknownSD
HIP1SNVMissense_Mutationrs782471782c.1729C>Tp.Arg577Trpp.R577WO00291protein_codingdeleterious(0)benign(0.309)TCGA-A8-A09Z-01Breastbreast invasive carcinomaFemale>=65I/IIUnknownUnknownSD
HIP1SNVMissense_Mutationc.3067N>Cp.Glu1023Glnp.E1023QO00291protein_codingtolerated(0.09)benign(0.006)TCGA-AC-A23H-01Breastbreast invasive carcinomaFemale>=65I/IIUnknownUnknownPD
HIP1SNVMissense_Mutationc.2572C>Gp.Pro858Alap.P858AO00291protein_codingtolerated(0.68)benign(0.012)TCGA-B6-A0I8-01Breastbreast invasive carcinomaFemale<65I/IIUnknownUnknownPD
HIP1SNVMissense_Mutationc.757N>Ap.Asp253Asnp.D253NO00291protein_codingdeleterious(0)probably_damaging(1)TCGA-B6-A1KF-01Breastbreast invasive carcinomaFemale>=65I/IIUnknownUnknownSD
HIP1SNVMissense_Mutationrs587756668c.2482N>Cp.Thr828Prop.T828PO00291protein_codingdeleterious(0)probably_damaging(0.994)TCGA-D8-A1X7-01Breastbreast invasive carcinomaFemale<65I/IIChemotherapyHormone Therapydoxorubicine+cyclophosphamide+tamoxifenSD
HIP1SNVMissense_Mutationnovelc.2213N>Ap.Ser738Tyrp.S738YO00291protein_codingdeleterious(0.04)benign(0.003)TCGA-E9-A1RB-01Breastbreast invasive carcinomaFemale<65I/IIChemotherapymethotrexateSD
HIP1insertionFrame_Shift_Insnovelc.338_339insTCTGTCTGCACCTATAAAATGTTGGCAACTATGTAGTCp.Ser114LeufsTer15p.S114Lfs*15O00291protein_codingTCGA-A2-A0EV-01Breastbreast invasive carcinomaFemale>=65I/IIUnknownUnknownSD
HIP1SNVMissense_Mutationrs782794159c.228C>Gp.Phe76Leup.F76LO00291protein_codingdeleterious(0.01)probably_damaging(1)TCGA-IR-A3LL-01Cervixcervical & endocervical cancerFemale<65I/IIChemotherapycisplatinCR
HIP1SNVMissense_Mutationc.2855N>Tp.Ser952Leup.S952LO00291protein_codingdeleterious(0)probably_damaging(0.962)TCGA-Q1-A73P-01Cervixcervical & endocervical cancerFemale<65I/IIUnknownUnknownSD
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Related drugs of malignant transformation related genes

check buttonIdentification of chemicals and drugs interact with genes involved in malignant transfromation
(DGIdb 4.0)
Entrez IDSymbolCategoryInteraction TypesDrug Claim NameDrug NamePMIDs
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