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Gene: FASTK |
Gene summary for FASTK |
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Gene information | Species | Human | Gene symbol | FASTK | Gene ID | 10922 |
Gene name | Fas activated serine/threonine kinase | |
Gene Alias | FAST | |
Cytomap | 7q36.1 | |
Gene Type | protein-coding | GO ID | GO:0000959 | UniProtAcc | Q14296 |
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Malignant transformation analysis |
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Entrez ID | Symbol | Replicates | Species | Organ | Tissue | Adj P-value | Log2FC | Malignancy |
10922 | FASTK | HTA11_2487_2000001011 | Human | Colorectum | SER | 1.91e-04 | 2.80e-01 | -0.1808 |
10922 | FASTK | HTA11_1938_2000001011 | Human | Colorectum | AD | 9.57e-04 | 3.32e-01 | -0.0811 |
10922 | FASTK | HTA11_78_2000001011 | Human | Colorectum | AD | 2.73e-02 | 1.85e-01 | -0.1088 |
10922 | FASTK | HTA11_347_2000001011 | Human | Colorectum | AD | 1.61e-13 | 3.16e-01 | -0.1954 |
10922 | FASTK | HTA11_2112_2000001011 | Human | Colorectum | SER | 1.65e-04 | 5.59e-01 | -0.2196 |
10922 | FASTK | HTA11_3361_2000001011 | Human | Colorectum | AD | 3.46e-03 | 2.50e-01 | -0.1207 |
10922 | FASTK | HTA11_83_2000001011 | Human | Colorectum | SER | 7.84e-04 | 2.60e-01 | -0.1526 |
10922 | FASTK | HTA11_696_2000001011 | Human | Colorectum | AD | 2.74e-11 | 3.64e-01 | -0.1464 |
10922 | FASTK | HTA11_866_2000001011 | Human | Colorectum | AD | 4.32e-03 | 1.64e-01 | -0.1001 |
10922 | FASTK | HTA11_1391_2000001011 | Human | Colorectum | AD | 9.18e-07 | 3.99e-01 | -0.059 |
10922 | FASTK | HTA11_5216_2000001011 | Human | Colorectum | SER | 1.93e-02 | 4.15e-01 | -0.1462 |
10922 | FASTK | HTA11_10711_2000001011 | Human | Colorectum | AD | 8.21e-05 | 2.71e-01 | 0.0338 |
10922 | FASTK | HTA11_7696_3000711011 | Human | Colorectum | AD | 2.12e-10 | 3.39e-01 | 0.0674 |
10922 | FASTK | HTA11_6818_2000001021 | Human | Colorectum | AD | 1.25e-04 | 3.60e-01 | 0.0588 |
10922 | FASTK | HTA11_99999970781_79442 | Human | Colorectum | MSS | 2.20e-02 | 1.31e-01 | 0.294 |
10922 | FASTK | HTA11_99999971662_82457 | Human | Colorectum | MSS | 5.72e-04 | 2.06e-01 | 0.3859 |
10922 | FASTK | HTA11_99999974143_84620 | Human | Colorectum | MSS | 1.68e-08 | 3.70e-01 | 0.3005 |
10922 | FASTK | LZE2T | Human | Esophagus | ESCC | 5.77e-04 | 3.86e-01 | 0.082 |
10922 | FASTK | LZE4T | Human | Esophagus | ESCC | 3.76e-11 | 2.74e-01 | 0.0811 |
10922 | FASTK | LZE7T | Human | Esophagus | ESCC | 3.81e-16 | 7.19e-01 | 0.0667 |
Page: 1 2 3 4 5 6 7 8 |
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∗log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage. |
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Malignant transformation related pathway analysis |
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Tissue | Disease Stage | Enriched GO biological Processes |
Colorectum | AD | ![]() |
Colorectum | SER | ![]() |
Colorectum | MSS | ![]() |
Colorectum | MSI-H | ![]() |
Colorectum | FAP | ![]() |
∗Top 15 enriched GO BP terms are showed in the bar plot of each disease state in each tissue. Each row represents a significant GO biological process which is colored according to the -log10(p.adjust). |
Page: 1 2 3 4 5 6 7 8 9 |
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GO ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | Count |
GO:0006402112 | Thyroid | PTC | mRNA catabolic process | 139/5968 | 232/18723 | 9.59e-19 | 1.12e-16 | 139 |
GO:0071826113 | Thyroid | PTC | ribonucleoprotein complex subunit organization | 134/5968 | 227/18723 | 2.34e-17 | 2.24e-15 | 134 |
GO:0006417113 | Thyroid | PTC | regulation of translation | 236/5968 | 468/18723 | 2.70e-17 | 2.52e-15 | 236 |
GO:0034655112 | Thyroid | PTC | nucleobase-containing compound catabolic process | 211/5968 | 407/18723 | 2.72e-17 | 2.52e-15 | 211 |
GO:0022618113 | Thyroid | PTC | ribonucleoprotein complex assembly | 130/5968 | 220/18723 | 6.25e-17 | 5.47e-15 | 130 |
GO:0042273113 | Thyroid | PTC | ribosomal large subunit biogenesis | 57/5968 | 72/18723 | 1.79e-16 | 1.51e-14 | 57 |
GO:0046700111 | Thyroid | PTC | heterocycle catabolic process | 221/5968 | 445/18723 | 2.43e-15 | 1.72e-13 | 221 |
GO:0044270111 | Thyroid | PTC | cellular nitrogen compound catabolic process | 223/5968 | 451/18723 | 3.34e-15 | 2.31e-13 | 223 |
GO:0034250113 | Thyroid | PTC | positive regulation of cellular amide metabolic process | 98/5968 | 162/18723 | 5.26e-14 | 3.04e-12 | 98 |
GO:0019439111 | Thyroid | PTC | aromatic compound catabolic process | 225/5968 | 467/18723 | 8.51e-14 | 4.71e-12 | 225 |
GO:0045727113 | Thyroid | PTC | positive regulation of translation | 84/5968 | 136/18723 | 6.52e-13 | 3.08e-11 | 84 |
GO:1901361111 | Thyroid | PTC | organic cyclic compound catabolic process | 231/5968 | 495/18723 | 2.55e-12 | 1.12e-10 | 231 |
GO:0043487111 | Thyroid | PTC | regulation of RNA stability | 97/5968 | 170/18723 | 9.51e-12 | 3.97e-10 | 97 |
GO:0061013111 | Thyroid | PTC | regulation of mRNA catabolic process | 94/5968 | 166/18723 | 3.55e-11 | 1.29e-09 | 94 |
GO:0043488111 | Thyroid | PTC | regulation of mRNA stability | 90/5968 | 158/18723 | 5.98e-11 | 2.11e-09 | 90 |
GO:0042255113 | Thyroid | PTC | ribosome assembly | 43/5968 | 61/18723 | 6.72e-10 | 2.04e-08 | 43 |
GO:0000027113 | Thyroid | PTC | ribosomal large subunit assembly | 20/5968 | 27/18723 | 8.23e-06 | 9.43e-05 | 20 |
GO:01400536 | Thyroid | PTC | mitochondrial gene expression | 51/5968 | 108/18723 | 6.04e-04 | 3.83e-03 | 51 |
GO:00325437 | Thyroid | PTC | mitochondrial translation | 38/5968 | 76/18723 | 7.52e-04 | 4.67e-03 | 38 |
GO:002261334 | Thyroid | ATC | ribonucleoprotein complex biogenesis | 292/6293 | 463/18723 | 3.05e-39 | 9.63e-36 | 292 |
Page: 1 2 3 4 5 6 7 8 9 10 11 12 13 14 15 |
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Pathway ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | qvalue | Count |
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Cell-cell communication analysis |
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Ligand | Receptor | LRpair | Pathway | Tissue | Disease Stage |
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Single-cell gene regulatory network inference analysis |
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TF | Cell Type | Tissue | Disease Stage | Target Gene | RSS | Regulon Activity |
∗The dot plots of a searched regulon are shown for all cell subpopulations in each disease state of each tissue based on the regulon specific score inferred using pySCENIC and by calculating the average expression. |
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Somatic mutation of malignant transformation related genes |
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Hugo Symbol | Variant Class | Variant Classification | dbSNP RS | HGVSc | HGVSp | HGVSp Short | SWISSPROT | BIOTYPE | SIFT | PolyPhen | Tumor Sample Barcode | Tissue | Histology | Sex | Age | Stage | Therapy Types | Drugs | Outcome |
FASTK | SNV | Missense_Mutation | novel | c.1490C>G | p.Ser497Trp | p.S497W | Q14296 | protein_coding | deleterious(0) | probably_damaging(1) | TCGA-C8-A138-01 | Breast | breast invasive carcinoma | Female | <65 | III/IV | Unknown | Unknown | SD |
FASTK | SNV | Missense_Mutation | c.1298N>A | p.Leu433Gln | p.L433Q | Q14296 | protein_coding | deleterious(0.02) | probably_damaging(0.977) | TCGA-E9-A1ND-01 | Breast | breast invasive carcinoma | Female | >=65 | I/II | Hormone Therapy | aromasin | SD | |
FASTK | SNV | Missense_Mutation | novel | c.94C>T | p.Pro32Ser | p.P32S | Q14296 | protein_coding | tolerated_low_confidence(0.1) | benign(0.011) | TCGA-2W-A8YY-01 | Cervix | cervical & endocervical cancer | Female | <65 | I/II | Chemotherapy | cisplatin | CR |
FASTK | SNV | Missense_Mutation | rs374560885 | c.1541N>T | p.Pro514Leu | p.P514L | Q14296 | protein_coding | tolerated(0.05) | benign(0.007) | TCGA-JW-A5VI-01 | Cervix | cervical & endocervical cancer | Female | <65 | I/II | Chemotherapy | topotecan | PD |
FASTK | SNV | Missense_Mutation | rs774195132 | c.1627N>T | p.Arg543Cys | p.R543C | Q14296 | protein_coding | tolerated_low_confidence(0.25) | benign(0) | TCGA-A6-5657-01 | Colorectum | colon adenocarcinoma | Male | >=65 | III/IV | Ancillary | leucovorin | SD |
FASTK | SNV | Missense_Mutation | novel | c.1229N>A | p.Arg410His | p.R410H | Q14296 | protein_coding | tolerated(0.18) | benign(0.086) | TCGA-AZ-4315-01 | Colorectum | colon adenocarcinoma | Male | <65 | I/II | Unknown | Unknown | SD |
FASTK | SNV | Missense_Mutation | c.328N>T | p.Arg110Cys | p.R110C | Q14296 | protein_coding | tolerated_low_confidence(0.22) | benign(0) | TCGA-CK-4951-01 | Colorectum | colon adenocarcinoma | Female | >=65 | I/II | Unknown | Unknown | PD | |
FASTK | deletion | In_Frame_Del | novel | c.456_458delCTT | p.Phe153del | p.F153del | Q14296 | protein_coding | TCGA-5M-AAT4-01 | Colorectum | colon adenocarcinoma | Male | >=65 | III/IV | Unknown | Unknown | PD | ||
FASTK | deletion | Frame_Shift_Del | c.1224delN | p.Leu409CysfsTer14 | p.L409Cfs*14 | Q14296 | protein_coding | TCGA-CK-5916-01 | Colorectum | colon adenocarcinoma | Female | >=65 | I/II | Unknown | Unknown | PD | |||
FASTK | SNV | Missense_Mutation | novel | c.1411C>G | p.Arg471Gly | p.R471G | Q14296 | protein_coding | tolerated(0.39) | benign(0) | TCGA-2E-A9G8-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | <65 | III/IV | Chemotherapy | taxol | CR |
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Related drugs of malignant transformation related genes |
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(DGIdb 4.0) |
Entrez ID | Symbol | Category | Interaction Types | Drug Claim Name | Drug Name | PMIDs |
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