Tissue | Expression Dynamics | Abbreviation |
Esophagus | | ESCC: Esophageal squamous cell carcinoma |
HGIN: High-grade intraepithelial neoplasias |
LGIN: Low-grade intraepithelial neoplasias |
Liver | | HCC: Hepatocellular carcinoma |
NAFLD: Non-alcoholic fatty liver disease |
Oral Cavity | | EOLP: Erosive Oral lichen planus |
LP: leukoplakia |
NEOLP: Non-erosive oral lichen planus |
OSCC: Oral squamous cell carcinoma |
Skin | | AK: Actinic keratosis |
cSCC: Cutaneous squamous cell carcinoma |
SCCIS:squamous cell carcinoma in situ |
Thyroid | | ATC: Anaplastic thyroid cancer |
HT: Hashimoto's thyroiditis |
PTC: Papillary thyroid cancer |
GO ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | Count |
GO:004348812 | Lung | AIS | regulation of mRNA stability | 30/1849 | 158/18723 | 3.46e-04 | 6.25e-03 | 30 |
GO:006101312 | Lung | AIS | regulation of mRNA catabolic process | 31/1849 | 166/18723 | 3.77e-04 | 6.61e-03 | 31 |
GO:004348712 | Lung | AIS | regulation of RNA stability | 31/1849 | 170/18723 | 5.76e-04 | 8.97e-03 | 31 |
GO:006101412 | Lung | AIS | positive regulation of mRNA catabolic process | 19/1849 | 87/18723 | 7.09e-04 | 1.04e-02 | 19 |
GO:001058612 | Lung | AIS | miRNA metabolic process | 9/1849 | 27/18723 | 7.88e-04 | 1.11e-02 | 9 |
GO:000640112 | Lung | AIS | RNA catabolic process | 44/1849 | 278/18723 | 1.15e-03 | 1.47e-02 | 44 |
GO:006115712 | Lung | AIS | mRNA destabilization | 18/1849 | 84/18723 | 1.22e-03 | 1.55e-02 | 18 |
GO:005077912 | Lung | AIS | RNA destabilization | 18/1849 | 88/18723 | 2.13e-03 | 2.30e-02 | 18 |
GO:001058711 | Lung | AIS | miRNA catabolic process | 5/1849 | 12/18723 | 4.08e-03 | 3.65e-02 | 5 |
GO:190331132 | Lung | MIAC | regulation of mRNA metabolic process | 45/967 | 288/18723 | 2.75e-11 | 4.70e-08 | 45 |
GO:000989632 | Lung | MIAC | positive regulation of catabolic process | 54/967 | 492/18723 | 1.42e-07 | 3.64e-05 | 54 |
GO:000641733 | Lung | MIAC | regulation of translation | 51/967 | 468/18723 | 3.94e-07 | 6.52e-05 | 51 |
GO:003133132 | Lung | MIAC | positive regulation of cellular catabolic process | 46/967 | 427/18723 | 2.00e-06 | 2.44e-04 | 46 |
GO:004348831 | Lung | MIAC | regulation of mRNA stability | 23/967 | 158/18723 | 6.62e-06 | 6.29e-04 | 23 |
GO:004348731 | Lung | MIAC | regulation of RNA stability | 24/967 | 170/18723 | 7.20e-06 | 6.53e-04 | 24 |
GO:006101331 | Lung | MIAC | regulation of mRNA catabolic process | 23/967 | 166/18723 | 1.52e-05 | 1.07e-03 | 23 |
GO:000640231 | Lung | MIAC | mRNA catabolic process | 28/967 | 232/18723 | 2.65e-05 | 1.66e-03 | 28 |
GO:190331322 | Lung | MIAC | positive regulation of mRNA metabolic process | 17/967 | 118/18723 | 1.17e-04 | 4.92e-03 | 17 |
GO:006115722 | Lung | MIAC | mRNA destabilization | 13/967 | 84/18723 | 3.55e-04 | 1.04e-02 | 13 |
GO:006101422 | Lung | MIAC | positive regulation of mRNA catabolic process | 13/967 | 87/18723 | 5.03e-04 | 1.34e-02 | 13 |
TF | Cell Type | Tissue | Disease Stage | Target Gene | RSS | Regulon Activity |
DIS3 | TFH | Endometrium | EEC | TFIP11,SNHG9,NBEAL1, etc. | 5.05e-02 | |
DIS3 | TH17 | Endometrium | EEC | TFIP11,SNHG9,NBEAL1, etc. | 3.02e-02 | |
DIS3 | TREG | Lung | IAC | H1F0,VDR,FUT11, etc. | 2.01e-01 | |
DIS3 | MAIT | Lung | IAC | H1F0,VDR,FUT11, etc. | 4.77e-05 | |
DIS3 | BMEM | Lung | IAC | H1F0,VDR,FUT11, etc. | 6.06e-05 | |
DIS3 | MDSC | Lung | IAC | H1F0,VDR,FUT11, etc. | 9.15e-05 | |
DIS3 | INFIB | Thyroid | ADJ | ZC3H11A,CHMP4C,MTCO2P12, etc. | 4.20e-01 | |
DIS3 | ICAF | Thyroid | goiters | ZC3H11A,CHMP4C,MTCO2P12, etc. | 2.22e-16 | |
DIS3 | MSC.MVA | Thyroid | Healthy | ZC3H11A,CHMP4C,MTCO2P12, etc. | 3.56e-02 | |
DIS3 | ICAF | Thyroid | Healthy | ZC3H11A,CHMP4C,MTCO2P12, etc. | 0.00e+00 | |
Hugo Symbol | Variant Class | Variant Classification | dbSNP RS | HGVSc | HGVSp | HGVSp Short | SWISSPROT | BIOTYPE | SIFT | PolyPhen | Tumor Sample Barcode | Tissue | Histology | Sex | Age | Stage | Therapy Types | Drugs | Outcome |
DIS3 | SNV | Missense_Mutation | | c.2066N>A | p.Arg689Gln | p.R689Q | Q9Y2L1 | protein_coding | deleterious(0) | probably_damaging(0.976) | TCGA-AN-A046-01 | Breast | breast invasive carcinoma | Female | >=65 | I/II | Unknown | Unknown | SD |
DIS3 | SNV | Missense_Mutation | | c.1001T>C | p.Val334Ala | p.V334A | Q9Y2L1 | protein_coding | tolerated(0.82) | benign(0) | TCGA-BH-A0DX-01 | Breast | breast invasive carcinoma | Female | <65 | I/II | Chemotherapy | taxotere | CR |
DIS3 | SNV | Missense_Mutation | rs760670933 | c.616G>A | p.Glu206Lys | p.E206K | Q9Y2L1 | protein_coding | tolerated(0.33) | benign(0.149) | TCGA-BH-A1F8-01 | Breast | breast invasive carcinoma | Female | >=65 | III/IV | Unknown | Unknown | PD |
DIS3 | SNV | Missense_Mutation | | c.1662N>G | p.Asp554Glu | p.D554E | Q9Y2L1 | protein_coding | tolerated(0.21) | benign(0.018) | TCGA-BH-A1FN-01 | Breast | breast invasive carcinoma | Female | <65 | I/II | Unknown | Unknown | PD |
DIS3 | insertion | Frame_Shift_Ins | novel | c.2032dupA | p.Ile678AsnfsTer3 | p.I678Nfs*3 | Q9Y2L1 | protein_coding | | | TCGA-AN-A0AK-01 | Breast | breast invasive carcinoma | Female | >=65 | I/II | Unknown | Unknown | SD |
DIS3 | deletion | Frame_Shift_Del | novel | c.527delN | p.Asn176MetfsTer10 | p.N176Mfs*10 | Q9Y2L1 | protein_coding | | | TCGA-EW-A2FV-01 | Breast | breast invasive carcinoma | Female | <65 | III/IV | Chemotherapy | docetaxel | SD |
DIS3 | SNV | Missense_Mutation | novel | c.2257T>C | p.Tyr753His | p.Y753H | Q9Y2L1 | protein_coding | deleterious(0) | probably_damaging(1) | TCGA-2W-A8YY-01 | Cervix | cervical & endocervical cancer | Female | <65 | I/II | Chemotherapy | cisplatin | CR |
DIS3 | SNV | Missense_Mutation | rs757306363 | c.1831C>T | p.Arg611Cys | p.R611C | Q9Y2L1 | protein_coding | deleterious(0) | probably_damaging(1) | TCGA-2W-A8YY-01 | Cervix | cervical & endocervical cancer | Female | <65 | I/II | Chemotherapy | cisplatin | CR |
DIS3 | SNV | Missense_Mutation | novel | c.2164N>A | p.Ala722Thr | p.A722T | Q9Y2L1 | protein_coding | deleterious(0) | probably_damaging(0.979) | TCGA-EA-A3HS-01 | Cervix | cervical & endocervical cancer | Female | <65 | I/II | Unknown | Unknown | SD |
DIS3 | SNV | Missense_Mutation | | c.2348C>T | p.Ala783Val | p.A783V | Q9Y2L1 | protein_coding | deleterious(0.01) | benign(0.247) | TCGA-AA-3819-01 | Colorectum | colon adenocarcinoma | Female | <65 | I/II | Unknown | Unknown | SD |