Tissue | Expression Dynamics | Abbreviation |
Colorectum (GSE201348) | ![The image shows the transcriptomic changes along malignancy continuum.log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage.](images/deg_images/Colorectum/Becker/DISC1_pca_on_diff_genes.png) | FAP: Familial adenomatous polyposis |
CRC: Colorectal cancer |
Colorectum (HTA11) | ![The image shows the transcriptomic changes along malignancy continuum.log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage.](images/deg_images/Colorectum/Chen/DISC1_pca_on_diff_genes.png) | AD: Adenomas |
SER: Sessile serrated lesions |
MSI-H: Microsatellite-high colorectal cancer |
MSS: Microsatellite stable colorectal cancer |
Endometrium | ![The image shows the transcriptomic changes along malignancy continuum.log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage.](images/deg_images/Endometrium/DISC1_pca_on_diff_genes.png) | AEH: Atypical endometrial hyperplasia |
EEC: Endometrioid Cancer |
Lung | ![The image shows the transcriptomic changes along malignancy continuum.log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage.](images/deg_images/Lung/DISC1_pca_on_diff_genes.png) | AAH: Atypical adenomatous hyperplasia |
AIS: Adenocarcinoma in situ |
IAC: Invasive lung adenocarcinoma |
MIA: Minimally invasive adenocarcinoma |
GO ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | Count |
GO:00109754 | Colorectum | CRC | regulation of neuron projection development | 82/2078 | 445/18723 | 2.51e-06 | 1.19e-04 | 82 |
GO:00107204 | Colorectum | CRC | positive regulation of cell development | 60/2078 | 298/18723 | 3.27e-06 | 1.47e-04 | 60 |
GO:00071604 | Colorectum | CRC | cell-matrix adhesion | 50/2078 | 233/18723 | 3.28e-06 | 1.47e-04 | 50 |
GO:00485883 | Colorectum | CRC | developmental cell growth | 50/2078 | 234/18723 | 3.73e-06 | 1.61e-04 | 50 |
GO:19033625 | Colorectum | CRC | regulation of cellular protein catabolic process | 53/2078 | 255/18723 | 4.58e-06 | 1.87e-04 | 53 |
GO:00486383 | Colorectum | CRC | regulation of developmental growth | 64/2078 | 330/18723 | 5.74e-06 | 2.26e-04 | 64 |
GO:00313464 | Colorectum | CRC | positive regulation of cell projection organization | 67/2078 | 353/18723 | 7.45e-06 | 2.72e-04 | 67 |
GO:00019544 | Colorectum | CRC | positive regulation of cell-matrix adhesion | 19/2078 | 58/18723 | 8.80e-06 | 3.11e-04 | 19 |
GO:19901382 | Colorectum | CRC | neuron projection extension | 39/2078 | 172/18723 | 9.95e-06 | 3.31e-04 | 39 |
GO:00507673 | Colorectum | CRC | regulation of neurogenesis | 68/2078 | 364/18723 | 1.11e-05 | 3.62e-04 | 68 |
GO:00163584 | Colorectum | CRC | dendrite development | 50/2078 | 243/18723 | 1.13e-05 | 3.67e-04 | 50 |
GO:00600704 | Colorectum | CRC | canonical Wnt signaling pathway | 59/2078 | 303/18723 | 1.15e-05 | 3.74e-04 | 59 |
GO:00486753 | Colorectum | CRC | axon extension | 30/2078 | 120/18723 | 1.40e-05 | 4.40e-04 | 30 |
GO:00433935 | Colorectum | CRC | regulation of protein binding | 42/2078 | 196/18723 | 2.01e-05 | 5.90e-04 | 42 |
GO:00301773 | Colorectum | CRC | positive regulation of Wnt signaling pathway | 33/2078 | 140/18723 | 2.01e-05 | 5.90e-04 | 33 |
GO:00457325 | Colorectum | CRC | positive regulation of protein catabolic process | 47/2078 | 231/18723 | 2.75e-05 | 7.49e-04 | 47 |
GO:00459274 | Colorectum | CRC | positive regulation of growth | 51/2078 | 259/18723 | 3.23e-05 | 8.27e-04 | 51 |
GO:19030505 | Colorectum | CRC | regulation of proteolysis involved in cellular protein catabolic process | 45/2078 | 221/18723 | 3.96e-05 | 9.60e-04 | 45 |
GO:00507703 | Colorectum | CRC | regulation of axonogenesis | 34/2078 | 154/18723 | 6.37e-05 | 1.39e-03 | 34 |
GO:00486393 | Colorectum | CRC | positive regulation of developmental growth | 37/2078 | 174/18723 | 7.23e-05 | 1.53e-03 | 37 |
Hugo Symbol | Variant Class | Variant Classification | dbSNP RS | HGVSc | HGVSp | HGVSp Short | SWISSPROT | BIOTYPE | SIFT | PolyPhen | Tumor Sample Barcode | Tissue | Histology | Sex | Age | Stage | Therapy Types | Drugs | Outcome |
DISC1 | SNV | Missense_Mutation | | c.613G>T | p.Ala205Ser | p.A205S | Q9NRI5 | protein_coding | tolerated(0.69) | benign(0.055) | TCGA-A7-A26G-01 | Breast | breast invasive carcinoma | Female | <65 | I/II | Chemotherapy | taxotere | SD |
DISC1 | SNV | Missense_Mutation | | c.2300N>C | p.Gln767Pro | p.Q767P | | protein_coding | tolerated(0.29) | probably_damaging(0.935) | TCGA-A8-A08F-01 | Breast | breast invasive carcinoma | Female | <65 | III/IV | Chemotherapy | 5-fluorouracil | CR |
DISC1 | SNV | Missense_Mutation | | c.878C>G | p.Ser293Cys | p.S293C | Q9NRI5 | protein_coding | deleterious(0.04) | probably_damaging(0.964) | TCGA-AC-A23H-01 | Breast | breast invasive carcinoma | Female | >=65 | I/II | Unknown | Unknown | PD |
DISC1 | SNV | Missense_Mutation | novel | c.1698N>C | p.Met566Ile | p.M566I | Q9NRI5 | protein_coding | tolerated(0.24) | benign(0.137) | TCGA-AC-A5XS-01 | Breast | breast invasive carcinoma | Female | >=65 | I/II | Hormone Therapy | femara | SD |
DISC1 | insertion | In_Frame_Ins | novel | c.981_982insGACCCGCGATGTCTCTCTCAGCCCTTCAGTCTCTTGGCT | p.Asp327_Thr328insAspProArgCysLeuSerGlnProPheSerLeuLeuAla | p.D327_T328insDPRCLSQPFSLLA | Q9NRI5 | protein_coding | | | TCGA-A8-A09E-01 | Breast | breast invasive carcinoma | Female | >=65 | III/IV | Hormone Therapy | anastrozole | SD |
DISC1 | deletion | Frame_Shift_Del | novel | c.851delG | p.Ser284ThrfsTer59 | p.S284Tfs*59 | Q9NRI5 | protein_coding | | | TCGA-D8-A27V-01 | Breast | breast invasive carcinoma | Female | <65 | I/II | Hormone Therapy | tamoxiphen | SD |
DISC1 | SNV | Missense_Mutation | | c.2002A>G | p.Thr668Ala | p.T668A | | protein_coding | tolerated(0.68) | benign(0.068) | TCGA-C5-A3HE-01 | Cervix | cervical & endocervical cancer | Female | <65 | I/II | Unknown | Unknown | PD |
DISC1 | insertion | Frame_Shift_Ins | novel | c.1976_1977insA | p.Tyr660LeufsTer2 | p.Y660Lfs*2 | Q9NRI5 | protein_coding | | | TCGA-DS-A1OA-01 | Cervix | cervical & endocervical cancer | Female | >=65 | I/II | Chemotherapy | carboplatin | PD |
DISC1 | insertion | Frame_Shift_Ins | novel | c.1978_1979insTTGAGATT | p.Tyr660PhefsTer57 | p.Y660Ffs*57 | Q9NRI5 | protein_coding | | | TCGA-DS-A1OA-01 | Cervix | cervical & endocervical cancer | Female | >=65 | I/II | Chemotherapy | carboplatin | PD |
DISC1 | SNV | Missense_Mutation | | c.2339N>T | p.Ser780Ile | p.S780I | | protein_coding | deleterious(0.01) | possibly_damaging(0.839) | TCGA-AA-3672-01 | Colorectum | colon adenocarcinoma | Female | >=65 | III/IV | Unknown | Unknown | SD |